Comparative Pharmacokinetics and Pharmacodynamics of Two Recombinant Human Interferon Beta la (IFNβ-1a) Products Administered Intramuscularly in Healthy Male and Female Volunteers Silvano Fumero Letter to the Editor Pages: 1 - 1
Comparative Pharmacokinetics and Pharmacodynamics of Two Recombinant Human Interferon Beta la (IFNβ-1a) Products Administered Intramuscularly in Healthy Male and Female Volunteers Ernest C. Borden Letter to the Editor Pages: 2 - 3
Evaluation of the Proposed FDA Pilot Dose-response Methodology for Topical Corticosteroid Bioequivalence Testing Gur Jai Pal SinghNicholas FleischerRoger Williams Letter to the Editor Pages: 4 - 7
Education in Pharmaceutical Sciences Needs a Brand New Direction to Meet the Challenges of Drug Research and Development Abu T. M. Serajuddin Commentary Pages: 8 - 10
Dissolution Testing as a Prognostic Tool for Oral Drug Absorption: Immediate Release Dosage Forms Jennifer B. DressmanGordon L. AmidonVinod P. Shah ReviewPaper Pages: 11 - 22
The How and Why of Protein-carbohydrate Interaction: A Primer to the Theoretical Concept and a Guide to Application in Drug Design Hans-Joachim Gabius ReviewPaper Pages: 23 - 30
Design, Synthesis, and Biological Evaluation of Spider Toxin (Argiotoxin-636) Analogs as NMDA Receptor Antagonists Scott T. MoeDaryl L. SmithAlan L. Mueller OriginalPaper Pages: 31 - 38
Synthesis and Anti-inflammatory Effect of Chalcones and Related Compounds Hsin-Kaw HsiehTai-Hua LeeChun-Nan Lin OriginalPaper Pages: 39 - 46
Human Drug Absorption Kinetics and Comparison to Caco-2 Monolayer Permeabilities James E. PolliMark J. Ginski OriginalPaper Pages: 47 - 52
Modulation of the Tight Junctions of the Caco-2 Cell Monolayers by H2-antagonists Liang-Shang L. GanSouzan YanniDhiren R. Thakker OriginalPaper Pages: 53 - 57
Influence of Chitosan Microspheres on the Transport of Prednisolone Sodium Phosphate Across HT-29 Cell Monolayers Frank Ch. MoorenAchim BertholdJörg Kreuter OriginalPaper Pages: 58 - 65
The Influence of Intestinal Mucus Components on the Diffusion of Drugs Agneta Wikman LarhedPer ArturssonErik Björk OriginalPaper Pages: 66 - 71
Effects of Organic Anions and Bile Acid Conjugates on Biliary Excretion of Pravastatin in the Rat Satoko FukumuraHajime TakikawaMasami Yamanaka OriginalPaper Pages: 72 - 76
Nasal Absorption Kinetic Behavior of Azetirelin and Its Enhancement by Acylcarnitines in Rats Seiya KagataniNoriko InabaTakashi Sonobe OriginalPaper Pages: 77 - 81
Human Cadaver Skin Viability for In Vitro Percutaneous Absorption: Storage and Detrimental Effects of Heat-Separation and Freezing Ronald C. WesterJulie ChristoffelJames Forsell OriginalPaper Pages: 82 - 84
Low Intensity Ultrasound as a Probe to Elucidate the Relative Follicular Contribution to Total Transdermal Absorption V. M. MeidanM. DockerW. J. Irwin OriginalPaper Pages: 85 - 92
Rapid Determination of Oral Pharmacokinetics and Plasma Free Fraction Using Cocktail Approaches: Methods and Application Mary C. AlienToral S. ShahWesley W. Day OriginalPaper Pages: 93 - 97
Evaluation of Bioequivalence of Highly Variable Drugs Using Clinical Trial Simulations. II: Comparison of Single and Multiple-Dose Trials Using AUC and Cmax Ahmed A. El-TahtawyThomas N. TozerRoger Williams OriginalPaper Pages: 98 - 104
Health Status Utility Assessment by Standard Gamble: A Comparison of the Probability Equivalence and the Lottery Equivalence Approaches Anandi V. LawDev S. PathakMark R. McCord OriginalPaper Pages: 105 - 109
A 31P CP/MAS NMR Study on Dehydration of Disodium Clodronate Tetrahydrate Juha T. TimonenEsko PohjalaTuula T. Pakkanen OriginalPaper Pages: 110 - 115
Terplex DNA Delivery System As a Gene Carrier Jin-Seok KimAtsushi MaruyamaSung Wan Kim OriginalPaper Pages: 116 - 121
Cytostatic and Apoptotic Effects of Paclitaxel in Human Ovarian Tumors Nancy J. MillenbaughYuebo GanJessie L.-S. Ail OriginalPaper Pages: 122 - 127
Effect of Particle Size and Charge on the Disposition of Lipid Carriers After Intratumoral Injection into Tissue-isolated Tumors Takehiko NomuraNoriko KoreedaMitsuru Hashida OriginalPaper Pages: 128 - 132
Determination of Free Extracellular Levels of Methotrexate by Microdialysis in Muscle and Solid Tumor of the Rabbit Sylvain DukicMatthieu L. KaltenbachRichard Vistelle OriginalPaper Pages: 133 - 138
Tissue Disposition of Zidovudine and Its Phosphorylated Metabolites in Zidovudine-treated Healthy and Retrovirus Infected Mice Hsiao-Hui ChowGary BrookshierPing Li OriginalPaper Pages: 139 - 144
Unusual Reduction of the In Vitro Skin Permeation of [3H]dexetimide by Atropine Ingrid J. BosmanKees EnsingRokus A. de Zeeuw BriefCommunication Pages: 145 - 148
The Effect of Jet-Milling on Lyophilized Liposomes W. Cary Mobley BriefCommunication Pages: 149 - 152
Utilizing Bacterial Mechanisms of Epithelial Cell Entry: Invasin-induced Oral Uptake of Latex Nanoparticles Nasir HussainAlexander T. Florence BriefCommunication Pages: 153 - 156