News from the National Institute of General Medical Sciences (NIGMS) Rochelle M. Long News Pages: 1 - 1
Tumor Vascular Endothelium: Barrier or Target in Tumor Directed Drug Delivery and Immunotherapy Grietje MolemaLou F. M. H. de LeijDirk K. F. Meijer ReviewPaper Pages: 2 - 10
Esterase-Sensitive Cyclic Prodrugs of Peptides: Evaluation of a Phenylpropionic Acid Promoiety in a Model Hexapeptide Giovanni M. PaulettiSanjeev GangwarRonald T. Borchardt OriginalPaper Pages: 11 - 17
Influence of Fluorescent Labelling of Polystyrene Particles on Phagocytic Uptake, Surface Hydrophobicity, and Plasma Protein Adsorption Rainer H. MüllerDörte RühlBernd.-R. Paulke OriginalPaper Pages: 18 - 24
Assembly and Dissociation of Human Insulin and LysB28ProB29-Insulin Hexamers: A Comparison Study Duane T. BirnbaumMaureen A. KilcomonsJohn M. Beals OriginalPaper Pages: 25 - 36
Tensioactivity and Supramolecular Organization of the Palmitoyl Prodrug of Timolol Brigitte PechJacques-Emile ProustJean-Pierre Benoit OriginalPaper Pages: 37 - 41
In Vitro Human Skin Barrier Modulation by Fatty Acids: Skin Permeation and Thermal Analysis Studies Hanafi TanojoJoke A. BouwstraHarry E. Boddé OriginalPaper Pages: 42 - 49
Selegiline Percutaneous Absorption in Various Species and Metabolism by Human Skin Shashank RohatagiJeffrey S. BarrettAnthony R. DiSanto OriginalPaper Pages: 50 - 55
In Vivo Evaluation of Acyclovir Prodrug Penetration and Metabolism Through Rat Skin Using a Diffusion/Bioconversion Model Hiroto BandoMikiko SahashiMitsuru Hashida OriginalPaper Pages: 56 - 62
Drug Reservoir Composition and Transport of Salmon Calcitonin in Transdermal Iontophoresis Patrizia SantiPaolo ColomboNadia Maria Volpato OriginalPaper Pages: 63 - 66
Extrahepatic Ischemia-Reperfusion Injury Reduces Hepatic Oxidative Drug Metabolism as Determined by Serial Antipyrine Clearance Bill J. GurleyGary W. BaroneAntionetta Harden OriginalPaper Pages: 67 - 72
Interaction Between Polyalkylcyanoacrylate Nanoparticles and Peritoneal Macrophages: MTT Metabolism, NET Reduction, and NO Production Teresa CruzRogério GasparCeleste Lopes OriginalPaper Pages: 73 - 79
Intravenous Infusion of RMP-7 Increases Ocular Uptake of Ganciclovir Peter J. ElliotRaymond T. BartusBerislav V. Zlokovic OriginalPaper Pages: 80 - 85
Renal Disposition of Recombinant Human Interleukin-11 in the Isolated Perfused Rat Kidney Akira TakagiYoshiyuki YabeMitsuru Hashida OriginalPaper Pages: 86 - 90
Prospective Use of Population Pharmacokinetics/ Pharmacodynamics in the Development of Cisatracurium Virginia D. SchmithJill Fiedler-KellyThaddeus H. Grasela Jr. OriginalPaper Pages: 91 - 97
Mirtazapine Pharmacokinetics with Two Dosage Regimens and Two Pharmaceutical Formulations Cees J. TimmerJan E. PaanakkerMaria Vrijmoed-de Vries OriginalPaper Pages: 98 - 102
The Use of Scintigraphy to Provide 'Proof of Concept' for Novel Polysaccharide Preparations Designed for Colonic Drug Delivery Dawn A. AdkinCarole J. KenyonIan R. Wilding OriginalPaper Pages: 103 - 107
Near-Infrared Spectroscopy as a Nondestructive Alternative to Conventional Tablet Hardness Testing Karen M. MorisseauChristopher T. Rhodes OriginalPaper Pages: 108 - 111
Nebulization of NanoCrystals™: Production of a Respirable Solid-in-Liquid-in-Air Colloidal Dispersion Timothy S. WiedmannLan DeCastroRay W. Wood Note Pages: 112 - 116