Intravenous Microdialysis in the Mouse and the Rat: Development and Pharmacokinetic Application of a New Probe Pierre A. EvrardG. DeridderRoger K. Verbeeck OriginalPaper Pages: 12 - 17
Concentration-Dependent Plasma Protein Binding of Flurbiprofen in the Rat: An in Vivo Microdialysis Study Pierre A. EvrardJean CumpsRoger K. Verbeeck OriginalPaper Pages: 18 - 22
An Integrated Method to Determine Epithelial Transport and Bioactivity of Oral Drug Candidates in Vitro Werner RubasMary E. M. CromwellKathleen A. Elias OriginalPaper Pages: 23 - 26
Targeting of Drug to the Hepatocytes by Fatty Acids. Influence of the Carrier (Albumin or Galactosylated Albumin) on the Fate of the Fatty Acids and Their Analogs Vinciane CharbonIsabella LatourBernard Gallez OriginalPaper Pages: 27 - 31
Albumin Nanospheres as Carriers for Passive Drug Targeting: An Optimized Manufacturing Technique Bernhard G. MüllerHans LeuenbergerThomas Kissel OriginalPaper Pages: 32 - 37
Pharmacokinetics and Biodistribution of Oligonucleotide Adsorbed onto Poly(isobutylcyanoacrylate) Nanoparticles After Intravenous Administration in Mice Yuichiro NakadaElias FattalPatrick Couvreur OriginalPaper Pages: 38 - 43
Physicochemical Characterization of Protein-Free Low Density Lipoprotein Models and Influence of Drug Loading Astrid GerkeKirsten WestesenMichel H. J. Koch OriginalPaper Pages: 44 - 51
The Influence of Buffer Species and Strength on Diltiazem HC1 Release from Beads Coated with the Aqueous Cationic Polymer Dispersions, Eudragit RS, RL 30D Roland BodmeierXiaodi GuoPaul F. Skultety OriginalPaper Pages: 52 - 56
Enhanced Cellular Uptake of Oligonucleotides by EGF Receptor-Mediated Endocytosis in A549 Cells Deepa DeshpandeDavid Toledo-VelasquezYon Rojanasakul OriginalPaper Pages: 57 - 61
Derivatives of Dexanabinol. I. Water-Soluble Salts of Glycinate Esters Emil PopZong Zheng LiuAnat Biegon OriginalPaper Pages: 62 - 69
Acyloxymethyl as a Drug Protecting Group. Part 3. Tertiary O-Amidomethyl Esters of Penicillin G: Chemical Hydrolysis and Anti-Bacterial Activity Rui MoreiraTeresa CalheirosJim Iley OriginalPaper Pages: 70 - 75
Effects of Phospholipid Chain Length, Concentration, Charge, and Vesicle Size on Pulmonary Insulin Absorption Yuping LiAshim K. Mitra OriginalPaper Pages: 76 - 79
Pulmonary Delivery of Salmon Calcitonin Dry Powders Containing Absorption Enhancers in Rats Shinzo KobayashiShuji KondoKazuhiko Juni OriginalPaper Pages: 80 - 83
A Pharmacokinetic Approach for Evaluating Cytokine Binding Macromolecules as Antagonists Murali Ramanathan OriginalPaper Pages: 84 - 90
Pharmacokinetic-Pharmacodynamic Modeling of the Antibiotic Effect of Piperacillin in Vitro Arno NoltingTeresa Dalla CostaHartmut Derendorf OriginalPaper Pages: 91 - 96
Interspecies Scaling of Bosentan, A New Endothelin Receptor Antagonist and Integration of in Vitro Data into Allometric Scaling Thierry LavePhilippe CoassoloRuby C. Chou OriginalPaper Pages: 97 - 101
Enteral Bioavailability of Human Granulocyte Colony Stimulating Factor Conjugated with Poly(ethylene glycol) Kathleen E. Jensen-PippoK. Lane WhitcombAlan D. Habberfield OriginalPaper Pages: 102 - 107
Determining Intestinal Metabolism and Permeability for Several Compounds in Rats. Implications on Regional Bioavailability in Humans Patrick J. SinkoPeidi Hu OriginalPaper Pages: 108 - 113
Intestinal Absorption Barriers and Transport Mechanisms, Including Secretory Transport, for a Cyclic Peptide, Fibrinogen Antagonist Bruce J. AungstHiroshi Saitoh OriginalPaper Pages: 114 - 119
In Vitro Permeability Through Caco-2 Cells is not Quantitatively Predictive of in Vivo Absorption for Peptide-Like Drugs Absorbed via the Dipeptide Transporter System Saeho ChongSandra A. DandoRichard A. Morrison OriginalPaper Pages: 120 - 123
First-Pass Metabolism of Diltiazem in Anesthetized Rabbits: Role of Extrahepatic Organs Marc LefebvreWalid HomsyPatrick du Souich OriginalPaper Pages: 124 - 128
Atom Level Electrotopological State Indexes in QSAR: Designing and Testing Antithyroid Agents Rafiq R. A. Abou-ShaabanHamad A. Al-KhameesAnthony. P. Simonelli OriginalPaper Pages: 129 - 136
FK506 (Tacrolimus) and Its Immunoreactive Metabolites in Whole Blood of Liver Transplant Patients and Subjects with Mild Hepatic Dysfunction Yuji TokunagaAla M. Alak OriginalPaper Pages: 137 - 140
Liposomal Methylprednisolone in Rats: Dose-Proportionality and Chronic-Dose Pharmacokinetics/Pharmacodynamics Elena V. MishinaWilliam J. Jusko OriginalPaper Pages: 141 - 145
Maltodextrins as Lyoprotectants in the Lyophilization of a Model Protein, LDH Sam CorveleynJean-Paul Remon OriginalPaper Pages: 146 - 150
Polymorphism of Sulfanilamide: (II) Stability Hierarchy of α-, β- and γ- Forms from Energy Calculations by the Atom-Atom Potential Method and from the Construction of the p, T Phase Diagram S. ToscaniA. DzyabchenkoR. Céolin OriginalPaper Pages: 151 - 154
Effect of Change in Shape Factor of a Single Crystal on Its Dissolution Behavior Mandar V. DaliJ. T. Carstensen OriginalPaper Pages: 155 - 162
Estimation of the Increase in Solubility of Drugs as a Function of Bile Salt Concentration Sabena D. MithaniVassiliki BakatselouJennifer B. Dressman OriginalPaper Pages: 163 - 167
Percutaneous Absorption of Ketoprofen from Different Anatomical Sites in Man Ajit K. ShahGreg WeiScott J. Weir OriginalPaper Pages: 168 - 172
The Effect of Octanoic Acid on the Binding of the Enantiomers of Ibuprofen and Naproxen to Human Serum Albumin: A Chromatographic Implication Vandana K. CheruvallathChristopher M. RileyJohn H. Perrin OriginalPaper Pages: 173 - 178
Triazolines 34. Structure and Stability Relationships of Novel Δ2-l,2,3-Triazoline Anticonvulsants Albert H. L. ChowFrancis C. K. ChiuPankaja K. Kadaba Note Pages: 179 - 182