Hydrolysis of Carbonates, Thiocarbonates, Carbamates, and Carboxylic Esters of α-Naphthol, β-Naphthol, and p-Nitrophenol by Human, Rat, and Mouse Liver Carboxylesterases Tien L. HuangAndrás SzékácsBruce D. Hammock OriginalPaper Pages: 639 - 648
Formulation Design of Acidic Fibroblast Growth Factor P. K. TsaiDavid B. VolkinC. Russell Middaugh OriginalPaper Pages: 649 - 659
Enkephalin Antisense Peptides: Design, Synthesis, and Biological Activity Pravin K. MisraWahajul HaqBhola N. Dhawan OriginalPaper Pages: 660 - 661
Decomposition of Arteether in Simulated Stomach Acid Yielding Compounds Retaining Antimalarial Activity John K. BakerJames D. McChesneyHsien Tao Chi OriginalPaper Pages: 662 - 666
Thyrotropin-Releasing Hormone (TRH) Uptake in Intestinal Brush-Border Membrane Vesicles: Comparison with Proton-Coupled Dipeptide and Na+-Coupled Glucose Transport David T. ThwaitesNicholas L. SimmonsBarry H. Hirst OriginalPaper Pages: 667 - 673
Passive Transepithelial Absorption of Thyrotropin-Releasing Hormone (TRH) via a Paracellular Route in Cultured Intestinal and Renal Epithelial Cell Lines David T. ThwaitesBarry H. HirstNicholas L. Simmons OriginalPaper Pages: 674 - 681
Nasal Insulin Delivery with Dimethyl-β-Cyclodextrin as an Absorption Enhancer in Rabbits: Powder More Effective than Liquid Formulations Nicolaas G. M. SchipperStefan G. RomeijnFrans W. H. M. Merkus OriginalPaper Pages: 682 - 686
Aggregates Formed During Storage of β-Galactosidase in Solution and in the Freeze-Dried State Sumie YoshiokaYukio AsoTadao Terao OriginalPaper Pages: 687 - 691
Development of a Sensitive Radioimmunoassay for Fab Fragments: Application to Fab Pharmacokinetics in Humans Corinne Vo Thanh-BarthetMichel UrtizbereaJean-Michel G. Scherrmann OriginalPaper Pages: 692 - 696
Hydrogel-Based lontotherapeutic Delivery Devices for Transdermal Delivery of Peptide/Protein Drugs Ajay K. BangaYie W. Chien OriginalPaper Pages: 697 - 702
Prolongation of the Circulation Time of Doxorubicin Encapsulated in Liposomes Containing a Polyethylene Glycol-Derivatized Phospholipid: Pharmacokinetic Studies in Rodents and Dogs Alberto A. GabizonYechezkel BarenholzMeir Bialer OriginalPaper Pages: 703 - 708
Absorption, Gastrointestinal Transit, and Tablet Erosion of Felodipine Extended-Release (ER) Tablets Bertil AbrahamssonMagne AlpstenJukka Tölli OriginalPaper Pages: 709 - 714
Targeted Delivery of a Heme Oxygenase Inhibitor with a Lyophilized Liposomal Tin Mesoporphyrin Formulation John B. CannonCarrie MartinAttallah Kappas OriginalPaper Pages: 715 - 721
The Effect of Meal Composition on the Gastrocolonic Response: Implications for Drug Delivery to the Colon Jennifer M. C. PriceStanley S. DavisIan R. Wilding OriginalPaper Pages: 722 - 726
Dose-Dependent Intestinal Absorption and Significant Intestinal Excretion (Exsorption) of the β-Blocker Pafenolol in the Rat Hans LennernäsCarl-Gunnar Regårdh OriginalPaper Pages: 727 - 731
The Development of a Predictive Method for the Estimation of Flux Through Polydimethylsiloxane Membranes. III. Application to a Series of Substituted Pyridines Meng-wei HuLloyd E. Matheson OriginalPaper Pages: 732 - 736
Effects of Solute Characteristics and Concentration on a Lyotropic Liquid Crystal: Solute-Induced Phase Change Hussein G. IbrahimEl-Sayed SallamMayssoun Habboub OriginalPaper Pages: 737 - 742
Drug Absorption Limited by P-Glycoprotein-Mediated Secretory Drug Transport in Human Intestinal Epithelial Caco-2 Cell Layers Janice HunterBarry H. HirstNicholas L. Simmons OriginalPaper Pages: 743 - 749
Influence of Poly(DL-Lactide) Nanocapsules on the Biliary Clearance and Enterohepatic Circulation of Indomethacin in the Rabbit Fawaz FawazFrançois BoniniJean-Philippe Devissaguet OriginalPaper Pages: 750 - 756
Pharmacokinetic Analysis of an Oral Sustained-Release Diltiazem Preparation Using Multifraction Absorption Models Kazuo MurataKazuo Noda OriginalPaper Pages: 757 - 762
Absorption of 2′, 3′-Dideoxyinosine from Lower Gastrointestinal Tract in Rats and Kinetic Evidence of Different Absorption Rates in Colon and Rectum Steven L. BramerM. Guillaume WientjesJessie L.-S. Au OriginalPaper Pages: 763 - 770
Simplified Synthesis of Mono(4-aminophenyl)-3′ -Thymidilic Acid Ester Used as Thymidine Kinase Specific Ligand for Affinity Chromatography Kurt EgerEberhard KlünderUlrich Schloz Note Pages: 771 - 773
The Influence of Free Fatty Acid Formation on the pH of Phospholipid-Stabilized Triglyceride Emulsions Clifford J. HermanMichael J. Groves Note Pages: 774 - 776
Theoretical Considerations for the Design and Development of a Drug: Influence of Pharmacokinetics and Dosage Regimen on Receptor Interactions Joyce MordentiAldo Rescigno Note Pages: 777 - 782