Abstract
This paper described the development of chitosan composites containing precipitated hydroxyapatite particles for potential applications in orthopaedic surgery or waste water treatment. The synthetic process and morphology of hydroxyapatite were reported. The effects of hydroxyapatite content on the microstructure and mechanical properties of composites were investigated. It was found that the Young’s Modulus of the composites decreases with hydroxyapatite content while the failure strength and strain increase with the hydroxyapatite content.
Article PDF
Similar content being viewed by others
Explore related subjects
Discover the latest articles, news and stories from top researchers in related subjects.Avoid common mistakes on your manuscript.
References
Dash M, Chiellini F, Ottenbrite RM, Chiellini E. Chitosan-A versatile semi-synthetic polymer in biomedical applications. Progress in Polymer Science 2011, 36: 981–1014.
MartÍnez-Camacho AP, Cortez-Rocha MO, Ezquerra-Brauer JM, Graciano-Verdugo AZ, Rodriguez-Félix F, Castillo-Ortega MM, Yépiz-Gómez MS, Plascencia-Jatomea M. Chitosan composite films: Thermal, structural, mechanical and antifungal properties. Carbohydrate Polymers 2010, 82: 305–315.
Berger J, Reist M, Mayer JM, Felt O, Gurny R. Structure and interactions in chitosan hydrogels formed by complexation or aggregation for biomedical applications. European Journal of Pharmaceutics and Biopharmaceutics 2004, 57: 35–52.
Huang X-J, Ge D, Xu Z-K. Preparation and characterization of stable chitosan nanofibrous membrane for lipase immobilization. European Polymer Journal 2007, 43: 3710–3718.
Enel S, McClure SJ. Potential applications of chitosan in veterinary medicine. Advanced Drug Delivery Reviews 2004, 56: 1467–1480.
Glerentes P, Vachoud L, Doury J, Domard A. Study of a chitin-based gel as injectable material in periodontal surgery. Biomaterials 2002, 23: 1295–1302.
Kean T, Thanou M. Biodegradation, biodistribution and toxicity of chitosan. Advanced Drug Delivery Reviews 2010, 62: 3–11.
Wan Ngah WS, Teong LC, Hanafiah MAKM. Adsorption of dyes and heavy metal ions by chitosan composites: A review. Carbohydrate Polymers 2011, 83: 1446–1456.
Aoki H. Science and Medical Applications of Hydroxyapatite. Japanese Association of Apatite Science, Tokyo, Japan, 1991.
Hench LL. Bioceramics: from concept to clinic. J Am Ceram Soc 1991, 74: 1487–1510.
Suchanek W, Yoshimura M. Processing and properties of hydroxyapatite-based biomaterials for use as hard tissue replacement implants. J Mater Res 1998, 13: 94–117.
With G de, Van Dijk HJA, Hattu N, Prijs K. Preparation, micro-structure and mechanical properties of dense polycrystalline hydroxy apatite. J Mater Sci 1981, 16: 1592–1598.
Yamashita K, Kanazawa T. Inorganic Phosphate Materials. In: Kanazawa T Ed. Kodansha & Elsevier, Tokyo and Amsterdam, 1989.
LeGeros RZ. Calcium Phosphates in Oral Biology and Medicine. Karger, Basel, Switzerland, 1991.
Murugan R, Ramakrishna S. Aqueous mediated synthesis of bioresorbable nanocrystalline hydroxyapatite. J Cryst Growth 2005, 274: 209–213.
Le HR, Chen KY, Wang CA. Effect of pH and temperature on the morphology and phases of co-precipitated hydroxyapatite. Submitted to J Sol-gel Sci Tech 2011.
Rothwell RA, Pridham MS, Thomson GA. Preparation and characterisation of novel polycaprolactone-chitosan blends. Inter J Med Engine and Inform 2011, 3: 264–274.
Author information
Authors and Affiliations
Corresponding author
Additional information
This article is published with open access at Springerlink.com
Rights and permissions
Open Access This article is distributed under the terms of the Creative Commons Attribution 2.0 International License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
About this article
Cite this article
Le, H.R., Qu, S., Mackay, R.E. et al. Fabrication and mechanical properties of chitosan composite membrane containing hydroxyapatite particles. J Adv Ceram 1, 66–71 (2012). https://doi.org/10.1007/s40145-012-0007-z
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s40145-012-0007-z