Abstract
Linezolid, the first of a new class of antibacterial drugs, the oxazolidinones, has inhibitory activity against a broad range of gram-positive aerobic cocci and also against certain anaerobes. Although diarrhea is one of the most frequently encountered adverse effects of linezolid, Clostridium difficile-related complications are very uncommon. One case of fatal C. difficile colitis in a patient with spondylodiscitis, who had received a long-term course of linezolid therapy, is presented. Colitis was able to be exclusively assigned to linezolid. Factors contributing to the colitis are discussed.
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Zabel, L.T., Worm, S. Linezolid Contributed to Clostridium difficile Colitis with Fatal Outcome. Infection 33, 155–157 (2005). https://doi.org/10.1007/s15010-005-4112-6
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DOI: https://doi.org/10.1007/s15010-005-4112-6