Abstract
Although sickle cell anemia in India is believed to have a mild clinical presentation, few studies report severe disease in many patients from central India. Hence, we have retrospectively studied 316 children with SCA who were followed up for a period of 5.8±5.7 years. There were 55.4 blood transfusions, 43.3 episodes of vaso-occlusive crises requiring hospitalization, and 108.9 hospitalizations per 100 person years. Ninety six (30%) patients had severe disease whereas 74 patients also fulfilled the criteria for hydroxyurea therapy. Significant proportion of children with sickle cell anemia from central India present with severe clinical presentation and require regular medical attention.
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References
Lehman H, Cutbush M. Sickle-cell trait in southern India. Brit Med J. 1952;1: 404–405.
Mohanty D, Mukherjee M. Sickle cell disease in India. Curr Opin Hematol. 2002;9:117–122.
Kar BC. Sickle cell disease in India. J Assoc Physicians India. 1991;39:954–960.
Mukherjee MB, Lu CY, Ducrocq R, Gangakhedkar RR, Colah RB, Kadam MD, et al. α-thalassemia on sicklecell anemia linked to the Arab-Indian haplotype in India. Am J Hematol. 1997;55:104–109.
Italia K, Jain D, Gattani S, Jijina F, Nadkarni A, Sawant P, et al. Hydroxyurea in sickle cell disease — A study of clinico-pharmacological efficacy in the Indian haplotype. Blood Cells Mol Dis. 2009;42:25–31.
Labie D, Rao S, Dunda O, Dode C, Lapourmeroullie C, Devi S, et al. Haplotypes in tribal Indians bearing the sickle gene: Evidence for the unicentric origin of the bs mutation and the unicentric origin of the tribal populations of India. Hum Biol. 1989;61:479–491.
Patel AB, Athavale AM. Sickle cell disease in central India. Indian J Pediatr. 2004;71:789–793.
Kar BC, Devi S. Clinical profile of sickle cell disease in Orissa. Indian J Pediatr. 1997;64:73–77.
Redwood AM, Williams EM, Desal P, Serjeant GR. Climate and painful crisis of sickle-cell disease in Jamaica. Br Med J. 1976;1:66–68.
Gill FM, Sleeper LA, Weiner SJ, Brown AK, Bellevue R, Grover R, et al. Clinical events in the first decade in a cohort of infants with sickle cell disease. CooperativeStudy of Sickle Cell Disease. Blood. 1995;86:776–783.
Miller ST, Sleeper LA, Pegelow CH, Enos LE, Wang WC, Weiner SJ, et al. Prediction of adverse outcomes in children with sickle cell disease. N Engl J Med. 2000;342:83–89.
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Jain, D., Italia, K., Sarathi, V. et al. Sickle cell anemia from central India: A retrospective analysis . Indian Pediatr 49, 911–913 (2012). https://doi.org/10.1007/s13312-012-0217-z
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DOI: https://doi.org/10.1007/s13312-012-0217-z