Abstract
Incorporation of aliphatic units to poly(butylene terephthalate) (PBT) gives rise to biodegradable copolymers with tunable properties (e.g., degradability), depending on the selected comonomer and the specific composition. Specifically, a low molecular weight poly(butylene sebacate-co-terephthalate) (PBSeT) with a high ratio of aliphatic sebacate units (i.e., 70 mol-% with respect to the total dicarboxylate content) has been employed in this work to get new electrospun biodegradable scaffolds. Appropriate electrospinning conditions have been found despite the limited copolymer molecular weight. In addition, PBSeT has been employed to improve biocompatibility and biodegradability of scaffolds based on the PBT homopolymer. Scaffolds with different properties have been prepared following two strategies: Electrospinning of single solutions of PBT and PBSeT mixtures and co-electrospinning of independent PBT and PBSeT solutions. Characterization involved spectroscopic (FTIR, NMR), calorimetric (DSC, TGA) and surface hydrophobicity analyses. Hydrolytic and enzymatic degradation studies demonstrated the success of the approach due to the susceptibility of the PBSeT component towards the enzymatic attack with lipases from Pseudomonas cepacia and even towards high temperature hydrolysis.
Article PDF
Similar content being viewed by others
Explore related subjects
Discover the latest articles, news and stories from top researchers in related subjects.Avoid common mistakes on your manuscript.
References
Z. Zhang, F. Zhang, X. Jiang, Y. Liu, Z. Guo, and J. Leng, Fiber Polym., 15, 2290 (2014).
R. Scaffaro, F. Lopresti, A. Maio, L. Botta, S. Rigogliuso, and G. Ghersi, Compos. Part A-Appl. S., 92, 97 (2017).
R. Scaffaro, A. Maio, F. Lopresti, and L. Botta, Polymers, 9, 76 (2017).
M. Leno, R. Su, J. Clarke, Y. Lou, and E. Mele, Eur. Polym. J., 87, 241 (2017).
J. Zhu, S. Wei, D. Rutman, N. Haldolaarachchige, D. P. Young, and Z. Guo, Polymer, 52, 2947 (2011).
X. Hu, S. Liu, G. Zhou, Y. Huang, Z. Xie, and X. Jing, J. Control. Release, 185, 12 (2014).
Y.-E. Miao, S. He, Y. Zhong, Z. Yang, W. W. Tjiu, and T. Liu, Electrochim. Acta, 99, 117 (2013).
M. Gorji, A. Jeddi, and A. A. Gharehaghaji, J. Appl. Polym. Sci., 125, 4135 (2012).
S. Zhang, W. S. Shim, and J. Kim, Mater. Design, 30, 3659 (2009).
P. Tahira, S. A. Arvidson, C. D. Saquing, S. S. Shah, and S. A. Khan, Langmuir, 28, 5834 (2012).
R. A. Caruso, J. H. Schattka, and A. Greiner, Adv. Mater., 13, 1577 (2001).
J. Yoon, Y.-S. Jung, and J.-M. Kim, Adv. Funct. Mater., 19, 209 (2009).
Y. Zhang, H. Ouyang, C. T. Lim, S. Ramakrishna, and Z.-M. Huang, J. Biomed. Mater. Res. B, 72, 156 (2005).
E. Llorens, L. J. del Valle, R. Ferrán, A. Rodríguez-Galán, and J. Puiggalí, J. Polym. Res., 21, 360 (2014).
E. Llorens, S. Bellmunt, L. J. del Valle, and J. Puiggalí, J. Polym. Res., 21, 603 (2014).
R. Scaffaro, F. Lopresti, and L. Botta, Eur. Polym. J., 96, 266 (2017).
M.-X. Ma, Q. Liu, C. Ye, B. Grottkau, B. Guo, and Y.-F. Song, BioMed Res. Int., Article ID 9251806 (2017).
S. Danti, C. Mota, D. D’alessandro, L. Trombi, C. Ricci, S. L. Redmond, A. De Vito, R. Pini, R. J. Dilley, L. Moroni, and S. Berrettini, Hearing Balance Commun., 13, 133 (2015).
B. Ding, E. Kimura, T. Sato, S. Fujita, and S. Shiratori, Polymer, 45, 1895 (2004).
G. Mingbo, K. Wang, W. Li, C. Qin, J.-J. Wang, and L. Dai, Fiber Polym., 12, 65 (2011).
E. Llorens, H. Ibañez, L. J. del Valle, and J. Puiggalí, Mat. Sci. Eng. C, 49, 472 (2015).
Z. Sun, E. Zussman, A. L. Yarin, J. H. Wendorff, and A. Greiner, Adv. Mater., 15, 1929 (2003).
Y. Zhang, Z.-M. Huang, X. Xu, C. T. Lim, and S. Ramakrishna, Chem. Mater., 16, 3406 (2004).
X.-F. Wu, A. Rahman, Z. Zhou, D. D. Pelot, S. Sinha-Ray, B. Chen, S. Payne, and A. L. Yarin, J. Appl. Polym. Sci., 129, 1383 (2013).
P. T. Bertuoli, J. Ordoño, E. Armelin, S. Pérez-Amodio, A. F. Baldissera, C. A. Ferreira, J. Puiggalí, E. Engel, L. J. del Valle, and C. Alemán, ACS Omega, 4, 3660 (2019).
N. Heidarzadeh, M. Rafizadeh, F. A. Taromi, L. J. del Valle, L. Franco, and J. Puiggalí, J. Polym., 8, 253 (2016).
N. Heidarzadeh, M. Rafizadeh, F. A. Taromi, L. J. del Valle, L. Franco, and J. Puiggalí, Polym. Degrad. Stab., 135, 18 (2017).
S. Guo, Q. Ke, H. Wang, X. Jin, and Y. Li, J. Appl. Polym. Sci., 128, 3652 (2013).
O. Saligheh, M. Forouharshad, R. Arasteh, R. Eslami-Farsani, R. Khajavi, and B. Y. Roudbari, J. Polym. Res., 20, 65 (2013).
J. Malda, T. B. F. Woodfield, F. van der Vloodt, C. Wilson, D. E. Martens, J. Tramper, C. A. van Blitterswijk, and J. Riesle, Biomaterials, 26, 63 (2005).
L. Moroni, J. R. de Wijn, and C. A. van Blitterswijk, J. Biomed. Mater. Res. A, 75, 957 (2005).
H. Qingpu, D. W. Grijpma, and J. Feijen, Biomaterials, 24, 1937 (2003).
C. J. Ellison, A. Phatak, D. W. Giles, C. W. Macosko, and F. S. Bates, Polymer, 48, 3306 (2007).
S. Chen, W. Yu, and J. E. Spruiell, J. Appl. Polym. Sci., 34, 1477 (1987).
S. Kadhiravan, Y. Y. Fang, D. Y. Chou, S. S. Sparks, J. Hibbert, and C. J. Ellison, ACS Macro Lett., 1, 960 (2012).
E. S. Cozza, Q. Ma, O. Monticelli, and P. Cebe, Eur. Polym. J., 49, 33 (2013).
L. H. Catalani, G. Collins, and M. Jaffe, Macromolecules, 40, 1693 (2007).
T. B. F. Woodfield, J. Malda, J. de Wijn, F. Peters, J. Riesle, and C. A. van Blitterswijk, Biomaterials, 25, 4149 (2004).
Y. Ikada and H. Tsuji, Macromol. Rapid Commun., 21, 117 (2000).
S. J. Hollister, Nat. Mater., 4, 518 (2005).
C. T. Laurencin, A. M. A. Ambrosio, M. D. Borden, and J. A. Cooper, Annu. Rev. Biomed. Eng., 1, 19 (1999).
E. J. Kim, G. D. Yeo, C. M. Pai, and I. K. Kang, J. Biomed. Mater. Res. B, 90, 849 (2009).
V. Tserki, J. Philippou, and C. Panayiotou, P. I. Mech. Eng. N., 220, 71 (2006).
E. H. Jeong, S. S. Im, and J. H. Youk, Polymer, 46, 9538 (2005).
F. Huang, Q. Wei, J. Wang, Y. Cai, and Y. Huang, e-Polymers, 8, 1 (2008).
L. J. del Valle, R. Camps, A. Díaz, L. Franco, A. Rodríguez-Galán, and J. Puiggalí, J. Polym. Res., 18, 1903 (2011).
S. L. Shenoy, W. D. Bates, H. L. Frisch, and G. E. Wnek, Polymer, 46, 3372 (2005).
R. M. Lum, J. Polym. Sci. A1, 17, 203 (1979).
F. Samperi, C. Puglisi, R. Alicata, and G. Montaudo, Polym. Degrad. Stab., 83, 11 (2004).
T. Koshiduka, T. Ohkawa, and K. Takeda, Polym. Degrad. Stab., 79, 1 (2003).
Author information
Authors and Affiliations
Corresponding authors
Additional information
Publisher’s Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Acknowledgments: J. Puiggalí, L. J. D. Valle, and L. Franco are thankful for the supports from MINECO and FEDER (RTI2018-101827-B-I00) and the Generalitat de Catalunya (2017SGR373).
Electronic supplementary material
Rights and permissions
About this article
Cite this article
Heidarzadeh, N., del Valle, L.J., Franco, L. et al. Improvement of Biodegradability and Biocompatibility of Electrospun Scaffolds of Poly(butylene terephthalate) by Incorporation of Sebacate Units. Macromol. Res. 28, 23–32 (2020). https://doi.org/10.1007/s13233-020-8009-0
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s13233-020-8009-0