Abstract
Background
The effects of Helicobacter pylori (H. pylori) infection on growth are a controversial issue. We investigated the effects of long-term H. pylori infection on height and weight in children.
Methods
A total of 200 children of 7-18 years old suffering from dyspeptic complaints were classified into two groups: H. pylori positive and negative groups, respectively. Whether the infection was impoved was followed up while performing urea breath test, and according to exposure time to the infection, the children were further divided into group 1 (≤1.5 months), group 2 (>1.5-≤6 months) and group 3 (>6 months). Antropometric measurements were obtained and repeated every six months.
Results
Mean growth velocity scores in the H. pylori positive and negative groups were 0.49±3.85 [95% confidence interval (CI): -0.21-1.18] and 1.98±4.42 (95% CI: 1-2.96), respectively. The difference between both groups was statistically significant (P=0.012). Mean growth velocity scores in groups 1, 2 and 3 were 0.96±3.84, 0.16±4.51 and -0.85±3.09, respectively. Mean growth velocity scores of group 3 were significantly lower than those of groups 0 and 1 (P=0.005 and P=0.041). The mean weight scores in group 3 were similar to those in group 2, but the scores in group 3 were significantly lower than those in group 1 (-1.75±1.05, -1.21±1.37 and -0.88±1.49, respectively).
Conclusion
As the duration of exposure is prolonged in children with H. pylori infection, the negative effect of the infection on both height and weight is evident.
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References
Mégraud F, Brassens-Rabbé MP, Denis F, Belbouri A, Hoa DQ. Seroepidemiology of Campylobacter pylori infection in various populations. J Clin Microbiol 1989;27:1870–1873.
Bravo LE, Mera R, Reina JC, Pradilla A, Alzate A, Fontham E, et al. Impact of Helicobacter pylori infection on growth of children: a prospective cohort study. J Pediatr Gastroenterol Nutr 2003;37:614–619.
Passaro DJ, Taylor DN, Gilman RH, Cabrera L, Parsonnet J. Growth slowing after acute Helicobacter pylori infection is agedependent. J Pediatr Gastroenterol Nutr 2002;35:522–526.
Mera RM, Correa P, Fontham EE, Reina JC, Pradilla A, Alzate A, et al. Effects of a new Helicobacter pylori infection on height and weight in Colombian children. Ann Epidemiol 2006;16:347–351.
Dehghani SM, Karamifar H, Raeesi T, Haghighat M. Growth parameters in children with dyspepsia symptoms and Helicobacter pylori infection. Indian Pediatr 2013;50:324–326.
Thomas JE, Dale A, Bunn JE, Harding M, Coward WA, Cole TJ, et al. Early Helicobacter pylori colonisation: the association with growth faltering in The Gambia. Arch Dis Child 2004;89:1149–1154.
Soylu OB, Ozturk Y. Helicobacter pylori infection: effect on malnutrition and growth failure in dyspeptic children. Eur J Pediatr 2008;167:557–562.
Ozçay F, Demir H, Ozen H, Gürakan F, Saltik IN, Yüce A, et al. Normal growth in young children with Helicobacter pylori infection. J Pediatr Gastroenterol Nutr 2002;35:102.
Choe YH, Kim SK, Hong YC. Helicobacter pylori infection with iron deficiency anaemia and subnormal growth at puberty. Arch Dis Child 2000;82:136–140.
Cuoco L, Cammarota G, Jorizzo RA, Cianci R, Gasbarrini G. Iron deficiency anaemia, Helicobacter pylori infection and delayed pubertal growth. Arch Dis Child 2000;83:456.
Kocaoglu C, Atabek ME, Cayci M, Kurku H, Ozel A. The Effect of Helicobacter Pylori Infection on Plasma Ghrelin and on Anthropometry Dyspeptic Children. Acta Endo (Buc) 2014;10:203–210.
Fialho AM, Braga AB, Queiroz DM, Rodrigues MN, Herbster ID, Braga LL. The association between Helicobacter pylori infection and height in children from an urban community in north-east Brazil. Ann Trop Paediatr 2007;27:55–61.
Sood MR, Joshi S, Akobeng AK, Mitchell J, Thomas AG. Growth in children with Helicobacter pylori infection and dyspepsia. Arch Dis Child 2005;90:1025–1028.
Neyzi O, Furman A, Bundak R, Gunoz H, Darendeliler F, Bas F. Growth references for Turkish children aged 6 to 18 years. Acta Paediatr 2006;95:1635–1641.
Tasar A, Kibrisli E, Dallar Y. Seroprevalence of Helicobacter pylori in children with constitutional height retardation. Turk J Gastroenterol 2006;17:7–12.
Chimonas MA, Baggett HC, Parkinson AJ, Muth PT, Dunaway E, Gessner BD. Asymptomatic Helicobacter pylori infection and iron deficiency are not associated with decreased growth among Alaska Native children aged 7-11 years. Helicobacter 2006;11:159–167.
Perri F, Pastore M, Leandro G, Clemente R, Ghoos Y, Peeters M, et al. Helicobacter pylori infection and growth delay in older children. Arch Dis Child 1997;77:46–49.
Mera RM, Bravo LE, Goodman KJ, Yepez MC, Correa P. Longterm effects of clearing Helicobacter pylori on growth in schoolage children. Pediatr Infect Dis J 2012;31:263–266.
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Kocaoglu, C., Ozel, A., Cayci, M. et al. Effect of long-term Helicobacter pylori infection on growth of children: a cohort study. World J Pediatr 12, 196–201 (2016). https://doi.org/10.1007/s12519-015-0021-7
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DOI: https://doi.org/10.1007/s12519-015-0021-7