Abstract
Purpose
The aim of this study was to investigate the association of anxiety and depression symptoms with health related quality of life (HRQoL) and sleep quality in patients with beta-thalassemia.
Methods
In a cross-sectional study between 2006 and 2007, 292 thalassemic patients were assessed for symptoms of anxiety and depression (Hospital Anxiety Depression Scale; HADS), HRQoL (Short Form-36, SF-36) and quality of sleep (Pittsburgh Sleep Quality Index; PSQI). Linear regression models were used to determine possible predictive value of high anxiety and depressive symptoms on HRQoL and sleep quality, separately.
Results
Mental and physical quality of life scores were predicted by symptoms of depression and somatic comorbidities. Total sleep quality was predicted by anxiety symptoms and somatic comorbidities.
Conclusions
Screening for anxiety and depression in patients with thalassemia is essential. Further studies should test if appropriate treatment of these conditions may improve patients HRQoL and sleep quality or not.
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References
Dubey AP, Parakh A. Dublish S (2008) Current Trends in the Management of Beta Thalassemia. Indian Journal of Pediatrics 75:7
Weatherall DJ, Clegg JB (2001) Inherited haemoglobin disorders: an increasing global health problem. Bulletin of the World Health Organization 79:704–712
Musallam, K, Cappellini, MD, Taher A (2008) Challenges associated with prolonged survival of patients with thalassemia: transitioning from childhood to adulthood. Pediatrics 121(5):426–e1429
Guasco G, La Mantia A, Cuniolo A (1987) Psychological problems of thalassemic subjects. Pediatr Med Chir 9: 269–279
Olsson CA, Bond L, Johnson MW, Forer DL, Boyce MF, Sawyer SM (2003) Adolescent chronic illness: a qualitative study of psychosocial adjustment. Ann Acad Med Singapore 32:43–50
Huurre TM, Aro HM (2002) Long-term psychosocial effects of persistent chronic illness. A follow-up study of Finnish adolescents aged 16 to 32 years. Eur Child Adolesc Psychiatry 11:85–91
Meijer SA, Sinnema G, Bijstra JO, Mellenbergh GJ, Wolters WH (2002) Coping styles and locus of control as predictors for psychological adjustment of adolescents with a chronic illness. Soc Sci Med 54(9):1453–1461
Shaligram D, Girimaji SC, Chaturvedi SK (2007) Psychological problems and quality of life in children with thalassemia. Indian J Pediatr 74:727–730
Smith EM, Gomm SA, Dickens CM (2003) Assessing the independent contribution to quality of life from anxiety and depression in patients with advanced cancer. Palliat Med 17:509
Redeker NS, Lev EL, Ruggiero J (2000) Insomnia, fatigue, anxiety, depression, and quality of life of cancer patients undergoing chemotherapy. Sch Inq Nurs Pract 14:275
Montazeri A, Vahdaninia M, Ebrahimi M, Jarvandi S (2003) The hospital anxiety and depression scale (HADS): translation and validation study of the Iranian version. Health Qual Life Outcomes 28(1):14
Zigmond, AS; Snaith, RP (1983) The hospital anxiety and depression scale. Acta Psychiatr Scand 67:361–370
Puhan MA, Frey M, Büchi S, Schünemann HJ (2008) The minimal important difference of the hospital anxiety and depression scale in patients with chronic obstructive pulmonary disease. Health Qual Life Outcomes 2(6):46
Ifudu O, Paul HR, et al. (1998) Predictive value of functional status for mortality in patients on maintenance hemodialysis. Am J Nephrol 18:109–116
Ware JE Jr, Sherbourne CD (1992) The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care 30:473
Ware Jr J E et al. (1995) Comparison of methods for the scoring and statistical analysis of SF-36 health profile and summary measures: summary of results from the Medical Outcomes Study. Med Care 33[4 Suppl]:AS264–AS279
Khedmat H, Karami GR, Pourfarziani V, Assari S, Rezailashkajani M, Naghizadeh MM (2007) A logistic regression model for predicting health-related quality of life in kidney transplant recipients. Transplant Proc 39:917–922
Montazeri A, Goshtasebi A, Vahdaninia M, Gandek B (2005) The Short Form Health Survey (SF-36): translation and validation study of the Iranian version. Qual Life Res 14:875–882
Jafari H, Lahsaeizadeh S, Jafari P, Karimi M (2008) Quality of life in thalassemia major: Reliability and validity of the Persian version of the SF-36 questionnaire. J Postgrad Med 54:273–275
Buysse DJ, Reynolds III CF, Monk TH, et al. (1989) The PITTSBURG Sleep Quality Index. A new instrument for psychiatric practice and research. J Psych Research 28:193
Farrahi J, Nakhaee N, Sheibani V, Garrusi B, Amirkafi A (2008) Psychometric properties of the Persian version of the Pittsburgh Sleep Quality Index addendum for PTSD (PSQIA). Sleep Breath
Sareen J, Jacobi F, Cox BJ, Belik SL, Clara I, Stein MB (2006) Disability and poor quality of life associated with comorbid anxiety disorders and physical conditions. Arch Intern Med 23(166):2109–2116
Janssens AC, van Doorn PA, de Boer JB, et al. (2003) Anxiety and depression influence the relation between disability status and quality of life in multiple sclerosis. Mult Scler 9: 397
Noohi S, Khaghani-Zadeh M, Javadipour M, Assari S, Najafi M, Ebrahiminia M, Pourfarziani V (2007) Anxiety and depression are correlated with higher morbidity after kidney transplantation. Transplant Proc 39(4):1074–1078
Bélanger L, Morin CM, Langlois F, Ladouceur R (2004) Insomnia and generalized anxiety disorder: effects of cognitive behavior therapy for gad on insomnia symptoms. J Anxiety Disord 18(4):561–571
Mendlowicz MV, Stein MB (2000) Quality of life in individuals with anxiety disorders. Am J Psychiatry 157(5): 669–682
Wells KB, Stewart A, Hays RD, Burnam MA, Rogers W, Daniels M, Berry S, Greenfield S, Ware J (1989) The functioning and well-being of depressed patients. Results from the Medical Outcomes Study. JAMA 18;262(7):914–919
Kessler RC, Frank RG (1997) The impact of psychiatric disorders on work loss days. Psychol Med 27(4):861–873
Olfson M, Shea S, Feder A et al. Prevalence of anxiety, depression, and. substance use disorders in an urban general medicine practice. Arch Fam Med 9:876–883
Brenes GA, Penninx BW, Judd PH, Rockwell E, Sewell DD, Wetherell JL (2008) Anxiety, depression and disability across the lifespan. Aging Ment Health 12(1): 158–163
Wells KB, Sherbourne CD (1999) Functioning and utility of current health of patients with depression or chronic medical conditions in managed, primary care practices. Arch Gen Psychiatry 56:897–904
Khurana A, Katyal S, Marwaha RK (2006) Psychosocial Burden in Thalassemia. Indian Journal of Pediatrics 73: 877–880
Moorjani JD, Issac C (2006) Neurotic Manifestations in Adolescents With Thalassemia Major. Indian Journal of Pediatrics 73:603–607
Ramachandra P, Booth S, Pieters T, Vrotsou K, Huppert FA (2009) A brief self-administered psychological intervention to improve well-being in patients with cancer: results from a feasibility study. Psychooncology [Epub ahead of print]
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Hajibeigi, B., Azarkeyvan, A., Alavian, S.M. et al. Anxiety and depression affects life and sleep quality in adults with beta-thalassemia. Indian J Hematol Blood Transfus 25, 59–65 (2009). https://doi.org/10.1007/s12288-009-0015-5
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DOI: https://doi.org/10.1007/s12288-009-0015-5