Abstract
A new dihydroflavone, 5-carboxymethyl-7,4′-dihydroxyflavonone (1), and its glucoside 5-carboxymethyl-7,4′-dihydroxyflavonone-7-O-β-d-glucopyranoside (2), and one new monoterpene glucoside, (4Z,6E)-2,7-dimethyl-8-hydroxyocta-4,6-dienoic acid 8-O-β-d-glucopyranoside (3), were isolated from the whole plants of Selaginella moellendorffii. Their structures were determined by spectroscopic methods and chemical transformation. Compound 2 was evaluated for the ability to enhance glucose consumption in normal and insulin-resistant L6 muscle cells induced by high concentrations of insulin and glucose. Glucose consumption in insulin-resistant cells (but not in normal cells) was increased 15.2 ± 3.3% (p < 0.01) by compound 2 at a concentration of 0.1 μM in the presence of insulin (1 nM).
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Wang, HS., Sun, L., Wang, YH. et al. Carboxymethyl flavonoids and a monoterpene glucoside from Selaginella moellendorffii . Arch. Pharm. Res. 34, 1283–1288 (2011). https://doi.org/10.1007/s12272-011-0807-7
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DOI: https://doi.org/10.1007/s12272-011-0807-7