Abstract
Shen Yuan Gan (SYG) is a Chinese herbal prescription composed of total saponins of Panax ginseng and total oligosaccharide esters of Polygala tenuifolia (2:1). Our previous studies have demonstrated that SYG has antidepressant-like effects in various mouse models of behavioral depression. The present study aimed to test whether SYG affected chronic mild stress (CMS)-induced depression and cognitive impairment in mice. We found that a 5-week CMS schedule induced significant degradation of the coat state, decreased sucrose intake in the sucrose-preference test, and increased the latency to feed in the noveltysuppressed feeding test. All of these CMS-induced changes were ameliorated by SYG (100 and 200 mg/kg) and fluoxetine (10 mg/kg). In addition, SYG restored the decreased monoamine neurotransmitter concentrations (serotonin, dopamine, norepinephrine and acetylcholine) induced by CMS in the prefrontal cortex. Interestingly, SYG ameliorated CMS-induced cognitive impairment in the step-through test, and increased the acetylcholine level in the prefrontal cortex. These results suggest that SYG has an antidepressant-like action and enhances cognition by modulating the serotonin, dopamine, norepinephrine, and acetylcholine levels in the prefrontal cortex.
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Machado-Vieira R, Mallinger AG. Abnormal function of monoamine oxidase-A in comorbid major depressive disorder and cardiovascular disease: Pathophysiological and therapeutic implications (Review). Mol Med Report 2012, 6: 915–922.
Byers AL, Yaffe K. Depression and risk of developing dementia. Nat Rev Neurol 2011, 7: 323–331.
Mendlewicz J. Sleep disturbances: core symptoms of major depressive disorder rather than associated or comorbid disorders. World J Biol Psychiatry 2009, 10: 269–275.
Lorenz TA, Meston CM. Acute exercise improves physical sexual arousal in women taking antidepressants. Ann Behav Med 2012, 43: 352–361.
Hindmarch I, Hashimoto K. Cognition and depression: the effects of fluvoxamine, a sigma-1 receptor agonist, reconsidered. Hum Psychopharmacol 2010, 25: 193–200.
Sarris J. Herbal medicines in the treatment of psychiatric disorders: a systematic review. Phytother Res 2007, 21: 703–716.
Iovieno N, Dalton ED, Fava M, Mischoulon D. Secondtier natural antidepressants: Review and critique. J Affect Disord 2011, 130(3): 343–357.
An L, Zhang YZ, Liu XM, Yu NJ, Chen HX, Zhao N, et al. Total flavonoids extracted from Xiaobuxin-Tang on the hyperactivity of hypothalamic-pituitary-adrenal axis in chronically stressed rats. Evid Based Complement Alternat Med 2011, 2011: 367619.
Bao ZX, Zhao GP, Sun W, Chen BJ. Clinical curative effects of Kaixin Powder on depression with mild or moderate degree. Chin Arch Tradit Chin Med 2011, 29: 987–988. [Article in Chinese]
Dang H, Chen Y, Liu X, Wang Q, Wang L, Jia W, et al. Antidepressant effects of ginseng total saponins in the forced swimming test and chronic mild stress models of depression. Prog Neuro-Psychopharmacol Biol Psychiatry 2009, 33: 1417–1424.
Hu Y, Liao HB, Dai-Hong G, Liu P, Wang YY, Rahman K. Antidepressant-like effects of 3,6′-disinapoyl sucrose on hippocampal neuronal plasticity and neurotrophic signal pathway in chronically mild stressed rats. Neurochem Int 2010, 56: 461–465.
Sun X, Li T, Shi Z, Liu J, Pan R, Wang L, et al. Study of antidepressant-like effects of combination of Ginseng Total Saponins and Polygala Tenuifolia Total Glycosiders in mice. Chin J Comp Med 2012, 22: 30–36. [Article in Chinese]
Sun X, Shi Z, Li T, Pan R, Liu X, Bu L, et al. Antide-pressantlike effects of total saikosaponins of Bupleurum yinchowense in mice. J Med Plants Res 2012, 6: 4308–4316.
Detanico BC, Piato ÂL, Freitas JJ, Lhullier FL, Hidalgo MP, Caumo W, et al. Antidepressant-like effects of melatonin in the mouse chronic mild stress model. Eur J Pharmacol 2009, 607: 121–125.
Strekalova T, Spanagel R, Bartsch D, Henn FA, Gass P. Stress-induced anhedonia in mice is associated with deficits in forced swimming and exploration. Neuropsychopharmacology 2004, 29: 2007–2017.
VollenweiderI, Smith KS, Keist R, Rudolph U. Antidepressant-like properties of [alpha]2-containing GABAA receptors. Behav Brain Res 2011, 217: 77–80.
Xu SP, Yang YY, Xue D, Liu JX, Liu XM, Fan TP, et al. Cognitive-enhancing effects of polygalasaponin hydrolysate in abeta(25–35)-induced amnesic mice. Evid Based Complement Alternat Med 2011, 2011: 839720.
Willner P, Towell A, Sampson D, Sophokleous S, Muscat R. Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant. Psychopharmacology (Berl) 1987, 93: 358–364.
Willner P. Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation. Psychopharmacology (Berl) 1997, 134: 319–329.
Ducottet C, Griebel G, Belzung C. Effects of the selective nonpeptide corticotropin-releasing factor receptor 1 antagonist antalarmin in the chronic mild stress model of depression in mice. Prog Neuropsychopharmacol Biol Psychiatry 2003, 27: 625–631.
Onaivi ES, Ishiguro H, Gong JP, Patel S, Perchuk A, Meozzi PA, et al. Discovery of the presence and functional expression of cannabinoid CB2 receptors in brain. Ann N Y Acad Sci 2006, 1074: 514–536.
Ibarguen-Vargas Y, Surget A, Touma C, Palme R, Belzung C. Multifaceted strain-specific effects in a mouse model of depression and of antidepressant reversal. Psychoneuroendocrinology 2008, 33: 1357–1368.
Chopra K, Kumar B, Kuhad A. Pathobiological targets of depression. Expert Opin Ther Targets 2011, 15: 379–400.
Fibiger H. Neurobiology of depression: focus on dopamine. Adv Biochem Psychopharmacol 1995, 49: 1–17.
Kwon S, Lee B, Kim M, Lee H, Park HJ, Hahm DH. Antidepressant-like effect of the methanolic extract from Bupleurum falcatum in the tail suspension test. Prog Neuropsychopharmacol Biol Psychiatry 2010, 34: 265–270.
Stein RA, Strickland TL. A Review of the neuropsychological effects of commonly used prescription medications. Arch Clin Neuropsychol 1998, 13: 259–284.
Henningsen K, Andreasen JT, Bouzinova EV, Jayatissa MN, Jensen MS, Redrobe JP, et al. Cognitive deficits in the rat chronic mild stress model for depression: Relation to anhedonic-like responses. Behav Brain Res 2009, 198: 136–141.
Jesky R, Hailong C. Are herbal compounds the next frontier for alleviating learning and memory impairments? An integrative look at memory, dementia and the promising therapeutics of traditional chinese medicines. Phytother Res 2011, 25(8): 1105–1118.
Palumbo ML, Canzobre MC, Pascuan CG, Ríos H, Wald M, Genaro AM. Stress induced cognitive deficit is differentially modulated in BALB/c and C57Bl/6 mice: Correlation with Th1/Th2 balance after stress exposure. J Neuroimmunol 2010, 218: 12–20.
Cuadrado-Tejedor M, Ricobaraza A, Del Rio J, Frechilla D, Franco R, Perez-Mediavilla A, et al. Chronic mild stress in mice promotes cognitive impairment and CDK5-dependent tau hyperphosphorylation. Behav Brain Res 2011, 220: 338–343.
Song L, Che W, Min-Wei W, Murakami Y, Matsumoto K. Impairment of the spatial learning and memory induced by learned helplessness and chronic mild stress. Pharmacol Biochem Behav 2006, 83: 186–193.
Micheau J, Marighetto A. Acetylcholine and memory: A long, complex and chaotic but still living relationship. Behav Brain Res 2011, 221: 424–429.
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Sun, XP., Li, SD., Shi, Z. et al. Antidepressant-like effects and memory enhancement of a herbal formula in mice exposed to chronic mild stress. Neurosci. Bull. 29, 737–744 (2013). https://doi.org/10.1007/s12264-013-1378-z
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DOI: https://doi.org/10.1007/s12264-013-1378-z