Abstract
Stem cells capable of proliferating along neuronal and glial lines persist in the adult central nervous system (CNS). These cells are found pedominantly in the subventricular zones and in the hippocampus. The therapeutic potential of both endogenous and exogenous stem cells in achieving repair of the injured CNS is being explored. Stem cells from embyonal lines, mescnchymal stromal cells and neural stem cells are being investigated for their potential role in the management of neural loss due to traumatic hypoxic or inflammatory insult.
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References
Regner A, Alves LB, Chemde I et al (2001) Neurochemical characterization of traumatic brain injury in humans. J Neurotrauma 18(8):783–792
Einstein O, Gregoriadis N, Mizrachi-Kol et al (2006) Transplanted neural precursor cells reduce inflammation to attenuate chronic experimental autoimmune encephalomyelitis. Exp Neurol 198(2): 275–284
Hsu YC, Lee DC, Chiu IM (2007) Neural stem cells, neural progenitors and neurotrophic factors. Cell Transplant 16(2): 133–150
Alvarez-Buylla A, Herrera DG, Wichtule H (2000) The subventricular zone: source of neural precursors for brain repair. Prog Brain Res 127:1–11
Heins N, England MC, Sjoblom C et al (2004) Derivation, characterization and differentiation of human embryologic stem cells. Stem Cells 22(3):367–376
Agrawal S, Schoffer DV (2005) In situ stem cell therapy: novel targets, familiar challenges. Trends Biotechnol 23: 78–83
Giordono A, Galderisi U, Marino IR (2007) From the laboratory bench to the patient’s bedside. An update on clinical trials with mesenchymal stem cells. J Cell Physiol 211(1): 27–37
Lennon DP, Caplan AI (2006) Isolation of human marrow derived mesenchymal stem cells. Exp Hematol. 34(11): 1604–1605
Nishimura F, Toriumi H, Ishisaka S et al (2006) Use of differentiating embryonic stem cells in the Parkinson’s mouse model. Methods Mol Biol 329:485–493
Ucceli A, Moretti L, Pistoca V (2006) Immunoregulatory function of mesenchymal stem cells. Eur J Immunol 36(10): 2566–2573
Buhnemann C, Scholz A, Bernreuther C et al (2006) Neuronal differentiation of transplanted embryonic stem cell derived precursors in stroke lesions of adult rats. Brain 129(12):3238–3248
Rice AC, Khaldi A, Harvey HB et al (2003) Proliferation and mitotic differentiation of mitotically active cells following traumatic brain injury. Exp Neurol 183:406–417
Kang SM, Cho MS, Seo H et al (2007) Efficient induction of oligodendrocytes from human embryonic stem cells. Stem Cells 25(2):419–424
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Mathai, K.I., Shashivadhanan, Sudumbraker, S. et al. The role of stem cells in neural injury — emerging paradigms. Indian J Surg 70, 212–214 (2008). https://doi.org/10.1007/s12262-008-0061-5
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DOI: https://doi.org/10.1007/s12262-008-0061-5