Abstract
We investigated the effect of starfish (Asterina pectinifera) polysaccharide on the progression and metastasis of human breast cancer cells. At a concentration range of 10 ∼ 120 μg/mL the polysaccharide significantly decreased the expression of cyclooxygenase-2 (COX-2) protein induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) and of aromatase mRNA. In a wound healing assay, motility of human MDA-MB-231 breast cancer cells was prevented by the polysaccharide in a dose-dependent manner. These results indicate that starfish polysaccharide can prevent breast cancer progression and metastasis by decreasing prostaglandin E2 and estrogen biosynthesis by COX-2 and aromatase, and by inhibiting cell motility. This report presents information regarding the effectiveness of starfish polysaccharide as a chemopreventive agent against breast cancer.
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Lee, KS., Shin, JS. & Nam, KS. Cancer chemopreventive effects of starfish polysaccharide in human breast cancer cells. Biotechnol Bioproc E 16, 987–991 (2011). https://doi.org/10.1007/s12257-011-0226-0
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DOI: https://doi.org/10.1007/s12257-011-0226-0