Abstract
This study developed a partially water-soluble carboxymethyl chitosan (PWCS) fibers by ethanol-water exhaustion method. Sodium carboxylate was successfully introduced into chitosan fibers, as evidenced by FTIR, which enhanced natural chitosan water solubility. SEM-EDS revealed that the sodium carboxylate groups presented in a gradient distribution from the exterior to the interior of the PWCS fibers, which leads to a controllable swelling performance. Moreover, the PWCS fibers had excellent antibacterial ability against S. aureus and E. coli bacteria comparing with origin CS fibers. The cytotoxicity assay (CCK-8) and fluorescence staining confirmed that all developed samples showed non-toxicity towards MRC-5 and exhibited a surprising promoting effect on cell proliferation, corroborating their biocompatibility. Besides, due to its excellent controllable water selling ability and protonated amine groups, the PWCS fibers possessed an efficient hemostatic performance. In conclusion, PWCS fibers could become a promising material in hemostatic and wound healing applications.
Article PDF
Similar content being viewed by others
Explore related subjects
Discover the latest articles, news and stories from top researchers in related subjects.Avoid common mistakes on your manuscript.
References
Y. L. Wang, Y. N. Zhou, X. Y. Li, J. Huang, F. Wahid, C. Zhong, and L. Q. Chu, Int. J. Biol. Macromol., 156, 252 (2020).
K. M. Rao, M. Suneetha, G. T. Park, A. G. Babu, and S. S. Han, Int. J. Biol. Macromol., 155, 71 (2020).
Z. A. Raza, U. Bilal, U. Noreen, S. A. Munim, S. Riaz, M. U. Abdullah, and S. Abid, Fiber. Polym., 20, 1360 (2019).
L. Qu, X. Guo, M. Tian, and A. Lu, Fiber. Polym., 15, 1357 (2014).
K. Y. Lu, Y. C. Lin, H. T. Lu, Y. C. Ho, S. C. Weng, M. L. Tsai, and F. L. Mi, Carbohydr. Polym., 206, 664 (2019).
M. Lei, W. Huang, J. Sun, Z. Shao, W. Duan, T. Wu, and Y. Wang, J. Mol. Liq., doi: https://doi.org/10.1016/j.molliq.2020.113135 (2020).
Z. Wu, W. Zhou, W. Deng, C. Xu, Y. Cai, and X. Wang, ACS Appl. Mater. Interfaces, 12, 20307 (2020).
S. Liu, Z. Zheng, S. Wang, S. Chen, J. Ma, G. Liu, B. Wang, and J. Li, Carbohydr. Polym., 224, 115175 (2019).
Y. Ge, J. Tang, H. Fu, Y. Fu, and Y. Wu, Fiber. Polym., 20, 698 (2019).
K. Ravishankar, K. M. Shelly, R. P. Desingh, R. Subramaniyam, A. Narayanan, and R. Dhamodharan, ACS Sustainable Chem. Eng., 6, 15191 (2018).
M. A. Asghar, R. I. Yousuf, M. H. Shoaib, and M. A. Asghar, Int. J. Biol. Macromol., 160, 934 (2020).
M. Alavi and A. Nokhodchi, Carbohydr. Polym., 227, 115349 (2020).
D. Wang, N. Zhang, G. Meng, J. He, and F. Wu, Colloids Surf B Biointerfaces, 194, 111191 (2020).
J. M. Souza, M. Henriques, P. Teixeira, M. M. Fernandes, R. Fangueiro, and A. Zille, Fiber. Polym., 20, 922 (2019).
F. Cheng, Y. Wu, H. Li, T. Yan, X. Wei, G. Wu, J. He, and Y. Huang, Carbohydr. Polym., 207, 180 (2019).
L. Wang, Z. Luo, J. Yan, Z. Ban, M. Yang, M. Qi, Y. Xu, F. Wang, and L. Li, Ultrason Sonochem., doi: https://doi.org/10.1016/j.ultsonch.2020.105184 (2020).
F. Tang, F. Gao, W. Xie, S. Li, B. Zheng, M. Ke, and J. Huang, Carbohydr. Polym., 235, 115949 (2020).
T. Hemamalini, N. Vikash, P. Brindha, M. Abinaya, and V. R. G. Dev, Int. J. Biol. Macromol., 147, 493 (2020).
J. M. He, Y. D. Wu, F. W. Wang, W. L. Cheng, Y. D. Huang, and B. Fu, Fiber. Polym., 15, 504 (2014).
E. Fakhri, H. Eslami, P. Maroufi, F. Pakdel, S. Taghizadeh, K. Ganbarov, M. Yousefi, A. Tanomand, B. Yousefi, S. Mahmoudi, and H. S. Kafil, Int. J. Biol. Macromol., 162, 956 (2020).
X. Chen and H. Park, Carbohydr. Polym., 53, 355 (2003).
A. Plaza, B. Merino, N. Del Olmo, and M. Ruiz-Gayo, Br. J. Pharmacol., 176, 2678 (2019).
H. E. Salama and M. S. Abdel Aziz, Int. J. Biol. Macromol., 163, 649 (2020).
E. S. Hosseini, L. Manjakkal, D. Shakthivel, and R. Dahiya, ACS Appl. Mater. Interfaces, 12, 9008 (2020).
X. Yao, G. Zhu, P. Zhu, J. Ma, W. Chen, Z. Liu, and T. Kong, Adv. Funct. Mater., doi: https://doi.org/10.1002/adfm.201909389 (2020).
M. Lei, W. Huang, J. Sun, Z. Shao, T. Wu, J. Liu, and Y. Fan, Appl. Clay Sci., doi: https://doi.org/10.1016/j.clay.2020.105637 (2020).
Z. Kharat, M. Sadri, and M. Kabiri, Fiber Polym., doi: https://doi.org/10.1007/s12221-021-0490-3 (2021).
T. Hussain, R. Masood, M. Umar, T. Areeb, and A. Ullah, Fiber. Polym., 17, 1749 (2016).
T. Hemamalini, N. Vikash, P. Brindha, M. Abinaya, and V. R. Giri Dev, J. Bioact. Compat. Polym., 35, 92 (2020).
S. Liu, J. Li, S. Zhang, X. Zhang, J. Ma, N. Wang, S. Wang, B. Wang, and S. Chen, ACS Appl. Bio Mater., 3, 848 (2019).
S. Liu, J. Ma, S. Wang, S. Chen, B. Wang, and J. Li, Mater. Lett., doi: https://doi.org/10.1016/j.matlet.2019.126570 (2019).
M. Yin, Y. Wang, Y. Zhang, X. Ren, Y. Qiu, and T. Huang, Carbohydr. Polym., doi: https://doi.org/10.1016/j.carbpol.2019.115823 (2019).
M. Niu, X. Liu, J. Dai, H. Jia, L. Wei, and B. Xu, Fiber. Polym., 11, 1201 (2010).
Y. Ge and M. Ge, Fiber. Polym., 16, 308 (2015).
A. Ullah, S. Ullah, T. Areeb, M. Umar, P. D. Nam, R. Masood, S. Park, and I. S. Kim, Fiber. Polym., 21, 2494 (2020).
M. Lu, S. Yu, Z. Wang, Q. Xin, T. Sun, X. Chen, Z. Liu, X. Chen, J. Weng, and J. Li, Eur. Polym. J., doi: https://doi.org/10.1016/j.eurpolymj.2020.109821 (2020).
H. Ma, Y. Zhao, Z. Lu, R. Xing, X. Yao, Z. Jin, Y. Wang, and F. Yu, Int. J. Biol. Macromol., 164, 986 (2020).
Y. Li, X. Liu, L. Tan, Z. Cui, X. Yang, Y. Zheng, K. W. K. Yeung, P. K. Chu, and S. Wu, Adv. Funct. Mater., doi: https://doi.org/10.1002/adfm.201800299 (2018).
Y. Huang, X. Zhao, Z. Zhang, Y. Liang, Z. Yin, B. Chen, L. Bai, Y. Han, and B. Guo, Chem. Mater., 32, 6595 (2020).
M. Li, Z. Zhang, Y. Liang, J. He, and B. Guo, ACS Appl. Mater. Interfaces, 12, 35856 (2020).
E. P. Oliveira, T. S. O. Souza, D. Y. Okada, L. H. S. Damasceno, and R. B. Moura, Chem. Eng. J., doi: https://doi.org/10.1016/j.cej.2020.124988 (2020).
M. Shin, J. H. Ryu, K. Kim, M. J. Kim, S. Jo, M. S. Lee, D. Y. Lee, and H. Lee, ACS Biomater Sci. Eng., 4, 2314 (2018).
Y. Wang, D. Xiao, Y. Zhong, Y. Liu, L. Zhang, Z. Chen, X. Sui, B. Wang, X. Feng, H. Xu, and Z. Mao, Int. J. Biol. Macromol., 160, 18 (2020).
D. Yan, S. Hu, Z. Zhou, S. Zeenat, F. Cheng, Y. Li, C. Feng, X. Cheng, and X. Chen, Int. J. Biol. Macromol., 107, 463 (2017).
J. Qu, X. Zhao, Y. Liang, T. Zhang, P. X. Ma, and B. Guo, Biomaterials, 183, 185 (2018).
Acknowledgment
This work was partially supported by the China Postdoctoral Fund (NO. 2018M632618), National Key Research and Development Program of China (NO. 2017YFB0309805-02), National Natural Science Foundation of China (NO. 82001754) and National Key R&D Program of China (no. 2018YFA0900802).
Author information
Authors and Affiliations
Corresponding authors
Rights and permissions
About this article
Cite this article
Liu, S., Yu, Y., Jiang, S. et al. Biocompatible Gradient Chitosan Fibers with Controllable Swelling and Antibacterial Properties. Fibers Polym 23, 1–9 (2022). https://doi.org/10.1007/s12221-021-3276-8
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12221-021-3276-8