Abstract
The relationship of this country with dengue has been long and intense. The first recorded epidemic of clinically dengue-like illness occurred at Madras in 1780 and the dengue virus was isolated for the first time almost simultaneously in Japan and Calcutta in 1943–1944. After the first virologically proved epidemic of dengue fever along the East Coast of India in 1963–1964, it spread to allover the country. The first full-blown epidemic of the severe form of the illness, the dengue haemorrhagic fever/dengue shock syndrome occurred in North India in 1996. Aedes aegypti is the vector for transmission of the disease. Vaccines or antiviral drugs are not available for dengue viruses; the only effective way to prevent epidemic degure fever/dengue haemorrhagic fever (DF/DHF) is to control the mosquito vector, Aedes aegypti and prevent its bite. This country has few virus laboratories and some of them have done excellent work in the area of molecular epidemiology, immunopathology and vaccine development. Selected work done in this country on the problems of dengue is presented here.
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Abbreviations
- CF:
-
cytotoxic factor
- DF:
-
dengue fever
- DF/DHF:
-
degure fever/dengue haemorrhagic fever
- DSS:
-
dengue shock syndrome
- DV:
-
dengue viruses
- TS:
-
T cells
References
Abhyankar A V, Dash P K, Saxena P, Bhargava R, Parida M M, Jana A M, Sahni A K and Rao P V 2006 Comparison of a dipstick dot-ELISA with commercial assays for anti-dengue virus IgM antibodies; Viral Immunol. 19 630–636
Agarwal R, Chaturvedi U C, Misra A, Mukerjee R, Kapoor S, Nagar R, Tandon R and Mathur A 1998 Production of cytotoxic factor by peripheral blood mononuclear cells (PBMC) in patients with dengue haemorrhagic fever; Clin Exp Immunol. 112 340–344
Agarwal R, Kapoor S, Nagar R, Misra A, Tandon R, Mathur A, Misra A K, Srivastava K L and Chaturvedi U C 1999a A clinical study of the patients with dengue haemorrhgic fever during the epidemic of 1996 at Lucknow, India, Southeast Asian J. Trop. Med. Publ. Hlth. 30 735–740
Agarwal R, Elbishbishi E A, Chaturvedi U C, Nagar R and Mustafa A S 1999b Profile of transforming growth factor-beta1 in patients with dengue haemorrhagic fever; Int. J. Exp. Pathol. 80 143–149
Anandarao R, Swaminathan S, Fernando S, Jana A M and Khanna N 2005 A custom-designed recombinant multiepitope protein as a dengue diagnostic reagent; Protein Exp. Purif. 41 136–147
Anandarao R, Swaminathan S, Fernando S, Jana A M and Khanna N 2006 Recombinant multiepitope protein for early detection of dengue infections; Clin. Vaccine Immunol. 13 59–67
Angel B and Joshi V 2008 Distribution and seasonality of vertically transmitted dengue viruses in Aedes mosquitoes in arid and semi-arid areas of Rajasthan, India; J. Vector Borne Dis. 45 56–59
Arunachalam N, Murty U S, Kabilan L, Balasubramanian A, Thenmozhi V, Narahari D, Ravi A and Satyanarayana K 2004 Studies on dengue in rural areas of Kurnool District, Andhra Pradesh, India; J. Am. Mosq. Control Assoc. 20 87–90
Balaya S, Paul S D, D’Lima L V and Pavri K M 1969 Investigations on an outbreak of dengue in Delhi in 1967; Indian J Med Res. 57 767–774
Basu A, Jain P, Gangodkar S V, Shetty S and Ghosh K 2008 Dengue 2 virus inhibits in vitro megakaryocytic colony formation and induces apoptosis in thrombopoietin-inducible megakaryocytic differentiation from cord blood CD34+ cells; FEMS Immunol. Med. Microbiol. 53 46–51
Basu A and Chaturvedi U C 2008 Vascular endothelium: the battle field of dengue viruses; FEMS Immunol. Med. Microbiol. 53 287–299
Bharaj P, Chahar H S, Pandey A, Diddi K, Dar L, Guleria R, Kabra S K and Broor S 2008 Concurrent infections by all four dengue virus serotypes during an outbreak of dengue in 2006 in Delhi, India; Virol. J. 9 5–10
Bhargava A, Chaturvedi U C, Srivastava N and Mathur A 1990 Dengue virus-induced suppressor factor has two disulphide-bonded chains which bears anti-idiotypicc and I-A and I-J determinants; Curr. Sci. 58 157–160
Bhattacharjee N, Mukherjee K K, Chakravarti S K, Mukherjee M K, De P N, Sengupta M, Banik G B, Bhowmick P, Sinha S K and Chakraborty M S 1993 Dengue haemorrhagic fever (DHF) outbreak in Calcutta—1990; J. Commun. Dis. 25 10–14
Carey D E, Myers R M, Reuben R and Rodrigues F M 1966 Studies on dengue in Vellore, South India; Am. J. Trop. Med. Hyg. 15 580–587
Chatterjee S N, Chakravarti S K, Mitra A C and Sarkar J K 1965 Virological investigation of cases with neurological complications during the outbreak of haemorrhagic fever in Calcutta; J. Indian Med. Assoc. 45 314–316
Chaturvedi U C, Mathur A, Kapoor A K, Mehrotra N K and Mehrotra R M. 1970a Virological study of an epidemic of febrile illness with haemorrhagic manifestations at Kanpur, India, during 1968; Bull. World Health Organ. 43 289–293
Chaturvedi U C, Kapoor A K, Mathur A, Chandra D, Khan A M and Mehrotra RM. 1970b A clinical and epidemiological study of an epidemic of febrile illness with haemorrhagic manifestations which occurred at Kanpur, India, in 1968; Bull. World Health Organ. 43 281–287
Chaturvedi U C, Mathur A, Kapoor A K, Tandon H O and Mehrotra RM.1972 Clinico-virological study of the recurrence of dengue epidemic with haemorrhagic manifestations at Kanpur during 1969; Indian J. Med. Res. 60 329–233
Chaturvedi U C, Mathur A, Kapoor A K, Agarwal S K, Tandon H O and Mehrotra RM.1974 Clinico-virological study of an outbreak of dengue-like illness at Hardoi (U.P.); Indian J. Med. Res. 62 827–830
Chaturvedi U C 1984 Dengue virus-induced suppressor pathway; Curr. Sci. 53 971–976
Chaturvedi U C, Pahwa M and Mathur A 1987 Dengue virus-induced helper T cells; Indian J. Med. Res. 86 1–8
Chaturvedi U C, Dhawan R, Khanna M and Mathur A 1991a Breakdown of the blood-brain barrier during dengue virus infection of mice; J. Gen. Virol. 72 859–866
Chaturvedi P, Mukherjee R Chaturvedi U C and Mathur A 1991b Dengue virus-induced helper cytokine has two polypeptide chains which bear different determinants; Int. J. Exp. Pathol. 72 665–672
Chaturvedi P, Chaturvedi U C and Mukherjee R. 1992b Transmission of dengue virus-induced helper signal to B cell via macrophages; Int. J. Exp. Pathol. 73 773–782
Chaturvedi P, Mukherjee R, Chaturvedi U C and Mathur A. 1992a Characterization of the dengue virus-induced helper cytokine; Int. J. Exp. Pathol. 73 263–272
Chaturvedi U C, Mukerjee, R and Dhawan R 1994 Active immunization by a dengue virus-induced cytokine; Clin. Exp. Immunol. 96 202–207
Chaturvedi U C, Dhawan R and Mukerjee R 1997 Immunosuppression and cytotoxicity of dengue infection in the mouse model; in Dengue and dengue haemorrhagic fever (eds) D J Gubler and G Kuno (Wallingford, Oxon, UK: CAB International Press) pp 291–312
Chaturvedi U C, Raghupathy R, Pacsa A S, Elbishbishi E A, Agarwal R, Nagar R, Misra A, Kapoor S, Mathur A, Khan M A Y and Azizieh F 1999a Shift from a Th1-Type Response to Th2-Type in Dengue Haemorrhagic Fever; Curr. Sci. 76 63–69
Chaturvedi U C, Agarwal R, Misra A, Mukerjee R, Kapoor S and Nagar R 1999b Cytotoxic factor in dengue haemorrhagic fever; Med. Principles Pract. 8 26–31
Chaturvedi U C, Elbishbishi E A, Agarwal R, Raghupathy R, Nagar R, Tandon R, Younis O I and Azizeih F 1990c Sequential production of cytokines by dengue virus infected human peripheral blood leukocyte cultures; J. Med. Virol. 59 335–340
Chaturvedi U C, Agarwal R, Elbishbishi E A and Mustafa A S 2000 Cytokine Cascade in Dengue Haemorrhagic Fever: Implications for Pathogenesis; FEMS Immunol. Med. Microbiol. 28 183–188
Chaturvedi U C, Elbishbishi E A, Agarwal R and Mustafa A S. 2001 Cytotoxic factor-autoantibodies: possible role in the pathogenesis of dengue haemorrhagic fever; FEMS Immunol. Med. Microbiol. 30 181–186
Chaturvedi U C and Shrivastava R 2004 Dengue Haemorrhagic Fever: A Global Challenge; Indian J. Med. Microbiol. 22 5–6
Chaturvedi U C, Shrivastava R and Nagar R. 2005 Dengue vaccines: problems and prospects; Indian J. Med. Res. 121 639–652
Chaturvedi U C, Nagar R and Shrivastava R. 2006a Macrophage and dengue virus: friend or foe?; Indian J. Med. Res. 124 23–40
Chaturvedi U C, Nagar R and Shrivastava R 2006b Dengue and dengue haemorrhagic fever: implications of host genetics; FEMS Immunol. Med. Microbiol. 47 155–166
Chaturvedi U C, Shrivastava R, Tripathi R K and Nagar R 2007 Dengue virus-specifc suppressor T cells: current perspectives; FEMS Immunol. Med. Microbiol. 50 285–299
Chouhan G S, Rodrigues F M, Shaikh B H, Ilkal M A, Khangaro S S, Mathur K N, Joshi K R and Vaidhye N K 1990 Clinical & virological study of dengue fever outbreak in Jalore city, Rajasthan 1985; Indian J. Med. Res. 91 414–418
Cherian T, Ponnuraj E, Kuruvilla T, Kirubakaran C, John T J and Raghupathy P 1994 An epidemic of dengue haemorrhagic fever & dengue shock syndrome in & around Vellore; Indian J. Med. Res. 100 51–56
Dash P K, Parida M M, Saxena P, Kumar M, Rai A, Pasha S T and Jana A M.2004 Emergence and continued circulation of dengue-2 (genotype IV) virus strains in northern India; J. Med. Virol. 74 314–322
Dash P K, Saxena P, Abhyankar A, Bhargava R and Jana A M 2005 Emergence of dengue virus type-3 in northern India; Southeast Asian J. Trop. Med. Public Health 36 370–377
Dash P K, Parida M M, Saxena P, Abhyankar A, Singh C P, Tewari K N, Jana A M, Sekhar K and Rao P V 2006 Reemergence of dengue virus type-3 (subtype-III) in India: implications for increased incidence of DHF & DSS; Virol. J. 6 3–55
Dar L, Broor S, Sengupta S, Xess I and Seth P 1999 The first major outbreak of dengue hemorrhagic fever in Delhi, India; Emerg. Infect. Dis. 5 589–590
Dar L, Gupta E, Narang P and Broor S 2003 Co-circulation of dengue serotypes, Delhi, India, 2003; Letter to the editor. Emerg. Infect. Dis. 12 352–353
Garg P, Nagpal J, Khairnar P and Seneviratne S L 2008 Economic burden of dengue infections in India; Trans. R. Soc. Trop. Med. Hyg. 102 570–577
Ghosh S N, Pavri K M, Singh K R, Sheikh B H, D’lima L V, Mahadev P V and Ramachandra Rao T 1974 Investigations on the outbreak of dengue fever in Ajmer City, Rajasthan State in 1969. Part I. Epidemiological, clinical and virological study of the epidemic; Indian J. Med. Res. 62 511–522
Ghosh K, Gangodkar S, Jain P, Shetty S, Ramjee S, Poddar P and Basu A. 2008 Imaging the interaction between dengue 2 virus and human blood platelets using atomic force and electron microscopy; J. Electron Microsc. (Tokyo) 57 113–118
Gubler D J. 1997 Dengue/dengue haemorrhagic fever: its history and resurgence as a global public health problem; in Dengue and dengue haemorrhagic fever (eds) D J Gubler and G Kuno (Wallingford, Oxon, UK: CAB International Press) pp 1–22
Gulati S and Maheshwari A 2007 Atypical manifestations of dengue; Trop. Med. Int. Health 12 1087–1095
Gupta E, Dar L, Kapoor G and Broor S 2006 The changing epidemiology of dengue in Delhi, India; Virol. J. 3 92
Halstead S B 1970 Observations related to pathogenesis of dengue hemorrhagic fever. VI. Hypotheses and discussion; Yale J. Biol. Med. 42 350–362
Halstead S B 2002 Dengue; Curr. Opin. Infect. Dis. 15 471–476
Halstead S B 2007 Dengue; Lancet 370 1644–1652
Hapugoda M D, Batra G, Abeyewickreme W, Swaminathan S and Khanna N 2007 Single antigen detects both immunoglobulin M (IgM) and IgG antibodies elicited by all four dengue virus serotypes; Clin. Vaccine Immunol. 14 1505–1514
Jaiswal S, Khanna N and Swaminathan S 2004 High-level expression and one-step purification of recombinant dengue virus type 2 envelope domain III protein in Escherichia coli; Protein Exp. Purif. 33 80–91
Kabra S K, Verma I C, Arora N K, Jain Y and Kalra V 1992 Dengue haemorrhagic fever in children in Delhi; Bull. World Health Organ. 70 105–108
Khanam S, Khanna N and Swaminathan S 2006 Induction of neutralizing antibodies and T cell responses by dengue virus type 2 envelope domain III encoded by plasmid and adenoviral vectors; Vaccine. 24 6513–6525
Khanam S, Rajendra P, Khanna N and Swaminathan S 2007 An adenovirus prime/plasmid boost strategy for induction of equipotent immune responses to two dengue virus serotypes; BMC Biotechnol. 15 7–10
Kimura R and Hotta S 1944 Studies on dengue fever (IV). On inoculation of dengue virus into mice; Nippon Igaku No. 3379 629–633
Kumar A, Sharma S K, Padbidri V S, Thakare J P, Jain D C and Datta K K 2001 An outbreak of dengue fever in rural areas of northern India; J. Commun. Dis. 33:274–281
Kumar R, Tripathi S, Tambe J J, Arora V, and Nag V L 2008 Dengue encephalopathy in children in Northern India: Clinical features and comparison with non dengue; J. Neurol. Sci. 269 41–48
Kukreti H, Chaudhary A, Rautela R S, Anand R, Mittal V, Chhabra M, Bhattacharya D, Lal S and Rai A 2008 Emergence of an independent lineage of dengue virus type 1 (DENV-1) and its co-circulation with predominant DENV-3 during the 2006 dengue fever outbreak in Delhi; Int. J. Infect. Dis. PMID: 18495513 [PubMed [Epub ahead of print]]
Kurukumbi M, Wali J P, Broor S, Aggarwal P, Seth P, Handa R, Dhar L and Vajapayee M 2001 Seroepidemiology and active surveillance of dengue fever/dengue haemorrhagic fever in Delhi; Indian J. Med. Sci. 55 149–156
Mahadev P V, Kollali V V, Rawal M L, Pujara P K, Shaikh B H, Ilkal M A, Pathak V, Dhanda V, and Banerjee K 1993 Dengue in Gujarat state, India during 1988 & 1989; Indian J. Med. Res. 97 135–144
Mehendale S M, Risbud A R, Rao J A and Banerjee K 1991 Outbreak of dengue fever in rural areas of Parbhani district of Maharashtra (India); Indian J. Med. Res. 93 6–11
Mills K H G 2004 Regulatory T cells: Friend or foe in immunity to infection?; Nat. Rev. Immunol. 4 841–855
Misra A, Mukerjee, R and Chaturvedi, U C 1996a Production of nitrite by dengue virus-induced cytotoxic factor; Clin. Exp. Immunol. 104 650–655
Misra A, Mukerjee R and Chaturvedi U C 1996b Release of reactive oxygen intermediates by dengue virus-induced macrophage cytotoxin; Int. J. Exp. Pathol. 77 237–242
Misra A, Mukerjee R and Chaturvedi U C 1998 Respiratory burst by dengue virus-induced cytotoxic factor; Med. Principles Pract. 7 251–260
Mongkolsapaya J, Dejnirattisai W and Xu X N 2003 Original antigenic sin and apoptosis in the pathogenesis of dengue hemorrhagic fever; Nat. Med. 9 921–927
Mongkolsapaya J, Duangchinda T, Dejnirattisai W, Vasanawathana S, Avirutnan P, and Jairungsri A. 2006 T cell responses in dengue hemorrhagic fever: are cross-reactive T cells suboptimal?; J. Immunol. 176 3821–3829
Mosmann T R and Sad S 1996 The expanding universe of T cell subsets: Th1, Th2 and more; Immunol. Today 17 138–146
Mukherjee K K, Chakravarti S K, Dey P N, Dey S and Chakraborty M S 1987 Outbreak of febrile illness due to dengue virus type 3 in Calcutta during 1983; Trans. R. Soc. Trop. Med. Hyg. 81 1008–1010
Mukherjee R, Chaturvedi P and Chaturvedi U C 1993a Identification of a receptor on macrophages for the dengue virus-induced suppressor cytokine; Clin. Exp. Immunol. 91 257–265
Mukherjee R, Chaturvedi P and Chaturvedi, U C 1993b Binding of the two polypeptide chains of dengue virus-induced suppressor cytokine to its receptor isolated from macrophages; Int. J. Exp. Pathol. 74 259–266
Mukherjee R, Chaturvedi, P and Chaturvedi U C 1994 Specific receptor for dengue virus-induced suppressor cytokine on macrophages and lymphocytes; Int. J. Exp. Pathol. 75 29–36
Mukerjee R, Misra A and Chaturvedi U C 1996 Dengue virus-induced cytotoxin releases nitrite by spleen cells; Int. J. Exp. Pathol. 77 45–51
Mukerjee R, Chaturvedi U C, Vaughn D W and Kalayanarooj S 1997 Purification and pathogenicity of the cytotoxic factor from the cases of dengue haemorrhagic fever; Curr. Sci. 72 494–501
Myers R M and Carey D E 1967 Concurrent isolation from patient of two arboviruses, Chikungunya and dengue type 2; Science. 157 1307–1308
Myers R M, Carey D E, Banerjee K, Reuben R and Ramamurti D V 1968 Recovery of dengue type 3 virus from human serum and Aedes aegypti in South India; Indian J. Med. Res. 56 781–787
Myers R M, Carey D E, DeRanitz C M, Reuben R and Bennet B 1969 Virological investigations of the 1966 outbreak of Dengue type 3 in Vellore, Southern India; Indian J. Med. Res. 57 1392–1401
Myers R M, Varkey M J, Reuben R and Jesudass E S 1970 Dengue outbreak in Vellore, southern India, in 1968, with isolation of four dengue types from man and mosquitoes; Indian J. Med. Res. 58 24–30
Myers R M and Varkey M J 1971 A note on sequential dengue infection, presumptive and proved, with report of an instance of a third proved attack in one individual; Indian J. Med. Res. 59 1231–1236
Nagarkatti P S and Nagarkatti M 1983 Effect of experimental dengue virus infection on immune response of the host. I. Nature of changes in T suppressor cell activity regulating the B and T cell responses to heterologous antigens; J. Gen. Virol. 64 1441–1447
Padbidri V S, Thakre J P, Risbud A R, Joshi G D, Singh A, Mavale M S and Gupta V P 1996 An outbreak of dengue hemorrhagic fever in Jammu; Indian J. Virol. 12 83–87
Pattnaik P, Srivastava A, Abhyankar A, Dash P K, Parida M M and Lakshmana Rao P V 2006 Fusogenic peptide as diagnostic marker for detection of flaviviruses; J. Postgrad. Med. 52 174–178
Parida M M, Upadhyay C, Saxena P, Dash P K, Jana A M and Seth P 2001 Evaluation of a dipstick ELISA and a rapid immunochromatographic test for diagnosis of Dengue virus infection; Acta Virol. 45 299–304
Parida M M, Dash P K, Upadhyay C, Saxena P and Jana A M 2002 Serological and Virological investigation of an outbreak of dengue fever in Gwalior, India; Indian J. Med. Res. 116 248–254
Parida M M, Horioke K, Ishida H, Dash P K, Saxena P, Jana A. M, Islam M A, Inoue S, Hosaka N and Morita K 2005 Rapid detection and differentiation of dengue virus serotypes by a real-time reverse transcription-loop-mediated isothermal amplification assay; J. Clin. Microbiol. 43 2895–2903
Rigau-Perez J G, Clark G G, Gubler D J, Reiter P, Sanders E J and Vorndam A V 1998 Dengue and dengue hemorrhagic fever; Lancet 352 971–977
Rizvi N, Chaturvedi P and Chaturvedi U C 1993 Binding of macrophages and B lymphocytes mediated by dengue virus antigen and the virus-induced helper cytokine; Int. J. Exp. Pathol. 74 187–194
Rodrigues F M, Pavri K M, Dandawate C N, Banerjee K and Bhatt P N 1973 An investigation of the aetiology of the 1966 outbreak of febrile illness in Jabalpur, Madhya Pradesh; Indian J. Med. Res. 61 1462–1470
Sabin A B and Schlesinger M C 1945 Production of immunity to dengue with virus modified by propagationin mice; Science 101 640–642
Sarkar J K, Pavri K M, Chatterjee S N, Chakravarty S K and Anderson C R 1964 Virological and serological studies of cases of haemorrhagic fever in Calcutta; Indian J. Med. Res. 52 684–691
Saxena P, Dash P K, Santhosh S R, Srivastava A, Parida M M and Rao P V L 2008 Development and evaluation of one step single tube multiplex RT-PCR for rapid detection and typing of dengue viruses; Virol. J. 5 20
Saxena P, Parida M M, Dash P K, Santhosh S R, Shrivastava A, Tripathi N K, Gupta N, Sahani A K, Bhargava R, Singh C P, Tewari, K N, Sekhar K and Rao P V L 2006 Co-Circulation of Dengue Virus Serotypes in Delhi, India, 2005: Implication for Increased DHF/DSS; Dengue Bull. 30 283–287
Shah I, Deshpande G C and Tardeja P N. 2004 Outbreak of dengue in Mumbai and predictive markers for dengue shock syndrome; J. Trop. Pediatr. 50 301–305
Shrivastava R, Srivastava S, Upreti R K and Chaturvedi U C 2005 Effects of dengue virus infection on peripheral blood cells of mice exposed to hexavalent chromium with drinking water; Indian J. Med. Res. 122 111–119
Shrivastava R, Nagar R, Ravishankar G A, Upreti R K and Chaturvedi U C 2007 Effect of pretreatment with chromium picolinate on haematological parameters during dengue virus infection in mice; Indian J. Med. Res. 126 440–446
Shukla M I and Chaturvedi U C 1981 Dengue virus-induced suppressor factor stimulates production of prostaglandin to mediate suppression; J. Gen. Virol. 66 241–249
Shukla M I and Chaturvedi U C 1983 Transmission of dengue virus-induced suppressor signal from macrophage to lymphocyte occurs by cell contact; Br. J. Exp. Pathol. 64 87–92
Shukla M I and Chaturvedi U C 1982 In vivo role of macrophages in transmission of dengue virus-induced suppressor signal to T lymphocytes; Br. J. Exp. Pathol. 63 522–530
Sierra B, Garcia G, Perez A B, Morier L, Rodriguez R, Alvarez M and Guzman M G 2002 Long-term memory cellular immune response to dengue virus after a natural primary infection; Int. J. Infect. Dis. 6 125–128
Singh J, Balakrishnan N, Bhardwaj M, Amuthadevi P, George E G, Subramani K, Soundararajan K, Appavoo N C, Jain D C, Ichhpujani R L, Bhatia R. and Sokhey J. 2000 Silent spread of dengue and dengue haemorrhagic fever to Coimbatore and Erode districts in Tamil Nadu, India, 1998: need for effective surveillance to monitor and control the disease; Epidemiol. Infect. 125 195–200
Singh K R and Paul S D 1969 Isolation of dengue viruses in Aedes albopictus cell cultures; Bull. World Health Organ. 40 982–998
Singh U B, Maitra A, Broor S, Rai A, Pasha S T and Seth P 1999 Partial nucleotide sequencing and molecular evolution of epidemic causing Dengue 2 strains; J. Infect. Dis. 180 959–965
Soundravally R and Hoti S L 2007a Immunopathogenesis of dengue hemorrhagic fever and shock syndrome: role of TAP and HPA gene polymorphism; Hum. Immunol. 68 973–979
Soundravally R and Hoti S L 2008 Significance of Transporter Associated with Antigen Processing 2 (TAP2) Gene Polymorphisms in Susceptibility to Dengue Viral Infection; J. Clin. Immunol. 28 256–262
Soundravally R, Sankar P, Hoti S L, Selvaraj N, Bobby Z and Sridhar M G 2008 Oxidative stress induced changes in plasma protein can be a predictor of imminent severe dengue infection; Acta Trop. 106 156–161
Tai D F, Lin C Y, Wu T Z, Huang J H and Shu P Y 2006 Artificial receptors in serologic tests for the early diagnosis of dengue virus infection; Clin. Chem. 52 1486–1491
Tandon P, Chaturvedi U C and Mathur A 1979 Dengue virus-induced thymus-derived suppressor cells in the spleen of mice; Immunology 38 653–658
Tewari S C, Thenmozhi V, Katholi C R, Manavalan R, Munirathinam A and Gajanana A 2004 Dengue vector prevalence and virus infection in a rural area in south India; Trop. Med. Int. Health. 9 499–507
Tripathi N K, Shrivastva A, Pattnaik P, Parida M M, Dash P K, Gupta N, Jana A M and Rao P V L 2007a. Production of IgM specific recombinant dengue multiepitope protein for early diagnosis of dengue infection;. Biotechnol. Prog. 23 488–493
Tripathi N K, Shrivastva A, Pattnaik P, Parida M M, Dash P K, Jana A M and Rao P V L 2007b Production, purification and characterization of recombinant dengue multiepitope protein; Biotechnol. Appl. Biochem. 46 105–113
Tripathi R K, Khare M and Chaturvedi U C 1997 Internalization of dengue virus-induced suppressor cytokine during transmission of the suppressor signal via macrophage; Indian J. Exp. Biol. 35 850–854
World Health Organization 1997 Clinical diagnosis; in Dengue haemorrhagic fever: Diagnosis, treatment, prevention and control 2nd edition (Geneva: WHO) pp 12–23
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Chaturvedi, U.C., Nagar, R. Dengue and dengue haemorrhagic fever: Indian perspective. J Biosci 33, 429–441 (2008). https://doi.org/10.1007/s12038-008-0062-3
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DOI: https://doi.org/10.1007/s12038-008-0062-3