Abstract
This is the first report describing two novel chondroprotective activities of aqueous extracts of Withania somnifera root powder. First, these extracts had a statistically significant, short-term chondroprotective effect on damaged human osteoarthritic cartilage matrix in 50% of the patients tested. Second, these extracts caused a significant and reproducible inhibition of the gelatinase activity of collagenase type 2 enzyme in vitro.
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Abbreviations
- OA:
-
osteoarthritis
- GS:
-
glucosamine sulphate
- PG:
-
proteoglycan
- HPLC:
-
high performance liquid chromatography
- CM:
-
conditioned media
- PG:
-
proteoglycan
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Sumantran, V.N., Kulkarni, A., Boddul, S. et al. Chondroprotective potential of root extracts of Withania somnifera in osteoarthritis. J Biosci 32, 299–307 (2007). https://doi.org/10.1007/s12038-007-0030-3
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DOI: https://doi.org/10.1007/s12038-007-0030-3