Abstract
Agro-industrial by-products are rich sources of natural bioactive compounds and their valorisation is a must for global food sustainability. Along with conventional techniques, numerous novel methods have been developed and optimised to facilitate extraction of the bioactives in sustainable and efficient manner. This review summarises the recent advances in the application of novel extraction technologies for various classes of bioactive molecules from agro-industrial by-products with special emphasis on two emerging techniques, i.e. ultrasound- and pulsed electric field-assisted extraction. These two technologies have shown promising extraction efficacy with reduced usage of extraction solvents, thus saving time and cost. The mechanism through which these techniques aid extraction, the various parameters affecting their efficacy, integration with other novel techniques, and promising applications for by-product valorisation are discussed.
Similar content being viewed by others
Avoid common mistakes on your manuscript.
Introduction
Agricultural produce, such as cereal grains, fruits and vegetables, herbs and spices, nuts, etc., is a rich source of non-nutritive health-promoting compounds besides nutrients for growth and development. Many of these compounds are secondary metabolites (phytochemicals) produced by the plants’ defence mechanism or primary metabolites, which in addition to their nutritive value confer health protecting effects in humans (Joana Gil-Chávez et al. 2013). Apart from being consumed fresh, a number of processed products such as frozen or minimally processed produce, juices, nectars, pulps, concentrates, ketchups/sauces, pickles, jam/jellies/marmalades, soups, crisps/chips and flakes are popular among consumers because of their convenience. Industrial primary processing of plant foods generates in millions of tonnes of by-products annually. Classic examples of processing by-products are damaged raw materials, seeds, peels/skins, husk/hulls/cobs, brans, oilseed cakes, spent grains, molasses, etc., which account for approximately 190 million tonnes per year worldwide (FAO 2013), resulting in significant financial burden to the processors and cause environmental concerns. Several studies have revealed that these by-products are rich sources of non-nutritive but biologically active compounds, thus providing a valid rationale for their recovery from agro-industrial by-products. A variety of bioactive compounds such as phenolics, carotenoids, vitamins and dietary fibre derived from different agro-industrial by-products have been reviewed previously (Schieber et al. 2001; Ayala-Zavala et al. 2011; Balasundram et al. 2006; Larrauri 1999). Whilst knowledge of the hidden potential of these agro-industrial food by-products has been well known for over a decade, yet they are routinely utilised as animal feed or as fertilisers (Schieber et al. 2001). Efficient utilisation of by-products, a low-cost raw material could help to fulfil the growing demand for natural food ingredients and products in functional foods and nutraceuticals. A primary reason behind under-exploitation of by-products appears to be the flaws of extraction/purification techniques that include labour intensive, time consuming, and non-environmental friendly extraction and purification techniques of target compounds (Joana Gil-Chávez et al. 2013). Thus, the feasibility of realising the potential economic benefits of agricultural by-products could be improved by application of energy efficient, rapid, inexpensive, environmentally friendly, extraction techniques (Ayala-Zavala et al. 2011; Schieber et al. 2001).
There is also a growing realisation that whilst traditional solid–liquid extraction (SLE) techniques can be used to recover bioactive compounds from food processing by-products, they are often time consuming, expensive and un-sustainable. In the past two decades, many other techniques have been investigated including ultrasound-assisted extraction (UAE), pulsed electric field (PEF), pulsed light (PL), high voltage energy discharge (HVED), microwave-assisted extraction (MAE), supercritical fluid extraction (SFE), pressurised liquid extraction (PLE), high hydrostatic pressure extraction (HHP/HPE), enzyme-assisted extraction (EAE) and instant controlled pressure drop-assisted extraction (DIC) (Galanakis 2013; Joana Gil-Chávez et al. 2013, Hossain et al. 2015). These innovative extraction technologies have many advantages compared to traditional approaches (SLE, Soxhlet extraction and distillation) in terms of shorter extraction time at ambient or low temperatures whilst reduce the usage of organic solvents, higher yield and good quality extract (Azmir et al. 2013).
Wijngaard et al. (2012) have reviewed the effectiveness of novel techniques to extract bioactive compounds from by-products with special attention to PLE, SFE and MAE. However, no detailed review for by-products utilisation for recovery of various bioactive compounds using UAE and PEF currently exists. Therefore, the main aim of this review is to provide a recent update on the non-traditional extraction techniques with particular attention to UAE and PEF technologies. Some of the applications of UAE and PEF for extracting various classes of bioactives from diverse group of agro-industrial by-products are also discussed.
Prevalent Bioactives from Agro-Industrial By-products
A variety of bioactive compounds from agro-industrial by-products has been subject of a number of reviews. The commonly found bioactive compounds from various agro-industrial by-products and their biological properties are summarised in Table 1. These include the following: (i) bioactive polysaccharides, (ii) bioactive peptides, (iii) unsaturated fatty acids, (iv) carotenoids, (v) steroids, (vi) vitamins, (vii) pigments, (viii) essential oils, (ix) alkaloids and (x) phenolics. Generally, fruits and vegetables wastes are the most widely investigated substrates for the extraction of phenolic compounds and dietary fibres, whereas cereal crops and mushroom by-products have served as sources of bioactive polysaccharides (Cheung 2013; Wu et al. 2004), and pulses and oilseed crops residues for bioactive peptides and sterols, respectively (Galanakis 2012). For example, apple by-products have been reported to contain a variety of valuable compounds including pectin (a carbohydrate widely used as gelling and stabilising agent), low-molecular-weight polyphenols (flavonols, flavanols), organic acids such as malic acid, monosaccharides (fructose, glucose and sorbitol), cuticular waxes, highly unsaturated fatty oil, carotenoids, tocopherols and high molecular weight condensed polyphenols (Kammerer et al. 2014).
Polysaccharides are widely distributed in nature and they function as structural and storage components such as cellulose, hemicellulose (arabinoxylans), pectin, inulin, chitin/chitosan and β-glucans (Table 1). They are also abundantly present in a variety of agro-industrial by-products such as hulls, husks, pods, peels, stipes of mushroom, spent grains, shells, stems, seeds, stalks, bran and press cakes. Additionally, polysaccharides have shown various bioactive properties such as enhanced mineral absorption, antioxidative, antibacterial functions (Ren et al. 2014), stimulation of the immune system (Smiderle et al. 2011), regulation of lipid metabolism, appetite suppression, body fat reduction and attenuation of oxidative stress (Anderson et al. 1994). Oligosaccharides are low-molecular-weight polysaccharides present as storage carbohydrates and can also be derived from chemo-enzymatic treatment of a polysaccharide-rich by-product. Fructose oligosaccharides (FOS) are present in fruit and vegetable by-products, especially onion wastes (discarded onions) and impart prebiotic effects (Roldan-Marin et al. 2009). Raffinose, α-galacto-oligosaccharides and galactosyl-cyclitols are present in pulse by-products such as hulls, meal and soybean whey and have been purported to induce changes in colon micro biota (Dinoto et al. 2006). For example, inulin and FOS have been shown to improve bowel functionality (Kleessen et al. 1997). In addition, beneficial roles of processing derived oligosaccharides such as xylooligosaccharides from lingo-cellulosic biomass have been reported by Samanta et al. (2015). Some of the reported bioactive sugar alcohols showing functional properties are mannitols from yeast extract displaying diuretic activity (Zhao et al. 2009) and sorbitols from dried fruits and prunes, which confer a laxative effect (Stacewicz-Sapuntzakis et al. 2001).
Bioactive peptides are obtained by enzymatic hydrolysis of dietary proteins, which are otherwise usually inactive. In recent years, several studies have been conducted on the production and isolation of bioactive peptides from dietary proteins of plant origin (Gangopadhyay et al. 2016). However, only a small number of studies have been reported which outlines bioactive peptides from agro by-products in comparison with better protein sources such as dairy-derived protein fractions (Li et al. 2013; Xu et al. 2011; Hatanaka et al. 2012; Rayaprolu et al. 2013; Bandyopadhyay et al. 2008). Kannan et al. (2010) isolated a novel penta-peptide (Glu-Gln-Arg-Pro-Arg) with a molecular mass of 684.37 Da from heat stabilised defatted rice bran. This peptide showed inhibition against proliferation of colon, breast, lung and liver cancer cells. Some high value proteins, in spite of low lysine content, from sunflower press cake have been reported because these proteins are low in anti-nutritional factors and devoid of toxic substances (González-Pérez and Vereijken 2007). In another study, pea protein isolate from beach pea was analysed for its nutritive and functional characteristics. The protein isolates were reported as ideal protein due to adequate percent ratios of essential to total amino acids (above 36%) with more than 80% in vitro digestibly (Chavan et al. 2001).
Polyunsaturated fatty acid (PUFA) such as docohexaenoic acid (DHA, C22:6) and eicosapentaenoic acid (EPA C20:5), which are of great importance for cardiovascular health because of their ability to lower the LDL cholesterol level (Fernandez and West 2005) and for foetal brain development (Swanson et al. 2012), are also present in appreciable quantities in many plant food processed by-products. Grape seed oil is rich in unsaturated fatty acids particularly alpha-linolenic acid, a precursor of EPA and DHA (Ayala-Zavala et al. 2011). Apple seeds are reported to be rich in highly unsaturated fatty oil, PUFA (Fromm et al. 2012a).
Carotenoids (tetraterpenoids/octa-isoprene molecules with or without oxygen) are fat-soluble organic pigments of biological importance due to their health-promoting activities like pro-vitamin A activity, photo protective activity, preventing retinal degeneration and skin protectant and antioxidant activity (Stahl and Sies 2005). By-products from tomato processing industries have been exploited to recover lycopene and β-carotene having high antioxidant activity (Baysal et al. 2000). Citrus peel oil (limonene-a cyclic terpene) is a good source of essential oil and has antimicrobial activity (Bourgou et al. 2012).
Polyphenols comprise of diverse groups of phytochemicals ranging from benzoquinones to tannins (Table 1). These phenolic compounds are unevenly distributed in plant tissues, for instance flavonoids and phenolic acids in the outer layers of the skin, attractant anthocyanins in aleurone cells and deterrent tannins in seed coats and hulls. Polyphenols are present either in non-glycosylated form or as glycosides and/or associated with various organic acids and/or complex polymerised molecules with high molecular weights as in tannins (Kammerer et al. 2014). Several phenolic compounds have been identified in various agricultural by-products such as fruits and vegetables discards (Peschel et al. 2006), peanut hull (Francisco and Resurreccion 2009), rice bran (Pourali et al. 2010) and coffee by-products (Murthy and Naidu 2010). Generally, by-products, such as peel, seed, seed coats and hulls, contain higher phenolic compounds than the bulk edible parts (Balasundram et al. 2006; Ayala-Zavala et al. 2011). Some of the phenolic compounds possessing a C3 side chain as in eugenol (phenylpropanoids) from clove are referred as essential oils and possess antimicrobial activities (Cowan 1999).
Emerging Technologies for the Extraction of Bioactives
Extraction of bioactive compounds from a variety of substrates is a determinant factor dictating the feasibility of utilisation of by-products. In view of the diversity of target compounds, plant species, their location and interactions in plant matrix, it is essential to adopt an appropriate extraction technique (Pinelo et al. 2006). The success of extraction is a function of the mass transfer action of diffusion and permeation phenomenon of solvent and solute (Huang et al. 2013). Prior to extraction, macroscopic pretreatment such as wet milling, thermal and/or vacuum concentration, mechanical pressing, freeze drying, centrifugation and microfiltration and molecule separation like alcohol precipitation, ultrafiltration, isoelectric solubilisation-precipitation, extrusions, have been reported to play important role in recovery of high-added value components from food wastes (Galanakis 2012).
Traditional extraction methods suffer from many disadvantages. These include health hazards of toxic organic solvents, requiring large volume of solvents, long extraction time and high temperatures. Hence, many improved novel extraction methodologies have emerged in recent years. The principle, mechanism and process control parameters of some of the important novel extraction technologies are summarised in Table 2. The mode of action of these novel techniques are generally through enhanced mass transfer rate, due to increased cell permeabilisation and solvent diffusivity, caused by rupturing or degradation of cell membrane.
With respect to extraction of valuable components from plant food by-products by far the greatest numbers of studies have examined UAE and PEF processes. The subsequent sections examine the detailed use of UAE and PEF for extraction of valuable compounds with health-promoting properties from agro-industrial processing by-products. Various other effective contemporary extraction techniques include MAE, PLE or ASE, SCF, EAE, HHP/HPE, EAE and DIC.
Briefly, in microwave-assisted extraction (MAE), electromagnetic energy (frequency ranges from 300 MHz to 300 GHz) is generated through magnetrons of different power and converted to thermal energy. The induced energy is further transferred to the biological material via dipole rotation and ionic conduction. This thermal energy heats up the moisture inside the cells and causes evaporation, producing a high pressure on the cell wall. The built up pressure inside the biomaterial modifies the physical properties of the tissues (cell wall and organelles disruption) improving the porosity of the biological matrix. This causes better penetration of extracting solvent through the matrix and improves yield of the desired compounds. The microwaves heat the matrix internally and externally without a thermal gradient, which is advantageous over solid–liquid extraction. Flórez et al. (2015) have reviewed the MAE in detail with regard to mechanism and its utilisation in the extraction of various plant bioactive molecules such as polysaccharides, lipids, proteins, phenolics and essential oils.
Another novel and important technique with improved extraction yield is pressurised liquid extraction (PLE) where a high pressure–temperature combination is used to enhance the extraction. It is also known as pressurised fluid/solvent extraction or accelerated fluid/solvent (ASE) extraction. PLE is referred as pressurised/subcritical water extraction (SWE) when water is used as solvent. The applied high pressure elevates the boiling point of the solvent, facilitating use of higher temperature for extraction without changing the original physical state of the solvent. This elevated temperature increases the solubility and reduces the viscosity and surface tension of the solvent and thus increases the mass transfer rate. Azmir et al. (2013) have recommended PLE for extraction of natural bioactive products: isoflavones from soybean, terpenoids and sterols from tobacco, flavonoids from spinach and phenolic compounds from parsley flakes. Wijngaard et al. (2012) have summarised the application of PLE for efficient extraction of polyphenols from plant by-products such as procyanidins and anthocyanins from red grape pomace, flavonols from onion waste, phenolic acids from potato peels and polyphenols from apple pomace.
In regard to supercritical fluid extraction (SCF), Herrero et al. (2010) have extensively described its mechanism and application for extraction of various bioactives from plant by-products, i.e. caffeine from tea stalk, phytosterols from loquat seeds, polyphenols from pomegranate seeds and lycopenes from tomato waste.
Biologically assisted extraction or commonly known as enzyme-assisted extraction (EAE) is another novel and green extraction method in plant bioactives. The mechanism, benefits over chemical and physical extraction processes, and application of enzyme-assisted extraction (EAE) towards extraction of plant bioactives have been discussed and reviewed by Puri et al. (2012). The authors have enlisted a gamut of products obtained using EAE including oils and carotenoids, pectins, inulin, lignans, soluble fibres, phenolics, flavonoids and vanillin.
High hydrostatic pressure (HHP) or high pressure extraction (HPE) is another emerging technology for extraction purposes which works on pressure gradient principle. Very high pressure is applied in two stages: (i) below deformation limit that leads to extraction solvent inflow through micro channels of the cell wall and (ii) above deformation limit leading into cell deformation and cell wall damage causing increased permeability and decreased resistance for diffusion. At the final pressure relief stage, the pressure rapidly decreases causing cell expansion facilitating intracellular fluid outflow (Huang et al. 2013). Prasad et al. (2010) and Corrales et al. (2008) have showed the potential application of HPE in extraction of phenolic compounds from longan fruit pericarp tissues and grape by-products, respectively. The authors have demonstrated the higher total phenolic content and antioxidant activity of the HPE extracts compared to conventional extracts.
Instant controlled pressure drop (DIC) extraction technology is based on combined thermo-mechanical effects arising due to an abrupt pressure drop towards a vacuum after a short-time/high-temperature and pressure treatment of the sample. The abrupt pressure drop causes instantaneous cooling of the products and thereby preventing thermal-induced degradation. This leads to expansion of matrix structure and breaking of the cell wall, thus causing auto-vaporisation of volatile compounds and improved mass transfer of desired compounds (Mounir et al. 2014). Allaf et al. (2013) and Ben Amor and Allaf (2009) have reported the use of DIC as an effective pretreatment tool for enhanced extraction of anthocyanins from hibiscus flower and essential oil from orange peel, respectively.
Description and Applications of Ultrasound-Assisted Extraction
Ultrasound waves are high frequency (>20 kHz) sound waves beyond the threshold of human hearing. The basic principle of ultrasound-assisted extraction (UAE) is acoustic cavitation and micro-streaming. When high power ultrasound waves propagate through any medium, a sequence of compressions and rarefactions is induced in the molecules of the medium causing pressure alteration. The developed negative pressure during the rarefaction phase advances above tensile strength of the fluid causing the formation of cavitation bubbles from the gas nuclei of the medium. These bubbles grow over a number of cycles until they become unstable and finally violently collapse/implodes. This phenomenon of creation, expansion, and implosive collapse of bubbles in ultrasonicated medium is called acoustic cavitation phenomenon (Tiwari 2015). Figure 1 depicts the schematic representation of the acoustic cavitation mechanism. Since frequency is inversely proportional to the bubble size (Lorimer and Mason 1987), so in case of power ultrasound treatments, larger cavitation bubbles are formed. This implosion generates high temperature and pressure which in turn results into high sheer energy waves and turbulence causing combination of mechanical effect on the material (Soria and Villamiel 2010). It also develops strong micro-streaming currents that may alter the characteristic of the medium. These effects collectively cause disruption of cell wall resulting into greater diffusion and improved mass transfer rate causing better release of intracellular material. Thus, UAE can provide added benefit by increasing the extraction yield at lower temperatures and thus decreasing extraction time resulting in a better quality product (Mason et al. 1996). Additionally, commercial scale-up of UAE process is achievable with good return on capital investment (Patist and Bates 2008).
Two types of ultrasound equipment are most commonly used for extraction purposes, namely, ultrasonic water bath and ultrasonic probe system fitted with horn transducers. The factors affecting the efficiency of ultrasonic treatments can be divided into three categories: (1) process factors such as frequency, amplitude, power and treatment time; (2) product factors such as moisture content, particle size and compound of interest and (3) media factor such as pressure, temperature, viscosity and polarity of solvent (Wang and Weller 2006; Patist and Bates 2008). Ultrasonic intensity (UI in Watt/cm2) is expressed as actual power output per surface area of probe, i.e. 4P/πD2, where P = ultrasonic power, i.e. amount of energy (Q = mCp∆T) consumed per unit time and D is diameter of probe (Tiwari et al. 2008).
Optimal conditions (mostly response surface methodology (RSM)) for extraction of target bioactives from various agro-industrial by-products using UAE are outlined in Table 3. For example, Roselló-Soto et al. (2015) have shown that water extracts of olive kernel by-product yield approximately 1.5-fold to 2-fold higher proteins at 18 and 55 kJ/kg ultrasonic energy input, respectively. The extracts also had a higher level of carotenoids, chlorophylls (a and b), total phenolic content (TPC) and antioxidant capacity compared to untreated samples. Fu et al. (2006) have examined alkaline extraction of xyloglucan, a hemicellulose, from apple pomace using ultrasound-assisted extraction (operating power of 160 W) and found that the technique produced a comparable yield about three times faster than the traditional alkaline extraction method without UAE. The optimum ultrasonic extraction parameters (using RSM with central composite design (CCD)) were found to be liquid to solid ratio of 34.4:1 (v/w), 3.3 M potassium hydroxide concentration and an UAE time of 2.5 h. In another study, Minjares-Fuentes et al. (2014) observed 20% higher yields of pectins in UAE-pretreated (frequency 37 kHz, power 140 W and power density 0.05 W mL−1) grape pomace compared to control (extracted at same extraction conditions with no ultrasonic treatment). The optimal extraction conditions (RSM with Box-Behnken design (BBD)) was found to be solid to solvent ratio 1:10 (w/v), temperature 75 °C, time 60 min and pH 2.0, using citric acid as solvent. In addition, pectins from UAE exhibited a higher average molecular weight. In contrast, Samaram et al. (2015) concluded that application of UAE could not increase the yield of papaya seed oil (rich in MUFA) compared to Soxhlet solvent extraction. They indicated that among different ultrasound extraction variables (namely time, temperature, power and solvent to sample ratio), the extraction time and extraction temperature were the most significant (p < 0.05) variables; however, the efficiency of oil extraction was increased at higher ultrasound power for longer time. Tian et al. (2013) observed that application of UAE at an elevated power (140 W) and temperature (40 °C) with high proportion of solvent to sample ratio (10 mL/g) resulted into higher oil recovery (25.11% yield) compared to conventional Soxhlet extraction (20.5% yield) from pomegranate seed. Yield % was calculated by using the formula (Wo/Ws × 100), where Wo is the weight of the extracted material (g) and Ws is the weight of the sample (g). Similarly, rice bran, a major by-product from rice milling industry, was used by Tabaraki and Nateghi (2011) to optimise the UAE parameters (RSM with CCD) for extraction of polyphenols and antioxidants. Maximum extraction yield of 19.83% (calculated by using the formula Wo/Ws × 100) was attained at 60 °C of UAE temperature, 87% ethanol concentration and 28 min of treatment time, whereas UAE temperature of 54 °C, extraction time of 40 min and 67% ethanol concentration resulted into optimal total phenols (6.21 mg GAE/gDw). The maximum antioxidant activity (FRAP) (54.14 μmol Fe2+/gDw) and antiradical activity (DPPH) (52.83% inhibition) was achieved at 51 °C UAE temperature, 45 min treatment time and ethanol concentration of 65 and 67%, respectively. In another study, citrus peels were treated with ultrasound to obtain polyphenolic rich fractions (Ma et al. 2009). The authors observed that the yields of extracts, after UAE at 15 °C for 1 h, were significantly higher than those by conventional maceration treatment at 40 °C for 8 h. The UAE temperature above 40 °C for 20 min resulted into lower yields of phenolic acids. It was noted that caffeic, p-coumaric, ferulic and p-hydroxybenzoic acid decreased significantly from 99.3 to 57.3, 168.9 to 136.6, 2224.5 to 1242.152 and 47.2 to 30.5 μg/gDw, respectively. Similarly, the TPC increased approximately by twofold when grape by-products were subject to ultrasonic extraction in ultrasonic bath of 35 kHz frequency at 70 °C for 1 h (Corrales et al. 2008). Application of UAE in extraction of anthocyanins from black chokeberry wastes with enhanced extraction rate was reported by Galván D’Alessandro et al. (2014)). The authors noted that ultrasound (100 W, 30.8 kHz)-assisted extraction of anthocyanins (3.15 mg cyanidin-3-glucoside equivalent per gram dry weight (CGE/gDw)) with water (1:40 solid to solvent ratio) at 20 °C temperature reduced the extraction time by threefold compared to unassisted extraction. However, a reduction of 20% extraction time was observed whilst extracting 9.58 mg CGE/gDw of anthocyanin at 70 °C in water. Various examples discussed above suggest that the UAE can be an effective technique in valorisation of numerous agro-industrial by-products for a wide range of bioactive compounds.
Description and Applications of Pulsed Electric Field-Assisted Extraction
Pulsed electric field (PEF)-assisted extraction involves the application of short duration pulses (μs to ms) of moderate electric voltage (typically 0.5–20 kV/cm) to a substrate of choice placed between two electrodes. Using high electric voltage (5–50 kV/cm), the technology has been applied for preservation, enzyme and microbial inactivation purposes (Mohamed and Eissa 2012). Low to mild PEF treatment intensities are often considered an effective pretreatment method for enhancement of secondary metabolite extraction yields in cell cultures and plant systems (Balasa et al. 2011). The basic principle of PEF-assisted extraction is electroporation due to dielectric disruption of cell membrane (Zimmermann et al. 1974). It is assumed that cell membranes act like a capacitor with low dielectric constant having natural trans-membrane potential due to the presence of free charges of opposite polarities across the membrane. When the external electric field is applied, the trans-membrane potential is increased because of the accumulation of charges across the membrane. Subsequent exposure to electric field further increases the potential leading to electrostatic attraction between opposite charges across the membrane causing thinning of membrane. Breakdown of the membrane occurs if the critical breakdown voltage is reached by a further increase in the external field strength causing trans-membrane pore formation (Fig. 2). Permeabilisation can be reversible or irreversible depending on field strength, pulse duration and number of pulses. Breakdown is reversible if the pores are small in relation to the total membrane surface; however, reversible breakdown turns into irreversible breakdown if the size and number of pores become larger due to longer exposure time above critical field strengths. Cells remain viable in case of reversible electroporation whereas irreversible electroporation leads to mechanical destruction of the cell membrane and makes cells unviable. Efficiency of PEF treatment is often measured as cell disintegration index (Z) where ‘0’ denotes intact cells and ‘1’ indicates fully disintegrated cells (Knorr et al. 2001). Critical process factors in PEF application are electric field intensity, treatment time (t PEF = number of pulses x pulse duration), pulse waveform (mainly exponential decaying, square wave, oscillatory, bipolar or instant reverse charges), conductivity, pH and ionic strength of the medium (Vega-Mercado et al. 1996), product geometry and size. Praporscic et al. (2005) demonstrated the effect of size and dimension of the sample on the efficiency of PEF treatment. They observed that the larger sized sugar beet slices (7 × 3 × 35 mm) yielded lowest juice (approx. 70%), whereas the highest yield (approx. 85%) was obtained from the smallest sized samples (1.5 × 1 × 35 mm).
PEF has been extensively investigated as a non-thermal food processing, food preservation and microbial inactivation technique. On the other hand, use of PEF in the recovery of bioactive compounds from by-products is less explored but is an expanding field of study. PEF technology offers a great opportunity in the area of improved extraction of intracellular valuable compounds (Ade-Omowaye et al. 2001). It helps in permeabilisation of cell membranes, thus increasing the diffusivity of the intracellular substances and improving extraction efficiency by increased mass transfer rate. Table 4 details the PEF-assisted extraction studies applied for extraction of various bioactive compounds from plant by-products.
For instance, Boussetta et al. (2014) investigated the influence of PEF treatment in the range of 10–20 kV/cm electric field intensity and 1–10 ms treatment time (t PEF) for the recovery of total polyphenols from rehydrated flaxseed hulls. Although the maximum amount of total polyphenols (2.7 times higher than control) was achieved at 20 kV/cm field intensity and 10 ms t PEF, 4 ms t PEF was chosen (2.3 times higher at this condition) from an optimum energy consumption point of view. Following 20 min of SLE extraction after PEF pretreatment under these conditions (20 kV/cm, t PEF 4 ms), a fourfold increase in total polyphenol content was observed in the PEF-treated samples compared to the untreated sample. However, they have shown that lower electric field intensity treatment resulted in lower polyphenol recovery. Impact of low intensity PEF treatments (0.25–1 kV/cm, 5–500 pulses of 3 μs pulse width with frequency of 10 Hz) on glycoalkaloid recovery from potato peel was studied by Hossain et al. (2015). When PEF treatment with field strength of 0.75 kV/cm and 600 μs was applied, maximum total steroidal alkaloid (glycoalkaloids and aglycone alkaloids) yield was obtained, which was 99.9% higher than the untreated sample. The authors also demonstrated that levels of aglycone alkaloids, i.e. solanidine and demissidine, exhibited an increasing trend with increase in electric field strength up to 0.75 kV/cm except at 1 kV/cm at any given treatment time. The maximum yield of solanidine (1.35 mg/gDw) and demissidine (0.26 mg/gDw) was achieved at electric field strength of 0.75 kV/cm with 1500 μs treatment time, which was 130.86 and 56.37% higher than the control, respectively. Interestingly, the authors suggested that the glycoalkaloids are more susceptible to PEF-induced degradation than their aglycones.
In another study, Parniakov et al. (2014) concluded that PEF pretreatment at electric field strength of 13.33 kV/cm in a batch process for 2720 s with 400 pulses prior to aqueous extraction from papaya peel waste caused significant enhancement in yield of proteins, carbohydrates and phenolic compounds even at moderate temperature of 50 °C and neutral pH compared to untreated samples.
The majority of PEF-assisted extraction studies from by-products have targeted the polyphenolic compounds; nevertheless, extraction of polysaccharides, proteins, isothiocyanates, phytosterols, steroidal alkaloids, seed and germ oil, etc. have also been investigated (Roselló-Soto et al. 2015; Sarkis et al. 2015; Parniakov et al. 2015). In recent years, research interests have grown towards the application of PEF for recovery of value-added products from by-products. In general, most of the research works have demonstrated advantages of the application of moderate electric field pulse technology either as pretreatment step or as continuous extraction system in the area of phytochemical extraction from by-products.
Integrated Novel Extraction Technologies in Combination to UAE and PEF
The integration of UAE and PEF-assisted extraction techniques with each other or with other novel extraction techniques like MAE, SFE, EAE and DIC with the objective to improve process efficiency is an area of current research interest. Whilst most of the combination studies adopt a sequential approach, very little is known about their simultaneous/coupled application. Additionally, there is limited literature on the use of combined novel extraction technologies with respect to bioactive recovery from agro-industrial by-products. Some of the examples describing the combination studies with UAE and/or PEF for extraction of bioactive compounds from agro-industrial wastes are outlined in Table 5.
Zhu et al. (2015a) investigated the combination of PEF and ohmic heating (pulsed ohmic heating) as a pretreatment step prior to solid–liquid extraction of inulin from chicory roots. Results showed that higher ohmic heating (55 °C) combined with electroporation (800 V/cm) causes more damage to chicory tissues (Z = 0.9 after t PEF = 0.3 s) compared to low temperature ohmic heating (30 °C) at the same PEF strength (Z = 0.75 and t PEF = 2 s). Moreover, the solute diffusivity D, for the different PEF treatments at constant temperature (30 °C), was found to be nearly the same for same values of Z. The authors also reported that preheated tissues at 50 and 70 °C had very low levels of cell disintegration in absence of electroporation. This shows that conventional heating or PEF treatment without ohmic heating applied separately is less effective than the pulsed ohmic heating treatment in combination with PEF for chicory tissue permeabilisation. Likewise, Praporscic et al. (2005) studied the combined effect of PEF with ohmic acid for the extraction of juice from sugar beet cuts. They reported enhanced recovery of juice up to 87.5% when ohmic heating at 60 °C for 10 min was followed by PEF treatment (600 V/cm, 400 pulses of 100 μs width and t PEF of 0.04 s) compared to 77% yield with only ohmic heating.
The application of PEF either as pretreatment prior to pressing or as combined treatment with pressing for extraction of juices from apple, sugar beet, carrot and spinach have been described by Vorobiev and Lebovka (2006). The authors noted increase in sugar beet juice yield with PEF pretreatment and combined PEF treatment with pressing (compressive pressure at 10 bars) by 62.3 and 82.4%, respectively, compared to pressing alone. Moreover, the qualities of the juice from PEF-treated sugar beet samples were better in terms of colour (less coloured), purity (no pectin contamination) and sugar concentration (high). Similar improvements were observed for carrot and spinach juice where total yield was improved to 38.3 and 60.6% with combined PEF treatment compared to 25.6 and 30% yield from conventional pressing process at 5 and 10 bars, respectively.
In another study, Pasquel Reátegui et al. (2014) investigated the use of supercritical CO2 (SFE) at 15 MPa operating pressure and 40 °C coupled with an ultrasonic probe of 13 mm diameter (working power of 200 W) on the upper end of the supercritical fluid extraction cell. The combined treatment of SFE and ultrasonics enhanced the yield of phenolics by 30% from blackberry bagasse with a reduction in extraction time compared to uncoupled supercritical extraction. The authors also observed that using 10% water as a co-solvent at a working temperature of 60 °C resulted into the highest total phenolics (49.36 ± 0.27 mg GAE/gDw extract), ABTS antioxidant activity (154.98 ± 1.83 μmol TE/gDw extract) and anthocyanin recovery (6.594 ± 0.40 mg/gDw extract). The enhanced mass transfer with ultrasound coupling was attributed to structural changes of the substrate as observed by the scanning electron microscopy image analyser. It can be seen from the above-mentioned examples that the combined techniques can be more efficient than the techniques used in isolation. However, more such studies are required with different combinations to provide better understanding on the most effective combinations.
Some researchers have also examined the use of extraction techniques in sequence. For example, Liu et al. (2011) observed 21.39% increase in oil extraction efficiency from watermelon seeds when seeds were ultrasonicated at 547 W and 48 °C for 23 s prior to aqueous enzymatic extraction. Similarly, ultrasound-assisted-enzymatic extraction of arabinoxylan from wheat bran was investigated by Wang et al. (2014). The authors obtained an arabinoxylan yield of 3.12 ± 0.05 mg/gDw of destarched and deproteined wheat bran. Using the optimum raw material concentration, they observed a 40% improvement in arabinoxylan yield for EAE with UAE in comparison to EAE alone.
Teh et al. (2015) used a PEF pretreatment in combination to UAE to extract polyphenols from defatted canola seed cake and optimised the process using RSM. The optimised conditions resulted in higher total phenolic content (as gallic acid equivalent (GAE)) and flavonoid content (as luteolin equivalent (LUE)) compared to conventional extraction methods. However, separate application of PEF or UAE alone was not conducted, making it difficult to judge the best possible novel technique either in isolation or in combination.
The effect of instant controlled pressure drop (DIC) combined with UAE for recovery of the antioxidant compounds hesperidin and naringin from orange peel was also evaluated by Allaf et al. (2013). The authors reported that the highest extraction yield of both naringin (~0.065 g/gDw) and hesperidin (~ 0.82 g/gDw) was recorded with DIC-pretreated samples combined with UAE using 80% ethanol as a solvent, and solid to solvent ratio of 1:20 at 40 °C for 60 min in ultrasonic bath operating at 25 kHz frequency with 150 W output power. The authors reported the order of extraction yield of naringin as well as hesperidin as DIC-UAE > DIC-SLE > UAE > SLE. They also noted that DIC pretreatment reduced the time to achieve 95% of the final extraction yield of naringin by an hour and a half compared to solid–liquid extraction and less than an hour with UAE.
In the above sections, the application of UAE and PEF along with their integration with each other or with other novel extraction techniques with respect to by-product utilisation has been emphasised. However, studies in which direct comparison of UAE and PEF with respect to agro-industrial by-product valorisation are also of interest despite the fact that only a small number of such studies have been conducted. Notwithstanding this, Corrales et al. (2008) compared the effect of UAE (35 kHz, 70 °C, 1 min) and PEF pretreatment (3 kV/cm, 30 pulses, 10 kJ/kg, 70 °C, 15 s) with 1 h of diffusion in 50% ethanol at 1:4.5 solid to liquid ratio, on the extraction of total phenolics and anthocyanins from grape by-products. Although twofold increase in TPC was noted for both UAE and PEF-treated samples compared to untreated samples, no significant difference between UAE and PEF treatment was observed. On the other hand, PEF treatment was found to be more effective for anthocyanins extraction (1.8-fold increase); however, UAE treatment showed no significant increase. Additionally, PEF-treated samples showed 4.2-fold increase in antioxidant activity against only 1.6-fold increase for UAE samples when compared to untreated samples making PEF a better choice. In another study of UAE and PEF for extraction of protein and phenolic compounds from olive kernel (Roselló-Soto et al. 2015), 18 kJ/kg energy input for both UAE- and PEF-treated samples resulted into total phenolics of 100 mg GAE/L, whereas protein recovery was approximately 175 and 100 mg/L, respectively. Similarly, at highest energy input (109 kJ/kg), TPC content was 150 mg GAE/L for both UAE- and PEF-treated samples and protein recovery was ~250 and ~100 mg/L, respectively, showing UAE as more efficient extraction novel technique. Moreover, a previous work on protein and polyphenol extraction using UAE and PEF from vine shoot interestingly validated that PEF pretreatment (13.3 kV/cm, 0–1500 pulses, 10 μs pulse width, 0.5 Hz pulse frequency, 50 °C, 0–762 kJ/kg) was more efficient than UAE (ultrasonic probe of 14 mm diameter, 24 kHz, 400 W, 50 °C, 3 h diffusion, 0–3428 kJ/kg) (Rajha et al. 2014). A relative increase of 2.1 and 1.5 in total phenolics recovery was obtained at highest energy input of 762 and 3428 kJ/kg for PEF and UAE, respectively, demonstrating the much lower energy requirement by PEF treatment. Specifically, the content of individual phenolic compounds, i.e. kaempferol (0.156 mg/g), epicatechin (1.747 mg/g), resveratrol (0.032 mg/g) was higher in PEF-treated extracts compared to UAE extracts (kaempferol (0.097 mg/g), epicatechin (0.671 mg/g) and resveratrol (0.024 mg/g). Recently, Barba et al. (2015) demonstrated that DPPH antioxidant activity and total anthocyanins concentrations from fermented grape pomace were significantly higher with PEF treatment at cell disintegration index of Z ≥ 0.6 compared to UAE. However, no significant difference was evident in case of TPC. They also reported that the energy consumption to achieve 1 mg of TPC or anthocyanin was always higher for UAE than PEF. From the above examples, it is apparent that both PEF and UAE has potential for intensified bioactive extraction; however, choosing between the two technology depends on various factors like type of substrate material, amount of energy input and quality of the extract.
Impact of UAE and PEF Extraction Techniques on Stability of Bioactives
The application of UAE and PEF at various stages of bioactive extraction from agro by-products is reviewed in the previous sections. The discussions were based primarily on the effect of these technologies on extraction efficiency and yield. There is however the potential of degradation effect of UAE and PEF treatments during extraction; a vast majority of the studies have mainly concentrated on the quantity of the compound rather than the type and structure of the new compounds formed by degradation (Rostagno et al. 2003; Chukwumah et al. 2009; Guderjan et al. 2005; Corrales et al. 2008). For example, Sun et al. (2011) observed that when dichloromethane was used as solvent whilst UAE extraction from mandarin peel, all-trans-β-carotene (a type of carotenoid) was absent compared to control (~3.8 μg/gDw) suggesting degradation of all-trans-β-carotene upon ultrasound application. However, authors did not report the type of degradation products formed during extraction. In contrast, the effect of novel processing techniques on the stability of health-promoting compounds in some food products (especially juices, puree and oils) have been studied and reviewed from a processing and preservation viewpoint. The most studied alterations in food product processing using ultrasound and PEF appear to be related to pigment compounds (anthocyanin, carotenoids), together with antioxidant activity, vitamin C content and fatty acid composition (Rawson et al. 2011; Pingret et al. 2013). Whilst very few fundamental studies elucidating the effect of UAE- and PEF-assisted extraction on the structure of the specific components from generic substrates have been conducted, the small number of studies examining the structural modification effect of ultrasound- and PEF-assisted extraction on the targeted compounds pertaining to agro by-products are outlined in Table 6. Furthermore, some studies using different model systems by employing ultrasound or PEF treatments on pure form of targeted bioactive compounds instead of food matrix have been conducted to examine the effect of sonication and PEF on the stability of bioactive compounds like carotenoids, phenolic acids and flavonoids.
The degradation of all-trans-lycopene via isomerisation during UAE extraction from red grape fruit has been reported by Xu and Pan (2013). The authors tentatively identified various isomers of all-trans-lycopene such as 9,13′-di-cis-, 9,13-di-cis-, 15-cis-, 13-cis- and 9-cis-lycopene isomers by HPLC-PAD. Ultrasonic extraction of oil from kiwi seed having nutritionally interesting fatty acid profile showed differences in the fatty acid composition compared to conventionally extracted oil with the detection of marker lipid degradation compounds such as limonene (Z)-hept-2-enal and (2E, 4E)-deca-2,4-dienal (Cravotto et al. 2011). Zhao et al. (2006) examined the effect of ultrasonic treatment on the (all-E)-astaxanthin (a type of carotenoid) as a model compound and confirmed the degradation using HPLC analysis and UV/vis measurements into unidentified colourless compound. They also witnessed the detrimental effect of higher treatment time and ultrasonic power on the stability of the astaxanthin compound. Nevertheless, the study was conducted in model system rather than food matrix. Carail et al. (2015) studied the effect of high power ultrasound (20 kHz) on the stability of all-E-beta-carotene with respect to ultrasonic intensity, sonication time and temperature using a model system as well. The results showed the degradation effect in the order of sonication time > ultrasonic intensity > temperature. The authors also characterised the newly formed products using UPLC-MS/MS and tentatively identified four Z-isomers and seven β-apo-carotenals along with some unidentifiable oxygenated β-carotene derivatives. They also noted that degradation was more predominant in aqueous system compared to organic solvents. Another study investigating the effect of ultrasound treatment on seven phenolic acids in a model system revealed that the stability is not only dependent on type of phenolic acid but also on type of solvent and temperature of the system. Caffeic acid and sinapic acid were found to be more susceptible to degradation compared to protocatechuic acid, vanillic acid, p-hydroxybenzoic acid and p-coumaric acid. Ferulic was found to be the most stable. It was found that the degradation rate of caffeic acid was seven times faster at −5 °C compared to 25 °C. Analysis of the degradation product of caffeic acid and sinapic acid using HPLC-MS/MS and FT-IR indicated the occurrence of decarboxylation and polymerisation reactions leading to the presence of dimers; however, the structure of the degraded products was not investigated (Qiao et al. 2013). Luo et al. (2010) applied a PEF treatment on pure chitosan to conduct a study on physicochemical changes in chitosan structure. The result showed significant deformation in the chitosan granules with decrease in the molecular weight and reduction in crystallinity. Furthermore, the FT-IR spectra and UV absorption spectra confirmed that the carbonyl and carboxyl group bonds were weakened but no modification in chemical structure was observed.
It is evident from the above discussed facts that the nature of the stability of phytochemicals during ultrasound- or PEF-assisted extraction from plant matrices is poorly understood, although some studies on model system do exist. In particular, there is very little information on the type or structures of the newly degraded or regenerated products due to UAE or PEF treatments.
Conclusions and Future Trends
Agro-industrial by-products represent a potential source of natural food bioactives and the availability of economical and efficient extraction processes is a must to exploit the potential of low-cost by-products. Application of novel extraction technologies (recommended as clean, green extraction technology) can be a good choice as these emerging techniques employ less solvent and can be used with GRAS solvents and development of industrial scale UAE equipment is possible. Applications of PEF-assisted extractions represent the potential to implement energy efficient processes to enhance the recovery of bioactive compounds. Notably, the application of moderate PEF requiring low energy inputs has been shown to improve the extractability of valuable bioactive compounds from different food matrices. However, if the potential of these novel techniques is to be fully exploited, a number of urgent knowledge gaps need to be filled. In particular, research should focus on optimising and standardising UAE and PEF conditions for each application for industrial uptake. To date, limited information in the area of the stability studies following UAE- and PEF-assisted extractions provides unique opportunity for further research on individual bioactive component. Use of mass spectrometry and NMR spectroscopy can be of great help in the stability research. More experimental studies on direct comparison of PEF against UAE extraction are necessary to establish the relative merits of these two techniques.
References
Ade-Omowaye, B. I. O., Angersbach, A., Taiwo, K. A., & Knorr, D. (2001). Use of pulsed electric field pre-treatment to improve dehydration characteristics of plant based foods. Trends in Food Science & Technology, 12(8), 285–295. doi:10.1016/S0924-2244(01)00095-4.
Allaf, T., Tomao, V., Ruiz, K., & Chemat, F. (2013). Instant controlled pressure drop technology and ultrasound assisted extraction for sequential extraction of essential oil and antioxidants. Ultrasonics Sonochemistry, 20(1), 239–246. doi:10.1016/j.ultsonch.2012.05.013.
Alzate, L. M., González, D., & Londoño-Londoño, J. (2013). Recovery of carotenoids from agroindustrial by-products using clean extraction techniques: supercritical fluid extraction and ultrasound assisted extraction. Colombia: Paper presented at the III Iberoamerican Conference on supercritical fluids.
Anderson, J. W., Smith, B. M., & Gustafson, N. J. (1994). Health benefits and practical aspects of high-fiber diets. The American Journal of Clinical Nutrition, 59(5), 1242S–1247S.
Ayala-Zavala, J. F., Vega-Vega, V., Rosas-Domínguez, C., Palafox-Carlos, H., Villa-Rodriguez, J. A., Siddiqui, M. W., et al. (2011). Agro-industrial potential of exotic fruit byproducts as a source of food additives. Food Research International, 44(7), 1866–1874. doi:10.1016/j.foodres.2011.02.021.
Azmir, J., Zaidul, I. S. M., Rahman, M. M., Sharif, K. M., Mohamed, A., Sahena, F., et al. (2013). Techniques for extraction of bioactive compounds from plant materials: a review. Journal of Food Engineering, 117(4), 426–436. doi:10.1016/j.jfoodeng.2013.01.014.
Balasa, A., Janositz, A., & Knorr, D. (2011). Electric field stress on plant systems. Encyclopedia of Biotechnology in Agriculture and Food, 2, 208–211. doi:10.1081/E-EBAF-120045407.
Balasundram, N., Sundram, K., & Samman, S. (2006). Phenolic compounds in plants and agri-industrial by-products: antioxidant activity, occurrence, and potential uses. Food Chemistry, 99(1), 191–203. doi:10.1016/j.foodchem.2005.07.042.
Bandyopadhyay, K., Misra, G., & Ghosh, S. (2008). Preparation and characterisation of protein hydrolysates from Indian defatted rice bran meal. Journal of Oleo Science, 57(1), 47–52.
Barba, F. J., Brianceau, S., Turk, M., Boussetta, N., & Vorobiev, E. (2015). Effect of alternative physical treatments (ultrasounds, pulsed electric fields, and high-voltage electrical discharges) on selective recovery of bio-compounds from fermented grape pomace. Food and Bioprocess Technology, 8(5), 1139–1148. doi:10.1007/s11947-015-1482-3.
Baysal, T., Ersus, S., & Starmans, D. (2000). Supercritical CO2 extraction of β-carotene and lycopene from tomato paste waste. Journal of Agricultural and Food Chemistry, 48(11), 5507–5511.
Ben Amor, B., & Allaf, K. (2009). Impact of texturing using instant pressure drop treatment prior to solvent extraction of anthocyanins from Malaysian Roselle (Hibiscus sabdariffa). Food Chemistry, 115(3), 820–825. doi:10.1016/j.foodchem.2008.12.094.
Bocco, A., Cuvelier, M.-E., Richard, H., & Berset, C. (1998). Antioxidant activity and phenolic composition of citrus peel and seed extracts. Journal of Agricultural and Food Chemistry, 46(6), 2123–2129.
Bourgou, S., Rahali, F. Z., Ourghemmi, I., & Saïdani Tounsi, M. (2012). Changes of peel essential oil composition of four Tunisian citrus during fruit maturation. The Scientific World Journal, 2012, 1–10. doi:10.1100/2012/528593.
Boussetta, N., Soichi, E., Lanoisellé, J. L., & Vorobiev, E. (2014). Valorization of oilseed residues: extraction of polyphenols from flaxseed hulls by pulsed electric fields. Industrial Crops and Products, 52, 347–353. doi:10.1016/j.indcrop.2013.10.048.
Carail, M., Fabiano-Tixier, A.-S., Meullemiestre, A., Chemat, F., & Caris-Veyrat, C. (2015). Effects of high power ultrasound on all-E-β-carotene, newly formed compounds analysis by ultra-high-performance liquid chromatography–tandem mass spectrometry. Ultrasonics Sonochemistry, 26, 200–209. doi:10.1016/j.ultsonch.2015.04.003.
Charrouf, Z., & Guillaume, D. (2007). Phenols and polyphenols from Argania spinosa. American Journal of Food Technology, 2(7), 679–683.
Chavan, U. D., McKenzie, D. B., & Shahidi, F. (2001). Functional properties of protein isolates from beach pea (Lathyrus maritimus L.) Food Chemistry, 74(2), 177–187. doi:10.1016/S0308-8146(01)00123-6.
Chen, Y., Luo, H., Gao, A., & Zhu, M. (2011). Ultrasound-assisted extraction of polysaccharides from litchi (Litchi chinensis Sonn.) seed by response surface methodology and their structural characteristics. Innovative Food Science & Emerging Technologies, 12(3), 305–309. doi:10.1016/j.ifset.2011.03.003.
Chen, J., Chen, L., Lin, S., Liu, C., & Cheung, P. C. K. (2015a). Preparation and structural characterization of a partially depolymerized beta-glucan obtained from Poria cocos sclerotium by ultrasonic treatment. Food Hydrocolloids, 46, 1–9. doi:10.1016/j.foodhyd.2014.12.005.
Chen, M., Zhao, Y., & Yu, S. (2015b). Optimisation of ultrasonic-assisted extraction of phenolic compounds, antioxidants, and anthocyanins from sugar beet molasses. Food Chemistry, 172, 543–550. doi:10.1016/j.foodchem.2014.09.110.
Cheung, P. C. K. (2013). Mini-review on edible mushrooms as source of dietary fiber: preparation and health benefits. Food Science and Human Wellness, 2(3–4), 162–166. doi:10.1016/j.fshw.2013.08.001.
Chukwumah, Y. C., Walker, L. T., Verghese, M., & Ogutu, S. (2009). Effect of frequency and duration of ultrasonication on the extraction efficiency of selected isoflavones and trans-resveratrol from peanuts (Arachis hypogaea). Ultrasonics Sonochemistry, 16(2), 293–299. doi:10.1016/j.ultsonch.2008.07.007.
Corrales, M., Toepfl, S., Butz, P., Knorr, D., & Tauscher, B. (2008). Extraction of anthocyanins from grape by-products assisted by ultrasonics, high hydrostatic pressure or pulsed electric fields: a comparison. Innovative Food Science & Emerging Technologies, 9(1), 85–91. doi:10.1016/j.ifset.2007.06.002.
Cowan, M. M. (1999). Plant products as antimicrobial agents. Clinical Microbiology Reviews, 12(4), 564–582.
Cravotto, G., Boffa, L., Mantegna, S., Perego, P., Avogadro, M., & Cintas, P. (2008). Improved extraction of vegetable oils under high-intensity ultrasound and/or microwaves. Ultrasonics Sonochemistry, 15(5), 898–902. doi:10.1016/j.ultsonch.2007.10.009.
Cravotto, G., Bicchi, C., Mantegna, S., Binello, A., Tomao, V., & Chemat, F. (2011). Extraction of kiwi seed oil: Soxhlet versus four different non-conventional techniques. Natural Product Research, 25(10), 974–981.
Da Porto, C., Porretto, E., & Decorti, D. (2013). Comparison of ultrasound-assisted extraction with conventional extraction methods of oil and polyphenols from grape (Vitis vinifera L.) seeds. Ultrasonics Sonochemistry, 20(4), 1076–1080. doi:10.1016/j.ultsonch.2012.12.002.
Da Porto, C., Natolino, A., & Decorti, D. (2015). The combined extraction of polyphenols from grape marc: ultrasound assisted extraction followed by supercritical CO2 extraction of ultrasound-raffinate. LWT - Food Science and Technology, 61(1), 98–104. doi:10.1016/j.lwt.2014.11.027.
Delgado-Pelayo, R., Gallardo-Guerrero, L., & Hornero-Méndez, D. (2014). Chlorophyll and carotenoid pigments in the peel and flesh of commercial apple fruit varieties. Food Research International, 65(Part B), 272–281. doi:10.1016/j.foodres.2014.03.025.
Dinoto, A., Suksomcheep, A., Ishizuka, S., Kimura, H., Hanada, S., Kamagata, Y., et al. (2006). Modulation of rat cecal microbiota by administration of raffinose and encapsulated Bifidobacterium breve. Applied and Environmental Microbiology, 72(1), 784–792. doi:10.1128/AEM.72.1.784-792.2006.
Eikani, M. H., Golmohammad, F., & Homami, S. S. (2012). Extraction of pomegranate (Punica granatum L.) seed oil using superheated hexane. Food and Bioproducts Processing, 90(1), 32–36. doi:10.1016/j.fbp.2011.01.002.
El Darra, N., Grimi, N., Vorobiev, E., Louka, N., & Maroun, R. (2013). Extraction of polyphenols from red grape pomace assisted by pulsed ohmic heating. Food and Bioprocess Technology, 6(5), 1281–1289. doi:10.1007/s11947-012-0869-7.
FAO. (2013). Food Wastage Footprint: Impacts on Natural Resources: Summary Report: FAO.
Fernandez, M. L., & West, K. L. (2005). Mechanisms by which dietary fatty acids modulate plasma lipids1. The Journal of Nutrition, 135(9), 2075–2078.
Flórez, N., Conde, E., & Domínguez, H. (2015). Microwave assisted water extraction of plant compounds. Journal of Chemical Technology & Biotechnology, 90(4), 590–607. doi:10.1002/jctb.4519.
Francisco, M. L. L. D., & Resurreccion, A. V. A. (2009). Total phenolics and antioxidant capacity of heat-treated peanut skins. Journal of Food Composition and Analysis, 22(1), 16–24. doi:10.1016/j.jfca.2008.05.012.
Fromm, M., Bayha, S., Carle, R., & Kammerer, D. (2012a). Comparison of fatty acid profiles and contents of seed oils recovered from dessert and cider apples and further Rosaceous plants. European Food Research and Technology, 234(6), 1033–1041. doi:10.1007/s00217-012-1709-8.
Fromm, M., Bayha, S., Carle, R., & Kammerer, D. R. (2012b). Characterization and quantitation of low and high molecular weight phenolic compounds in apple seeds. Journal of Agricultural and Food Chemistry, 60(5), 1232–1242. doi:10.1021/jf204623d.
Fu, C., Tian, H., Li, Q., Cai, T., & Du, W. (2006). Ultrasound-assisted extraction of xyloglucan from apple pomace. Ultrasonics Sonochemistry, 13(6), 511–516. doi:10.1016/j.ultsonch.2005.09.007.
Galanakis, C. M. (2012). Recovery of high added-value components from food wastes: conventional, emerging technologies and commercialized applications. Trends in Food Science & Technology, 26(2), 68–87. doi:10.1016/j.tifs.2012.03.003.
Galanakis, C. M. (2013). Emerging technologies for the production of nutraceuticals from agricultural by-products: a viewpoint of opportunities and challenges. Food and Bioproducts Processing, 91(4), 575–579. doi:10.1016/j.fbp.2013.01.004.
Galván D’Alessandro, L., Dimitrov, K., Vauchel, P., & Nikov, I. (2014). Kinetics of ultrasound assisted extraction of anthocyanins from Aronia melanocarpa (black chokeberry) wastes. Chemical Engineering Research and Design, 92(10), 1818–1826. doi:10.1016/j.cherd.2013.11.020.
Gangopadhyay, N., Wynne, K., O’Connor, P., Gallagher, E., Brunton, N. P., Rai, D. K., et al. (2016). In silico and in vitro analyses of the angiotensin-I converting enzyme inhibitory activity of hydrolysates generated from crude barley (Hordeum vulgare) protein concentrates. Food Chemistry, 203, 367–374. doi:10.1016/j.foodchem.2016.02.097.
Ghasemzadeh, A., Jaafar, H. Z., Juraimi, A. S., & Tayebi-Meigooni, A. (2015). Comparative evaluation of different extraction techniques and solvents for the assay of phytochemicals and antioxidant activity of Hashemi rice bran. Molecules, 20(6), 10822–10838. doi:10.3390/molecules200610822.
Ghoreishi, S., & Shahrestani, R. G. (2009). Subcritical water extraction of mannitol from olive leaves. Journal of Food Engineering, 93(4), 474–481.
Giannuzzo, A. N., Boggetti, H. J., Nazareno, M. A., & Mishima, H. T. (2003). Supercritical fluid extraction of naringin from the peel of Citrus paradisi. Phytochemical Analysis, 14(4), 221–223. doi:10.1002/pca.706.
Gil-Ramírez, A., Aldars-García, L., Palanisamy, M., Jiverdeanu, R. M., Ruiz-Rodríguez, A., Marín, F. R., et al. (2013). Sterol enriched fractions obtained from Agaricus bisporus fruiting bodies and by-products by compressed fluid technologies (PLE and SFE). Innovative Food Science & Emerging Technologies, 18, 101–107. doi:10.1016/j.ifset.2013.01.007.
González-Pérez, S., & Vereijken, J. M. (2007). Sunflower proteins: overview of their physicochemical, structural and functional properties. Journal of the Science of Food and Agriculture, 87(12), 2173–2191.
Guderjan, M., Töpfl, S., Angersbach, A., & Knorr, D. (2005). Impact of pulsed electric field treatment on the recovery and quality of plant oils. Journal of Food Engineering, 67(3), 281–287. doi:10.1016/j.jfoodeng.2004.04.029.
Hanmoungjai, P., Pyle, D. L., & Niranjan, K. (2001). Enzymatic process for extracting oil and protein from rice bran. Journal of the American Oil Chemists' Society, 78(8), 817–821. doi:10.1007/s11746-001-0348-2.
Hatanaka, T., Inoue, Y., Arima, J., Kumagai, Y., Usuki, H., Kawakami, K., et al. (2012). Production of dipeptidyl peptidase IV inhibitory peptides from defatted rice bran. Food Chemistry, 134(2), 797–802. doi:10.1016/j.foodchem.2012.02.183.
Herrero, M., Mendiola, J. A., Cifuentes, A., & Ibanez, E. (2010). Supercritical fluid extraction: recent advances and applications. Journal of Chromatography. A, 1217(16), 2495–2511. doi:10.1016/j.chroma.2009.12.019.
Hossain, M. B., Tiwari, B. K., Gangopadhyay, N., O'Donnell, C. P., Brunton, N. P., & Rai, D. K. (2014). Ultrasonic extraction of steroidal alkaloids from potato peel waste. Ultrasonics Sonochemistry, 21(4), 1470–1476. doi:10.1016/j.ultsonch.2014.01.023.
Hossain, M. B., Aguiló-Aguayo, I., Lyng, J. G., Brunton, N. P., & Rai, D. K. (2015). Effect of pulsed electric field and pulsed light pre-treatment on the extraction of steroidal alkaloids from potato peels. Innovative Food Science & Emerging Technologies, 29, 9–14. doi:10.1016/j.ifset.2014.10.014.
Huang, H. W., Hsu, C. P., Yang, B. B., & Wang, C. Y. (2013). Advances in the extraction of natural ingredients by high pressure extraction technology. Trends in Food Science & Technology, 33(1), 54–62. doi:10.1016/j.tifs.2013.07.001.
Joana Gil-Chávez, G., Villa, J. A., Fernando Ayala-Zavala, J., Basilio Heredia, J., Sepulveda, D., Yahia, E. M., et al. (2013). Technologies for extraction and production of bioactive compounds to be used as nutraceuticals and food ingredients: an overview. Comprehensive Reviews in Food Science and Food Safety, 12(1), 5–23. doi:10.1111/1541-4337.12005.
Kadam, S. U., Tiwari, B. K., & O'Donnell, C. P. (2013). Application of novel extraction technologies for bioactives from marine algae. Journal of Agricultural and Food Chemistry, 61(20), 4667–4675. doi:10.1021/jf400819p.
Kammerer, D. R., Kammerer, J., Valet, R., & Carle, R. (2014). Recovery of polyphenols from the by-products of plant food processing and application as valuable food ingredients. Food Research International, 65, 2–12. doi:10.1016/j.foodres.2014.06.012.
Kannan, A., Hettiarachchy, N. S., Lay, J. O., & Liyanage, R. (2010). Human cancer cell proliferation inhibition by a pentapeptide isolated and characterized from rice bran. Peptides, 31(9), 1629–1634. doi:10.1016/j.peptides.2010.05.018.
Khan, M. K., Abert-Vian, M., Fabiano-Tixier, A.-S., Dangles, O., & Chemat, F. (2010). Ultrasound-assisted extraction of polyphenols (flavanone glycosides) from orange (Citrus sinensis L.) peel. Food Chemistry, 119(2), 851–858. doi:10.1016/j.foodchem.2009.08.046.
Kleessen, B., Sykura, B., Zunft, H.-J., & Blaut, M. (1997). Effects of inulin and lactose on fecal microflora, microbial activity, and bowel habit in elderly constipated persons. American Journal of Clinical Nutrition, 65(5), 1397–1402.
Knorr, D., Angersbach, A., Eshtiaghi, M. N., Heinz, V., & Lee, D.-U. (2001). Processing concepts based on high intensity electric field pulses. Trends in Food Science & Technology, 12(3–4), 129–135. doi:10.1016/S0924-2244(01)00069-3.
Korkina, L., Kostyuk, V., De Luca, C., & Pastore, S. (2011). Plant phenylpropanoids as emerging anti-inflammatory agents. Mini Reviews in Medicinal Chemistry, 11(10), 823–835.
Kubrakova, I. V., & Toropchenova, E. S. (2008). Microwave heating for enhancing efficiency of analytical operations. Inorganic Materials, 44(14), 1509–1519. doi:10.1134/s0020168508140069.
Kumari, B., Tiwari, B. K., Hossain, M. B., Rai, D. K., & Brunton, N. P. (2017). Ultrasound-assisted extraction of polyphenols from potato peels: profiling and kinetic modelling. International Journal of Food Science & Technology, 52(6), 1432–1439. doi:10.1111/ijfs.13404.
Larrauri, J. A. (1999). New approaches in the preparation of high dietary fibre powders from fruit by-products. Trends in Food Science & Technology, 10(1), 3–8. doi:10.1016/S0924-2244(99)00016-3.
Li, L., Zong, X. Y., Zhang, J., Wei, C. H., Huang, Z. G., & Luo, H. B. (2013). Antibacterial activity of brewer’s spent grains peptides to Staphylococcus aureus. [Peer reviewed papers from the 2013 International Conference on Materials Science and Chemical Engineering (MSCE 2013), Singapore]. Advanced Materials Research, 699, 320–325. doi:10.4028/www.scientific.net/AMR.699.320.
Lingyun, W., Jianhua, W., Xiaodong, Z., Da, T., Yalin, Y., Chenggang, C., et al. (2007). Studies on the extracting technical conditions of inulin from Jerusalem artichoke tubers. Journal of Food Engineering, 79(3), 1087–1093. doi:10.1016/j.jfoodeng.2006.03.028.
Liu, S., Jiang, L., & Li, Y. (2011). Research of aqueous enzymatic extraction of watermelon seed oil of ultrasonic pretreatment assisted. Procedia Engineering, 15, 4949–4955. doi:10.1016/j.proeng.2011.08.921.
Loginova, K. V., Lebovka, N. I., & Vorobiev, E. (2011). Pulsed electric field assisted aqueous extraction of colorants from red beet. Journal of Food Engineering, 106(2), 127–133. doi:10.1016/j.jfoodeng.2011.04.019.
Lorimer, J. P., & Mason, T. J. (1987). Sonochemistry. Part 1—the physical aspects. Chemical Society Reviews, 16, 239–274. doi:10.1039/CS9871600239.
Luengo, E., Álvarez, I., & Raso, J. (2013). Improving the pressing extraction of polyphenols of orange peel by pulsed electric fields. Innovative Food Science & Emerging Technologies, 17, 79–84. doi:10.1016/j.ifset.2012.10.005.
Luo, W. B., Han, Z., Zeng, X. A., Yu, S. J., & Kennedy, J. F. (2010). Study on the degradation of chitosan by pulsed electric fields treatment. Innovative Food Science & Emerging Technologies, 11(4), 587–591. doi:10.1016/j.ifset.2010.04.002.
Ma, Y.-Q., Chen, J.-C., Liu, D.-H., & Ye, X.-Q. (2009). Simultaneous extraction of phenolic compounds of citrus peel extracts: effect of ultrasound. Ultrasonics Sonochemistry, 16(1), 57–62. doi:10.1016/j.ultsonch.2008.04.012.
Mason, T. J., Paniwnyk, L., & Lorimer, J. P. (1996). The uses of ultrasound in food technology. Ultrasonics Sonochemistry, 3(3), S253–S260. doi:10.1016/S1350-4177(96)00034-X.
Minjares-Fuentes, R., Femenia, A., Garau, M. C., Meza-Velázquez, J. A., Simal, S., & Rosselló, C. (2014). Ultrasound-assisted extraction of pectins from grape pomace using citric acid: a response surface methodology approach. Carbohydrate Polymers, 106, 179–189. doi:10.1016/j.carbpol.2014.02.013.
Mohamed, M. E. A., & Eissa, A. H. A. (2012). Pulsed electric fields for food processing technology. In A. A. Eissa (Ed.), Structure and Function of Food Engineering (pp. 275–306). Rijeka: InTech.
Moreau, R. A., Singh, V., Nunez, A., & Hicks, K. B. (2000). Phytosterols in the aleurone layer of corn kernels. Biochemical Society Transactions, 28(6), 803–806.
Mounir, S., Allaf, T., Berka, B., Hassani, A., & Allaf, K. (2014). Instant controlled pressure drop technology: from a new fundamental approach of instantaneous transitory thermodynamics to large industrial applications on high performance–high controlled quality unit operations. Comptes Rendus Chimie, 17(3), 261–267. doi:10.1016/j.crci.2013.10.019.
Murthy, P. S., & Naidu, M. M. (2010). Recovery of phenolic antioxidants and functional compounds from coffee industry by-products. Food and Bioprocess Technology, 5(3), 897–903. doi:10.1007/s11947-010-0363-z.
Mussatto, S. I., Fernandes, M., & Roberto, I. C. (2007). Lignin recovery from brewer’s spent grain black liquor. Carbohydrate Polymers, 70(2), 218–223. doi:10.1016/j.carbpol.2007.03.021.
O'Connell, O. F., Ryan, L., & O'Brien, N. M. (2007). Xanthophyll carotenoids are more bioaccessible from fruits than dark green vegetables. Nutrition Research, 27(5), 258–264. doi:10.1016/j.nutres.2007.04.002.
Olas, B., & Wachowicz, B. (2005). Resveratrol, a phenolic antioxidant with effects on blood platelet functions. Platelets, 16(5), 251–260.
Parniakov, O., Barba, F. J., Grimi, N., Lebovka, N., & Vorobiev, E. (2014). Impact of pulsed electric fields and high voltage electrical discharges on extraction of high-added value compounds from papaya peels. Food Research International, 65(Part C), 337–343. doi:10.1016/j.foodres.2014.09.015.
Parniakov, O., Rosello-Soto, E., Barba, F. J., Grimi, N., Lebovka, N., & Vorobiev, E. (2015). New approaches for the effective valorization of papaya seeds: extraction of proteins, phenolic compounds, carbohydrates, and isothiocyanates assisted by pulsed electric energy. Food Research International, 77, 711–717. doi:10.1016/j.foodres.2015.03.031.
Pasquel Reátegui, J. L., Machado, A. P., Barbero, G. F., Rezende, C. A., & Martínez, J. (2014). Extraction of antioxidant compounds from blackberry (Rubus sp.) bagasse using supercritical CO2 assisted by ultrasound. The Journal of Supercritical Fluids, 94, 223–233. doi:10.1016/j.supflu.2014.07.019.
Patist, A., & Bates, D. (2008). Ultrasonic innovations in the food industry: from the laboratory to commercial production. Innovative Food Science & Emerging Technologies, 9(2), 147–154. doi:10.1016/j.ifset.2007.07.004.
Peschel, W., Sánchez-Rabaneda, F., Diekmann, W., Plescher, A., Gartzía, I., Jiménez, D., et al. (2006). An industrial approach in the search of natural antioxidants from vegetable and fruit wastes. Food Chemistry, 97(1), 137–150. doi:10.1016/j.foodchem.2005.03.033.
Pinelo, M., Arnous, A., & Meyer, A. S. (2006). Upgrading of grape skins: significance of plant cell-wall structural components and extraction techniques for phenol release. Trends in Food Science & Technology, 17(11), 579–590. doi:10.1016/j.tifs.2006.05.003.
Pingret, D., Fabiano-Tixier, A.-S., & Chemat, F. (2013). Degradation during application of ultrasound in food processing: a review. Food Control, 31(2), 593–606. doi:10.1016/j.foodcont.2012.11.039.
Pourali, O., Asghari, F. S., & Yoshida, H. (2010). Production of phenolic compounds from rice bran biomass under subcritical water conditions. Chemical Engineering Journal, 160(1), 259–266. doi:10.1016/j.cej.2010.02.057.
Praporscic, I., Ghnimi, S., & Vorobiev, E. (2005). Enhancement of pressing of sugar beet cuts by combined ohmic heating and pulsed electric field treatment. Journal of Food Processing and Preservation, 29(5–6), 378–389. doi:10.1111/j.1745-4549.2005.00035.x.
Prasad, K. N., Yang, B., Zhao, M., Sun, J., Wei, X., & Jiang, Y. (2010). Effects of high pressure or ultrasonic treatment on extraction yield and antioxidant activity of pericarp tissues of longan fruit. Journal of Food Biochemistry, 34(4), 838–855. doi:10.1111/j.1745-4514.2010.00335.x.
Puri, M., Sharma, D., & Barrow, C. J. (2012). Enzyme-assisted extraction of bioactives from plants. Trends in Biotechnology, 30(1), 37–44. doi:10.1016/j.tibtech.2011.06.014.
Qiao, L., Ye, X., Sun, Y., Ying, J., Shen, Y., & Chen, J. (2013). Sonochemical effects on free phenolic acids under ultrasound treatment in a model system. Ultrasonics Sonochemistry, 20(4), 1017–1025.
Rajha, H. N., Boussetta, N., Louka, N., Maroun, R. G., & Vorobiev, E. (2014). A comparative study of physical pretreatments for the extraction of polyphenols and proteins from vine shoots. Food Research International, 65, 462–468.
Rawson, A., Patras, A., Tiwari, B. K., Noci, F., Koutchma, T., & Brunton, N. (2011). Effect of thermal and non thermal processing technologies on the bioactive content of exotic fruits and their products: review of recent advances. Food Research International, 44(7), 1875–1887. doi:10.1016/j.foodres.2011.02.053.
Rayaprolu, S. J., Hettiarachchy, N. S., Chen, P., Kannan, A., & Mauromostakos, A. (2013). Peptides derived from high oleic acid soybean meals inhibit colon, liver and lung cancer cell growth. Food Research International, 50(1), 282–288. doi:10.1016/j.foodres.2012.10.021.
Ren, L., Hemar, Y., Perera, C. O., Lewis, G., Krissansen, G. W., & Buchanan, P. K. (2014). Antibacterial and antioxidant activities of aqueous extracts of eight edible mushrooms. Bioactive Carbohydrates and Dietary Fibre, 3(2), 41–51. doi:10.1016/j.bcdf.2014.01.003.
Roldan-Marin, E., Krath, B. N., Poulsen, M., Binderup, M. L., Nielsen, T. H., Hansen, M., et al. (2009). Effects of an onion by-product on bioactivity and safety markers in healthy rats. The British Journal of Nutrition, 102(11), 1574–1582. doi:10.1017/S0007114509990870.
Roselló-Soto, E., Barba, F., Parniakov, O., Galanakis, C., Lebovka, N., Grimi, N., et al. (2015). High voltage electrical discharges, pulsed electric field, and ultrasound assisted extraction of protein and phenolic compounds from olive kernel. Food and Bioprocess Technology, 8(4), 885–894. doi:10.1007/s11947-014-1456-x.
Rostagno, M. A., Palma, M., & Barroso, C. G. (2003). Ultrasound-assisted extraction of soy isoflavones. Journal of Chromatography A, 1012(2), 119–128. doi:10.1016/S0021-9673(03)01184-1.
Routray, W., & Orsat, V. (2011). Microwave-assisted extraction of flavonoids: a review. Food and Bioprocess Technology, 5(2), 409–424. doi:10.1007/s11947-011-0573-z.
Sahena, F., Zaidul, I. S. M., Jinap, S., Karim, A. A., Abbas, K. A., Norulaini, N. A. N., et al. (2009). Application of supercritical CO2 in lipid extraction—a review. Journal of Food Engineering, 95(2), 240–253. doi:10.1016/j.jfoodeng.2009.06.026.
Samanta, A. K., Jayapal, N., Jayaram, C., Roy, S., Kolte, A. P., Senani, S., et al. (2015). Xylooligosaccharides as prebiotics from agricultural by-products: production and applications. Bioactive Carbohydrates and Dietary Fibre, 5(1), 62–71. doi:10.1016/j.bcdf.2014.12.003.
Samaram, S., Mirhosseini, H., Tan, C. P., Ghazali, H. M., Bordbar, S., & Serjouie, A. (2015). Optimisation of ultrasound-assisted extraction of oil from papaya seed by response surface methodology: oil recovery, radical scavenging antioxidant activity, and oxidation stability. Food Chemistry, 172, 7–17. doi:10.1016/j.foodchem.2014.08.068.
Sarkis, J. R., Boussetta, N., Blouet, C., Tessaro, I. C., Marczak, L. D. F., & Vorobiev, E. (2015). Effect of pulsed electric fields and high voltage electrical discharges on polyphenol and protein extraction from sesame cake. Innovative Food Science & Emerging Technologies, 29(0), 170–177. doi:10.1016/j.ifset.2015.02.011.
Schieber, A., Stintzing, F. C., & Carle, R. (2001). By-products of plant food processing as a source of functional compounds—recent developments. Trends in Food Science & Technology, 12(11), 401–413. doi:10.1016/S0924-2244(02)00012-2.
Shan, T., Ma, Q., Guo, K., Liu, J., Li, W., Wang, F., et al. (2011). Xanthones from mangosteen extracts as natural chemopreventive agents: potential anticancer drugs. Current Molecular Medicine, 11(8), 666–677.
Singh, B., Sharma, H. K., & Sarkar, B. C. (2012). Optimization of extraction of antioxidants from wheat bran (Triticum spp.) using response surface methodology. Journal of Food Science and Technology, 49(3), 294–308. doi:10.1007/s13197-011-0276-5.
Smiderle, F., Ruthes, A., van Arkel, J., Chanput, W., Iacomini, M., Wichers, H., et al. (2011). Polysaccharides from Agaricus bisporus and Agaricus brasiliensis show similarities in their structures and their immunomodulatory effects on human monocytic THP-1 cells. BMC Complementary and Alternative Medicine, 11(1), 58.
Soliva-Fortuny, R., Balasa, A., Knorr, D., & Martín-Belloso, O. (2009). Effects of pulsed electric fields on bioactive compounds in foods: a review. Trends in Food Science & Technology, 20(11–12), 544–556. doi:10.1016/j.tifs.2009.07.003.
Soria, A. C., & Villamiel, M. (2010). Effect of ultrasound on the technological properties and bioactivity of food: a review. Trends in Food Science & Technology, 21(7), 323–331. doi:10.1016/j.tifs.2010.04.003.
Stacewicz-Sapuntzakis, M., Bowen, P. E., Hussain, E. A., Damayanti-Wood, B. I., & Farnsworth, N. R. (2001). Chemical composition and potential health effects of prunes: a functional food? Critical Reviews in Food Science and Nutrition, 41(4), 251–286.
Stahl, W., & Sies, H. (2005). Bioactivity and protective effects of natural carotenoids. Biochimica et Biophysica Acta, 1740(2), 101–107. doi:10.1016/j.bbadis.2004.12.006.
Sun, Y., Liu, D., Chen, J., Ye, X., & Yu, D. (2011). Effects of different factors of ultrasound treatment on the extraction yield of the all-trans-β-carotene from citrus peels. Ultrasonics Sonochemistry, 18(1), 243–249. doi:10.1016/j.ultsonch.2010.05.014.
Swanson, D., Block, R., & Mousa, S. A. (2012). Omega-3 fatty acids EPA and DHA: health benefits throughout life. Advances in Nutrition, 3(1), 1–7. doi:10.3945/an.111.000893.
Tabaraki, R., Heidarizadi, E., & Benvidi, A. (2012). Optimization of ultrasonic-assisted extraction of pomegranate (Punica granatum L.) peel antioxidants by response surface methodology. Separation and Purification Technology, 98, 16–23. doi:10.1016/j.seppur.2012.06.038.
Tabaraki, R., & Nateghi, A. (2011). Optimization of ultrasonic-assisted extraction of natural antioxidants from rice bran using response surface methodology. Ultrasonics Sonochemistry, 18(6), 1279–1286. doi:10.1016/j.ultsonch.2011.05.004.
Teh, S.-S., Niven, B. E., Bekhit, A. E.-D. A., Carne, A., & Birch, E. J. (2015). Microwave and pulsed electric field assisted extractions of polyphenols from defatted canola seed cake. International Journal of Food Science & Technology, 50(5), 1109–1115. doi:10.1111/ijfs.12749.
Tian, Y., Zeng, H., Xu, Z., Zheng, B., Lin, Y., Gan, C., et al. (2012). Ultrasonic-assisted extraction and antioxidant activity of polysaccharides recovered from white button mushroom (Agaricus bisporus). Carbohydrate Polymers, 88(2), 522–529. doi:10.1016/j.carbpol.2011.12.042.
Tian, Y., Xu, Z., Zheng, B., & Martin Lo, Y. (2013). Optimization of ultrasonic-assisted extraction of pomegranate (Punica granatum L.) seed oil. Ultrasonics Sonochemistry, 20(1), 202–208. doi:10.1016/j.ultsonch.2012.07.010.
Tiwari, B. K. (2015). Ultrasound: a clean, green extraction technology. TrAC Trends in Analytical Chemistry, 71, 100–109. doi:10.1016/j.trac.2015.04.013.
Tiwari, B. K., Muthukumarappan, K., O’Donnell, C. P., & Cullen, P. J. (2008). Effects of sonication on the kinetics of orange juice quality parameters. Journal of Agricultural and Food Chemistry, 56(7), 2423–2428. doi:10.1021/jf073503y.
Vega-Mercado, H., Pothakamury, U. R., Chang, F.-J., Barbosa-Cánovas, G. V., & Swanson, B. G. (1996). Inactivation of Escherichia coli by combining pH, ionic strength and pulsed electric fields hurdles. Food Research International, 29(2), 117–121.
Vilkhu, K., Mawson, R., Simons, L., & Bates, D. (2008). Applications and opportunities for ultrasound assisted extraction in the food industry—a review. Innovative Food Science & Emerging Technologies, 9(2), 161–169. doi:10.1016/j.ifset.2007.04.014.
Vorobiev, E., & Lebovka, N. I. (2006). Extraction of intercellular components by pulsed electric fields. In J. Raso, & V. Heinz (Eds.), Pulsed Electric Fields Technology for the Food Industry: Fundamentals and Applications (pp. 153–193). Boston, MA: Springer US.
Wang, L., & Weller, C. L. (2006). Recent advances in extraction of nutraceuticals from plants. Trends in Food Science & Technology, 17(6), 300–312. doi:10.1016/j.tifs.2005.12.004.
Wang, J., Sun, B., Cao, Y., Tian, Y., & Li, X. (2008). Optimisation of ultrasound-assisted extraction of phenolic compounds from wheat bran. Food Chemistry, 106(2), 804–810. doi:10.1016/j.foodchem.2007.06.062.
Wang, J., Sun, B., Liu, Y., & Zhang, H. (2014). Optimisation of ultrasound-assisted enzymatic extraction of arabinoxylan from wheat bran. Food Chemistry, 150, 482–488. doi:10.1016/j.foodchem.2013.10.121.
Wijngaard, H., Hossain, M. B., Rai, D. K., & Brunton, N. (2012). Techniques to extract bioactive compounds from food by-products of plant origin. Food Research International, 46(2), 505–513. doi:10.1016/j.foodres.2011.09.027.
Wu, T., Zivanovic, S., Draughon, F. A., & Sams, C. E. (2004). Chitin and chitosanvalue-added products from mushroom waste. Journal of Agricultural and Food Chemistry, 52(26), 7905–7910. doi:10.1021/jf0492565.
Xu, Y., & Pan, S. (2013). Effects of various factors of ultrasonic treatment on the extraction yield of all-trans-lycopene from red grapefruit (Citrus paradise Macf.) Ultrasonics Sonochemistry, 20(4), 1026–1032. doi:10.1016/j.ultsonch.2013.01.006.
Xu, X., Yan, H., Chen, J., & Zhang, X. (2011). Bioactive proteins from mushrooms. Biotechnology Advances, 29(6), 667–674. doi:10.1016/j.biotechadv.2011.05.003.
Xue, D., & Farid, M. M. (2015). Pulsed electric field extraction of valuable compounds from white button mushroom (Agaricus bisporus). Innovative Food Science & Emerging Technologies, 29, 178–186. doi:10.1016/j.ifset.2015.03.012.
Zhao, L., Zhao, G., Chen, F., Wang, Z., Wu, J., & Hu, X. (2006). Different effects of microwave and ultrasound on the stability of (all-e)-Astaxanthin. Journal of Agricultural and Food Chemistry, 54(21), 8346–8351. doi:10.1021/jf061876d.
Zhao, Y. Y., Xie, R. M., Chao, X., Zhang, Y., Lin, R. C., & Sun, W. J. (2009). Bioactivity-directed isolation, identification of diuretic compounds from Polyporus umbellatus. Journal of Ethnopharmacology, 126(1), 184–187. doi:10.1016/j.jep.2009.07.033.
Zhao, W., Yu, Z., Liu, J., Yu, Y., Yin, Y., Lin, S., et al. (2011). Optimized extraction of polysaccharides from corn silk by pulsed electric field and response surface quadratic design. Journal of the Science of Food and Agriculture, 91(12), 2201–2209. doi:10.1002/jsfa.4440.
Zhao, D., Zeng, X.-A., Sun, D.-W., & Liu, D. (2013). Effects of pulsed electric field treatment on (+)-catechin–acetaldehyde condensation. Innovative Food Science & Emerging Technologies, 20, 100–105. doi:10.1016/j.ifset.2013.07.007.
Zhu, C., & Liu, X. (2013). Optimization of extraction process of crude polysaccharides from pomegranate peel by response surface methodology. Carbohydrate Polymers, 92(2), 1197–1202. doi:10.1016/j.carbpol.2012.10.073.
Zhu, Z., Bals, O., Grimi, N., Ding, L., & Vorobiev, E. (2015a). Better damage of chicory tissue by combined electroporation and ohmic heating for solute extraction. Food and Bioproducts Processing, 94, 248–254. doi:10.1016/j.fbp.2014.03.003.
Zhu, C. P., Zhai, X. C., Li, L. Q., Wu, X. X., & Li, B. (2015b). Response surface optimization of ultrasound-assisted polysaccharides extraction from pomegranate peel. Food Chemistry, 177, 139–146. doi:10.1016/j.foodchem.2015.01.022.
Zimmermann, U., Pilwat, G., & Riemann, F. (1974). Dielectric breakdown of cell membranes. In U. Zimmermann, & J. Dainty (Eds.), Membrane Transport in Plants (pp. 146–153). Berlin, Heidelberg: Springer Berlin Heidelberg.
Acknowledgments
The authors acknowledge financial support from the ‘NovTechIng’ project funded under the Food Institutional Research Measure (Project No. FIRM/11/F/050) by the Irish Department of Agriculture, Food and Marine.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Kumari, B., Tiwari, B.K., Hossain, M.B. et al. Recent Advances on Application of Ultrasound and Pulsed Electric Field Technologies in the Extraction of Bioactives from Agro-Industrial By-products. Food Bioprocess Technol 11, 223–241 (2018). https://doi.org/10.1007/s11947-017-1961-9
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11947-017-1961-9