Abstract
Lower urinary tract dysfunction is a common problem among individuals with spinal cord injury (SCI) that results from a disruption of coordinated control among the brain, spinal cord, and bladder. SCI initially induces areflexic bladder and urinary retention followed by the emergence of automatic micturition mediated by spinal reflex pathways. Experimental research has permitted insight into the pathophysiology of SCI and bladder dysfunction, thereby lending investigators the opportunity to discover therapeutic options. This review provides the reader with an overview of post-SCI bladder dysfunction and the use of currently available pharmacologic therapies to improve lower urinary tract dysfunction. It also highlights some of the promising treatment options on the horizon, such as bladder function restoration via tissue engineering and neurostimulation.
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Baptiste, D.C., Elkelini, M., Hassouna, M. et al. The dysfunctional bladder following spinal cord injury: From concept to clinic. Curr Bladder Dysfunct Rep 4, 192–201 (2009). https://doi.org/10.1007/s11884-009-0028-9
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DOI: https://doi.org/10.1007/s11884-009-0028-9