Abstract
The utilization of dietary docosahexaenoic acid (DHA; 22:6n−3) as a source of eicosapentaenoic acid (EPA; 20:5n−3) via retroconversion was investigated in both vegetarians and omnivores. For this purpose, an EPA-free preparation of DHA was given as a daily supplement (1.62 g DHA) over a period of 6 wk. The dietary supplement provided for a marked increase in DHA levels in both serum phospholipid (from 2.1 to 7.1 mol% in vegetarians and 2.2 to 7.6 mol% in omnivores) and platelet phospholipid (from 1.1 to 3.4 mol% in vegetarians and 1.4 to 3.9 mol% in omnivores). EPA levels rose to a significant but much lesser extent, while 20:4n−6, 22:5n−6, and 22:5n−3 all decreased. Based on the serum phospholipid data, the retroconversion of DHA to EPA in vivo was estimated to be 9.4% overall with no significant difference between omnivores and vegetarians.
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Abbreviations
- ACD:
-
acid citrate dextrose
- DHA:
-
docosahexaenoic acid
- EPA:
-
eicosapentaenoic acid
References
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Conquer, J.A., Holub, B.J. Dietary docosahexaenoic acid as a source of eicosapentaenoic acid in vegetarians and omnivores. Lipids 32, 341–345 (1997). https://doi.org/10.1007/s11745-997-0043-y
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DOI: https://doi.org/10.1007/s11745-997-0043-y