Summary
Coronavirus disease 2019 (COVID-19) occurs in the influenza season and has become a global pandemic. The present study aimed to examine severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) co-infection with influenza A virus (IAV) in an attempt to provide clues for the antiviral interventions of co-infected patients. We described two patients who were co-infected with SARS-CoV-2 and IAV treated at Wuhan Union Hospital, China. In addition, we performed a review in PubMed, Web of Science and CNKI (from January 1 up to November 1, 2020) with combinations of the following key words: “COVID-19, SARS-COV-2, influenza A and co-infection”. A total of 28 co-infected patients were enrolled in the analysis. Of the 28 patients, the median age was 54.5 years (IQR, 34.25–67.5) and 14 cases (50.0%) were classified as severe types. The most common symptoms were fever (85.71%), cough (82.14%) and dyspnea (60.71%). Sixteen patients had lymphocytopenia on admission and 23 patients exhibited abnormal radiological changes. The median time from symptom onset to hospital admission was 4 days (IQR, 3–6), and the median time of hospital stay was 14 days (IQR, 8.5–16.75). In conclusion, patients with SARS-COV-2 and IAV co-infection were similar to those infected with SARS-COV-2 alone in symptoms and radiological images. SARS-COV-2 co-infection with IAV could lead to more severe clinical condition but did not experience longer hospital stay compared with patients infected with SARS-COV-2 alone.
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This work was supported by the National Natural Science Foundation of China (No. 81973990, No. 81900096, and No.81770090) and Fundamental Research Funds for the Central Universities (No. 2020kfyXGYJ030).
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The authors declare that there is no conflict of interest with any financial organization or corporation or individual that can inappropriately influence this work.
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Xiang, X., Wang, Zh., Ye, Ll. et al. Co-infection of SARS-COV-2 and Influenza A Virus: A Case Series and Fast Review. CURR MED SCI 41, 51–57 (2021). https://doi.org/10.1007/s11596-021-2317-2
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DOI: https://doi.org/10.1007/s11596-021-2317-2