Summary
This study was to determine the protective effect of ω-3 polyunsaturated fatty acids (ω-3PUFAs) on MK-801-induced cognitive impairment in schizophrenia (SZ) rats and the underlying mechanism. A rat model of schizophrenia was induced by MK-801. The cognitive function of rats was assessed using a Morris water maze. The number of hippocampal neurons was measured by Nissl staining. The expression of CREB, p-CREB, BDNF, TrkB, p-TrkB, AKT, p-AKT, ERK, and p-ERK in the hippocampus of rats was detected by Western blotting. The results showed that ω-3PUFAs attenuated MK-801-induced cognitive impairment and hippocampal neurons loss, reversed the injury of the CREB/BDNF/TrkB pathway induced by MK-801, and antagonized MK-801-induced down-regulation of p-AKT and p-ERK in the hippocampus of rats. In conclusion, ω-3PUFAs enhances the CREB/BDNF/TrkB pathway by activating ERK and AKT, thereby increasing the synaptic plasticity and decreasing neuron loss, and antagonizing MK-801-induced cognitive impairment in schizophrenic rats.
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This study was supported in parts by grants from the Hubei Province Key Technology R&D Program (No. 2015BCE094), Wuhan Science and Technology Bureau Dawn Plan Project (No. 201507040410216), Clinical Research Physician Program of Tongji Medical College, HUST and the Academic Frontier Youth Team Project of HUST.
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Fang, Ms., Li, X., Qian, H. et al. ω-3PUFAs prevent MK-801-induced cognitive impairment in schizophrenic rats via the CREB/BDNF/TrkB pathway. J. Huazhong Univ. Sci. Technol. [Med. Sci.] 37, 491–495 (2017). https://doi.org/10.1007/s11596-017-1762-4
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DOI: https://doi.org/10.1007/s11596-017-1762-4