Abstract
The physical principles of dual-energy computed tomography (DECT) are as old as computed tomography (CT) itself. To understand the strengths and the limits of this technology, a brief overview of theoretical basis of DECT will be provided. Specific attention will be focused on the interaction of X-rays with matter, on the principles of attenuation of X-rays in CT toward the intrinsic limits of conventional CT, on the material decomposition algorithms (two- and three-basis-material decomposition algorithms) and on effective Rho-Z methods. The progresses in material decomposition algorithms, in computational power of computers and in CT hardware, lead to the development of different technological solutions for DECT in clinical practice. The clinical applications of DECT are briefly reviewed in relation to the specific algorithms.
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Introduction
“…It is possible to use the machine for determining approximately the atomic number of the material within the slice. Two pictures are taken of the same slice, one at 100 kV and the other at 140 kV. … One picture can then be subtracted from the other by the computer so that areas containing high atomic numbers can be enhanced. … For example, tests carried out to date have shown that iodine (Z = 53) can be readily distinguished from Calcium (Z = 20). …” [1]. Sir G.N. Hounsfield while describing his new computerized axial tomography system observed that elements with atomic number (Z) can be easily recognized and distinguished one each other. This was the first empirical observation of material decomposition in computed tomography (CT) opening a new research field: material decomposition in dual-energy computed tomography (DECT) [2, 3]. This technology remained secondary to conventional CT until 2005, with the introduction of the dual-source DECT (dsDECT) [4]. In the following years, several technologies have been developed and the applications of DECT are more widely spread in the clinical routine.
This review will provide a brief overview on theoretical principles behind DECT (better understood after reviewing the interactions of X-rays with matter), the available technologies and the main clinical applications.
X-rays: interaction with matter
The polychromatic spectrum (photons with different wavelengths and energies) of X-rays produced by the tube interacts and exchange energy with the biological matter with a combination of several phenomena: Rayleigh scattering, photoelectric absorption, Compton scattering, and pair production. The probability of each of them, expressed as cross section (σ), is related to the energy of the incident photon and properties of the material [5]. The Rayleigh scattering (R) and the pair production give minor contribution to X-ray attenuation and are considered of minor relevance at energies used in CT [5].
The photoelectric absorption (τ) involves the electrons of the inner shells (K or L). The energy is completely transferred from the photon to the electron which is ejected; the vacancy is filled by an electron from outer shells with emission of characteristic radiation or an Auger electron. The probability of photoelectric interaction as linear attenuation coefficient (μτ, see the next section) follows the rule:
where k is a constant depending on the electron shell, ρ is the density, Z is the atomic number of the target, A the atomic weight, h is the Planck’s constant, ν is the speed of photon, and E is the energy of the incident photon. The photoelectric interaction greatly increases with the atomic number of the target (∝Z~4). When the photon energy reaches the binding energy of the electron, there is a peak in the probability of photoelectric absorption (absorption edge, k-edge if an electron in the k-shell is involved). For energies above the absorption edge, the probability of interactions rapidly decreases (∝1/E3) [5, 6].
The Compton scattering (c) involves the electrons in the outer shell. The incident photon exchanges part of the kinetic energy with the electron; the electron is ejected, and the scattered photon continues the travel with a lower energy and a scatter angle. The probability of Compton scattering is proportional to the electron density (number of electrons per gram, ne), which is quite constant for most materials except for hydrogen. For most of biological tissues, the electron density is proportional physical density ρ. The probability of Compton scattering, described as linear attenuation coefficient (μC), can be approximated as proportional to the electron density and inversely proportional to the X-ray photon energy [7]:
Limits of computed tomography (CT) and physical principles of dual-energy CT (DECT)
Experimentally, when a monochromatic (one specific energy) X-ray beam with an energy E and intensity I0 is attenuated by a homogeneous material, the residual intensity after at a thickness x (Ix) follows the Lambert–Beer’s law:
where e is th Euler’s or Napier’s constant and the linear attenuation coefficient μ (the fractional attenuation of the X-ray beam per unit thickness of the attenuating material) is a function of the energy of the X-ray beam (E), the atomic number (Z) and the physical density (ρ) of the material [8]. In CT, the linear attenuation coefficient of each scanned voxel (r, the considered unit volume) can be derived from the CT number (CT#) in the Hounsfield’s equation [1, 9]:
The linear attenuation coefficient is related to the physical density ρ, and its application in the attenuation of biological tissues can be less convenient. Indeed, each unitary volume of biological tissues is composed by a mixture of different compounds present at variable relative quantities. The physical density ρ of the attenuating material is influenced by the physical state of the matter; however, the energies involved in photon–electron interactions are much greater than the energies involved in molecular bindings; thus, the linear attenuation coefficient μ can be considered approximately proportional the physical density ρ and Eq. 3 can be written as:
where μ/ρ can is the mass attenuation coefficient [8]. In the case of a mixture of materials, such as biological tissues, the mass attenuation coefficient can be approximated as the sum of the mass attenuation coefficients of each compound:
where wi is the weight fraction of each compound of the mixture [8]. This is the mathematical expression of the intrinsic limits of CT: considering the attenuation of a mixture with two known materials at unknown proportions, Eq. 6 has no solution because it is an equation in two unknowns (w1 and w2) and one solution (μ, or CT#) [8, 9]. Since the CT number refers to the total linear attenuation coefficient of a mixture (biological tissue) composed by different compounds at unknown densities (but known attenuation curves), it can be impossible to differentiate the different materials present in the compound (Fig. 1). It is common experience that the iodine and calcium present at different densities (concentrations) may have the same attenuation (i.e., the same CT number), such as microcalcifications in an enhancing mass (Fig. 2). However, different materials, such as iodine and calcium, have different attenuation curves (linear attenuation coefficients as function of energy), and if scanned at different energies, they can be differentiated (Figs. 1 and 2). Starting from this problem, the algorithms of material decomposition in dual-energy CT were developed [10].
Returning to Eq. 6, the mass attenuation coefficient of a given material exposed to X-ray at a given X-ray energy can be expressed as the sum of the cross sections of each attenuation phenomenon or the sum of the relative mass attenuation coefficients of each phenomenon, being the most relevant the photoelectric and the Compton interactions [8, 11, 12]:
This principle is at the basis of the first two-basis-material decomposition algorithm developed by Alvarez and Macovski. This demonstrates that when using a conventional X-ray beam, the effective attenuation coefficient can be calculated from the contribution of Compton and photoelectric interactions modeled on the effective ρeff (density) and Zeff (atomic number) of the material:
where α and β are constants, d ≈ 3 − 4, g ≈ 3 − 3.5 and fKN(E) is the Klein–Nishina function. The right term of the third part of Eq. 8 is the linear combination, respectively, of the photoelectric [\(\alpha \left( {Z_{\text{eff}}^{d} /E^{g} } \right)]\) and Compton [\(\beta f_{KN} \left( E \right)]\) interactions. Conversely, after obtaining two measurements of attenuation coefficient with two different X-ray energies, any material can be characterized in terms of ρeff and Zeff. The work of Alvarez and Macovski is at the basis of the Rho-Z (ρZ) algorithms for material decomposition and the two-basis-material decomposition in the projection domain (raw data) (Fig. 3) [2, 3].
Starting from the work of Alvarez and Macovski, Kalender et al. defined the mass attenuation coefficient of a given mixture, as function of energy [(μ/ρ)(E)], with a linear combination of the mass attenuation coefficients of two hypothetical known basis materials (1 and 2) present at different mass densities (ρ1 and ρ2, see also the weight fractions wi in Eq. 6) at the spatial location r:
The linear attenuation coefficient at a given spatial location μ(r,E) (i.e., the measured attenuation in CT) is the sum of two known materials with known mass attenuation coefficients [(μ/ρ)1,2] present at unknown mass densities within the voxel (unknown ρ1,2); the equation has no solution when a single X-ray spectrum is used [13].
If we measure the attenuation coefficients after irradiation with two X-ray energies (high and low, H and l, IH and Il), Eq. 9 can be solved as a system of two equations with two solutions (μ(r,E)H, l) and two unknowns (ρ1,2). This concept transferred to CT imaging with polychromatic X-ray beams by the implementation of the line integral over the linear attenuation coefficient for each X-ray projection, and by the definition of the area densities (δ1,2), which are calculated from the unknowns ρ1,2 (see Eqs. 3, 5 and 9):
with
The application of this algorithm allows for obtaining material-selective images, where the basis materials (e.g., calcium and iodine) are detected, labeled, quantified, displayed or subtracted (e.g., the iodine maps or the virtual non-contrast images) (Fig. 3) [13].
After calculation of the effective densities of the basis materials (ρ1 and ρ2), the linear attenuation coefficient of the mixture μ(r,E), thus the CT numbers, can be calculated by simulating the irradiation with a virtual monochromatic beam in a wide range of energies even out of the energy range effectively used. These images are called virtual monoenergetic images (VMI) (Fig. 3). VMI at low keV are useful for highlighting focal lesions in condition of low contrast (e.g., in liver or pancreas) (Fig. 4) or for improvement of the contrast-to-noise ratio and reduction of the administered contrast material [14]. Conversely, VMI at high keV are useful for reduction of proton-starving and beam-hardening artifacts in the presence of metallic objects at the expense of contrast (Fig. 5) [15]. A drawback of some VMI algorithms is the increasing noise at lower energies; this problem has been addressed with the introduction of noise-corrected VMI (MonoPlus, Monoenergetic Plus, Siemens Healthineers) [16]. The theoretical advantage of the approach in the projection domain is the avoidance of beam-hardening artifacts: the linear attenuation coefficient is obtained from the attenuation coefficient of the basis materials at the calculated mass densities [13].
A critical issue of the projection domain approach is the large amount of data processed and the high computational power required: the post-processing of dual-energy data could be easier on reconstructed images (Fig. 3) [13]. Equation 8 can be defined as the linear combination of the mass attenuation coefficients of two basis materials present in the mixture with fractional masses of m1+ m2= 1 (being m2= 1-m1). Also, the effective linear attenuation coefficient (μeff) can be calculated from the CT numbers (CT#) as in Eq. 4:
The effective linear attenuation coefficient is calculated from the CT number (CT#), it is a function of photoelectric and Compton interaction of a mixture with an atomic number Zeff but can also be defined as a function of two unknowns: the effective mass density (ρeff) and the fractional mass of one basis material (m1). The CT acquisition with two different X-ray energy spectra (H and l) provides two datasets of reconstructed images that can be processed to obtain the two unknowns:
This is the concept behind the material decomposition on image domain. In this case, since the reconstructed images are used, the beam-hardening artifacts are not automatically removed and need to be corrected [17]. Maas et al. proposed a hybrid algorithm with a pre-processing in the projection domain to reduce beam-hardening artifacts [18].
An interesting point is that any material with different atomic number than the chosen basis material variably contributes (and is characterized as) to the attenuation of each of the basis material in all of these algorithms [13]. Theoretically, the more the basis materials are included, the more accurate it is in quantification of basis materials. A classical case was the calcium quantification in osteoporosis with dual-energy acquisitions of vertebral bones, with a mixture of calcium, fat (yellow marrow) and water or soft tissue (red marrow). A two-basis-material decomposition algorithm will not be accurate enough for calcium estimation due to the significant differences in attenuation of soft tissue and fat. A three-basis-material decomposition algorithm would be a more accurate model. The easier way comes from Goodsitt et al. [19]. The authors started from the hypothesis that the effective linear attenuation coefficient in function of X-ray energy μeff(E) comes from the sum of the mass attenuation coefficients of each basis material (i) multiplied by their concentrations (the concentration ci is defined as the product between the fractional volume Vi and mass density ρi), similarly to what expressed in Eqs. 6, 9, 10, 12, and 13:
If the linear attenuation coefficients in Eq. 14 are substituted as in Eq. 4 and the conservation of volumes is respected, a system of three equations in three unknowns (fractional volumes Vi) can be solved after CT acquisition at two energies (H, l):
where CT#i(E) are the CT numbers of pure basis materials at the given X-ray energy, previously obtained (e.g., calcium hydroxyapatite as a model for bone). This model allows for calculation, in the image domain, of relative quantities (fractional volumes) of three basis materials, by two measurements (acquisitions at two different energies) with a third condition (the conservation of volume). The model cannot be generalized because the conservation of volume is not always respected (e.g., salt in water or iron in fat or soft tissue).
A more generalized model was proposed by Liu et al. [20], based on conservation of mass. In the first step of the model, the dual-energy datasets are used to calculate the ρeff and Zeff. In the second step, the ρeff is used in a system of three equations where the fractional masses of the three materials are the unknowns and the conservation of mass is respected:
This is the concept behind the three-basis-material (or multimaterial) decomposition algorithms. Nowadays, the material decomposition and labeling algorithms on the different scanners may use algorithms with graphic vectors based on equations described in this section (Fig. 6) [21, 22].
Dual-energy CT: the technology
Five different technologies are available for acquisition of DECT datasets: dual-source, fast kVp switching, layer detector, twin beam and consecutive scans (Fig. 7).
Dual-source dual-energy CT (dsDECT)
The dsDECT was the first technology introduced in clinical routine since 2006 by Siemens Healthineers (Forchheim, Germany) with the three generations of Somatom scanners (Definition [1st], Flash [2nd], and Force [3rd]). The scanners have two independent X-ray tubes coupled with two independent detectors; each set is mounted within the gantry with an offset of ~ 90°. The main purpose of this architecture was of achieving a temporal resolution acceptable for cardiac studies (< 100 ms: 65–85 ms) with both tubes working (Flash or TurboFlash acquisition, Siemens Healthineers); the dual-energy mode with the two tubes at different kVp is a natural corollary in these scanners [4, 23].
Due to engineering issues (balance and space in the gantry), the two detectors are asymmetrical with the smaller detector B limited to a field of view (FOV) of 266 mm in the first generation (thus limiting the FOV for material decomposition). This drawback was improved in the second and third generations by increasing the offset and allowing for bigger detector B (FOV up to 355 mm in Force) (Fig. 7).
A second important point is the tube technology. The Straton tube in the first generation was capable of 20 kV steps between 80 and 140 kV in the first generation, allowing for the combination of 80/140 kV in dual-energy acquisitions. In the second generation, a tin filter (0.4 mm) was added to improve the spectral separation (the robustness of material decomposition algorithms is proportional to separation of the two X-ray spectra) allowing for two combinations in dual-energy acquisitions (80/140 kV; 100/140 Sn kV) [24]. In the third generation, the Vectron tube was introduced: it is capable of 10 kV steps between 70 kV and 150 kV with a maximum current of 1300 mA at 70 kV. This technology allows for (1) a more frequent use of low voltages (contrast and dose reduction) and (2) better spectral separation (70–100 kV/140–150 Sn kV). Moreover, the higher power allows for a more aggressive filtration at high voltages (0.6 mm tin) with further improvement of spectral separation (Fig. 7) [25].
With the newer generations, the rotation speed was improved (up to 0.25s) with no limitations for dual energy, together with the Z-axis coverage and the introduction of integrated Stellar detectors (the lower noise in the stellar detectors improved the material decomposition). Iterative reconstructions can be used with both tubes [25].
This technical solution requires the material decomposition to be performed on image domain (due to ~ 90° offset of the projections), and adequate algorithms are implemented to reduce the cross-scattered radiation between the two systems. Besides the material decomposition, virtual monochromatic and Rho-Z methods, the scanner provides the blended (mixed) images for reading and reporting, in which the pixels are a weighted sum of the CT numbers from the high- and low-energy datasets, without any material decomposition performed (Fig. 3) [23].
Fast kVp switching
In the fast kVp switching scanners (Discovery CT 750 HD and Revolution, GE Healthcare, Milwaukee, WI), the X-ray tube switches between 80 and 140 kVp in less than 0.2 ms, thus acquiring high- and low-energy projections within the same rotation with almost no-temporal mismatch and at a full FOV of 50 cm.
Regarding the X-ray tube, the spectral separation (and the material decomposition) is affected by the ramp-up and ramp-down of the tube voltages while switching. At low voltage, the photon output is lower and the noise increases: higher current and longer exposure time are necessary at low kV (typical exposure ratio: 80/140 kVp = 60%/40%); the automatic current modulation is not feasible in this configuration, and the dose reduction is implemented only with the iterative reconstructions. A too fast rotation speed reduces the number of projections acquired with poor quality of datasets; the rotation time is limited to 0.5s.
A detector with adequate response is also necessary: the Gemstone Clarity detector (GE Healthcare, Milwaukee WI) has a primary decay faster than and an afterglow significantly lower than Gd-based scintillators (Fig. 7).
The small offset between the projections at high and low energies (< 0.5°) allows for material decomposition in projection domain (Fig. 3) [26].
Dual-layer detectors
In the iQon Spectral (Philips Healthcare, The Netherlands) the tube gives a polychromatic X-ray beam (120 or 140 kVp), and the spectral separation is performed by the layer detector and not by the tube.
The layer detector is composed of two layers: the inner one, with ZnSe crystals, is sensitive to low energies, while the external one (with GdOS detectors) is sensitive to the higher energy of the spectrum (Fig. 7). A challenge for the detector is the presence of high-attenuation objects reducing the lower component of the spectrum for the internal layer. The remnant X-ray beam arriving at the external layer results from a strong filtration of internal layer. Other challenges in detector design are the position of the photodiodes and the necessary presence of an antiscatter grid reducing the optical sensitivity when compared to conventional detectors with photodiodes below the scintillator. Moreover, scattering may cause cross talk between layers.
The dual-energy datasets are acquired at a full FOV with no limits in rotation speed. The material decomposition is performed in the projection domain thanks to the null offset of the projections (Fig. 3). Conventional CT images are reconstructed by weighted summation of the high- and low-energy datasets; iterative reconstructions can be used for dose reduction [22].
The split filter
The split filter in the Somatom Edge TwinBeam (Siemens Healthineers, Forchheim, Germany) is composed of two different metals: tin and gold, which, respectively, filter the low and high components to split a polychromatic X-ray beam. The dual-energy datasets are acquired with each half of the detector receiving the split beam. This allows for dual-energy information at full FOV of 50 cm with no limitations in rotation speed. Potential drawbacks are the short pitch values (0.3–0.5), the necessary high power of the tube because of filtration, with potential limitations in larger patients, and the limited spectral separation (Fig. 7) [27].
Consecutive acquisitions
This method does not require a dedicated hardware. However, the low temporal resolution and related motion artifacts limit the application to non-contrast studies or to anatomical districts without significant movements. Dose reduction techniques, such as automatic current modulation, can be used (Fig. 7) [28].
Dual-energy CT: post-processing and clinical applications
The applications of dual-energy can be divided in material-selective and energy-selective. The former includes material decomposition with material labeling, quantification (distribution maps) and subtraction (VNC); the latter includes the monoenergetic imaging, effective atomic number and effective electron density (Rho-Z maps). Table 1 provides an overview of the algorithms and main clinical application dual-energy techniques.
Material-selective images: material subtraction, quantification and labeling
With material-selective images, a given basis material is detected, labeled and subtracted: iodine, calcium or other known materials (e.g., monosodium urate) are frequently used as basis material.
In neuroradiology, the main application of material decomposition is the material labeling and quantification of iodine in the presence of hemorrhagic material. The evaluation of contrast enhancement of a hemorrhagic brain lesion may be challenging in both CT and in magnetic resonance (MRI), while DECT is able to distinguish the different spectral characteristics of iodine and iron. Kim et al. [29] demonstrated a significantly higher sensitivity of iodine maps fused with virtual unenhanced images for detection of enhancing hemorrhagic brain lesions.
In thoracic imaging, iodine maps allow for the evaluation of perfusion defects in pulmonary embolism, beyond the CT angiography, in acute and chronic setting (Fig. 8) [30, 31]. Gases with high atomic number, such as xenon or krypton, have been used for the evaluation of lung ventilation. Promising results have been recorded both with single-phase acquisitions and with dynamic studies [32, 33].
In cardiovascular imaging, the iodine maps are useful for the evaluation of myocardial perfusion while the selective subtraction of iodine in virtual non-contrast (VNC) images provided good results for the calcium score [34,35,36]. Calcium labeling and subtraction with dual energy is useful for bone removal and plaque removal, improving the evaluation of vascular studies and the evaluation of vascular lumen [35, 36]. An interesting application of material decomposition is the characterization of the atherosclerotic plaque. Obaid et al. recorded an improved diagnostic accuracy with DECT in characterization lipidic, necrotic, fibrous components and calcium in atherosclerotic plaques [37].
An application of material decomposition in abdominal and oncological studies is the VNC reconstructions with avoidance of basal acquisitions and dose reduction, particularly relevant in selected populations (e.g., pediatric population) [38,39,40,41,42]. It has to be pointed that small, often unimportant, differences in attenuation values need to be accounted when using virtual non-contrast images in abdomen (Fig. 9) [43, 44]. The role of iodine maps is qualitative and quantitative. The evaluation of iodine maps allows for accurate discrimination between enhancing and unenhancing lesions: this may be relevant in complicated cystic lesions of the kidney [45]. The quantitative evaluation of iodine maps may be helpful for lesion characterization: Lv et al. [46] found significant differences in iodine uptake between hepatic hemangioma and hepatocellular carcinoma. Regarding treatment response, the iodine quantification showed promising results: changes in iodine uptake are a more accurate indicator of treatment response to target or antiangiogenic agents than morphological criteria [47,48,49]. The evaluation of iodine maps has demonstrated their utility in the evaluation of the gastrointestinal tract, improving the detection of inflammatory, vascular (ischemic) and neoplastic lesions [50]. Skornitzke et al. [51] tried to investigate the role of iodine uptake as surrogate of perfusion parameters, but the results are still under debate. Material labeling has been successfully implemented for the evaluation of urinary stone composition or for the labeling of iodine and calcium (Fig. 2) [52]. In liver imaging, the iron quantification with DECT is an important tool when MRI is contraindicated [53].
In musculoskeletal radiology, material labeling is useful for the quantification of monosodium urate crystals in gout and differentiation with other crystal arthropathies (Fig. 10) [54, 55]. Moreover, DECT allows for demonstration of hemosiderin deposits in pigmented villonodular synovitis [56]. The evaluation of bone marrow disorders, typically evaluated with MRI, is an expanding application of material decomposition: DECT is useful for depiction of bone marrow edema and bone lesions (three-material decomposition and virtual non-calcium) [57, 58]. VNC and iodine subtraction are also useful in the case of intravenous contrast injection or in CT arthrography [59, 60].
Energy-selective applications: virtual monoenergetic images and Rho-Z methods
VMI are produced with the linear attenuation coefficients of basis materials obtained from the material decomposition, with the possibility of reconstruction of simulated images in a wide range of energy levels, within or out of the ranges effectively used. The utility in clinical practice relies in the use of a monochromatic beam close to the k-edge of a basis material (e.g., iodine) resulting in improved visualization of that given material (e.g., better contrast). Conversely, the use of a virtual monochromatic beam far for the attenuation edge of a given material may be helpful for reduction of proton-starving and beam-hardening artifacts [15, 61].
VMI at low keV improves the detection of low-enhancing lesions, particularly in organs with relatively poor contrast (Fig. 4). The VMI reconstructions have demonstrated promising results for the evaluation of pancreatic adenocarcinomas, focal liver lesions (Fig. 4) or for the extension of endometrial adenocarcinomas [61,62,63]. Another field of applications is the optimization of contrast, similarly to acquisitions at low voltages (not always possible), with potential reduction of the dose of contrast material, in particular in cardiovascular imaging, and in the evaluation of pulmonary embolism [14, 64,65,66]. VMI at high keV simulate the use of high-energy X-ray beams and are useful for attenuation of beam-hardening artifacts at the expense of contrast (Fig. 5) [15].
A material or a mixture with unknown attenuation coefficients can be semiquantitatively assessed on the spectral curve and highlighted; this is the case of biliary non-calcific stones or foreign bodies, such as in drug mules [67,68,69].
Finally, the Rho-Z methods still have more limited implementation: interesting applications in tissue characterization, mainly in cartilages and tendons [59].
Conclusion
In this review, we have provided a brief overview on physical and theoretical principles, and clinical applications of dual-energy CT, which is a growing technique with expanding applications.
Abbreviations
- σ :
-
Cross section, or the probability of interaction photon–electron
- R :
-
Rayleigh scattering
- τ :
-
Photoelectric absorption
- K, L :
-
Inner electron shells
- Z :
-
Atomic number
- E :
-
Energy
- k :
-
Constant
- ρ :
-
Physical density
- A :
-
Atomic weight
- h :
-
Plank’s constant
- ν :
-
Speed of photon
- ∝:
-
Proportional to
- c:
-
Compton scattering
- n e :
-
Electron density
- I :
-
Intensity
- x :
-
Thickness
- e:
-
Euler’s number or Napier’s constant
- CT# :
-
CT number in Hounsfield’s units
- μ/ρ :
-
Mass attenuation coefficient
- ∑:
-
Summation of multiple terms
- ≈ :
-
Approximately equal to
- α :
-
Constant in Eq. 8
- β :
-
Constant in Eq. 8
- d :
-
Exponent in Eq. 8
- g :
-
Exponent in Eq. 8
- f KN(E):
-
Klein–Nishina function
- ρZ and Rho-Z :
-
Material decomposition method using effective density and atomic numbers
- r :
-
Spatial location of the unit volume
- ρ i :
-
Physical density of the ith basis material
- δi :
-
Area density of the ith basis material
- Vi:
-
Fractional volume of the ith basis material
- mi :
-
Fractional mass of the ith basis material
- DECT:
-
Dual-energy CT
- CT:
-
Computed tomography
- Z:
-
Atomic number
- dsDECT:
-
Dual-source dual-energy CT
- VMI:
-
Virtual monoenergetic images
- FOV:
-
Field of view
- VNC:
-
Virtual non-contrast
- MRI:
-
Magnetic resonance imaging
- VR:
-
Volume rendering
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Agostini, A., Borgheresi, A., Mari, A. et al. Dual-energy CT: theoretical principles and clinical applications. Radiol med 124, 1281–1295 (2019). https://doi.org/10.1007/s11547-019-01107-8
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DOI: https://doi.org/10.1007/s11547-019-01107-8