Abstract
Purpose
The purpose of our study was to retrospectively evaluate the feasibility, safety and effectiveness of microwave ablation (MWA) in nine patients with unresectable lung tumour.
Materials and methods
Ten lesions were treated in ten ablation sessions in nine patients. The treatments were performed with a microwave generator with 45 W and 915 MHz connected to a 14.5-gauge antenna for 10 min. Antenna placement was performed with computed tomography (CT) fluoroscopy guidance or XperGuide. All patients underwent CT follow-up at 1, 3 and 6 months from the procedure.
Results
Technical success was obtained in all cases; mortality at 30 days was 0%.
Conclusions
This study shows that in selected patients, MWA is a valid alternative to other ablative techniques. Further studies are required to demonstrate the short- and long-term effects of this technique and to make a comparison with other available ablation systems, especially with radiofrequency.
Riassunto
Obiettivo
Lo scopo dello studio è stato quello di valutare il successo tecnico, la sicurezza, l’efficacia della metodica del trattamento ablativo mediante microonde (MW) in 9 pazienti affetti da neoplasia polmonare non trattabile chirurgicamente.
Materiali e metodi
Sono state trattate 10 masse polmonari in 10 sessioni d’ablazione in 9 pazienti. È stato utilizzato un sistema ablativo costituito da un generatore di MW a 45 W e 915 MHz connesso ad un antenna 14,5 G, per un tempo di ablazione totale di 10 minuti. Il posizionamento dell’antenna è stato eseguito sotto guida fluoro-tomografia computerizzata (TC) o XperGuide. I pazienti sono stati sottoposti a follow-up mediante TC a 1, 3, 6 mesi dalla procedura.
Risultati
Si è ottenuto un successo tecnico in tutti i casi; il tasso di mortalità a 30 giorni è stato dello 0%.
Conclusioni
Questo studio dimostra che, in pazienti selezionati, la termoablazione con microonde rappresenta una valida alternativa ad altre tecniche ablative. Sono tuttavia necessari ulteriori studi per confermare a breve e lungo termine l’efficacia di questa metodologia e permettere un confronto con altri sistemi ablativi, in particolare rispetto alla radiofrequenza.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References/Bibliografia
Shugarman LR, Mack K, Sorbero ME et al (2009) Race and sex differences in the receipt of timely and appropriate lung cancer treatment. Med Care 47:774–781
Rossi A, Maione P, Colantuoni G et al (2009) Recent developments of targeted therapies in the treatment of non-small cell lung cancer. Curr Drug Discov Technol 6:91–102
Simon CJ, Dupuy DE, DiPetrillo TA et al (2007) Pulmonary radiofrequency ablation: long-term safety and efficacy in 153 patients. Radiology 243:268–275
Grieco CA, Simon CJ, Mayo-Smith WW et al (2006) Percutaneous image-guided thermal ablation and radiation therapy: outcomes of combined treatment for 41 patients with inoperable stage I/II non-small-cell lung cancer. J Vasc Interv Radiology 17:1117–1124
Simon CJ, Dupuy DE, Mayo-Smith WW (2005) Microwave ablation: principles and applications. RadioGraphics 25:S69–S83
Carrafiello G, Laganà D, Mangini M et al (2008) Microwave tumors ablation: principles, clinical applications and review of preliminary experiences. Int J Surg 6:65–69
Goetz MP, Callstrom MR, Charboneau JW et al (2004) Percutaneous image-guided radiofrequency ablation of painful metastases involving bone. A multicenter study. J Clin Oncol 22:300–306
Solbiati L, Livraghi T, Goldeberg SN et al (2001) Percutaneous radio-frequency ablation of hepatic metastases from colorectal cancer: long-term results in 117 patients. Radiology 221:150–166
Livraghi T, Goldeberg SN, Lazzaroni S et al (2000) Hepatocellular carcinoma: radiofrequency ablation of medium and large lesion. Radiology 214:1761–1768
Gervais DA, McGovern FJ, Arellano RS et al (2003) Renal cell carcinoma: clinical experience and technical successs with radio-frequency ablation of 41 tumors. Radiology 226:417–424
Cariati M, Giordano G, Midulla M et al (2007) Radiofrequency ablation of pulmonary lesions. Radiology Med 112:149–156
Wolf FJ, Grand DJ, Machan JT et al (2008) Microwave ablation of lung malignancies: effectiveness, CT findings, and safety in 50 patients. Radiology 247:871–879
Wright SA, Sampson LA, Warner TF et al (2005) Radiofrequency versus microwave ablation in a hepatic porcine model. Radiology 236:132–139
Carrafiello G, Laganà D, Ianniello A et al (2007) Post-radiofrequency ablation syndrome after percutaneous radiofrequency of abdominal tumours: one centre experience and review of published works. Australas Radiology 51:550–554
Fen W, Liu W, Li C et al (2002) Percutaneous microwave coagulation therapy for lung cancer. Zhounghua Zhong Liu Za Zhi 24:388–390
Wright SA, Lee FT, Mahvi DM (2003) Hepatic microwave ablation with multiple antennae results in synergistically larger zones of coagulation necrosis. Ann Surg Oncol 10:275–283
Skinner MG, Iizuka MN, Kolios MC et al (1998) A theoretical comparison of energy sources-microwave, ultrasound and laser-for interstitial thermal therapy. Phys Med Biol 43:3535–3547
Shock SA, Meredith K, Warner TF (2004) Microwave ablation with loop antenna: in vivo porcine liver model. Radiology 231:143–149
Stauffer PR, Rossetto F, Prakash M et al (2003) Phantom and animal tissues for modelling the electrical properties of human liver. Int J Hyperthermia 19:89–101
Brace CL, Hinshaw JL, Laeseke PF et al (2009) Pulmonary thermal ablation: comparison of radiofrequency and microwave devices by using gross pathologic and CT findings in a swine model. Radiology 251:705–711
Durick NA, Laeseke PF, Broderick LS et al (2008) Microwave ablation with triaxial antennas tuned for lung: results in an in vivo porcine model
Sacks D, McClenny TE, Cardella JF et al (2003) Society of Interventional Radiology Clinical Practice Guidelines. J Vasc Interv Radiology 14:199–202
Hollen PJ, Gralla RJ, Kris MG et al (2005) A comparison of visual analogue and numerical rating scale formats for the Lung Cancer Symptom Scale (LCSS): does format affect patient ratings of symptoms and quality of life quality of life? Qual Life Res 14:837–847
Kaplan EL, Meier P (1958) Nonparametric estimation from incomplete observations. J Am Stat Assoc 53:457–481
de Baere T, Palussiere J, Auperin A et al (2006) Midterm local efficacy and survival after radiofrequency ablation of lung tumors with minimum follow-up of 1 year: prospective evaluation. Radiology 240:587–596
Goldberg SN, Stein MC, Gazelle GS et al (1999) Percutaneous radiofrequency tissue ablation: optimization of pulsed-radiofrequency technique to increase coagulation necrosis. J Vasc Interv Radiology 10:907–916
Lu DS, Raman SS, Limanond P et al (2003) Influence of large peritumoral vessels on outcome of radiofrequency ablation of liver tumors. J Vasc Interv Radiology 14:1267–1274
Oshima F, Yamakado K, Akeboshi M et al (2004) Lung radiofrequency ablation with and without bronchial occlusion: experimental study in porcine lungs. Vasc Interv Radiology 15:1451–1456
Gazelle GS, Goldberg SN, Solbiati L et al (2000) Tumor ablation with radiofrequency energy. Radiology 217:633–646
Jin GY, Lee JM, Lee YC et al (2004) Primary and secondary lung malignancies treated with percutaneous radiofrequency ablation: evaluation with follow-up helical CT. AJR Am J Roentgenol 183:1013–1020
Belfiore G, Moggio G, Tedeschi E et al (2004) CT-guided radiofrequency ablation: a potential complementary therapy for patients with unresectable primary lung cancer-a preliminary report of 33 patients. AJR Am J Roentgenol 183:1003–1011
Yasui K, Kanazawa S, Sano Y et al (2004) Thoracic tumors treated with CT-guided radiofrequency ablation: initial experience. Radiology 231:850–857
Allen MS, Darling GE, Pechet TT et al (2006) Morbidity and mortality of major pulmonary resections in patients with early-stage lung cancer: initial results of randomized, prospective trial. Ann Thorac Surg 81:1013–1020
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Carrafiello, G., Mangini, M., De Bernardi, I. et al. Microwave ablation therapy for treating primary and secondary lung tumours: technical note. Radiol med 115, 962–974 (2010). https://doi.org/10.1007/s11547-010-0547-7
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11547-010-0547-7