Abstract
In the field of biosensing, plasmonics has gained momentum recently as it enables plasmon based circuits to merge two fields of photonics and electronics at nanoscale and also provides the advantage of label-free detection. A Metal Insulator Metal based plasmonic refractive index sensor is conceptualised on panda ring design. Finite Difference Time Domain method is employed to study the transmittance characteristics of the sensor. The transmittance curve exhibits triple Fano Resonances resulting in high sensitivities of 922 nm/RIU, 1730 nm/RIU and 2092.3 nm/RIU for the fano dips at 0.949 µm, 1.728 µm and 2.103 µm respectively. Further investigation is also done with respect to fabrication complexities which may arise using a square slit and its consequent effect on the efficiency of the sensor. The sensor performance is also investigated based on figure of merit which is obtained at a high value of 46.18 RIU\(^{-1}\). The proposed sensor is investigated further for probable detection of cancerous cells namely Jurkat, PC-12, MDA-MB-231, MCF-7 and Basal Cell.
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Introduction
Surface Plasmon Resonance (SPR) [1] has been recently investigated very widely in plasmonics based research. SPR is fundamentally a photonics based quantum electromagnetic phenomenon arising out of interaction of light and free electrons at a metal dielectric interface [2]. SPRs provide a number of advantages which includes real-time and label-free detection, immunity to electromagnetic interference and rapid response time [3]. Plasmonic sensing has emerged as a crucial area of research involving biosensing widely used for sensing traces of biological and chemical molecules [4, 5]. The plasmonic sensor devices are basically based on Metal Insulator Metal (MIM) or Insulator Metal Insulator (IMI) waveguides coupled with cavity resonators [6]. The MIM SPR system provides advantages such as stronger field enhancement, wide range of available frequencies, good properties of light confinement and reduce bending loss [7]. Hence, MIM SPR system becomes one of the best methods in realising nanoscale integrated photonic devices.
Fano Resonance (FR), owing to its useful properties has been exploited in plasmonic sensing applications [8]. The independent tunability of the FRs helps in achieving demands in application with convenience through easy manipulation. Hence, it is efficiently used in chemical and biosensing applications. A great use of plasmonics is in the excitation of the FR, it is achieved via the interaction of the dark and bright mode of the radiative spectrum [9]. A distinctive feature of the FR which makes it attractive in the sensing application is the high value of the quality factor which enhances the photon lifetime in the resonator hence enabling a longer light matter interaction [10, 11]. FR differs from the Lorentzian curve as the FR based systems exhibit asymmetrical profile.
Finite Difference Time domain (FDTD) method [12] is employed, a method used to solve electromagnetic problems having time dependencies. It solves Maxwell’s equations on a mesh and computes ‘E’ and ‘H’ at grid points. FDTD has advantages over similar methods available for time dependent problem solving, such as Finite Element Method (FEM) [13]. The main advantage of FDTD over FEM is that, unlike FEM, which only addresses uncoupled harmonic issues, FDTD’s time dependence is transient or pulsed and can be converted into frequency domain problems.
Recently a plasmonic based sensor has been reported by [14] for virus detection based on tuned light metamaterial absorber; however, apart from the complex design, the sensitivity of the virus sensor is on the lower side of 76 nm/RIU; moreover, only a comparative analysis has been done based on structure dimension with respect to the reported sensors without mentioning the FOM. [15] proposed a sensor for biological and chemical sensing based on gold nano array with a FOM of 98 RIU\(^{-1}\); however, the highest sensitivity obtained is still on the lower side with a value of 880 nm/RIU. A bowtie cavity based glucose sensor is reported by [16] with sensitivity of 1500 nm/RIU and highest FOM of 50 RIU\(^{-1}\); however, the design complexities may pose an issue with regard to fabrication. [17] proposed a temperature sensor based on ring encapsulated circular cavity with a FOM of 18.74 RIU\(^{-1}\) and sensitivity of 1350 nm/RIU which is still on the lower side compared to the already reported sensors. [18] proposed a sensor based on gold plasmonic square nanohole arrays deposited on a silicon dioxide substrate with a sensitivity of 944 nm/RIU and a FOM of 15.25 without mentioning any specific applications. The structure becomes complex due to the presence of nanohole arrays which might lead to fabrication issues. [19] reported a sensor based on slot cavity resonant system with a sensitivity of 1000 nm/RIU and a FOM of \(\sim\)38 dB at 890 nm. The authors proposed the applicability of the structure for not only refractive index sensing but also in the fast/slow light region. The structure might have fabrication issues due to the presence of multiple slots as well as the lower sensitivity fails to justify the complexity of the structure. [20] proposed a sensor based on a four-step stub waveguide; however, its reported sensitivity of 1078 nm/RIU still falls on the lower side with FOM\(^*\) value of \(1.54\times 10^{-6}\) without any specific applications. [21] designed a microsensor based on whistle shaped cavity with a sensitivity of 1229 nm/RIU without mentioning FOM and applications, the design becomes a bit complicated for practical applications.
In this paper we proposed a plasmonic refractive index sensor based on MIM SPR system with panda ring resonators. FDTD has been used to study the transmittance characteristics of the device along with Perfect Matched Layer (PML) boundary condition. The transmission characteristics exhibit multiple FRs and investigation is also done for biosensing applications. The organisation of the paper is as follows: the ‘Theoretical Model and Structure of the Proposed Sensor’ section provides detailed description about the theoretical background of the proposed design as well as explains the structural parameters followed by the ‘Results and Discussions’ section explaining the results and includes discussion on potential fabrication issues along with sensitivity and a comparative analysis with the existing sensors. The ‘Application Prospects’ section explains the biosensing application prospects of the proposed design and finally the ‘Conclusion’ section concludes the paper.
Theoretical Model and Structure of the Proposed Sensor
Figure 1 illustrates the schematic of the proposed sensor, the structure consists of a MIM waveguide coupled with a panda ring resonator. The width ‘w’ for all the waveguides is fixed at \(w=50\) nm to ensure the availability of single fundamental transverse mode (TM). The radius of the central ring is kept at R = 180 nm and the radius of the two adjacent rings is kept at r = 113 nm. The separation between the linear waveguide and the panda ring resonator is kept at \(g=10\) nm. The total length and width of the structure under simulation is 2.8 µm and 1.5 µm respectively, which is smaller in compared to [22]. Silver (Ag) is used as the metallic component of the MIM waveguide because compared to other noble metals it has better optical properties. The dispersive metal property is defined using the Lorentz dispersive model which explains the frequency dependency of the dielectric permittivity [23]. The fundamental TM mode is excited using the dispersion relation [24]:
where \(\kappa _{m}\) and \(\kappa _{d}\) are defined as: \(\kappa _{m}=\sqrt{\beta ^{2}-\epsilon _{m}\kappa _{o}^{2}}\) and \(\kappa _{d}=\sqrt{\beta ^{2}-\epsilon _{d}\kappa _{o}^{2}}\), \(\epsilon _{d}\) and \(\epsilon _{m}\) are the dielectric constants of insulator and metal respectively, \(\kappa _{o}=\frac{2\pi }{\lambda _{o}}\) is the wave vector of light where \(\lambda _{o}\) is the wavelength in free space, \(\beta\) denotes the propagation constant of the SPPs.
The incident light traversing along the waveguide gets coupled in the panda ring resonator creating a phase difference which is represented as [25]:
where L is the effective length of the resonators, \(\phi _{ref}\) represents the metal insulator interface phase shift and \(n_{eff}=\frac{\beta }{\kappa _{0}}\) represents the effective refractive index of the waveguide. The waves resonate in the cavity when \(\Delta \phi = 2\pi\)m (\(m=1, 2, 3, \ldots\)) and the resulting resonant wavelength is represented as [26]:
This equation implies that \(\lambda _{res}\) is directly proportional to L (effective length of the resonators) and \(n_{eff}\). Furthermore, the Multimode Interference Couple Mode Theory (MICMT) can be used to explain the transmittance characteristics of the coupled resonators and the relation between the resonators is given as [27]:
where \(\omega _{m}\) and \(a_{m}\) represents the resonant frequency and normalised amplitude of the \(m^{th}\) resonant mode, \(\tau _{m,in}\) represents the decay time of internal loss of \(m^{th}\) resonant mode, \(\tau _{m,1}\) and \(\tau _{m,2}\) are the decay time of the coupling between the resonators and the waveguides, \(k_{m1}\) and \(k_{m2}\) are the coupling coefficients connoting the coupling of \(m^{th}\) mode between the resonating structure and the waveguide [28].
Normalised amplitude at the input and output of MIM waveguides is denoted by \(S_{1,2+}\) and \(S_{1,2-}\) respectively and \(+\) and − are used to signify the incoming or outgoing signal; \(\phi _{m,1}\) and \(\phi _{m,2}\) are the coupling phases of \(m^{th}\) resonant modes. Considering \(\phi _{m}\) to be the \(m^{th}\) mode phase, the transmittance thus can be represented as [29]:
Results and Discussions
Using a two-dimensional FDTD method, the proposed sensor’s transmission characteristics are investigated. The boundary condition in effect across the sensor is the Perfect Matched Layer (PML) to minimise simulation errors and reflections from the side walls. SPPs can be excited at the metal insulator interface when the TM polarised light is incident to the rectangular waveguide. The investigation of the transmission spectrum is done with the help of power that is normalised for a p-polarised light with the input at the output. Figure 2 represents the transmission characteristics of the proposed sensor consisting of a rectangular waveguide coupled with a panda ring resonator in a MIM setup. In Fig. 2 the asymmetric dips are apparent, this behaviour of the graph can be attributed to Eq. (3).
In Fig. 2 it can be visualised in the transmission characteristics that three fano profiles are obtained with dips at \(\lambda =0.949\) µm (FR\(_1\)), \(\lambda =1.728\) µm (FR\(_2\)) and \(\lambda =2.103\) µm (FR\(_3\)) respectively. As per Eqs. (4–7), the SPPs are injected in the MIM waveguide through the input port, hence \(S_{2+}\) becomes zero. When the input and output waveguides are identical and are symmetrically distributed on both sides of the cavity resonators then \(\tau _{m}=\tau _{m1}=\tau _{m2}=\tau _{m3}\), where \(\tau _{m}\) is the algebraic value replacing \(\tau _{m1}\), \(\tau _{m2}\) and \(\tau _{m3}\). Also the coupling phase becomes equal to the phase difference between the resonators. Considering \(\phi _{m}\) to be the \(m^{th}\) mode phase, \(\phi _{m} = \phi _{m1} + \Delta \phi _{m}\) where \(\Delta \phi _{m}\) denotes the phase difference between input and output port. In relation to the transmittance curve obtained in Fig. 2 the above approximations compliments the FDTD methodology used.
Further, to understand the fundamental nature of the transmission spectrum FR magnetic profile is investigated as shown in Fig. 3. All field profiles have been normalised for better understanding. In Fig. 3b it is observed that SPPs pass through the linear rectangular waveguide despite of significant coupling in the panda ring resonators. Whereas, in Fig. 3a, c and d it can be observed that very little or no magnetic field is obtained at the output as the coupling in the panda ring resonators is very significant leading to destructive interference between the linear waveguide and the panda ring resonators. Hence, in Fig. 2 dips in the transmittance curve are observed which are asymmetric in nature. The asymmetric profile of the resonance is called as Fano Resonance (FR). These FRs helps in realisation of optical sensors via their consequent shifts in the transmittance graph. The application of FRs in sensing is enhanced due to the presence of multiple FRs. These multiple FRs help in better utilisation of light energy and they exist due to the presence of a number of discrete states born out of interaction between different resonating structures.
To better understand the performance of the device the effect of Refractive Index (RI) is investigated. In Fig. 4a a plot of transmittance curve can be seen with respect to RI. The RI is varied from 1.00 to 1.20 with a step size of 0.05. The variation in RI is tested in the panda ring resonant cavity, using ring resonators provides an additional advantage that the sensing can be tested for a small volume of sample specimen. A redshift is observed in Fig. 4a in the resonant wavelength with respect to variation in the RI. In Fig. 4b a linear relationship between wavelength and RI can be observed for FR\(_1\), FR\(_2\) and FR\(_3\). The linear coefficients of FR\(_1\), FR\(_2\) and FR\(_3\) are obtained as 0.999, 0.995 and 0.999 respectively, which signifies a good performance. Spectral sensitivity is an important parameter to judge the performance of the sensor, mathematically it is represented as \(S=\frac{\Delta \lambda }{\Delta n}\) where \(\Delta \lambda\) is the redshift in the resonant wavelength and \(\Delta n\) is the change in RI. From Fig. 4a the spectral sensitivity is found as 922 nm/RIU, 1730 nm/RIU and 2092.3 nm/RIU at FR\(_1\), FR\(_2\) and FR\(_3\) respectively. Thus, it is observed that FR\(_3\) has a superior spectral sensitivity for RI sensing compared to FR\(_1\) and FR\(_2\).
Investigation is also done for fabrication issues arising out of deviation from the optimised structure. The investigation is done with respect to improper etching process represented using slits at different positions on the panda ring resonator as shown in Fig. 5a, b and c respectively. The effect on the transmittance of the sensor due to the presence of the slits can be observed in Fig. 5d and its consequent effect on the sensitivity can be seen in Fig. 5e. The sensitivity is investigated for FR\(_3\) only as it exhibits the highest value. As shown in Fig. 5a, b and c the slits are placed in three different configurations along the panda ring. When a single slit is introduced only in the central ring a decrease in the sensitivity by a value of 75 nm/RIU from the peak value is observed irrespective of the width and position of the slit. Similarly, when slits are introduced in the outer two rings and all the three rings a significant decrease of 109 nm/RIU and 107 nm/RIU from the peak value is observed in the sensitivity compared to the optimised design. These variations can be understood from Fig. 5d, it is evident from the graph that as slits are introduced in the structure a blue shift can be observed with increase in the number of slits. This blueshift occurs due to the interruption in the otherwise continuous coupling inside the panda ring due to the presence of the slit, hence resulting in consequent decease in the sensitivity of the sensor. Hence, the potential effect of improper etching process can be deduced based on the above results.
Additionally, Figure of Merit (FOM) is also factored in to investigate the performance of the sensor, it is represented as [30]:
where \(T(\lambda )\) is the transmittance at a particular wavelength and \(\frac{dT(\lambda )}{dn(\lambda )}\) is the change in transmittance at a fixed wavelength induced by the change in refractive index. The FOM of the structure is analysed for a change in refractive index varying from 1 to 1.1, and the consequent change in resonant wavelength at the dip of the transmittance curve results in a shift from 2103 nm to 2304 nm, based on Eq. (8), a high FOM of 955.7 RIU\(^{-1}\) is achieved. This FOM is generally termed as FOM\(^*\) [31]. FOM is also calculated using the conventional formula, i.e. \(FOM = \frac{S}{FWHM}\) and is found to be 46.18 RIU\(^{-1}\), where S is the sensitivity of the sensor and FWHM is the Full Width Half Maxima [32] of the FR\(_3\).
A comparative analysis of different plasmonic sensors as described in [32, 34,35,36,37] along with the proposed device is shown in Table 1. It is evident from Table 1 that compared to [33] the performance parameters of the proposed sensor is much better in terms of sensitivity of the reported sensor. In [34] the reported sensor has a lower sensitivity as well as lower FOM compared to the proposed sensor. The spectral sensitivity is the most important parameter for a RI sensor, in [35] not only the FOM achieved is lower but also the sensitivity obtained is comparatively lower than the proposed sensor. In [36] although the FOM obtained is higher but the spectral sensitivity is still lower than the proposed design. In [37] it can be seen that in comparison to the proposed sensor the FOM and sensitivity of the reported sensor is lower. There is a minimum trade-off between the complexity of the structure and the performance parameters for the proposed sensor. A relatively higher value of FOM is produced as a result of the presence of a sharp and narrow FWHM asymmetric Fano Resonance profile. All these significant properties of the proposed device helps us to consider it as a contender for on-chip optical sensor applications. On-chip optical sensing is made possible by the proposed sensor’s high sensitivity and FOM with triple Fano Resonance profile.
Application Prospects
The sensing application is investigated for the detection of five different cells effected by cancer. The cells that are considered for investigation are Jurkat, PC-12, MDA-MB-231, MCF-7 and Basal Cell [38]. The refractive index of the cancer infected cells of the aforementioned cells are 1.39, 1.395, 1.399, 1.401 and 1.38 respectively [39]. The analyte consisting of the cancer cells under investigation is introduced in the panda ring cavity. A redshift is observed in the transmittance curve with respect to RI of the cancer cells as evident from Fig. 6. It can be visualised that the resonant wavelength is shifting with the variation of RI. Fabrication of the device can be done using Electron-beam lithography or nano-imprint lithograph [40]. Cavity attraction method can be used to introduce the material under test into the cavity [41]. In Fig. 7 a linear relationship between the resonant wavelength and RI is obtained with linear coefficients of 1, 0.998 and 1 respectively which denotes towards a good performance. The circled area in Fig. 7 represents the area of interest for sensing at FR\(_3\). The same area of interest can also be used for detection at FR\(_1\) and FR\(_2\) but with a reduced sensitivity compared to FR\(_3\).
Conclusion
A plasmonic MIM waveguide setup consisting of linear rectangular waveguide coupled with panda ring resonator is proposed and its transmission characteristics is investigated. The transmission characteristics exhibits three Fano resonances at 0.949 µm, 1.728 µm and 2.103 µm respectively. Sensitivity and FOM are used to examine the proposed sensor’s performance, which are both obtained at high levels of 2092 nm/RIU and 46.18 RIU−1 respectively. To identify the potential fabrication issues the proposed design is further investigated by introducing different number of slits. Moreover, the biosensing application is also investigated using five different types of cancerous cells. The transmittance curve shows a visible redshift and the sensitivity graph exhibits a linear relationship between the resonant wavelength and RI. Highest sensitivity of 2076.8 nm/RIU for the cancer cell detection is obtained, which nearly matches the performance of the proposed sensor. Hence, the bio-analyte sensing potential of the proposed sensor is investigated.
Data Availability
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Gaurav Kumar Yadav: conceptualisation, device design, simulation and analysis, manuscript preparation. Sanjeev Kumar Metya: manuscript finalisation and supervision.
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Yadav, G.K., Metya, S.K. Plasmonic Nanosensor for Cancer Cell Detection with Multi Fano Resonance. Plasmonics 18, 1195–1202 (2023). https://doi.org/10.1007/s11468-023-01842-9
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DOI: https://doi.org/10.1007/s11468-023-01842-9