Abstract
A series of novel atropisomeric diphosphine ligands termed TanPhos were designed and synthesized, which has a smaller bite angle compared with that of other ligands such as BINAP. TanPhos showed high reactivity and enantioselectivity in the rhodium-catalyzed asymmetric hydrogenation of a-dehydro amino ketones, and up 99% yield and 99% ee were obtained for a wide range of chiral α-amino ketones.
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Acknowledgements
X. Zhang acknowledges the National Key R&D Program of China (2021YFA1500201), the Stable Support Plan Program of Shenzhen Natural Science Fund (20200925161222002), the Key-Area Research and Development Program of Guangdong Province (2020B010188001), the Innovative Team of Universities in Guangdong Province (2020KCXTD016), and the National Natural Science Foundation of China (21991113). G.-Q. Chen gratefully acknowledges the Guangdong Basic and Applied Basic Research Foundation (2022B1515020055), the National Natural Science Foundation of China (22171129) and Shenzhen Science and Technology Innovation Committee (JCYJ20210324104202007) for financial support.
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Design and Synthesis of Novel 1,3-Diene Bridged Chiral Atropoisomeric Diphosphine Ligands for Asymmetric Hydrogenation of α-Dehydro Amino Ketones
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Tan, X., Gao, S., Yang, C. et al. Design and synthesis of novel 1,3-diene bridged chiral atropoisomeric diphosphine ligands for asymmetric hydrogenation of α-dehydro amino ketones. Sci. China Chem. 66, 2847–2851 (2023). https://doi.org/10.1007/s11426-023-1798-1
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DOI: https://doi.org/10.1007/s11426-023-1798-1