Abstract
1,1-Diaryl moieties are core structures in a wide range of bioactive and pharmaceutical compounds. Transition-metal catalysis is a convenient approach to accessing these invaluable compounds affording high yields and enantioselectivities. This review summarizes 1,1-diarylalkanes synthesis through transition metal catalysis. Particular focus is given to recent developments, such as reductive cross-electrophile couplings, benzylic C–H bond arylation, transformations involving metal migration, asymmetric hydrogenation of 1,1-diarylalkenes and three-component coupling reactions.
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Acknowledgements
This work was supported by the National Natural Science Foundation of China (21702151, 21871211) and the Fundamental Research Funds for Central Universities (2042019kf0208). We thank Profs. Qianghui Zhou, Wen-Bo Liu, Aiwen Lei and Xumu Zhang at Wuhan University for lending lab space and sharing the basic instruments. We thank Dr. Simon Partridge from Liwen Bianji, Edanz Editing China (http://www.liwenbianji.cn/ac) for editing the English text of a draft of this manuscript.
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Belal, M., Li, Z., Lu, X. et al. Recent advances in the synthesis of 1,1-diarylalkanes by transition-metal catalysis. Sci. China Chem. 64, 513–533 (2021). https://doi.org/10.1007/s11426-020-9910-2
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DOI: https://doi.org/10.1007/s11426-020-9910-2