Abstract
As a result of a marked decline in dry matter intake (DMI) prior to parturition and a slow rate of increase in DMI relative to milk production after parturition, dairy cattle experience a negative energy balance. Changes in nutritional and metabolic status during the periparturient period predispose dairy cattle to develop hepatic lipidosis and ketosis. The metabolic profile during early lactation includes low concentrations of serum insulin, plasma glucose, and liver glycogen and high concentrations of serum glucagon, adrenaline, growth hormone, plasma β-hydroxybutyrate and non-esterified fatty acids, and liver triglyceride. Moreover, during late gestation and early lactation, flow of nutrients to fetus and mammary tissues are accorded a high degree of metabolic priority. This priority coincides with lowered responsiveness and sensitivity of extrahepatic tissues to insulin, which presumably plays a key role in development of hepatic lipidosis and ketosis. Hepatic lipidosis and ketosis compromise production, immune function, and fertility. Cows with hepatic lipidosis and ketosis have low tissue responsiveness to insulin owing to ketoacidosis. Insulin has numerous roles in metabolism of carbohydrates, lipids and proteins. Insulin is an anabolic hormone and acts to preserve nutrients as well as being a potent feed intake regulator. In addition to the major replacement therapy to alleviate severity of negative energy balance, administration of insulin with concomitant delivery of dextrose increases efficiency of treatment for hepatic lipidosis and ketosis. However, data on use of insulin to prevent these lipid-related metabolic disorders are limited and it should be investigated.
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Abbreviations
- A:
-
acidic
- apoB:
-
apolipoprotein B
- B:
-
basic
- BCS:
-
body condition score
- BHBA:
-
β-hydroxybutyrate
- BW:
-
body weight
- CPT-I:
-
carnitine palmitoyltransferase-I
- C-peptide:
-
connecting peptide
- DMI:
-
dry matter intake
- FA:
-
fatty acid
- G1P:
-
glucose-1-phosphate
- G6P:
-
glucose-6-phosphate
- GTT:
-
glucose tolerance test
- GLUT:
-
glucose transporter
- GLY:
-
glycogen
- GH:
-
growth hormone
- hCG:
-
human chorionic gonadotrophin
- IRS:
-
insulin receptor substrate
- LPL:
-
lipoprotein lipase
- MW:
-
molecular weight
- NEFA:
-
nonesterified fatty acid
- NEL:
-
net energy for lactation
- NFC:
-
non-fibre carbohydrates
- PI3:
-
phosphoinositol phosphate kinase
- RRI:
-
rapid-release insulin
- RER:
-
rough endoplasmic reticulum
- SRI:
-
slow-release insulin
- TCA:
-
tricarboxylic acid
- TG:
-
triglyceride
- VFA:
-
volatile fatty acids
- VLDL:
-
very low-density lipoprotein
References
Annison, E.F., Linzell, J.L., Fazakerley, S. and Nicholas, B.W., 1967. The oxidation and utilization of palmitate, stearate, oleate, and acetate by the mammary gland of the fed goat in relation to their overall metabolism and the role of plasma phospholipids and neutral lipid in milk fat synthesis. Biochemical Journal, 102, 637–641
Baile, C.A. and Mayer, J., 1968. Effects of insulin-induced hypoglycemia and hypoacetonemia on eating behavior in goats. Journal of Dairy Science, 51, 1495–1499
Baird, G.D., 1981. Lactation, pregnancy and metabolic disorder in ruminant. Proceedings of the Nutrition Society, 40, 115–120
Bauchart, D., 1993. Lipid absorption and transport in ruminants. Journal of Dairy Science, 76, 3864–3881
Bauman, D.E. and Currie, W.B., 1980. Partitioning of nutrients during pregnancy and lactation: a review of mechanisms involving homeostasis and homeorhesis. Journal of Dairy Science, 63, 1514–1529
Bell, A.W. 1995. Regulation of organic nutrient metabolism during transition from late pregnancy to early lactation. Journal of Animal Science, 73, 2804–2819
Bell, A.W., 1996. The transition cow: the actualized homeorhesis. Proceedings of the Cornell Nutrition Conference for Feed Manufacturers, Cornell University Press, Ithaca, NY, 150–157
Bergman, R.N. and Mittelman, S.D., 1998. Central role of the adipocyte in insulin resistance. Journal of Basic Clinical Physiology and Pharmacology, 9, 205–221
Bergman, E.N., Reulein, S.S. and Corlett, R.E., 1998. Effects of obesity on insulin sensitivity and responsiveness in sheep. American Journal of Physiology, 257, 772–781
Berne, R.M. and Levy, M.N., 1993. Hormones of the pancreatic islets. Physiology, 3rd edn, (Mosby Year Book, St Louis, MO), 851–875
Berson, S.A. and Yalow, R.S., 1970. Insulin antagonist and insulin resistance. In: M. Ellenberg and H. Rifkin (eds) Diabetes Mellitus: Theory and Practice, (McGraw-Hill, New York), 388–412
Bertics, S.J. and Grummer, R.R., 1999. Effects of fat and methionine hydroxy analog on prevention or alleviation of fatty liver induced by feed restriction. Journal of Dairy Science, 82, 2731–2736
Bertics, S.J., Grummer, R.R., Cadorniga-Valino, C. and Stoddard, E.E., 1992. Effect of prepartum dry matter intake on liver triglyceride concentration and early lactation. Journal of Dairy Science, 75, 1914–1922
Besong, S., Jackson, J.A., Trammell, D.S. and Akay, V., 2001. Influence of supplemental chromium on concentrations of liver triglyceride, blood metabolites and rumen VFA profile in steers fed a moderately high fat diet. Journal of Dairy Science, 84, 1679–1685
Beynen, A.C., Haagsman, H.P., van Golde, L.M.G. and Geelen, M.J.H., 1981. The effects of insulin and glucagon on the release of triacylglycerols by isolated rat hepatocytes are mere reflections of the hormonal effects on the rate of triacylglycerol synthesis. Biochemica et Biophysica Acta, 655, 1–7
Bjornsson, O.G., Duerden, J.M., Barlett, S.M., Sparks, J.D., Sparks, C.E. and Gibbons, G.F., 1992. The role of pancreatic hormones in the regulation of lipid storage, oxidation and secretion in primary cultures of rat hepatocytes. Biochemical Journal, 281, 381–386
Boden, G., 1977. Free fatty acids, insulin resistance, and type II diabetes mellitus. American Journal of Physiology, 111, 241–248
Bremmer, D.R., Trower, S.L., Bertics, S.J., Besong, S., Bernabucci, U. and Grummer, R.R., 2000 Etiology of fatty liver in dairy cattle: effects of nutritional and hormonal status on hepatic microsomal triglyceride transfer protein. Journal of Dairy Science, 83, 2239–2251
Brockman, R.P., 1978. Roles of glucagon and insulin in the regulation of metabolism in ruminants. Canadian Veterinary Journal, 19, 55–62
Brockman, R.P., 1979. Roles for insulin and glucagon in the development of ruminant ketosis. Canadian Veterinary Journal, 20, 121–126
Brockman, R.P., 1984. Pancreatic and adrenal hormonal regulation of metabolism. In Control of Digestion and Metabolism in Ruminants, Proc. 6th Int. Symp. on Ruminant Physiology, Banff, Canada, (Prentice-Hall, Englewood Cliffs, NJ), 405–419
Brockman, R.P. and Laarveld, B., 1986. Hormonal regulation of metabolism in ruminants. Livestock Production Science, 14, 313–334
Bruss, M.L., 1993. Metabolic fatty liver of ruminants. Advances in Veterinary Sciences and Comparative Medicine, 37, 417–449
Chirieac, D.V., Chirieac, L.R., Corsetti, J.P., Cianci, J., Sparks, C.E. and Sparks, J.D., 2000. Glucose-stimulated insulin secretion suppresses hepatic triglyceride-rich lipoprotein and apoB production. American Journal of Physiology, 279, E1003–E1011
Collier, R.J., McNamara, J.P., Wallace, C.R. and Dehoff, M.H., 1984. A review of endocrine regulation of metabolism during lactation. Journal of Animal Science, 59, 498–510
Collin, R.A. and Reid, I.M., 1980. A correlated biochemical and stereological study of periparturient fatty liver in the dairy cow. Research in Veterinary Science, 28, 373–376
Coppock, C.E., 1985. Energy nutrition and metabolism of the lactating dairy cow. Journal of Dairy Science, 68, 3403–3410
Correa, M.T., Curtis, C.R., Erb, H.N., Scarlett, J.M. and Smith, R.D., 1990. An ecological analysis of risk factors for postpartum disorders of Holstein–Friesian cows from thirty-two New York farms. Journal of Dairy Science, 73, 1515–1524
Correa, M.T., Erb, H.N. and Scarlett, J., 1993. Path analysis for seven postpartum disorders of Holstein cows. Journal of Dairy Science, 76, 1305–1312
Curtis, C.R., Erb, H.N., Sniffen, C. J., Smith, R. D. and Kronfeld, D.S., 1985. Path analysis of dry period nutrition, postpartum metabolism and reproductive disorders, and mastitis in Holstein cows. Journal of Dairy Science, 68, 2347–2360
Dann, H.M., Varga, G.A. and Putnam, D.E., 1999. Improving energy supply to late gestation and earlypostpartum dairy cows. Journal of Dairy Science, 82, 1765–1778
DeBoer, G., Trenkle, A. and Young, J.W., 1985. Glucagon, insulin, growth hormone, and some blood metabolites during energy restriction ketonemia of lactating cows. Journal of Dairy Science, 68, 326–337
Debrass, E., Grizard, J., Aina, E., Tesseraud, S., Champredon, C. and Arnal, M., 1989. Insulin sensitivity and responsiveness during lactation and dry period in goats. American Journal of Physiology, 256, E295–E302
Deetz, L.E. and Wangsness, P.J., 1980. Effects of intrajugular administration of insulin on feed intake, plasma glucose and plasma insulin of sheep. Journal of Nutrition, 110, 1976–1982
Deetz, L.E. and Wangsness, P.J., 1981. Influence of intrajugular administration of insulin, glucagon and propionate on voluntary feed intake of sheep. Journal of Animal Science, 53, 427–433
Deetz, L.E., Wangsness, P.J., Kavanaugh, J.F. and Griel, Jr. E.C., 1980.Effect of intraportal and continuous administration of insulin on feeding in sheep. Journal of Nutrition, 110, 1983–1991
DeFronzo, R.A., Bonadonna, R.C. and Ferrannini, E., 1992. Pathogenesis of NIDDM. Diabetes Care, 3, 318–368
Drackley, J.K., 1999. Biology of dairy cows during the transition period: the final frontier? Journal of Dairy Science, 82, 2259–2273
Drackley, J.K, Richard, M.J., Beitz, D.C. and Young, J.W., 1992. Metabolic changes in dairy cows with ketonemia in response to feed restriction and dietary 1,3-butanediol. Journal of Dairy Science, 75, 1622–1634
Drackley, J.K, Overton, T.R. and Douglas, G.N., 2001. Adaptations of glucose and long-chain fatty acid metabolism in liver of dairy cows during the periparturient period. Journal of Dairy Science, 84, E100–E112
Driksen, G., Liebich, H. and Mayer, K., 1985. Adaptive changes of the ruminal mucosa and functional and clinical significance. Bovine Practitioner, 20, 116–120
Emery, R.S., Liesman, J.S. and Herdt, T.H., 1992. Metabolism of long chain fatty acids by ruminant liver. Journal of Nutrition, 122, 832–837
Farrer, M., Fulcher, G.R., Johnson, A.J. and Alberti, K.G., 1992. Effects of acute inhibition of lipolysis on operation of the glucose-fatty acid cycle in hepatic cirrhosis. Metabolism, 41, 465–470
Faulkner, A. and Pollock, H.T., 1990. Metabolic responses to euglycaemic hyperinsulinaemia in lactating and non-lactating sheep in vivo. Journal of Endocrinology, 124, 59–66
Fickova, M., Zorad, S. and Macho, L., 1997. The effect of in vivo thyroxin treatment on insulin receptors, glucose transport and GLUT4 in rat adipocytes. Hormone and Metabolism Research, 29, 16–19
Fleming, S.A., 1990. Ketosis of ruminants (acetonemia). In: B.P. Smith (ed), Large Animal Internal Medicine. (C. V. Mosby, St Louis, MO), 1306–1314
Flipot, P.M., Roy, G.L. and Dufuour, J.J., 1988. Effect of peripartum energy concentration on production performance of Holstein cows. Journal of Dairy Science, 71, 1840–1850
Forbes, J.M., 1996. Integration of regulatory signals controlling forage intake in ruminants. Journal of Animal Science, 74, 3029–3035
Forhead, A.J. and Dobson, H., 1997. Plasma glucose and cortisol responses to exogenous insulin in fasted donkey. Research in Veterinary Medicine, 62, 256–269
Franklin, S.T., Young, J.W. and Nonnecke, B.J., 1991. Effects of ketones, acetate, butyrate, and glucose on bovine lymphocyte proliferation. Journal of Dairy Science, 74, 2507–2516
Fronk, T.J., Schultz, L.H. and Hardie, A.R., 1980. Effect of dry period overconditioning on subsequent metabolic disorders and performance of dairy cows. Journal of Dairy Science, 63, 1080–1090
Garnsworthy, P.C. and Topps, J.H., 1982. The effect of body condition of dairy cows at calving on their food intake and performance when given complete diets. Animal Production, 35, 113–119
Garvey, W.T., Olefsky, J.M. and Marshall, S., 1986. Insulin induces progressive insulin resistance in cultures rat adipocytes: sequential effects at receptor and multiple post-receptor sites. Diabetes, 35, 258–267
Gerloff, B.J., Herdt, T.H. and Emery, R.S., 1986a. Relationship of hepatic lipidosis to health and performance in dairy cattle. Journal of American Veterinary Medicine, 188, 845–850
Gerloff, B.J., Herdt, T.H., Wells, W.W., Liesman, J.S. and Emery, R.S., 1986b. Effect of inositol supplementation and time from parturition on liver and serum lipids in dairy cattle. Journal of Animal Science, 62, 1682–1692
Gibbons, G.F., 1990. Assembly and secretion of hepatic very-low density lipoprotein. Biochemical Journal, 268, 1–13
Goff, J.P. and Horst, R.L., 1997. Physiological changes at parturition and their relationship to metabolic disorders. Journal of Dairy Science, 80, 1260–1268
Goth, A., 1968. Medical Pharmacology, 4th edn, (C. V. Mosby, St Louis, MO), 489–502
Grantham, B.D. and Zammit, V.A., 1988. Role of carnitine palmitoyltransferase I in the regulation of hepatic ketogenesis during the onset and reversal of chronic diabetes. Biochemical Journal, 249, 409–419
Grovum, W.L., 1995. Mechanisms explaining the effects of short chain fatty acids on feed intake in ruminants–-osmotic pressure, insulin and glucagon. In: W.V. Engelhardt, A. L. Marek, G. Breves, and D. Giesexke (eds), Ruminant Physiology: Digestion, Metabolism, Growth and Reproduction, (Ferdinand Enke Verlag, Stuttgart) 173–197
Gruffat, D., Durand, D., Graulet, B. and Bauchart, D., 1996. Regulation of VLDL synthesis and secretion in the liver. Reproduction, Nutrition, Development, 36, 375–389
Gruffat, D., Durand, D., Chillard, Y., Williams, P. and Bauchart, D., 1997. Hepatic gene expression of apolipoprotein B100 during early lactation in underfed, high producing dairy cows. Journal of Dairy Science, 80, 657–666
Grummer, R.R., 1993. Etiology of lipid-related metabolic disorders in periparturient dairy cows. Journal of Dairy Science, 76, 3882–3896
Grummer, R.R., 1995. Impact of changes in organic nutrient metabolism on feeding the transition dairy cow. Journal of Animal Science, 73, 2820–2833
Guesnet, P.M., Massoud, M.J. and Demarne, Y., 1991. Regulation of adipose tissue metabolism during pregnancy and lactation in the ewe: the role of insulin. Journal of Animal Science, 69, 2057–2065
Hadley, M.E., 1996. Pancreatic hormones and metabolic regulation. Endocrinology. 4th edn, (Prentice Hall, Upper Saddle River, NJ), 231–255
Hartwell, J.R., Cecava, M.J. and Donkin, S.S., 2000. Impact of dietary rumen undegradable protein and rumen-protected choline on intake, peripartum liver triglyceride, plasma metabolites, and milk production in transition dairy cows. Journal of Dairy Science, 83, 2907–2917
Hay, W.W.J, Lin, C. and Meznarich, H.K., 1988. Effect of high levels of insulin on glucose utilization and glucose production in pregnant and nonpregnant sheep. Proceedings of the Society for Experimental Biology and Medicine, 189, 275–284
Hayirli, A. and Grummer, R.R., 2004. Factors affecting dry matter intake prepartum in relationship to etiology of peripartum lipid-related metabolic disorders. Canadian Journal of Animal Science, 84, 337–347
Hayirli, A., Bremmer, D.R., Bertics, S.J., Socha, M.T. and Grummer, R.R., 2001. Effect of chromium supplementation on production and metabolic parameters in periparturient dairy cows. Journal of Dairy Science, 84, 1218–1230
Hayirli, A., Bertics, S.J. and Grummer, R.R., 2002a. Effects of slow-release insulin on production, liver triglyceride, and metabolic profiles of Holsteins in early lactation. Journal of Dairy Science, 85, 2180–2191
Hayirli, A., Grummer, R.R., Nordheim, E.V. and Crump, P.M., 2002b. Animal and dietary factors affecting feed intake during the prefresh transition period in Holsteins. Journal of Dairy Science, 85, 3430–3443
Hegardt, F.G., 1999. Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase: a control enzyme in ketogenesis. Biochemistry Journal, 338, 569–582
Heimberg, M. and Wilcox, H.G., 1972. The effect of palmitic and oleic acids on the properties and composition of very low-density lipoprotein secreted by the liver. Journal of Biological Chemistry, 247, 875–879
Hennes, M.M., Shrago, E. and Kissebah, A.H., 1990. Receptor and post-receptor effects of free fatty acids on hepatocytes insulin dynamics. International Journal of Obesity, 14, 831–841
Herbein, J.H., Aiello, R.J., Eckler, L.I., Pearson, R.E. and Akers, R.M., 1985. Glucagon, insulin, growth hormone, and glucose concentrations in plasma of lactating dairy cows. Journal of Dairy Science, 68, 320–325
Herdt, H., Liesman, J.S., Gerloff, B.J. and Emery, E.S., 1983. Reduction of serum triacylglycerol-rich lipoprotein concentrations in cows with hepatic lipidosis. American Journal of Veterinary Research, 44, 293–296
Herdt, T.H., Wensing, T., Haagsman, H.P., van Golde, L.M.G. and Breunink, H.J., 1988. Hepatic triacylglycerol synthesis during a period of fatty liver development in sheep. Journal of Animal Science, 66, 1997–2003
Hjolliund, E., Pedersen, O., Espersen, T. and Klebe, J.G., 1986. Impaired insulin receptor binding and postbinding defects of adipocytes from normal and pregnant women. Diabetes, 35, 598–603
Holtenius, P., 1993. Hormonal regulation related to the development of fatty liver and ketosis. Acta Veterinaria Scandinavia, 89, S55–S60
Holtenius, K., Agenäs, S., Delavaud, C. and Chilliard, Y., 2003. Effects of feeding intensity during the dry period. 2. Metabolic and hormonal responses. Journal of Dairy Science, 86, 883–891
Hood, R.L., Thompson, E.H. and Allen, C.E., 1972. The role of acetate, propionate, and glucose as substrates for lipogenesis in bovine tissues. International Journal of Biochemistry, 3, 598–606
Horino, M., Machlin, L.J., Hertelendy, F. and Kipnis, D.M., 1968. Effect of short-chain fatty acids on plasma insulin in ruminant and nonruminant species. Endocrinology, 83, 118–128
Hsu, W.H. and Crump, M.H., 1989. The endocrine pancreas. In: L. E. McDonald (ed), Veterinary Endocrinology and Reproduction, 4th edn, (Lea and Febiger, Philadelphia, PA), 186–201
Ingle, D.L., Bauman, D.E. and Garrigus, U.S., 1972. Lipogenesis in the ruminant: in vitro study of tissue sites, carbon source and reducing equivalent generation for fatty acid synthesis. Journal of Nutrition, 102, 609–616
Jarret, I.G., Filsell, O.H. and Ballard, F.J., 1976. Utilization of oxidizable substrates by the sheep hind limb: effects of starvation and exercise. Metabolism, 25, 523–531
Johnson, L.R., 1997. Pancreatic secretion. Gastrointestinal Physiology, 5th edn, (Mosby, St. Louis, MO), 89–100
Kahn, C.R., 1978. Insulin resistance, insulin sensitivity, and insulin unresponsiveness: a necessary distinction. Metabolism, 27, 1893–1902
Kahn, C.R., 1994. Insulin action, diabetogenes, and the cause of type II diabetes. Diabetes, 43, 1066–1084
Kaneene, J.B., Miller, R., Herdt, T.H. and Gardiner, J.C., 1997. The association of serum nonesterified fatty acids and cholesterol, management and feeding practices with peripartum disease in dairy cows. Preventive Veterinary Medicine, 31, 59–72
Katzung, B.G., 1995. Pancreatic hormones and antidiabetic drugs. Basic and Clinical Pharmacology. 6th edn., (Appleton and Lange, Norwalk, CT), 637–654
Kleppe, B.B., Aiello, R.J., Grummer, R.R. and Armentano, L.E., 1988. Triglyceride accumulation and very low-density lipoprotein secretion by rat and goat hepatocytes in vitro. Journal of Dairy Science, 71, 1813–1822
Koopmans, S.J., Sips, H.C. and Krans, H.M., 1996. Pulsatile intravenous insulin replacement in streptozotocin diabetic rats is more efficient than continuous delivery: effect of glycemic control, insulin-mediated glucose metabolism and lipolysis. Diabetologia, 39, 391–400
Kronfeld, D.S., 1982. Major metabolic determinants of milk volume, mammary efficiency, and spontaneous ketosis in dairy cows. Journal of Dairy Science, 65, 2204–2212
Kronfeld, D.S., Mayer, G.P., Robertson, J.M. and Raggi, F., 1963. Depression of milk secretion during insulin administration. Journal of Dairy Science, 46, 559–563
Laarveld, B., Christensen, D.A. and Brockman, R.P., 1981. The effect of insulin on net metabolism of glucose by the bovine mammary gland. Endocrinology, 108, 2217–2221
Laville, M., Rigalleau, V., Riou, J.P. and Beylot, M., 1995. Respective role of plasma nonesterified fatty acid oxidation and total lipid oxidation in lipid-induced insulin resistance. Metabolism, 44, 639–644
Le Marchand-Brustel, Y., Tanti, J.F., Cormont, M., Ricort, J.M., Gremeaux, T. and Grillo, S., 1999. From insulin receptor signaling to GLUT-4 translocation abnormalities in obesity and insulin resistance. Journal of Receptor and Signal and Transduction Research, 19, 217–228
Lin, M.C., Gordon, D. and Wetterau, J.R., 1995. Microsomal triglyceride protein (MTP) regulation in HepG2 cells: insulin negatively regulates MTP gene expression. Journal of Lipid Research, 36, 1073–1081
Littledike, E.T., Young, J.W. and Beitz, D.C., 1981. Common metabolic diseases of cattle: ketosis, milk fever, grass tetany, and downer cow complex. Journal of Dairy Science, 64, 1465–1482
Mahler, R.J., 1981. The relationship between the hyperplastic pancreatic islet and insulin sensitivity in obesity. Acta Diabetologica, 18, 1–17
Mallard, B.A., Deffers, J.C., Ireland, M.J., Leslie, K.E., Sharif, S., Vankampen, C.L., Wagter, L. and Wilkie, B.N., 1998. Alteration in immune responsiveness during the periparturient period and its ramification on dairy cows and calf health. Journal of Dairy Science, 81, 585–595
McCance, K.L. and Huether, S.E., 1994. Alterations of hormonal regulations. Pathophysiology, 2nd edn., (Mosby, St Louis, MO), 674–692
McCann, J.P. and Reimers, T.J., 1985. Glucose response to exogenous insulin and kinetics of insulin metabolism in obese and lean heifer. Journal of Animal Science, 61, 612–618
McCann, J.P., Ullmann, M.B., Temple, M.R., Reimes, T.J. and Bergman, E.N., 1986. Insulin and glucose response to glucose injection in fed and fasted obese and lean sheep. Journal of Nutrition, 116, 1287–1297
Minor, D.J., Trower, S.L., Strang, D.B., Shaver, R.D. and Grummer, R.R., 1998. Effects of nonfiber carbohydrate and niacin on periparturient metabolic status of lactating dairy cows. Journal of Dairy Science, 81, 189–200
Nieuwenhuizen, A.G., Schuiling, G.A., Moes, H. and Koiter, T.R., 1997. Role of increased insulin demand in the adaptation of the endocrine pancreas to pregnancy. Acta Physiologica Scandinavica, 159, 302–312
Nieuwenhuizen, A.G., Schuiling, G.A., Bonen, A., Paans, A.M., Waalburg, W. and Koiter, T.R., 1998. Glucose consumption by various tissues in pregnant rats: effects of a 6-day euglycaemic hyperinsulinaemic clamp. Acta Physiologica Scandinavica, 164, 325–334
Nocek, J.E., 1995. Nutritional aspects of the transition cow. Proceedings of the Cornell Nutrition Conference for Feed Manufacturers, Cornell University Press, Ithaca, NY, 121–137
Noshiro, O., Hirayama, R., Shimaya, A., Yoneta, T., Niigata, K. and Shikama, H., 1997. Role of plasma insulin concentration in regulating glucose and lipid metabolism in lean and obese Zucker rats. International Journal of Obesity and Related Metabolic Disorders, 21, 115–121
Oakes, N.D., Cooney, G.J., Camilleri, S., Chisholm, D.J. and Kraegen, E.W., 1997. Mechanisms of liver and muscle insulin resistance induced by chronic high-fat feeding. Diabetes, 14, 1768–1774
O’Brien, R.M. and Granner, D.K., 1990. PEPCK gene as a model of inhibitory effects of insulin on gene transcription. Diabetes Care, 13, 327–334
Okitolonda, W., Pttier, S.M. and Henquin, J.C., 1988. Influence of low- and high–protein diets on glucose homeostasis in the rat. British Journal of Nutrition, 60, 509–516
Ortmeyer, H.K. and Hansen, B.C., 1998. Lack of defect in insulin action on hepatic glycogen synthase and phosphorylase in insulin-resistant monkeys. American Journal of Physiology, 274, G1005–G1010
Pearson, E.G. and Maas, J., 1990. Hepatic lipidosis. In: B. P. Smith (ed), Large Animal Internal Medicine, (C. V. Mosby, St Louis, MO), 860–866
Pechova, A., Podhorsky, A., Lokajova, E., Pavlata, L. and Illek, J., 2002. Metabolic effects of chromium supplementation in dairy cows in the peripartal period. Acta Veterinarni Bruno, 71, 9–18
Petterson, J.A., Slepetis, R., Ehrhardt, R.A., Dunshea, F.R. and Bell, A.W., 1994. Pregnancy but not moderate undernutrition attenuates suppression of fat mobilization in sheep. Journal of Nutrition, 124, 2431–2436
Piepenbrink, M.S. and Overton, T.R., 2003. Liver metabolism and production of cows fed increasing amounts of rumen-protected choline during the periparturient period. Journal of Dairy Science, 86, 1722–1733
Prior, R. L. and Christenson, R.K., 1978. Insulin and glucose effects on glucose metabolism in pregnant and nonpregnant ewes. Journal of Animal Science, 46, 201–210
Prior, R. L. and Scott, R.A., 1980. Effects of intravenous infusions of glucose, lactate, propionate or acetate on the induction of lipogenesis in bovine adipose tissue. Journal of Nutrition, 110, 2011–2019
Rabelo, E., Rezende, R.L., Bertics, S.J. and Grummer, R.R., 2003. Effects of transition diets varying in energy density on lactation performance and ruminal parameters of dairy cows. Journal of Dairy Science, 86, 916–925
Reid, I.M., 1980. Incidence and severity of fatty liver in dairy cows. The Veterinary Record, 107, 281–284
Reid, I.M., Roberts, C.J., and Manston, R., 1979a. Reduced fertility associated with fatty liver in high yielding dairy cows. Veterinary Research Communications, 3, 231–236
Reid, I.M., Roberts, C.J. and Manston, R., 1979b. Fatty liver and infertility in high-yielding dairy cows. The Veterinary Record, 104, 75–76
Reid, I.M., Roberts, C.J., Treacher, R.J. and Williams, L.A., 1986. Effect of body condition at calving on tissue mobilization, development of fatty liver, and blood chemistry of dairy cows. Animal Production, 43, 7–15
Reis, M.A., Carnerio, E.M., Mello, M.A., Boschero, A.C., Saad, M.J. and Vellosa, L.A., 1997. Glucose induced insulin secretion is impaired and insulin-induced phosphorylation of the insulin receptor and insulin receptor subtrate-1 are increased in protein deficient rats. Journal of Nutrition, 127, 403–410
Reynolds, J.E.F., 1989. Insulin. In: Martindale: The Extra Pharmacopoeia. 29th edn., (Pharmaceutical Press, London), 391–398
Reynolds, C.K, Aikman, P.C., Lupoli, B., Humphries, D.J. and Beever, D.E., 2003. Splanchnic metabolism of dairy cows during the transition from late gestation through early lactation. Journal of Dairy Science, 86, 1201–1217
Roberts, C.J., Reid, I.M., Rowlands, G.J. and Patterson, A., 1981. A fat mobilization syndrome in dairy cows in early lactation. Veterinary Record, 108, 7–9
Ropstad, E., Larsen, H.J. and Refsdal, O.A., 1989. Immune function in dairy cows related to energy balance and metabolic status in early lactation. Acta Vetetrinaria Scandinavica, 30, 209–219
Rukkwamsuk, T., Wensing, T. and Geelen, M.J.H., 1998. Effect of overfeeding during the dry period on regulation of adipose tissue metabolism in dairy cows during the periparturient period. Journal of Dairy Science, 81, 2904–2911
Rukkwamsuk, T., Wensing, T. and Geelen, M.J.H., 1999a. Effect of fatty liver on hepatic gluconeogenesis in periparturient period. Journal of Dairy Science, 82, 500–505
Rukkwamsuk, T., Wensing, T. and Geelen, M.J.H., 1999b. Effect of overfeeding during the dry period on the rate of esterification in adipose tissue of dairy cows during the periparturient period. Journal of Dairy Science, 82, 1164–1169
Ruth, B.S.H., 1992. Adipocyte insulin responsiveness in female Spraugue-Dawley rats fed a low fat diet containing a fat-mimetic carbohydrate. Journal of Nutrition, 122, 1802–1810
Ruth, B.S.H. and Kor, H., 1992. Insulin sensitivity is rapidly reversed in rats by reducing dietary fat from 40 to 30% of energy. Journal of Nutrition 122 1811–1822
Ryan, E.A. and Enns, L., 1988. Role of gestational hormones in the induction of insulin resistance. Journal of Clinical Endocrinology and Metabolism 67 341–347
Sakai, T., Hayakawa, T., Hamakawa, M., Ogura, K. and Kubo, S., 1993. Therapeutic effects of simultaneous use of glucose and insulin in ketotic dairy cows. Journal of Dairy Science 76 109–114
Sakata, T., Hikosaka, Y., Shimura, Y. and Tamate, H., 1980. Stimulatory effect of insulin on rumen epithelium cell mitosis in adult sheep. British Journal of Nutrition 44 325–331
Sano, H., Nakai, M., Kondo, T. and Terashima, Y., 1991. Insulin responsiveness to glucose and tissue responsiveness to insulin in lactating, pregnant, and nonpregnant, nonlactating beef cows. Journal of Animal Science 69 1122–1127
Sano, H., Narahara, S., Kondo, T., Takahashi, A. and Terashima, Y., 1993. Insulin responsiveness to glucose and tissue responsiveness to insulin during lactation in dairy cows. Domestic Animal Endocrinology 10 191–197
Sato, T., Taguchi, K., Nagao, K. and Matsumoto, A., 1986. Therapeutic use of insulin in diseases showing hyperlipoproteinemia in dairy cows. Journal of Veterinary Clinics (Jpn) 273 5
Sato, S., Suzuki, T. and Okada, K., 1994. Suppression of mitogenic response of bovine peripheral blood lymphocytes by ketone bodies. Journal of Veterinary Medicine Science 57 183–188
Satoh, S., Inoue, S., Egawa, M., Takamura, Y. and Murase, T., 1987. Insulin increases triglyceride secretion rate in rats in vivo. International Journal of Obesity 11 325–331
Schalm, J.W. and Schultz, L.H., 1976. Relationship of insulin concentration to blood metabolites in dairy cows. Journal of Dairy Science 59 255–261
Schlumbohm, C., Sporleder, H.P., Burtler, H. and Harmeyer, J., 1997. Effect of insulin on glucose and fat metabolism in ewes during various reproductive states in normal and hypocalcemia. Deutsche Tierarztliche Wochenschrift 104 359–365
Schmidt, G.H., 1966. Effect of insulin on yield and composition of milk of dairy cows. Journal of Dairy Science 49 381–385
Schultz, L.H., 1971. Management and nutritional aspects of ketosis. Journal of Dairy Science 54 962–973
Sebokova, E., Klimes, I., Moss, R., Mitkova, A., Wiersma, M. and Bohov, P., 1995. Decreased glucose transporter protein (GLUT4) in skeletal muscle of hypertriglyceridemic insulin-resistant rat. Physiology Research 44 87–92
Skaar, T.C., Grummer, R.R., Dentine, M.R. and Stauffacher, R.H., 1989. Seasonal effects of prepartum and postpartum fat and niacin feeding on lactation performance and lipid metabolism. Journal of Dairy Science 72 2028–2038
Smith, S.B., 1983. Contribution of the pentose cycle to lipogenesis in bovine adipose tissue. Archives of Biochemistry and Biophysics 221 46–56
Smith, T.R., Elmendorf, J.S., David, T.S. and Turisky, J., 1997. Growth hormone-induced insulin resistance: role of the insulin receptor, IRS-1, GLUT-1, and GLUT-4. American Journal of Physiology 272 1071–1079
Sparks, J.D. and Sparks, C.E., 1995. Insulin regulation of triacylglycerol-rich lipoprotein synthesis and secretion. Biochemica et Biophysica Acta 1215 9–32
Spector, A.A. and Fletcher, J.E., 1978. Transport of fatty acids in the circulation. Disturbances in Lipid and Lipoprotein Metabolism. (American Physiology Society, Bethesda, MD), 232–235
Steen, A., Grantor, H. and Tureen, P.A., 1997. Glucose and insulin responses to glucagon injection in dairy cows with ketosis and fatty liver. Journal of Veterinary Medicine 44 521–530
Strang, B.D., Bertics, S.J., Grummer, R.R. and Armentano, L.E., 1998. Effect of long-chain fatty acids on triglyceride accumulation, gluconeogenesis, ureagenesis in bovine hepatocytes. Journal of Dairy Science 81 728–739
Studer, V.A., Grummer, R.R., Bertics, S.J. and Reynolds, C.K., 1993. Effect of prepartum propylene glycol administration on periparturient fatty liver in dairy cows. Journal of Dairy Science 76 2931–2939
Subiyatno, A., Mowat, D.N. and Yang, Z.W., 1996. Metabolic and hormonal responses to glucose and propionic acid infusions in periparturient cows supplemented with chromium. Journal of Dairy Science 79 1436–1445
Targowski, S.P., Klucinski, W. and Littledike, T., 1985. Suppression of mitogenic response of bovine lymphocytes during experimental ketosis in calves. American Journal of Veterinary Research 46 1378–1384
Tayoda, Y., Nasu, M., Sakai, K., Shigematsu, K. and Watanabe, K., 1987. Effects of insulin therapy to hyperlipoproteinemia and fatty liver in dairy cows. Journal of Veterinary Clinics (Jpn) 288 13
Treacher, R.J., Reid, I.M. and Roberts, C.J., 1986. Effect of body condition at calving on the health and performance of dairy cows. Animal Production 43 1–6
Tse, E.O., Gregoire, F.M., Reusens, B., Remacle, C., Hoet, J.J., Johnson, P.R. and Stern, J.S., 1998
Changes of islet size and islet distribution resulting from protein-malnutrition in lean (Fa/Fa) and obese (fa/fa) Zucker rats. Obesity Research 5 563–571
Van Den Top, A.M., Geelen, M.J.H., Wensing, T., Wentink, G.H., Klooster, A.T.V. and Beynen, A.C., 1996. Higher postpartum hepatic triacylglycerol concentrations in dairy cows with free rather than restricted access to feed during the dry period are associated with lower activities of hepatic glycerolphosphate acyltransferase. Journal of Nutrition 126 76–85
Van Epps-Fung, M., Williford, J., Wells, A. and Hardy, R.W., 1997. Fatty-acid induced insulin resistance adipocytes. Endocrinology 138 4338–4345
Van Putten, J., Wieringa, P.T. and Krans, H.M., 1985. Low pH and ketoacidosis induce insulin receptor binding and postbinding alterations in cultured 3T3 adipocytes. Diabetes 34 744–750.
Van Saun, J.R., 1991. Dry cow nutrition: the key to improve fresh cow performance. Veterinary Clinics of North America: Food Animal Practice 7 599–620
Vazquez-Anon, M., Bertics, S.J., Luck, M. and Grummer, R.R., 1994. Peripartum liver triglyceride and plasma metabolites. Journal of Dairy Science 77 1521–1528
Veenhuizen, J.J., Drackley, J.K., Richard, M.J., Sanderson, T.P., Miller, L.D. and Young, J.W., 1991. Metabolic changes in blood and liver during development and early treatment of experimental fatty liver and ketosis in cows. Journal of Dairy Science 74 4238–4253
Walker, M., Fulcher, G.R., Sum, C.F., Orskow, H. and Albert, K.G., 1991. Effect of hypoglycemia and non-esterified fatty acids on forearm glucose uptake in normal humans. American Journal of Physiology 261 304–311
Walker, M., Agius, L., Orskow, H. and Albert, K.G., 1993. Peripheral and hepatic insulin sensitivity in non-insulin-dependent diabetes mellitus: effects of non-esterified fatty acids. Metabolism 42 601–608
Watari, T., Kobayashi, M., Sasaoka, T., Iwasaki, M. and Shigeta, Y., 1988. Alteration of insulin receptor kinase activity by fat feeding. Diabetes 37 1397–1404
Yang, W.Z., Mowat, D.N., Subiyatno, A. and Liptrap, R.M., 1996. Effects of chromium supplementation on early lactation performance of Holstein cows. Canadian Journal of Animal Science 76 221–230
Yki-Jarvinen, H. and Koivisto, V.A., 1984. Insulin sensitivity in newly diagnosed type 1 diabetics after ketoacidosis and after three months of insulin therapy. Journal of Clinical Endocrinology and Metabolism 59 371–378.
Young, J.W., 1976. Gluconeogenesis in cattle: significance and methodology. Journal of Dairy Science 60 1–15
Zammit, V.A., 1981. Extrahepatic regulation of ketogenesis. Trends in Biochemical Sciences 6 46–49
Zammit, V.A., 1990. Ketogenesis in the liver of ruminants—adaptations to a challenge. Journal of Agricultural Sciences 115 155–162
Zammit, V.A., 1996. Role of insulin in hepatic fatty acid partitioning: emerging concepts. Biochemical Journal 314 1–14
Zhao, F.Q., Glimmer, D.R. and Kennel, J.J., 1993. Distribution of mammalian facilitative glucose transporter messenger RNA in bovine tissues. International Journal of Biochemistry 25 1897–1992
Zhou, L., Chen, H., Up, P., Cong, L.N., Sciacchitano, S., Li, Y., Graham, D., Jacobs, A.R., Taylor, S.I. and Quon, M.J., 1999. Action of insulin receptor subtrate-2 (IRS-3) and IRS-4 to stimulate translocation of GLUT4 in rat adipose cells. Molecular Endocrinology 13 505–514
Zhu, L.H., Armentano, L.E., Bremmer, D.R., Grummer, R.R. and Bertics, S.J., 2000. Plasma concentration of urea, ammonia, glutamine around calving and their relation to liver triglyceride, to plasma ammonia removal and blood acid-base balance. Journal of Dairy Science 83 734–740
Zierath, J.R., Livingston, J.N., Thorne, A., Bolinder, J., Reynisdottir, S., Lonnqvist, F. and Arner, P., 1998. Regional difference in insulin inhibition of non-esterified fatty acid release from human adipocytes: relation to insulin receptor phosphorylation and intracellular signaling through the insulin receptor subtrate-1 pathway. Diabetologia, 41 1343–1354
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Hayirli, A. The Role of Exogenous Insulin in the Complex of Hepatic Lipidosis and Ketosis Associated with Insulin Resistance Phenomenon in Postpartum Dairy Cattle. Vet Res Commun 30, 749–774 (2006). https://doi.org/10.1007/s11259-006-3320-6
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DOI: https://doi.org/10.1007/s11259-006-3320-6