Abstract
The aim of this study was to investigate the levels of acute-phase proteins and minerals as indicators for the reactivity in 1-year-old sheep. A total of 26 Chios breed sheep were fed colostrum–breast milk (control, n = 15)or were deprived afterseparation from their mother immediately after birth(experimental, n = 11). Mannheimia (Pasteurella) haemolytica serotype A1 was inoculated intratracheally and blood samples were taken in vacuumed sera on days 0, 1, 4, 7, 10, 13, 16, 19 and 22. Antibiotic treatment was initiated after blood sampling on day 22, and blood samples were taken on days 1, 4 and 7 after the treatment. The levels of C-reactive protein (CRP), haptoglobin, ceruloplasmin, fibrinogen, zinc, iron and calcium, which are the indicators of immune function and infectious diseases were analysed. No significant difference between the control and trial groups before and after the infection was determined. However, serum CRP, haptoglobin, ceruloplasmin and fibrinogen levels were increased in the course of the infection. These levels were restored to normal following treatment.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
Abbreviations
- APP:
-
acute-phase proteins
- CRP:
-
C-reactive protein
- IL:
-
interleukin
- PMSG:
-
pregnant mare serum gonadotrophin
- TNF:
-
tumor necrosis factor
References
Ackerman, M.R. and Brogden, K., 2000. Response of ruminant respiratory tract to Mannheima (Pasteurella) haemolytica. Microbiology and Infection, 2, 1079–1088
Arthington, J.D., Cattel, M.B. and Quigley, J.D., 2000. Effect of dietary IgG source (colostrum, serum or milk-derived supplement) on the efficiency of Ig absorption in newborn Hostein calves. Journal of Dairy Science, 83, 1463–1467
Auer, D.E., Thompson, S., Inglis, A. and Seawright, A.A., 1989. Acute phase response in horses: changes in plasma cation concentrations after localised tisuue injury. Veterinary Record, 124, 235–239
Brennan, R.E., Corstvet, R.E. and Paulson, D.B., 1998. Antibody responses to Pasteurella haemolytica 1:A and three of its other membrane proteins in serum, nasal secretions, and bronchoalveolar lavage fluid. American Journal of Veterinary Research, 59(6), 727–732
Camas, H., Bildik, A. and Gülsever, F., 1999. Investigation of some trace elements (Cu, Mo, Zn, Co, Mn) and sulphate in soil, grass and sheeps blood. Veterinary Journal of Yuzuncu Yil University, 10, 87–91
Carlsted, F., Eriksson, M., Kiiski, R., Larson, A. and Lind, L., 2000. Hypocalcemia during porcine endotoxemic shock: effects of calcium administration. Critical Care Medicine, 28(8), 2909–2914
Caspi, D., Snel, J.J., Batt, R.M., Bennett, D., Rutteman, G.R., Hartman, E.G., Baltz, M.L. and Pepys, M.B., 1987. C-Reactive protein in dogs. American Journal of Veterinary Research, 48(6), 919–921
Clayes, R., Vinken, S., Spapen, H., Elst, K., Decokhez, K., Huyghens, L. and Gorus, F.K., 2002. Plasma paracalcitonin and C-reactive protein acute septic shock: clinical and biological corrolates. Critical Care Medicine, 30, 757–762
Colombo, J.P. and Richterich, R., 1964. Zur bestimmung des caeruloplasmin im plasma. Schweizerische Medizinische Wochenenschrift, 94, 715–720
Conner, J.G. and Eckersall, P.D., 1988. Bovine acute phase response following turbentine injection. Research in Veterinary Science, 44, 82–88
Conner, J.G., Eckersall, P.D., Wiseman, A., Bain, R.K. and Douglas, T.A., 1989. Acute phase response in calves following infection with Pasteurella haemolytica, Ostertagia ostertagi and endotoxin administration. Research in Veterinary Science, 47, 203–207
Dai, H.J., Lee, S.Y. and Wang, C.H., 1992. Effect of iron limitation on production of a siderophre outer membrane proteins and hemolysis and hydrophobicity cell adherence and lethality for mice of Vibrio parahemolyticus, Infection and Immunology, 60, 2932–2956
Deignan, T., Alwan, A., Kelly, J., Mcnair, J., Warren, T. and O'Farrely, C.O., 2000. Serum haptoglobin an objective indicator of experimentally induced salmonella infection in calves. Research in Veterinary Science, 69, 153–158
Depelchin, B.O., Bloden, M., Hooremans, M., Noirfalise, A. and Ansay, M., 1985. Clinical and experimental modifications of plasma iron and zinc concentrations in cattle. The Veterinary Record, 11, 519–521
Eckersall, P.D., 2000. Recent advances and future prospects for use of acute phase proteins as markers of disease in animals. Revue de Médicine Vétérinaire, 151(7), 577–584
Ganheim, C., Hulten, U., Kindahl, H., Niskanen, R. and Waller, K.P., 2003. The acute phase response in calves experimentally infected with Bovine Viral Diarrhoea virus and/or Manheimia haemolytica. Journal of Veterinary Medicine, 50, 183–190
Gdalevich, M., Mimouni, D. and Miomuni, M., 2001. Breast feeding and the risk of bronchial astma in childhood: a systemic review with analyses of prospective studies. The Journal of Pediatrics, 139, 261–266
Gruys, E., Oblowo, M.J. and Toussaint, J.M., 1994. Diagnosis significance of major acute phase proteins in veterinary clinical chemistry: a review. Veterinary Bulletin, 64(11), 1009–1015
Hayes, M.A., 1994. Functions of cytokines and acute phase proteins in inflammation. In: J. H. Lumsden (ed.), VIth Congress of the ISACB Proceedings, Guelph, Canada, 1–7
Hodgins, D.C. and Shewen, P.E., 2000. Vaccination of neonatal colostrums deprived calves against Pasteurella haemolytica A1. Canadian Journal of Veterinary Research, 50, 3–8
Horadogada, N.U., Knox, K.M.G., Gibbs, H.A., Reid, S.W.J., Horadogada, A., Edwards, S.E.R. and Eckersall, P.D., 1999. Acute phase proteins in cattle discrimination between acute and chronic inflammation. Veterinary Record, 144, 437–441
Kimberling, C.V., 1988. Disease of the respiratory system. In: Jensen and Swift's Diseases of Sheep, (Lea and Febiger, Philadelphia), 173–181
Kelly, G.S., 2003. Bovine colostrum: a review of clinical uses. Alternative Medicine Review, 8, 378–394
Kent, J., 1992. Acute phase proteins: their use in veterinary diagnosis. British Veterinary Journal, 148, 279–282
Lamotte, G.B., 1977. Total serum protein, serum protein fractions and serum immunoglobulins in colostrum fed and colostrum deprived calves. American Journal of Veterinary Science, 38(2), 263–268
Lee, W.C., Hsioo, H.C., Wu, Y.L., Lin, J.H., Fung, H.P., Chen, H.H., Chen, Y.H., and Chu, R.M., 2003. Serum C-reactive protein in dairy herds. Canadian Journal of Veterinary Research, 67, 102–107
Millar, H.R., Simpson, J.G. and Stolker, A.L., 1971. An elevation of heat precipitation method for plasma fibrinogen estimation. Journal of Clinical Pathology, 24, 827–830
O'Doherty, J.V. and Crosby, T.F., 1997. The effect of diet in late pregnancy on colostrum production and immunoglobulin absorption in sheep. Animal Science, 64, 87–96
Pattison, S.E., Davies, D.A.R. and Winter, A.C., 1995. Changes in the secretion rate and production of colostrum by ewes over first 24,h postpartum. Animal Science, 61, 63–68
Pfeffer, A., Rogers, K.M., O'Keeffe, L. and Osborn, P.J., 1993. Acute phase protein response, food intake, liveweight change and lesions following intrathoracic injection of yeast in sheep. Research in Veterinary Science, 55, 300–306
Saarinen, U.M. and Kajosaari, M., 1995. Breastfeeding as prophylaxis against atopic disease: prospective follow up study until 17 years old. The Lancet, 346, 1065–1069
Schrold, W., Kruger, M., Hien, T.T., Fuldner, M. and Kunze, R., 1995. C-Reactive protein as a new parameter of mastitis. Tierarztliche Praxis, 23, 337–341
Sears, M.R., Greene, M.J., Willan, R.A., Taylor, D.R., Flamery, E.M. and Cowan, J.O., 2002. Long-term relation between breastfeeding and development of atopy and asthma in children and young adults: a longitudinal study. The Lancet, 360, 901–907
Skinner, J.G., Brown, R.A. and Roberts, L., 1991. Bovine haptoglobin response in clinically defined field conditions. Veterinary Record, 128, 147–149
Smith, J.E. and Cipriano, J.E., 1987. Inflammation-induced changes in serum íron analyses and ceruloplasmin of Shetland ponies. Veterinary Pathology, 24, 354–356
Tamzali, Y., Guelfi, J.F. and Braun, J.P., 2001. Plasma fibrinogen measurement in the horse: comparison of Millar's technique with a chronometric technique and the QBC-Vet Autoreader. Research in Veterinary Science, 71, 213–217
Uruapka, F.O., Ismond, M.A.N. and Akobundu, E.N.T., 2002. Colostrum and its benefits: a review. Nutritional Research, 22, 755–767
Van Miert, A.S.J.P.A.M., 1991. Acute phase response and noncellular defense mechanisms. Flemish Veterinay Journal, 1, 69–91
Van Miert, A.S.J.P.A.M., 1995. Proinflammatory cytokines in a ruminant model: pathophysiological, pharmacological and therapeutic aspects. The Veterinary Quarterly, 17, 41–50
Wittum, T.E., Young, C.R., Stanker, L.H., Griffin, D.D., Perino, L.J. and Littledike, E.T., 1996. Haptoglobin response to clinical respiratory disease in fedlot cattle. American Journal of Veterinary Research, 57, 5, 646–649
Yamamato, S., Shida, T., Miyaji, S., Santsuka, H., Fujise, H., Mukawa, K., Furuka, E., Nagae, T. and Naiki, M., 1993. Changes in serum C-reactive protein levels in dogs with various disorders and surgical traumas. Veterinary Research Communications, 17, 85–93
Yamashita, K., Fujinaga, T., Okumura, M., Takiguchi, M., Tsunoda, N. and Mizuno, S., 1991. Serum C-reactive protein in horses: the effect of aging, sex, delivery and inflammations on its concentrations. Journal of Veterinary Medical Science, 53(6), 1019–1024
Vojtic, I. and Krajnc, S., 2000. Determination of C-reactive protein by turbidimetric immunoassay in sheep. Veterinarski Arhiv, 70(3), 151–157
Voyvoda, H., Sekin, S., Kaya, A. and Bildik, A., 1997. Modifications of serum iron, copper concentration (Si, Cu), total and latent iron-binding capacity (TIBC, LIBC), and transferrin saturation (TS) in natural Babesia ovis infection of sheep. Turkish Journal of Veterinary Animal Science Research, 21, 31–37
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Ulutas, P.A., Ozpinar, A. Effect of Mannheimia (Pasteurella) haemolytica Infection on Acute-phase Proteins and Some Mineral Levels in Colostrum–Breast Milk-fed or Colostrum–Breast Milk-deprived Sheep. Vet Res Commun 30, 485–495 (2006). https://doi.org/10.1007/s11259-006-3246-z
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/s11259-006-3246-z