Abstract
A novel dioxomolybdenum Schiff base complex, MoO2L·DMF, was synthesized by treating MoO2(acac)2 with an ONO donor Schiff base ligand (H2L) derived by the condensation of 4-aminobenzohydrazide and 3-methoxysalicylaldehyde. The synthesized ligand and complex were characterized by physicochemical and spectroscopic techniques. Single-crystal X-ray analysis was also accomplished to ensure the molecular structure of the complex. The geometry around the central metal atom in MoO2L·DMF was distorted octahedral as revealed by the data collected from diffraction studies. Theoretical calculations of the synthesized compounds were carried out by DFT at B3LYP/Def2-TZVP level of theory, which showed a good correlation with the experimental findings. Moreover, the homogeneous catalytic efficiency of the complex was investigated by the process of selective oxidation of benzylic alcohols using urea hydrogen peroxide (UHP) in acetonitrile under reflux conditions.
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Introduction
Selective oxidation of organic compounds to get valuable products is getting much more attention day by day. These reactions are very important from an industrial perspective for the production of oxygenated species [1]. The organic transformations are very slow and require a lot of time to complete. Finally, it becomes very costly and unaffordable to get the desired products from an economical point of view. Hence, the use of transition metals as homogeneous or heterogeneous catalysts in selective oxidation processes is becoming an important area of research in organic synthesis [2]. A very important and basic reaction at both laboratory and industrial scale is the partial oxidation of alcohols to their respective aldehydes and ketones [3]. For this, dozens of protocols have been invented by utilizing a variety of organic and inorganic reagents to attain the particular products [4].
Hydrazone-based Schiff bases establish a distinctive class of ligands with N- and O-atoms as donor sites. These Schiff bases, obtained by the treatment of aromatic acid hydrazides with the derivatives of salicylaldehydes, have high propensity to fabricate transition metal complexes [5]. These aroyl hydrazones can coordinate to the metal center in a tridentate fashion via iminic nitrogen of hydrazone part, amide oxygen atom and deprotonated ortho hydroxyl group [6]. Hydrazones can hold the transition metals in their highest oxidation states which give a plus point to their suitability to tolerate different reaction conditions for catalytic transformations [7].
Molybdenum is referred to as one of the very attractive and useful transition metals in industrial as well as in biochemical processes [8]. The dioxomolybdenum(VI) salt of acetylacetonate, utilized in numerous substitution reactions, is denoted as a very important molecular catalyst for homogeneous epoxidation of olefins [9]. The dioxomolybdenum(VI) complexes have been investigated expansively due to their key role in oxo-transfer reactions [4, 9]. Owing to their outstanding importance in enzymatic reactions in biological processes [10], particularly in oxidation of aldehydes, sulfides and purines [11], plenty of dioxomolybdenum complexes were synthesized to investigate their oxygen transfer features [4, 9, 12].
There are different kinds of compounds which are utilized as a source of oxygen but UHP is preferred over rest of these because of high oxygen content, easy operating procedure, inexpensive and environmentally friendly nature [13]. UHP usually reacts with metals to produce an active metal catalyst with a peroxy ligand (MOOR), which eventually shifts an O center to the substrate [14]. Among the catalysts which are metal based, the Mo containing complexes proved themselves to have potential for their utilization as effective catalysts for oxidation reactions in the presence of peroxides [4].
Although, quite a few dioxomolybdenum(VI) compounds are effectively being utilized in numerous oxidation reactions [15] but still there are very inadequate number of findings about the employing these complexes for the oxidation of alcohols into aldehydes and ketones [16]. Another important aspect of the modern era is the involvement of computational chemistry for theoretical calculations like density functional theory (DFT) to find out the molecular properties [17].
Getting motivation from remarkable properties of Mo complexes, current work is focused on the synthesis of dioxomolybdenum(VI) complex with hydrazone-based Schiff base ligand and its utilization as an effective catalyst for selective oxidation of benzylic alcohols and then conduction of their experimental and theoretical findings to explore their structural features.
Experimental
Materials and methods
All the chemicals employed in the current work were 99.9% pure and purchased from well-renowned suppliers like Sigma-Aldrich and Merck. The C, H and N microanalyses of the crystalline products were obtained with a Heraeus CHN–O–FLASH EA 1112 elemental analyzer. 1H and 13C NMR spectra of the powdered samples were measured at ambient temperature by using BRUKER AVANCE 400 MHz spectrometer by employing tetramethylsilane (TMS) as internal reference and dimethyl sulfoxide (DMSO-d6) as solvent. Coupling constant (J) and chemical shift (δ) values were reported in Hz and in ppm, respectively. Infrared spectra of the crystalline compounds were taken by making KBr disks on a Shimadzu FTIR IRPrestige-21 spectrophotometer.
Synthesis of H2L
4-aminobenzohydrazide (1.51 g, 10 mmol) and 3-methoxysalicylaldehyde (1.52 g, 10 mmol) were dissolved separately in hot methanol (25 mL). After complete dissolution, both solutions were mixed dropwise with continuous stirring. The resulting mixture was refluxed for approximately 3 h until the reaction was completed which was ensured by continuous monitoring with the help of TLC. On allowing the reaction mixture to attain the room temperature, the product was settled down leaving behind the impurities in the solvent. Finally, the desired product was collected by filtration, aided by suction apparatus and washed thrice with cold methanol to remove impurities if any.
H2L: Yield 0.23 g (81%). Anal. calcd. for C15H15N3O3 (%): C, 63.2; H, 5.3; N, 14.7. Found: C, 63.3; H, 5.4; N, 14.6. FTIR (KBr, cm−1); 3624 (\(\nu\) N–H); 1639 (\(\nu\) C=O); 1602 (\(\nu\) C=N); 1475, 1556 (\(\nu\) C=C); 1269 (\(\nu\) C–O); 1085 (\(\nu\) N–N). 1H NMR ( 400 MHz DMSO-d6, ppm): 3.81 [3 H, s, (–OCH3)], 5.88 [2 H, s, (–NH2),], 6.61 [2 H, (H–C12, H–C14), t, 3 J = 8.4 Hz], 6.88 [1 H, (H–C4), t, 3 J = 8.0 Hz], 7.02 [1 H, (H–C3), dd, 3 J = 8.0 Hz, 4 J = 1.2 Hz], 7.07 [1 H, (H–C5), dd, 3 J = 8.0 Hz, 4 J = 1.2 Hz], 7.68 [2 H, (H–C11, H–C15), d, 3 J = 8.4 Hz], 8.56 [1 H, s, (–CH=N),], 11.33 [1 H, s, (–NH)], 11.73 [1 H, s, (–OH)]. 13C NMR (100 MHz, DMSO-d6, ppm): 55.7 (C7), 112.7 (C12, C14), 113.5 (C3), 118.7 (C4), 119.0 (C6), 121.0 (C10), 121.3 (C5), 129.4 (C11, C15), 146.8 (C8), 147.0 (C2), 147.8 (C1), 152.4 (C13), 162.7 (C9).
Synthesis of MoVIO2L·DMF
Equimolar amounts of H2L (0.285 g, 1 mmol) and MoO2(acac)2 (0.330 g, 1 mmol) were suspended in methanol (100 mL) with continuous stirring to attain the uniformity. The suspension was refluxed for about 3 h and then 2/3rd of the solvent was evaporated to concentrate the mixture and the remaining solution was cooled over an ice bath to get the orange-colored product. These precipitates were dissolved in minimum amount of DMF to get the pure crystalline product suitable for single-crystal X-ray analysis. The crystals were collected by filtration and then washed carefully with water, methanol and diethyl ether, separately, and finally dried in vacuo.
MoO2L·DMF: Yield 0.35 g (73%) (Powdered sample). Anal. calcd. for C18H20MoN4O6 (%): C, 44.6; H, 4.2; N, 11.6. Found: C, 44.8; H, 4.2; N, 11.4. FTIR (KBr, cm−1); 1651 (\(\nu\) C=Odmf); 1604 (\(\nu\) C=N); 1465 (\(\nu\) C=N–N=C); 1436, 1544 (\(\nu\) C=C); 1346 (\(\nu\) C-Oenolate); 1261 (\(\nu\) C-Ophenolate); 1014 (\(\nu\) N–N); 935 (\(\nu\) O=Mo=O) asym; 912 (\(\nu\) O=Mo=O) sym; 898, 831 (\(\nu\) O=Mo-Odmf), 590 (\(\nu\) Mo–O); 466 (\(\nu\) Mo–N). 1H NMR (400 MHz, DMSO-d6, ppm): 3.80 [3 H, s, (–OCH3], 5.96 [2 H, s, (–NH2),], 6.60 [2 H, (H–C12, H–C14), t, 3 J = 8.4 Hz], 6.99 [1 H, (H–C4), t, 3 J = 8.0 Hz], 7.19 [1 H, (H–C3), d, 3 J = 8.0 Hz], 7.25 [1 H, (H–C5), d, 3 J = 8.0 Hz], 7.68 [2 H, (H–C11, H–C15), d, 3 J = 8.4 Hz], 8.76 [1 H, s, (–CH=N),]. 13C NMR (100 MHz, DMSO-d6, ppm): 55.7 (C7) 113.1 (C12, C14), 115.6 (C3), 116.2 (C4), 120.8 (C6), 121.2 (C10), 124.7 (C5), 129.9 (C11, C15), 148.4 (C1), 148.8 (C2), 152.6 (C13), 153.0 (C8), 169.4 (C9).
X-ray crystallographic data collection and structural determination of complex
Diffractometer, named as Bruker Kappa APEX-II CCD, is employed for the data collection of MoO2L·DMF equipped with an X-rays source in which the target is made up of molybdenum. X-rays are monochromated with the help of graphite-based monochromators to generate Mo–Kα radiations. APEX-II software [18] is employed for data collection and the absorption correction is performed by using ω-scan method in SADABS [19] software. Raw data are solved by employing a direct method in SHELXL-97 [20] software. Data refinement is performed by employing the full-matrix least-squares method on F2 in SHELXL [21] software. All the atoms are refined using anisotropic displacement parameters except H-atoms. H-atoms are placed at ideal positions by employing relative isotropic displacement parameters. For the sake of graphical representation of X-rays analysis results, ORTEP-3 [22], PLATON [23] and Mercury [24] software are employed. Experimental features related to X-ray’s analysis of MoO2L·DMF are specified in Table 1.
Computational details
Density functional theory (DFT) calculations were performed with the Gaussian 09 package [25] at B3LYP level of theory [26] by using Def2-TZVP basis set [27]. The solution phase was modeled by using IEFPCM with the consideration of solvent [28]. Geometry optimizations were tested by frequency analysis to ensure that they are at the local minima on the molecular potential energy surface (PES). The results showed that there is no imaginary frequency. The 1H and 13C NMR magnetic isotropic shielding tensors were calculated by the standard Gauge-Independent Atomic Orbital (GIAO) approach in the solution phase [29]. Chemical shift values of compounds calculated by using B3LYP/Def2-TZVP level and IEFPCM model as an implicit model for solvent and compared with experimental data obtained in DMSO-d6. The same solvent was used for all IEFPCM calculations for ligand, Mo complex and TMS. Chemical shifts were calculated by subtracting the appropriate isotropic part of the shielding tensor from that of TMS δi = σTMS − σi. The isotropic magnetic shielding tensors for TMS calculated in the solution phase at the B3LYP/Def2-TZVP level of theory were equal to 31.92 and 184.52 ppm for the 1H and the 13C nuclei, respectively. The Chemissian program was used to draw contour plots of highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) [30].
General procedure for the selective oxidation of benzylic alcohols catalyzed by MoO2L·DMF complex
The MoO2L·DMF catalyst (0.006 mmol) was added to a solution of benzylic alcohol (1 mmol) and UHP (2 mmol) in CH3CN (10 mL) and the reaction mixture was refluxed with continuous stirring for the specified intervals of times as listed in Table 10. The conversion of reactants into the products was observed continuously with the help of TLC plates by taking aliquots from reaction mixture. For this purpose, a mixture of n-hexane and ethyl acetate (7:3) was employed as an eluent. On complete conversion, the resultant mixture was filtered off and then the solvent was evaporated under reduced pressure. The corresponding benzaldehydes were finally obtained in pure form with the help of column chromatography by using silica gel. All products were known compounds and also acknowledged by comparing their physicochemical characteristics, like FTIR and NMR spectra, with those of authentic samples.
Results and discussion
Synthesis
The H2L was prepared by treating 4-aminobenzohydrazide with 3-methoxysalicylaldehyde in a methanolic environment. Reaction of MoO2(acac)2 with H2L in methanol under reflux conditions produces the targeted molybdenum complex (Scheme 1). After successful synthesis and characterization, the catalytic effectiveness of the complex was also checked by oxidizing various benzylic alcohols using UHP as a source of oxygen (Scheme 2).
Crystal structure determination
In MoO2L·DMF (Fig. 1, Table 1), the coordination sphere around central Mo-atom composes of phenolic O-atom (O1), enolic O-atom (O2) and imine N-atom (N1), from the tridentate chelating ligand, and O-atoms (O4/O5) of the oxo groups, and O-atom (O6) of the coordinating dimethylformamide (DMF) solvent. The DMF acts as co-ligand to complete the coordination of the central metal atom. The ligand coordinates with the Mo-atom in a planar fashion and results in the formation of a six-membered (Mo1/O1/N1/C1/C6/C8) and a five-membered (Mo1/O2/N1/N2/C9) chelating rings. Ring puckering inspection infers that a six-membered chelating ring is puckered with puckering amplitude Q = 0.261(5) Å, θ = 115.1(15)° and φ = 195.9(18)°. The bond lengths and bond angles in coordination sphere are such that distorted octahedral geometry is formed as the bond angles in coordination sphere range from 71.9 (2)° to 170.1 (2)°. The selected bond lengths and bond angles are specified in Table 2. The Mo–O6 bond length is significantly longer than other Mo–O bond lengths which gives an indication that dimethylformamide solvent is weakly bonded to Mo-atom. The equatorial sites are occupied by (O1/O2/N1) atoms of the chelating ligand and one of the O-atom (O4) of oxo groups. Whereas, the axial sites are occupied by the other O-atom (O5) of oxo group and O-atom (O6) of the coordinating dimethylformamide ligand. The central Mo-atom is deviated by 0.3143 Å from the equatorial plane defined by (O1/O2/O4/N1) atoms toward the Mo=O5 moiety. The equatorial plane A (O1/O2/O4/N1), anisole moiety B (O3/C1–C7), 1,2-dimethylhydrazine moiety C (N1/N2/C8/C9) and aniline group D (/N3C10–C15) are found to be planar with respective root-mean-square (r.m.s.) deviations of 0.0003, 0.0133, 0.0004 and 0.0089 Å. Moiety C makes the respective dihedral angles of 9.77 (7)° and 4.01 (8)° with moiety B and group D. Anisole moiety B is twisted at the angle of 13.8 (4)° with respect to group D. These dihedral angle inspection infers that the whole chelating ligand is almost planar. The atoms of dimethylamine moiety E (N4/C17/C18) of the dimethylformamide ligand (O6/N4/C16–C18) are disordered over two set of sites with occupancy ratio of 0.52(5): 0.48(5). The plane of the major part F (N4A/C17A/C18A) is twisted at the dihedral angle of 15.7 (8)° with respect to the plane of minor part G (N4B/C17B/C18B). The molecular configuration is stabilized by intramolecular C–H···O bonding and C–H···π interaction as displayed in Fig. 2 and specified in Table 2. In C–H···π interaction, CH from the dimethylformamide molecule interacts with a five-membered chelating ring of the same molecule with H···π distance of 2.89 Å. The molecules are connected with each other in the form of dimers through N3–H3B···O4 bonding to form \(R_{2}^{2}\) (20) loop as specified in Table 3 and displayed in Fig. 3. The dimers are further interlinked through N3–H3A···O5 bonding. Due to N3–H3A···O5, C11, a zigzag chain is formed that runs along the b crystallographic axis. The molecules are also interlinked by comparatively weak H-bonding of the type C–H···O to form a C7 chain that also runs along the b crystallographic axis. Due to abovementioned H-bonding, a 2D hydrogen bonding is formed with base vectors [010], [001] in a plane (100).
Computational and characterization
The gas phase optimized structures of the ligand and Mo(VI) complex are presented in Fig. 4. The optimized structural parameters, bond lengths and bond angles, for the MoO2L·DMF complex obtained from DFT calculations, are listed in Table 2 along with the X-ray data. As it can be seen from Table 2 that the theoretical data are quite comparable to the experimental results. The differences between the theoretical and experimental values may be emanated from this fact that the experimental data belong to the solid state, while the calculated values describe a single molecule in the gaseous state. In accordance with X-ray crystal structures, the coordination of nitrogen and oxygen atoms to the metal center of the Mo complex in the gas phase also exhibits the distorted octahedral geometry.
The H2L ligand deprotonates and coordinates with metal in a tridentate (N, O−, O−) dianionic fashion. The calculated N1–C8 (1.289 Å) and N2–C9 (1.304 Å) bond lengths are approximately close in value for a C=N double bond length. The calculated C1–O1 and C9–O3 bond lengths are 1.325 and 1.317 Å, respectively, which are fairly between the length of a carbon to oxygen single (C–O) (1.43 Å) and double bond (C=O) (1.21 Å). Also, the calculated bond lengths for C6–C8, C1–C6 and C9–C10 are 1.440, 1.408 and 1.465 Å, respectively, which are somewhat between the length of a C–C single bond (1.54 Å) and that of a C=C double bond (1.34 Å). These values suggest that the electronic density may be delocalized on the azomethine chromophore, carbonyl groups, aromatic rings and the C1–O1 bond. The sum of the electronic and the zero-point energy (EZPE), enthalpy (H), and Gibbs free energy (G) of both enol and keto forms of H2L Schiff base ligand are reported in Table 4. Data showed that keto form is more stable in both phases.
The atomic charge on the active centers of H2L ligand and MoO2L·DMF complex and the amount of charge transferred from the ligand to the central metal atoms, i.e., L → M are presented in Table 5. The charge on the metal atom is considerably less than that of the formal charge (6 +) of molybdenum, which indicates that the significant amount of charge density is transferred from the ligand to the metal atom. Also, the carbon atoms (C1 and C9) connected to oxygen atoms (O1 and O3) have the maximum variation in the charge density after the complexation with molybdenum.
A brief overview of experimental and calculated vibrational parameters of H2L and MoO2L·DMF is given in Table 6. It is obvious from the data that the relative error of deviation between experimental and theoretical values is ≤ 6.18%. This slight divergence arises due to the application of harmonic approximation, as the calculations are performed in the vacuum.
A stacked FTIR spectrum of the H2L ligand and MoO2L·DMF complex is presented in the form of Fig. 5. The two most important absorption peaks visible in the vibrational spectrum of the ligand at 3624 and 1639 cm−1 are attributed to the stretching vibration of ν(NH) and ν(C=O). These characteristic peaks disappeared on complexation with molybdenum, which indicate the dianionic nature as well as the sites of coordination of the ligand with metal. The absorption peak of the azomethine chromophore (HC=N) in the spectra of the H2L ligand and Mo complex appeared at 1602 and 1604 cm−1, respectively. The same pattern of shifting of the stretching vibrational peak of the phenolic oxygen of ligand from 1269 to 1261 cm−1 was also perceived [32] to prove the tridentate nature of the ligand. This proclamation is further supported by the data obtained in the light of SC-XRD analysis. The distinctive peaks of primary amine (NH2) in the spectrum of ligand at 3360 and 3441 cm−1 were marginally shifted to 3361 and 3466 cm−1 in MoO2L·DMF complex. Cis-Mo(O)2 fraction also gives its symmetric and asymmetric stretching vibrations bands at 912 and 935 cm−1 which are in accordance with the literature [32]. Moreover, some new Mo–O and Mo–N peaks are also visible at 590 and 466 cm−1 for Mo complex, which are also in agreement to the similar complexes reported earlier. The emergence of shoulder peak around 1651 cm−1 for C=O band indicates that the sixth coordination site is occupied by DMF. In addition to this, some new O=Mo–ODMF peaks are also visible at 898 and 831 cm−1 for Mo complex [33].
An evaluation of calculated FTIR results of the keto and enol forms of the H2L ligand and the MoO2L·DMF complex in the gas phase is shown in the form of stacked spectra in Fig. 6. As evident from the comparison of spectra obtained from experimental and theoretical form, there is a close correspondence in the structure of keto form of H2L and its Mo complex both in gas and solid states. The theoretical values, 1613 and 1602 cm−1, of vibrational data for azomethine chromophore for both of the synthesized compounds are related to experimental findings (1602 and 1604 cm−1).
While in the case of N–H stretching vibrational frequency values in theoretical (3400 cm−1) and experimental data (3624 cm−1) are far apart from each other. The same set of patterns is manifested in the illustration of C=O stretching frequency where theoretical value was appeared at 1683 cm−1, which is away from the experimental data (1639 cm−1). The difference in the values of vibrational frequencies is due to the involvement of these groups (N–H and C=O) in the hydrogen bonding in solid state.
The 1H and 13C NMR data of the H2L ligand and its Mo complex in DMSO are presented in the experimental section and the spectra are shown in Figs. 7, 8 and 9. Two signals appearing at δ = 11.73 and 11.33 ppm in the 1H NMR spectrum of ligand correspond to OH (phenolic) and NH protons, respectively, disappear on treatment with Mo salt demonstrate about the sites of coordination of the ligand with the molybdenum. This also ascertains the occurrence of keto-imine tautomerism upon complexation. Moreover, a singlet of azomethine proton (–HC=N) at δ = 8.56 ppm observed in the spectrum of the ligand was shifted downfield at δ = 8.76 ppm showing the deshielding due to the decrease in the electronic density upon the coordination of azomethine nitrogen with the metal atom. This is in accordance with the FTIR spectra of complex, where ν(HC=N) appears at higher wavenumber in comparison with the corresponding ligand. There is a slight shift in the positions of aromatic protons in the NMR spectra of the ligand upon complex formation. A singlet of amino proton (–NH2) at δ = 5.88 ppm observed in the spectrum of the ligand was shifted downfield at δ = 5.96 ppm showing the deshielding upon complex formation. The methoxy part of the ligand gives a singlet at δ = 3.81 ppm. These protons are failed to exhibit any noticeable shifts in their positions upon complexation.
The 13C NMR spectra of the ligand and its Mo complex are shown in Fig. 9. The signals for the carbonyl, phenolic and methine carbon were observed at 162.7, 152.4 and 147.0 ppm, respectively.
The chemical shift values of the carbons present in vicinity of the coordinating atoms (i.e., C9, C1 and C8) showed appreciable change in their position due to coordination-induced shifts confirming the association of these functionalities in coordination. The other aromatic carbon atoms of the ligand and the Mo complex appeared in their respective regions according to the literature. Hence, 13C NMR spectra also support the conclusions made from 1H NMR spectral data. The experimental and calculated 1H and 13C NMR chemical shifts of the ligand and its Mo complex are given in Table 7. It is obvious from the table that the theoretical data are in close agreement with the experimental findings.
The energy gap (ELUMO − EHOMO) is an important factor that helps to determine the kinetic stability and chemical reactivity of the molecule. The stability of the compound increases with the increase in the size of the energy gap. On the other hand, as the energy gap decreases, the reactivity increases and the amount of electronic charge transfer from the ligand to the central metal atom also increases, i.e., it easily offers electrons to an acceptor. The energy of the frontier HOMO and LUMO and their energy gaps (∆E) for the H2L ligand and MoO2L·DMF complex were computed by DFT at the B3LYP/Def2-TZVP level of theory. The results are shown in Fig. 10. The energy gaps for the H2L (keto), H2L (enol) and MoO2L·DMF were found to be 3.951, 3.768 and 4.165 eV, respectively. As it turns out, the keto form of the ligand is more stable than the enol form owing to its higher energy gap.
Molecular electrostatic potential (MEP) analysis provides information about the reactive sites of the molecules. The MEP can show positive regions (marked in blue) related to nucleophilic attack and negative regions (marked in red) relevant to electrophilic reactivity. The molecular electrostatic potential of the H2L ligand in both keto and enol tautomeric forms and the MoO2L·DMF complex was calculated and shown in Fig. 11, along with the values of electrostatic potentials. Theoretically, the electron-rich regions around the oxygen atoms of hydroxyl and carbonyl groups are potentially active sites of the ligand toward positively charged metal. These results are in agreement with the Mulliken atomic charges (Table 5).
Theoretical calculations confirm the results obtained from the experimental analysis that the metal atom coordinated to the Schiff base ligand via the azomethine nitrogen atom (N1), the oxygen of the deprotonated hydroxyl group (O1) and the oxygen of carbonyl group (O3) and hence, the ligand behaves in a tridentate fashion.
Catalytic oxidation results
Dioxomolybdenum complexes often show interesting catalytic properties, especially in oxidation reactions [34]. Compared to previously reported species, the present complex has excellent activity and selectivity. The catalytic activity of MoO2L·DMF complex was explored by the selective oxidation of benzylic alcohols to benzaldehydes.
In order to optimize the catalytic system, including the MoO2L·DMF complex as catalyst and UHP (2 mmol) as oxidant, the oxidation of 4-chlorobenzyl alcohol (1 mmol) was chosen as a model reaction, and the influence of different factors, that may affect the reaction, were investigated (Table 8). Various oxidants were tested (Entries 2–6), and the results showed that the UHP is the best oxygen source in this reaction. Different amounts of the catalyst were used (Entries 6–9) and it was observed that in the absence of the catalyst the reaction failed to proceed. The rate of conversion was increased with the increase in the amount of catalyst and complete transformation was observed when 0.006 mmol of Mo complex was used. The activity of the catalytic system was examined in various solvents under reflux conditions (Entries 6, 10–16) and it was found that acetonitrile is the best solvent for the reaction. Finally, by changing the reaction temperature, the catalytic oxidation reaction of 4-chlorobenzyl alcohol in the presence of MoO2L·DMF complex in acetonitrile was performed (Entries 6, 17–19). It is obvious that the rate of reaction increases with the increase in temperature and the best result was spotted under reflux conditions.
Selective oxidation of various substituted benzylic alcohols was evaluated under the optimized reaction conditions (Table 9). As shown in Table 9, a variety of benzylic alcohols, with both electron-donating and electron-withdrawing groups, are treated with UHP to give the corresponding substituted benzaldehydes in excellent yields. The chemoselectivity of the procedure was remarkable. The alcohols were oxidized under the affection of this catalytic system, and the desired aldehydes were obtained in 100% selectivity. The most important advantage of this method is that there is no evidence of overoxidation to the production of carboxylic acid in all substrates.
According to experimental findings and information found in relevant literature [4], for the oxidation reactions mediated by oxometal complexes, a plausible mechanism for oxidation of benzyl alcohol using UHP catalyzed by MoO2L·DMF complex is proposed and depicted in Scheme 3. The homogeneous catalyst, MoO2L·DMF, is inactive without the assistance of UHP in the oxidation process. As shown in the MEP diagram of MoO2L·DMF and also it was previously explained that the metal atom in the complex is electropositive and can be attacked by a nucleophile. Thus, the MoO2L·DMF complex reacts with a hydrogen peroxide molecule released from UHP to form the peroxo molybdenum species (Intermediate 1). This peroxo molybdenum intermediate is active in oxidation and after etherification by benzyl alcohol generates intermediate 2 and a molecule of water was produced in lieu of by-product. Ultimately, intermediate 2 also releases a water molecule and gives benzaldehyde as the target product and regenerates the MoO2L·DMF Schiff base complex.
The sum of the electronic and the zero-point energy (EZPE), enthalpy (H), and Gibbs free energy (G) of all the materials involved in the selective oxidation of benzyl alcohol to benzaldehyde using UHP in the presence of MoO2L·DMF catalyst are listed in Table 10. By use of these values, ∆EZPE, ∆H and ∆G of all steps for this reaction were calculated and presented in Table 11. As shown in Table 11, the first step of the reaction is endothermic (∆G = 28.87 kcal·mol−1) and can be carried out at 82 °C. The second and the last step of the reaction is exothermic with ∆G = −2.51 and − 109.19 kcal·mol−1, respectively, and overall, the reaction is exothermic.
Conclusion
In the current research work, we have synthesized a new tridentate ONO-donor Schiff base ligand and its Mo(VI) complex and characterized them by various physicochemical techniques. Theoretical calculations of the Schiff base ligand and its Mo complex were performed using DFT at B3LYP/Def2-TZVP level of theory. The results showed that the theoretical data are in good consensus with the experimental outcomes. The catalytic activity of the complex was also investigated for the selective oxidation of benzylic alcohols to benzaldehydes by using UHP in acetonitrile under reflux conditions. This method has numerous ascendancies such as high yield, short reaction time and excellent selectivity to produce corresponding benzaldehydes without overoxidation to benzoic acids.
Supplementary materials
Crystallographic data for the structural analysis have been deposited with the Cambridge Crystallographic Data Centre as supplementary publication no. CCDC 2,059,956 for the molybdenum complex. Copies of this information may be obtained free of charge via http://www.ccdc.cam.ac.uk/conts/retrieving.html or from The Director, CCDC, 12 Union Road, Cambridge, CB2 1EZ, UK.
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We gratefully acknowledge practical support of this study by Ardakan University and Payame Noor University.
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Kargar, H., Fallah-Mehrjardi, M., Behjatmanesh-Ardakani, R. et al. Selective oxidation of benzyl alcohols to benzaldehydes catalyzed by dioxomolybdenum Schiff base complex: synthesis, spectral characterization, crystal structure, theoretical and computational studies. Transit Met Chem 46, 437–455 (2021). https://doi.org/10.1007/s11243-021-00460-w
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DOI: https://doi.org/10.1007/s11243-021-00460-w