Abstract
Polyfunctional p-tert-butylthiacalix[4]arenes tetrasubstituted at the lower rim with nitrogen-containing fragments in the cone, partial cone, and 1,3-alternate conformations were investigated in the processes of calf thymus DNA packaging. The influence of the macrocycle structure and composition on their ability to pack DNA into nano-sized particles was considered. UV spectroscopy and dynamic light scattering results showed that the synthesized p-tert-butylthiacalix[4]arenes functionalized at the lower rim with polyamine fragments in the cone and 1,3-alternate conformations can compact calf thymus DNA into nanosized particles (<100 nm). A new type of synthetic receptors based on the 1,3-alternate stereoisomer of p-tert-butylthiacalix[4]arene with ester, hydroxy, and tertiary amino groups was suggested for packaging DNA to nanoparticles of 51—85 nm in size.
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Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 8, pp. 1515—1523, August, 2017.
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Yakimova, L.S., Puplampu, J.B., Evtugin, G.A. et al. Polyfunctional branched nitrogen-containing p-tert-butylthiacalix[4]arene derivatives as efficient agents for packaging calf thymus DNA. Russ Chem Bull 66, 1515–1523 (2017). https://doi.org/10.1007/s11172-017-1917-2
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DOI: https://doi.org/10.1007/s11172-017-1917-2