Abstract
Reaction of 2,6-disubstituted 5-acetyl-4-aminopyrimidine hydrochlorides with acetylacetone or benzoylacetone afforded new substituted 6-acylpyrido[2,3-d]pyrimidines. The reaction of these hydrochlorides with ethyl acetoacetate also proceeds according to the classical version of the Friedländer condensation to form the corresponding pyrido[2,3-d]pyrimidine-6-carboxylic acid esters.
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Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 11, pp. 2215–2219, November, 2007.
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Komkov, A.V., Dorokhov, V.A. Synthesis of 6-acylpyrido[2,3-d]pyrimidine derivatives from 5-acetyl-4-aminopyrimidine hydrochlorides. Russ Chem Bull 56, 2293–2297 (2007). https://doi.org/10.1007/s11172-007-0362-z
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DOI: https://doi.org/10.1007/s11172-007-0362-z