Abstract
Following the expression of the behavioral sensitization by repeated administration of methamphetamine (METH) (1 mg/kg, intraperitoneal (i.p.), once per day for five consecutive days), male ICR mice were treated with clorgyline (1 mg/kg, subcutaneous, once per day for five consecutive days), a monoamine oxidase-A inhibitor. Two hours after the final treatment with clorgyline, the mice were challenged with METH (1 mg/kg, i.p.) and locomotor activity was measured for 1 h. The mice treated with clorgyline showed a significant decrease in both vertical locomotion and horizontal rearing, compared with those treated with saline. Clorgyline treatment altered the effect of single METH challenges on apparent dopamine turnover in the cerebral cortex of the mice sensitized to METH. These results suggested a possible association of the inhibition by clorgyline of METH-induced behavioral sensitization with the alteration of dopamine turnover in the cerebral cortex of the mouse.
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E. H. Ellinwood M. M. Kilbey (1977) Chronic stimulant intoxication models of psychosis I. Hanin E. Usdin (Eds) Animal Models in Psychiatry and Neurology Pergamon Press New York 61–74
T. Nishikawa N. Mataga M. Takashima M. Toru (1983) ArticleTitleBehavioral sensitization and relative hyperresponsiveness of striatal and limbic dopaminergic neurons after repeated methamphetamine treatment Eur. J. Pharmacol. 88 195–203 Occurrence Handle1:CAS:528:DyaL3sXitV2qsr0%3D Occurrence Handle6133769
T. E. Robinson J. B. Becker (1986) ArticleTitleEnduring changes in brain and behavior produced by chronic amphetamine administration: a review and evaluation of animal models of amphetamine psychosis Brain Res. Rev. 11 157–198 Occurrence Handle1:CAS:528:DyaL28Xlt1Kmurs%3D
R. A. Wise K. Leeb (1993) ArticleTitlePsychomotor-stimulant sensitization: a unitary phenomenon? Behav Pharmacol. 4 339–349
T. E. Robinson K. C. Berridge (1993) ArticleTitleThe neural basis of drug craving: an incentive-sensitization theory of addiction Brain Res. Rev. 18 247–291 Occurrence Handle1:CAS:528:DyaK3sXlsFWnu78%3D Occurrence Handle8401595
R. C. Pierce P. W. Kalivas (1997) ArticleTitleA circuitry model of the expression of behavioral sensitization to amphetamine-like psychostimulants Brain Res. Rev. 25 192–216 Occurrence Handle1:CAS:528:DyaK2sXmtlejtbo%3D Occurrence Handle9403138
E. J. Nestler M. T. Berhow E. S. Brodkin (1996) ArticleTitleMolecular mechanisms of drug addiction: adaptations in signal transduction pathways Mol. Psychiat. 1 190–199 Occurrence Handle1:CAS:528:DyaK28XlvFart7o%3D
D. P. Holschneider K. Chen I. Seif J. C. Shih (2001) ArticleTitleBiochemical, behavioral, physiologic, and neurodevelopmental changes in mice deficient in monoamine oxidase A or B Brain Res. Bull. 56 453–462 Occurrence Handle1:CAS:528:DC%2BD3MXptFylt7o%3D Occurrence Handle11750790
P. T. Männistö S. Kaakkola (1999) ArticleTitleCatechol-O-methyltransferase (COMT): biochemistry, molecular biology, pharmacology, and clinical efficacy of the new selective COMT inhibitors Pharmacol. Rev. 51 593–628 Occurrence Handle10581325
J. A. Gogos M. Morgan V. Luine M. Santha S. Ogawa D. Pfaff M. Karayiorgou (1998) ArticleTitleCatechol-O-methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior Proc. Natl. Acad. Sci. USA 95 9991–9996 Occurrence Handle1:CAS:528:DyaK1cXlsFWjsbc%3D Occurrence Handle9707588
J. P. Finberg M. B. Youdim (1983) ArticleTitleSelective MAO A and B inhibitors: their mechanism of action and pharmacology Neuropharmacology 22 441–446 Occurrence Handle1:CAS:528:DyaL3sXhsFCrsL4%3D Occurrence Handle6304562
N. Kitanaka J. Kitanaka M. Takemura (2005) ArticleTitleInhibition of methamphetamine-induced hyperlocomotion in mice by clorgyline, a monoamine oxidase-A inhibitor, through alteration of the 5-hydroxytryptamine turnover in the striatum Neuroscience 130 295–308 Occurrence Handle1:CAS:528:DC%2BD2MXhvFCmtw%3D%3D Occurrence Handle15664686
M. Ohno S. Watanabe (1995) ArticleTitleNitric oxide synthase inhibitors block behavioral sensitization to methamphetamine in mice Eur. J. Pharmacol. 275 39–44 Occurrence Handle1:CAS:528:DyaK2MXjvVentLo%3D Occurrence Handle7539765
Y. Itzhak J. L. Martin (2000) ArticleTitleEffect of riluzole and gabapentin on cocaine- and methamphetamine-induced behavioral sensitization in mice Psychopharmacology 151 226–233 Occurrence Handle1:CAS:528:DC%2BD3cXmtFyksL4%3D Occurrence Handle10972469
InstitutionalAuthorNameInstitute of Laboratory Animal Resources, (1996) Guide for Care and Use of Laboratory Animals National Academy Press Washington, D.C
N. Kitanaka J. Kitanaka M. Takemura (2003) ArticleTitleBehavioral sensitization and alteration in monoamine metabolism in mice after single versus repeated methamphetamine administration Eur. J. Pharmacol. 474 63–70 Occurrence Handle1:CAS:528:DC%2BD3sXlvFyms78%3D Occurrence Handle12909196
M. De Vries Particle J. Odink (1991) ArticleTitleSimultaneous measurement of serotonin and 5-hydroxyindoleacetic acid in rat brain using a liquid chromatographic method with electrochemical detection J. Chromatogr. 564 250–257 Occurrence Handle1:CAS:528:DyaK3MXhslyntLo%3D Occurrence Handle1713597
T. Karhunen C. Tilgmann I. Ulmanen P. Panula (1995) ArticleTitleCatechol-O-methyltransferase (COMT) in rat brain: Immunoelectron microscopic study with an antiserum against rat recombinant COMT protein Neurosci. Lett. 187 57–60 Occurrence Handle1:CAS:528:DyaK2MXksV2isbs%3D Occurrence Handle7617303
E. W. II. Pelton H. K. Kimelberg S. V. Shipherd R. S. Bourke (1981) ArticleTitleDopamine and norepinephrine uptake and metabolism by astroglial cells in culture Life Sci. 28 1655–1663 Occurrence Handle1:CAS:528:DyaL3MXhslWlur8%3D Occurrence Handle7242252
E. Hansson H. Isacsson A. Sellstrom (1984) ArticleTitleCharacteristics of dopamine and GABA transport in primary cultures of astroglial cells Acta Physiol. Scand. 121 333–341 Occurrence Handle1:CAS:528:DyaL2cXkvVCnt7o%3D Occurrence Handle6485835
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Kitanaka, N., Kitanaka, J. & Takemura, M. Repeated Clorgyline Treatment Inhibits Methamphetamine- induced Behavioral Sensitization in Mice. Neurochem Res 30, 445–451 (2005). https://doi.org/10.1007/s11064-005-2679-z
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DOI: https://doi.org/10.1007/s11064-005-2679-z