Abstract
In the experimental setting, taurine is known to be released from swollen cells to reestablish their normal volume. However, its clinical relevance has not been fully understood. This study was undertaken to reveal changes in cerebrospinal fluid (CSF) amino acids concentration in patients with severe traumatic brain injury (TBI). The study included eight patients, in whom a ventricular catheter was inserted to measure intracranial pressure and obtain CSF samples for 5 days. CSF obtained from patients with normal pressure hydrocephalus served as a control. CSF taurine concentration increased 1.8 times control (P < 0.05) after TBI and returned to control value approximately 67 h after injury. Taurine decreased further and remained lower than control thereafter. Phosphoethanolamine showed similar increase, whereas glutamine decreased transiently and arginine remained close to control value. The present data support the period of astrocytic swelling observed after TBI in other morphological studies. The mechanism and consequences of CSF taurine decrease in the subacute stage of TBI need to be elucidated.
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R. Bullock W. L. Maxwell D. I. Graham G. M. Teasdale J. H. Adams (1991) ArticleTitleGlial swelling following human cerebral contusion: an ultrastructural study J. Neurol. Neurosurg. Psychiatry 54 427–434
H. K. Kimelberg (1995) ArticleTitleCurrent concepts of brain edema. Review of laboratory investigations. J. Neurosurg. 83 1051–1059
H.K. Kimelberg E. Rutledge S. Goderie C. Charniga (1995) ArticleTitleAstrocytic swelling due to hypotonic or high K+ medium causes inhibition of glutamate and aspartate uptake and increases their release J. Cereb. Blood Flow Metab. 15 409–416
A. Schousboe H. Pasantes-Morales (1992) ArticleTitleRole of taurine in neural cell volume regulation Can. J. Physiol. Pharmacol. 70 S356–S361
F. Staub A. Baethmann J. Peters P. H. Weigt O. Kempski (1990) ArticleTitleEffects of lactacidosis on glial cell volume and viability J. Cereb. Blood. Flow Metab. 10 866–876
A.Y. Estevez M.H. O’Regan D. Song J.W. Phillis (1999) ArticleTitleEffects of anion channel blockers on hyposmotically induced amino acid release from the in vivo rat cerebral cortex Neurochem. Res. 24 447–452 Occurrence Handle10.1023/A:1020902104056
H. Pasantes-Morales O. Quesada J. Morán (1998) Taurine: an osmolyte in mammalian tissues Schaffer (Eds) Taurine 3 Plenum Press New York 209–217
H. Pasantes-Morales A. Schousboe (1989) ArticleTitleRelease of taurine from astrocytes during potassium-evoked swelling Glia 2 45–50 Occurrence Handle1:STN:280:BiaB3M3nvFw%3D Occurrence Handle2523338
J.M. Solís A.S. Herranz O. Herreras J. Lerma R. Martín del Río (1988) ArticleTitleDoes taurine act as an osmoregulatory substance in the rat brain? Neurosci. Lett. 91 53–58 Occurrence Handle10.1016/0304-3940(88)90248-0
P. L. Y. Lee R. H. Slocum (1988) ArticleTitleA high-resolution method for amino acid analysis of physiological fluids containing mixed disulfides Clin. Chem. 34 719–723
P. S. Jackson R. Morrison K. Strange (1994) ArticleTitleThe volume-sensitive organic osmolyte-anion channel VSOAC is regulated by nonhydrolytic ATP binding Am. J. Physiol. 267(5 Pt1) C1203–C1209
T. C. Birdsall (1998) ArticleTitleTherapeutic applications of taurine Alt. Med. Rev. 3 128–136
P.P. Stapleton L. O’Flaherty H.P. Redmond D.J. Bouchier-Hayes (1998) ArticleTitleHost defense-a role for the amino acid taurine JPEN. 22 42–48
Y. Katayama D. P. Becker T. Tamura D. A. Hovda (1990) ArticleTitleMassive increases in extracellular potassium and the indiscriminate release of glutamate following concussive brain injury J. Neurosurg. 73 889–900
R. McD Anderson K. Opeskin (1998) ArticleTitleTiming of early changes in brain trauma Am. J. Forensic. Med. Pathol. 61 1–9 Occurrence Handle10.1097/00000433-199803000-00001
J. F. Stover M. C. Morganti-Kossmann P. M. Lenzlinger R. Stocker O. S. Kempski T. Kossmann (1999) ArticleTitleGlutamate and taurine are increased in ventricular cerebrospinal fluid of severely brain-injured patients J. Neurotrauma. 16 135–142
G. A. Rosenberg W. T. Kyner E. Estrada (1980) ArticleTitleBulk flow of brain interstitial fluid under normal and hyperosmolar conditions. Am. J. Physiol. 238 F42–F49
N. Shimada R. Graf G. Rosner W-D. Heiss (1993) ArticleTitleIschemia-induced accumulation of extracellular amino acids in cerebral cortex, white matter, and cerebrospinal fluid J. Neurochem. 60 66–71
K. C. Hayes (1985) ArticleTitleTaurine requirement in primates Nutr Rev. 43 65–70
J. D. Paauw A. T. Davis (1990) ArticleTitleTaurine concentrations in serum of critically injured patients and age- and sex-matched healthy control subjects Am. J. Clin. Nutr. 52 657–660
E. H. F. McGale I. F. Pye C. Stonier E. C. Hutchinson G. M. Aber (1977) ArticleTitleStudies of the inter-relationship between cerebrospinal fluid and plasma amino acid concentrations in normal individuals J. Neurochem. 29 291–297
N. Pomara R. Singh D. Deptula J. C-Y. Chou M. B. Schwartz P. A. LeWitt (1992) ArticleTitleGlutamate and other CSF amino acids in Alzheimer’s disease Am. J. Psychiatry 149 251–254
Y. Liu M. Tonna-DeMasi E. Park G. Schuller-Levis M. R. Quinn (1998) ArticleTitleTaurine chloramine inhibits production of nitric oxide and prostaglandin E2 in activated C6 glioma cells by suppressing inducible nitric oxide synthase and cyclooxygenase-2 expression Mol. Brain. Res. 59 189–195 Occurrence Handle10.1016/S0169-328X(98)00145-4
H. P. Redmond P. P. Stapleton P. Neary D. Bouchier-Hayes (1998) ArticleTitleImmunonutrition: the role of taurine Neutrition 14 599–604
E. Park J. Alberti M. R. Quinn G. Schuller-Levis (1998) ArticleTitleTaurine chloramine inhibits the production of superoxide anion, IL-6 and IL-8 in activated human polymorphonuclear leukocytes Adv. Exp. Med. Biol. 442 177–182
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Seki, Y., Kimura, M., Mizutani, N. et al. Cerebrospinal Fluid Taurine after Traumatic Brain Injury. Neurochem Res 30, 123–128 (2005). https://doi.org/10.1007/s11064-004-9693-4
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DOI: https://doi.org/10.1007/s11064-004-9693-4