Abstract
Gold nanoshells are concentric spherical constructs that possess highly desirable optical responses in the near infrared. Gold nanoshells consist of a thin outer gold shell and a silica core and can be used for both diagnostic and therapeutic purposes by tuning the optical response through changing the core–shell ratio as well as the overall size. Although optical properties of gold nanoshells have already been well documented, the reflectance characteristics are not well understood and have not yet been elucidated by experimental measurements. Yet, in order to use gold nanoshells as an optical contrast agent for scattering-based optical methods such as reflectance spectroscopy, it is critical to characterize the reflectance behavior. With this in mind, we used a fiber-optic-based spectrometer to measure diffuse reflectance of gold nanoshell suspensions from 500 nm to 900 nm. Experimental results show that gold nanoshells cause a significant increase in the measured reflectance. Spectral features associated with scattering from large angles (~180°) were observed at low nanoshell concentrations. Monte Carlo modeling of gold nanoshells reflectance demonstrated the efficacy of using such methods to predict diffuse reflectance. Our studies suggest that gold nanoshells are an excellent candidate as optical contrast agents and that Monte Carlo methods are a useful tool for optimizing nanoshells best suited for scattering-based optical methods.
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Abbreviations
- NIR:
-
near infrared
- OCT:
-
optical coherence tomography
- CCD:
-
charge-coupled device
- POI:
-
point of photon insertion
- LAS:
-
large angle scattering
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Acknowledgements
We would like to acknowledge the following funding agencies for their generous support: National Science Foundation (BES 022–1544 and EEC-0118007); DOD CDRMP DAMD17-03-1-0384; the Welch Foundation, and the Beckman Foundation.
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Lin, A.W.H., Lewinski, N.A., Lee, MH. et al. Reflectance spectroscopy of gold nanoshells: computational predictions and experimental measurements. J Nanopart Res 8, 681–692 (2006). https://doi.org/10.1007/s11051-006-9136-z
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DOI: https://doi.org/10.1007/s11051-006-9136-z