Abstract
A one-pot multi-component reaction for the synthesis of β-acetamido carbonyl compounds is reported. The reaction uses a variety of aldehydes, acetophenone derivatives or methyl acetoacetate, acetonitrile, and acetyl chloride in the presence of ferric perchlorate, a mild, efficient and inexpensive catalyst effective under solvent free conditions.
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Heravi, M.M., Behbahani, F.K., Daraie, M. et al. Fe(ClO4)3· 6H2O: a mild and efficient catalyst for one-pot three component synthesis of β-acetamido carbonyl compounds under solvent-free conditions. Mol Divers 13, 375–378 (2009). https://doi.org/10.1007/s11030-009-9118-z
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DOI: https://doi.org/10.1007/s11030-009-9118-z