Summary
The reaction between alkyl(aryl) isocyanides and dibenzoylacetylene in the presence of ethyl bromopyruvate leads to ethyl 3,4-dibenzoyl-2-bromomethyl-5-alkyl(aryl)imino-2,5-dihydro-furan-2-carboxylates in high yields. Dialkyl acetylenedicarboxylates react with tert-butyl isocyanide and ethyl bromopyruvate to produce 3,4-dialkyl 2-ethyl 2-bromomethyl-5-tert-butylimino-2,5-dihydro-furan-2,3,4-tricarboxylates.
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Yavari, I., Hossaini, Z. & Sabbaghan, M. Synthesis of functionalized 5-imino-2,5-dihydro-furans through the reaction of isocyanides with activated acetylenes in the presence of ethyl bromopyruvate. Mol Divers 10, 479–482 (2006). https://doi.org/10.1007/s11030-006-9034-4
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DOI: https://doi.org/10.1007/s11030-006-9034-4