Abstract
A study of 2′,3′-dideoxyinosine (ddI) stability and its interaction with human serum albumin (HSA) was carried out by differential scanning microcalorimetry DSC. Scan rate dependent and irreversible endothermic thermal degradation of ddI was analyzed with use of kinetic approach. Observed process could be interpreted in terms of simple first-order one step kinetic model. Moreover it was shown that ddI bound weakly to the human serum albumin and stabilized this protein.
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Michalik, K., Drzazga, Z. & Michnik, A. Calorimetric characterization of 2′,3′-dideoxyinosine water solution. J Therm Anal Calorim 93, 521–526 (2008). https://doi.org/10.1007/s10973-007-8795-z
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DOI: https://doi.org/10.1007/s10973-007-8795-z