Abstract
The successful combination of microscopy with thermogravimetry-differential thermal analysis is reported. Simultaneous use of all three techniques is made possible by custom fitting a quartz glass window into the furnace of a commercially available TG-DTA. The quartz window enabled direct observations from a microscope mounted above the furnace throughout the entirety of the thermal analytical experiments. Several examples are provided for the use of this combined system for evaluating dehydrations, degradation and phase conversions in pharmaceutical materials. In some examples, microscopy provided information not accessible from the thermal analytical data alone. In others, the thermal analytical data was more informative than the microscopy.
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Grundner, C.L., Poiesz, K.B. & Redman-Furey, N.L. Development and use of a TG-DTA-microscope for evaluation of pharmaceutical materials. J Therm Anal Calorim 85, 91–98 (2006). https://doi.org/10.1007/s10973-005-7352-x
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DOI: https://doi.org/10.1007/s10973-005-7352-x