Summary
Inclusion complexation between dimethyl-β-cyclodextrin and a very poorly water-soluble serum lipid-regulating agent, gemfibrozil, was studied. Products were prepared by several methods (physical mixing, kneading, spray-drying and ultrasonic treatment) in four different molecular ratios (2:1, 1:1, 1:2 and 1:3). The possibility of complex formation between the drug and the host molecule was studied by thermal analysis. Supplementary techniques, such as Fourier transformation-infrared spectroscopy and X-ray diffractometry, were also applied to interpret the results of thermal study of the products.
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Aigner, Z., Hassan, H., Berkesi, O. et al. Thermoanalytical, FTIR and X-ray studies of gemfibrozil-cyclodextrin complexes. J Therm Anal Calorim 81, 267–272 (2005). https://doi.org/10.1007/s10973-005-0777-4
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DOI: https://doi.org/10.1007/s10973-005-0777-4