Summary
Kanamycin is an antibiotic used for treatment of infections when penicillin or other less toxic drugs cannot be used. Kanamycin was labeled with technetium-99m pertechnetate using SnCl2 . 2H2O as reducing agent. The labeling efficiency depends on the ligand/reductant ratio, pH, and volume of reaction mixture. Radiochemical purity and stability of 99mTc-Kanamycin was determined by thin layer chromatography. Biodistribution studies of 99mTc-Kanamycin were performed in rats and rabbits. A significantly higher accumulation of 99mTc-Kanamycin was seen at sites of S. aureusinfected animals (rat/rabbit).
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Roohi, S., Mushtaq, A., Jehangir, M. et al. Synthesis, quality control and biodistribution of 99mTc-Kanamycin. J Radioanal Nucl Chem 267, 561–566 (2006). https://doi.org/10.1007/s10967-006-0087-8
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DOI: https://doi.org/10.1007/s10967-006-0087-8