Summary
The aim of this study was to label exorphin C with 99mTc and to examine its usefulness as opioid receptor binding radiopharmaceutical in Albino Wistar rats. Exorphin C, which is a peptide with 5 aminoacids, was labeled with 99mTc using glucoheptonate (GH) as a bifunctional chelating agent. Labeling efficiency was higher than 98%. The compound was stable for at least 5 hours at room temperature. Mammary tumor bearing Albino Wistar rats were imaged using gamma-camera. Biodistribution studies were also performed. Results demonstrated that 99mTc-glucoheptonate-exorphin C (99mTc-GE) analogs may be useful as a new class of receptor-binding peptides for the diagnosis and therapy of some cancer diseases related with opioid receptor-expressing tissues.
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Ertay, T., Unak, P., Tasci, C. et al. 99mTc-exorphin C: A new peptide radiopharmaceutical for tumor imaging. J Radioanal Nucl Chem 265, 473–479 (2005). https://doi.org/10.1007/s10967-005-0851-1
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DOI: https://doi.org/10.1007/s10967-005-0851-1