Abstract
This study describes the preparation and the evaluation of biodegradation monomethoxy (polyethylene glycol)-poly (lactide-co-glycolide)-monomethoxy (polyethyleneglycol) (mPEG-PLGA-mPEG, PELGE) nanoparticles (PELGE-NP) containing mitoxantrone (DHAQ) as a model drug. PELGE copolymers with various molar ratios of lactic to glycolic acid and different molecular weights and various content mPEG were synthesized by ring-opening polymerization. mPEG with weight-average molecular weight (Mw) 2000 or 5000 was introduced as a hydrophilic segment into a hydrophobic PLGA. A double emulsion method with dextran70 as stabilizer in the external aqueous phase was used to prepare the nanoparticles. The drug entrapment efficiencies were more than 80% and the mean diameters of the nanoparticles were less than 200 nm. Various PELGE was studied as biodegradable drug carriers and there in vitro/in vivo release profiles were examined. It was found that drug loading, polymer molecular weight, copolymer composition and end group modifications were critical factors affecting the in vitro/in vivo release properties. The amount of drug released increased as the mPEG contents increased and the molar ratios of lactic acid decreased in vitro. The intravenous (i.v.) administration of mPEG-PLGA–mPEG nanoparticles of DHAQ in mice resulted in prolonged DHAQ residence in systemic blood circulation compared to the intravenous administration of PLGA nanoparticles.
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References
Y. I. JEONG and J. W. NAH, J. Appl. Polym. Sci. 80 (2001) 2228.
J. Y. YOON, http://www.nanotech.orkr/younjung.doc.04/01/2002.
S. M. LI, in Degradable Polymers: Principles and Applications (Chapman and Hall, London, 1995) p. 43.
R. GREF and A. DOMB, Adv. Drug. Deliv. Rev. 16 (1995) 215.
N. V. MAJETI and R. KUMAR, J. Pharm. Pharmaceut. Sci. 3 (2000) 234.
K. AVGOUSTAKIS and D. S. ITHAKISSIOS, J. Contr. Rel. 79 (2002) 123.
E. CHIOTELIS and J. G. MCAFEE, Int. J. Nucl. Med. Biol. 4 (1977) 29.
G. SPENLEHAUER and J. P. BENOIT, Biomaterials 10 (1989) 557.
R. H. MULLER and O. KAYSER, Adv. Drug. Deliv. Rev. 47 (2001) 3.
M. L. HANS and A. M. LOWMAN, Curr. Opin. Solid State Mat. Sci. 6 (2002) 319.
T. REIHS and M. MULLER, J. Colloid. Interface Sci. 271 (2004) 69.
A. J. RAJEEV, Biomaterials 21 (2000) 2475.
R. GREF and R. LANGER, Science 263 (1994) 1600.
H. FESSI and S. BENITA, Int. J. Pharm. 55 (1989) R1.
J. W. FONG and H. V. MAULDING, J. Contr. Rel. 3 (1986) 119.
D. BAZILE and M. VEILLARD, J. Pharm. Sci. 84 (1995) 493.
J. W. NAH and C. S. CHO, J. Polym. Sci. B : Polym. Phys. 36 (1998) 415.
M. VITTAZ and G. SENLEHAUER, Biomaterials 17 (1996) 1575.
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Duan, Y., Sun, X., Gong, T. et al. Preparation of DHAQ-loaded mPEG-PLGA-mPEG nanoparticles and evaluation of drug release behaviors in vitro/in vivo. J Mater Sci: Mater Med 17, 509–516 (2006). https://doi.org/10.1007/s10856-006-8933-3
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DOI: https://doi.org/10.1007/s10856-006-8933-3