Abstract
This paper describes the synthesis and characterization of a block copolymer of L-lactide (LL) and ε -caprolactone (CL) and its subsequent melt spinning into a monofilament fiber. The synthesis reaction was a two-step process. In the first step, an approximately 50:50 mol% random copolymer, P(LL-co-CL), was synthesized via bulk copolymerization of LL and CL. This first-step prepolymer then became the macroinitiator in the second-step reaction in which more LL monomer was added to form a block copolymer, PLL-b-P(LL-co-CL)-b-PLL. Both the prepolymer and block copolymer were characterized by a combination of analytical techniques comprising dilute-solution viscometry, GPC, 1H and 13C NMR, DSC and TG. The block copolymer was then processed into a monofilament fiber using a small-scale melt spinning apparatus. The fiber was spun with a minimum amount of chain orientation and crystallinity so that its semi-crystalline morphology could be constructed under more controlled conditions in subsequent off-line hot-drawing and annealing steps. In this way, the fiber’s tensile properties and dimensional stability were developed, as indicated by the changes in its stress-strain curve. The final drawn and annealed fiber had a tensile strength (> 400 MPa) approaching that of a commercial PDS II suture of similar size. It is considered that this type of block copolymer has the potential to be developed further as a lower-cost alternative to the current commercial monofilament surgical sutures.
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References
A. SCHINDLER, R. JEFFCOAT, G. L. KIMMEL, C. G. PITT, M. E. WALL and R. ZWEIDINGERZ, in “Contemporary Topics in Polymer Science,” edited by J. R. Pearce and E. M. Schaefger (Plenum, New York, USA, 1977) Vol. 2, p. 251.
H. GE, Y. HU, S. YANG, X. JIANG and C. YANG, J. Appl. Polym. Sci. 75 (2000) 874.
T. NAKAMURA, Y. SHIMIZU, T. MATSUI, N. OKUMURA, S. H. HYON and K. NISHIYA, in “Degradation Phenomena in Polymeric Materials,” edited by H. Planck, M. Dauner and M. Renardy (Springer-Verlag, Berlin, Germany, 1992) p. 153.
J. P. PENNING, H. DIJKSTRA and A. J. PENNINGS, Polymer 34 (1993) 942.
K. TOMIHATA, M. SUZUKI, T. OKA and Y. IKADA, Polym. Degrad. Stab. 59 (1998) 13.
K. TOMIHATA, I SASAKI and M. SUZUKI, U.S. Patent No. 5,797,962 (1998).
W. F. A. DEN DUNNEN, B. VAN DER LEI, P. H. ROBINSON, A. HOLWERDA, A. J. PENNINGS and J. M. SCHAKENRAAD, J. Biomed. Mater. Res. 29 (1995) 757.
D. W. GRIJPMA, G. J. ZONDERVAN and A. J. PENNINGS, Polym. Bull. 25 (1991) 327.
D. W. GRIJPMA and A. J. PENNINGS, ibid. 25 (1991) 335.
E. J. CHOI, J. K. PARK and H. N. CHANG, J. Polym. Sci., Part B: Polym. Phys. Edn. 32 (1994) 2481.
M. HILJANEN-VAINIO, T. KARJALAINEN and J. SEPPÄLÄ, J. Appl. Polym. Sci. 59 (1996) 1281.
P. J. A. IN’T VELD, E. M. VELNER, P. VAN DE WITTE, J. HAMBUIS, P. J. DIJKSTRA and J. FEIJEN, J. Polym. Sci., Part A: Polym. Chem. Edn. 35 (1997) 219.
P. VANHOORNE, PH. DUBOIS, R. JEROME and PH. TEYSSIE, Macromolecules 25 (1992) 37.
R. S. BEZWADA, D. D. JAMIOLKOWSKI, I-Y. LEE, V. AGARWAL, J. PERSIVALE, S. TRENKA-BENTHIN, M. ERNETA, J. SURYADEVARA, A. YANG and S. LIU, Biomaterials 16 (1995) 1141.
R. S. BEZWADA, D. D. JAMIOLKOWSKI and S. W. SHALABY, U. S. Patent No. 5,133,739 (1992).
A. KOWALSKI, A. DUDA and S. PENCZEK, Macromolecules 33 (2000) 689.
A. KOWALSKI, J. LIBISZOWSKI, A. DUDA and S. PENCZEK, ibid. 33 (2000) 1964.
A. KOWALSKI, A. DUDA and S. PENCZEK, ibid. 33 (2000) 7359.
A-C. ALBERTSSON and I. K. VARMA, Biomacromolecules 4 (2003) 1466.
H. TSUJI, A. MIZUNO and Y. IKADA, J. Appl. Polym. Sci. 76 (2000) 947.
D. E. PERRIN and J. P. ENGLISH, in “Handbook of Biodegradable Polymers,” edited by A. J. Domb, J. Kost and D. M. Wiseman (Harwood Academic Publishers, Amsterdam, Netherlands, 1997) Chapt. 1 and 3.
W. TANG, S. MURTHY, F. MARES, M. MCDONNELL and S. CURRAN, J. Appl. Polym. Sci. 74 (1999) 1858.
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Baimark, Y., Molloy, R., Molloy, N. et al. Synthesis, characterization and melt spinning of a block copolymer of L-lactide and ε -caprolactone for potential use as an absorbable monofilament surgical suture. J Mater Sci: Mater Med 16, 699–707 (2005). https://doi.org/10.1007/s10856-005-2605-6
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DOI: https://doi.org/10.1007/s10856-005-2605-6