Abstract
Purpose: To evaluate the efficacy and safety of 1% rimexolone versus 1% prednisolone acetate ophthalmic suspension in the treatment of anterior uveitis. Methods: A randomised triple masked, parallel comparison of rimexolone and prednisolone acetate ophthalmic suspensions was carried out on 78 patients with acute, chronic and recurrent anterior uveitis. Treatment regimen included instillation of one or two drops of drug one hourly through the waking hours during the first week, two hourly in the second week, four times a day in the third week, two times a day for the first 4 days and once a day for the 3 days in the last week. The patient was clinically evaluated on the 3–4th, 7–10th, 14th, 21st and 28th days. The patient was also reviewed on the 30th day. Anterior chamber cells and flare reactions were compared for evaluating the efficacy of the drugs. Result: Rimexolone is as effective as prednisolone acetate ophthalmic suspension in the treatment of anterior uveitis. The largest difference found was 0.1 in the flare reaction (statistically insignificant; p=0.3) and 0.2 score units (statistically significant; p=0.01) in the cells. Overall, comparison of the drugs shows no clinical significance in the treatment of anterior uveitis by either drug. Difference in intraocular pressure (IOP) was also statistically insignificant (p>0.05). However, three patients in the prednisolone acetate group and 1 patient from the rimexolone group showed a rise in IOP. Conclusion: Rimexolone 1% ophthalmic suspension is as effective as and safer than prednisolone acetate 1% ophthalmic suspension in the treatment of anterior uveitis.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
J Biswas S Narain D Das SK Ganesh (1996) ArticleTitlePattern of uveitis in a referral uveitis clinic in India. Int Ophthalmol 20 223–228
CS Foster G Alter LR Debarge MB Raizman et al. (1996) ArticleTitleEfficacy and safety of rimexolone 1% ophthalmic suspension vs 1% prednisolone acetate in the treatment of uveitis. Am J Ophthalmol 122 171–182
MF Armaly (1963) ArticleTitleEffects of corticosteroid on intraocular pressure and fluid dynamics: 1. The effect of dexamethasone in the normal eye Arch Ophthalmol 70 483–491
B Becker SW Mill (1963) ArticleTitleCorticosteroids and intraocular pressure Arch. Ophthalmol 70 500–507
WD Faibairn JC Thorson (1971) ArticleTitleFluoromethalone: anti-inflammatory and intraocular pressure effects. Arch Ophthalmol 86 138–141
JS Mindel HO Tavitian H Jr Smith EC Walker (1980) ArticleTitleComparative ocular pressure elevation by medrysone, fluorometholone, and dexamethasone phosphate. Arch Ophthalmol 98 1577–1578
LL Covell (1958) ArticleTitleGlaucoma induced by systemic steroid therapy. Am J Ophthalmol 45 108–109
Axelrod L. The side effects of glucocorticoid therapy. In: Schleimer RP, Claman HN, Oronsky AL, eds. Anti-inflammatory steroid action. San Diego: Academic Press, 1989, p. 377.
B Becker (1965) ArticleTitleIntraocular pressure response to topical corticosteroid. Invest Ophthalmol Vis Sci 4 198–205
JJ Stern (1953) ArticleTitleAcute glaucoma during cortisone therapy. Am J Ophthalmol 36 389–390
H Goldman (1962) ArticleTitleCortisone glaucoma. Arch Ophthalmol 68 621–626
RC Urban SuffixJr E Cotlier (1986) ArticleTitleCorticosteroid-induced cataracts. Surv Ophthalmol 31 102–110 Occurrence Handle10.1016/0039-6257(86)90077-9 Occurrence Handle1:CAS:528:DyaL2sXhs1Cksw%3D%3D Occurrence Handle3541262
CS Foster (1993) ArticleTitleMedical treatment of intermediate uveitis. Dev Ophthalmol 23 156–157
JA Dunne JP Travers (1979) ArticleTitleDouble-blind clinical trial of topical steroids in anterior uveitis. Br J Ophthalmol 63 762–767
PJ Hunter PD Fowler P Wilkinson (1973) ArticleTitleTreatment of anterior uveitis: comparison of oral oxyphenbutazone and topical steroids. Br J Ophthalmol 57 892–896
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Biswas, J., Ganeshbabu, T.M., Ramesh Raghavendran, S. et al. Efficacy and safety of 1% rimexolone versus 1% prednisolone acetate in the treatment of anterior uveitis – a randomized triple masked study. Int Ophthalmol 25, 147–153 (2004). https://doi.org/10.1007/s10792-004-5195-2
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/s10792-004-5195-2