Abstract
1-Substituted 1,2,3,4-tetrahydroisoquinoline systems were prepared by reaction of cotarnine with the NH-and CH-acids methyl- and acyl derivatives of pyrazole and 1,3-dicarbonyl reagents. Depending on the structure and reaction conditions, bifunctional pyrazole nucleophiles can give substitution products at the N atom, methyl, or acyl group; 1,3-diketones, at the terminal methyl. Rearrangements occurring during the reaction of cotarnine with bifunctional substrates were studied.
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Translated from Khimiya Prirodnykh Soedinenii, No. 4, pp. 360–364, July–August, 2005.
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Krasnov, K.A., Kartsev, V.G. & Vasilevskii, S.F. Chemical Modification of Plant Alkaloids. 4. Reaction of Cotarnine with Bifunctional NH- and CH-Acids. Chem Nat Compd 41, 446–450 (2005). https://doi.org/10.1007/s10600-005-0174-z
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DOI: https://doi.org/10.1007/s10600-005-0174-z