Abstract
Many selenoorganic compounds play an important role in biochemical processes and act as antioxidants, enzyme inhibitors, or drugs. The effects of five new synthesized selenoorganic compounds (2-(5-chloro-2-pyridyl)-7-azabenzisoselenazol-3(2H)-one; 2-phenyl-7-azabenzisoselenazol-3(2H)-one; 2-(pyridyl)-7-azabenzisoselenazol-3(2H)-one; 7-azabenzisoselenazol-3(2H)-one; bis(2-aminophenyl) diselenide) on oxidative changes in human blood platelets and in plasma were studied in vitro and compared with those of ebselen, a well known antioxidant. Our studies demonstrated that bis(2-aminophenyl) diselenide has distinctly protective effects against oxidative stress in blood platelets and in plasma. It might have greater biological relevance and stronger pharmacological effects than ebselen.
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Abbreviations
- CGSH:
-
cysteinylglycine
- CSH:
-
cysteine
- DTNB:
-
5,5′-dithiobis(2-nitrobenzoic acid)
- GPx:
-
glutathione peroxidase
- GSH:
-
glutathione
- GSSG:
-
oxidized glutathione
- HPLC:
-
high-performance liquid chromatography
- PDI:
-
protein disulfide isomerase
- SDS:
-
sodium dodecyl sulfate
- TBARS:
-
thiobarbituric acid-reactive substances
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Saluk-Juszczak, J., Wachowicz, B., Wójtowicz, H. et al. Novel selenoorganic compounds as modulators of oxidative stress in blood platelets. Cell Biol Toxicol 22, 323–329 (2006). https://doi.org/10.1007/s10565-006-0091-3
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DOI: https://doi.org/10.1007/s10565-006-0091-3