Summary
We assessed the impact of participating to clinical research among 1727 women with localized breast cancer. Using as referent individuals not treated according to guidelines for systemic therapy, the adjusted hazard ratio of death was 0.70 (95% confidence interval (CI): 0.54,0.90, p-value: 0.006) in those treated according to current guidelines and 0.45 (95% CI: 0.27,0.73, p-value: 0.001) in participants to research. Participation to clinical trials results in a substantial gain in survival.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
BK Edwards HL Howe LAG Ries MJ Thun HM Rosenberg R Yancik et al. (2002) ArticleTitleAnnual report to the nation on the status of cancer, 1973–1999, featuring implications of age and aging on US cancer burden Cancer 94 2766–2792 Occurrence Handle10.1002/cncr.10593 Occurrence Handle12173348
DP Goldman SH Berry MS McCabe ML Kilgore AL Potosky ML Schoenbaum et al. (2003) ArticleTitleIncremental treatment costs in National Cancer Institute-sponsored clinical trials JAMA 289 2970–2977 Occurrence Handle10.1001/jama.289.22.2970 Occurrence Handle12799405
HC Tate JB Rawlinson (1979) ArticleTitleRandomized comparative studies in the treatment of cancer in the United Kingdom: room for improvement? Lancet ii 623–625 Occurrence Handle10.1016/S0140-6736(79)91676-3
CJ Twelves CS Thomson J Young A Gould (1998) ArticleTitleEntry into clinical trials in breast cancer: the importance of specialists teams Eur J Cancer 34 1004–1007 Occurrence Handle10.1016/S0959-8049(97)10126-5 Occurrence Handle1:STN:280:DyaK1M%2Fms1ejuw%3D%3D Occurrence Handle9849447
RJ Prescott CE Counsell WJ Gillespie AM Grant IT Russell S Kiauka et al. (1999) ArticleTitleFactors that limit the quality, number and progress of randomised controlled trials Health Technol Assess 3 1–143 Occurrence Handle1:STN:280:DC%2BD3c7kvFartg%3D%3D
CB Begg (1988) ArticleTitleSelection of patients for clinical trials Sem Oncol 15 434–440 Occurrence Handle1:STN:280:BiaD3Mbkt1w%3D
SD Fossa E Skovlund (2002) ArticleTitleSelection of patients may limit the generalizability of results from cancer trials Acta Oncol 41 131–137 Occurrence Handle10.1080/028418602753669490 Occurrence Handle12102156
N Bijker JL Peterse IS Fentiman J-P Julien AAM Hart A Avril et al. (2002) ArticleTitleEffects of patient selection on the applicability of results from a randomised clinical trial (EORTC 10853) investigating breast-conserving therapy for DCIS Br J Cancer 87 615–620 Occurrence Handle10.1038/sj.bjc.6600514 Occurrence Handle1:STN:280:DC%2BD38vnsFWrsw%3D%3D Occurrence Handle12237770
AL Hallstrom L Friedman P Denes C Rizo-Patron M Morris InstitutionalAuthorNameThe CAST and AVID investigators (2003) ArticleTitleDo arrhythmia patients improve survival by participating in randomized clinical trials? Observations from the Cardiac Arrhythmia Suppression Trial (CAST) and the Antiarrhythmics versus Implantable Defibrillators Trial (AVID) Controlled Clin Trial 24 341–352 Occurrence Handle10.1016/S0197-2456(03)00002-3
MC Bahit CP Cannon EM Antman SA Murphy CM Gibson CH McCabe et al. (2003) ArticleTitleDirect comparison of characteristics, treatment, and outcomes of patients enrolled versus patients not enrolled in a clinical trial at centers participating in the TIMI 9 trail and TIMI 9 registry Am Heart J 145 109–117 Occurrence Handle10.1067/mhj.2003.43 Occurrence Handle12514662
HD Sesso JM Gaziano M VanDenburgh CH Hennekens RJ Glynn JE Buring (2002) ArticleTitleComparison of baseline characteristics and mortality experience of participants and nonparticipants in a randomised clinical trial: the Physicians’ Health Study Controlled Clin Trial 23 686–702 Occurrence Handle10.1016/S0197-2456(02)00235-0
JM Peppercorn JC Weeks EF Cook S Joffe (2004) ArticleTitleComparison of outcomes in cancer patients treated within and outside clinical trials: conceptual framework and structured review Lancet 363 263–270 Occurrence Handle10.1016/S0140-6736(03)15383-4 Occurrence Handle14751698
N Hébert-Croteau J Brisson J Latreille G Gariépy C Blanchette L Deschênes (1999) ArticleTitleTime trends in systemic adjuvant treatment for node-negative breast cancer J Clin Oncol 17 1458–1464 Occurrence Handle10334531
Hébert-Croteau N, Brisson J, Latreille J, Rivard M, Abdelaziz N, Martin G: Compliance with consensus recommendations for treatment improves survival of women with node-negative breast cancer. J Clin Oncol 22: 3685–3693, 2004.
ME Charlson P Pompei KL Ales CR MacKenzie (1987) ArticleTitleA new method of classifying prognostic comorbidity in longitudinal studies: development and validation J Chron Dis 40 373–383 Occurrence Handle10.1016/0021-9681(87)90171-8 Occurrence Handle1:STN:280:BiiC28nlsVc%3D Occurrence Handle3558716
RA Deyo DC Cherkin MA Ciol (1992) ArticleTitleAdapting a clinical comorbidity index for use with ICD-9-CM administrative databases J Clin Epidemiol 45 613–619 Occurrence Handle10.1016/0895-4356(92)90133-8 Occurrence Handle1:STN:280:By2A3c%2FjvFY%3D Occurrence Handle1607900
JH Glick RD Gelber A Goldhirsh H-J Senn (1992) ArticleTitleMeeting highlights: adjuvant therapy for primary breast cancer J Natl Cancer Inst 84 1479–1485 Occurrence Handle1:STN:280:ByyD2MbktF0%3D Occurrence Handle1433332
Author information
Authors and Affiliations
Corresponding author
Additional information
This work was presented at the 4th European Breast Cancer Conference, Hamburg, Germany, March 16–20, 2004.
Rights and permissions
About this article
Cite this article
Hébert-Croteau, N., Brisson, J., Lemaire, J. et al. The benefit of participating to clinical research. Breast Cancer Res Treat 91, 279–281 (2005). https://doi.org/10.1007/s10549-005-0320-0
Issue Date:
DOI: https://doi.org/10.1007/s10549-005-0320-0