Energy-dissipation in plant mitochondria can be mediated by inner membrane proteins via two processes: redox potential-dissipation or proton electrochemical potential-dissipation. Alternative oxidases (AOx) and the plant uncoupling mitochondrial proteins (PUMP) perform a type of intrinsic and extrinsic regulation of the coupling between respiration and phosphorylation, respectively. Expression analyses and functional studies on AOx and PUMP under normal and stress conditions suggest that the physiological role of both systems lies most likely in tuning up the mitochondrial energy metabolism in response of cells to stress situations. Indeed, the expression and function of these proteins in non-thermogenic tissues suggest that their primary functions are not related to heat production.
Similar content being viewed by others
References
A. M. Almeida W. Jarmuszkiewicz H. Khomsi P. Arruda A. E. Vercesi F. E. Sluse (1999) ArticleTitleCyanide-resistant, ATP-synthesis-sustained, and uncoupling-protein-sustained respiration during postharvest ripening of tomato fruit Plant Physiol. 119 1323–1329 Occurrence Handle10.1104/pp.119.4.1323 Occurrence Handle10198091
C. Affourtit K. Krab A. L. Moore (2001) ArticleTitleControl of plant mitochondrial respiration Biochim. Biophys. Acta 1504 58–69 Occurrence Handle11239485
D. Arsenijevic H. Onuma C. Pecqueur S. Raimbault B. S. Manning E. Couplan M. C. Alves-Guerra M. Goubern R. Surwit F. Bouillaud D. Richard S. Collins D. Ricquier (2000) ArticleTitleDisruption of the uncoupling protein 2 gene in mice reveals a role in immunity and reactive oxygen species production Nat. Genet. 26 435–439 Occurrence Handle10.1038/82565 Occurrence Handle11101840
H. Barata L. Meis Particlede (2002) ArticleTitleUncoupled ATP hydrolysis and thermogenic activity of the sarcoplasmic reticulum Ca2+-ATPase: coupling effects of dimethyl sulfoxide and low temperature J. Biol. Chem. 277 16868–16872 Occurrence Handle10.1074/jbc.M200648200 Occurrence Handle11880374
O. Barzu M. Satre (1970) ArticleTitleDetermination of oxygen affinity of respiratory systems using oxyhemoglobin as oxygen donor Analytic. Biochem. 36 428–433 Occurrence Handle10.1016/0003-2697(70)90379-9
D. S. Bendall W. D. Bonner (1971) ArticleTitleCyanide-insensitive respiration in plant mitochondria Plant Physiol. 47 236–245
D. A. Berthold J. N. Siedow (1993) ArticleTitlePartial purification of the cyanide-resistant alternative oxidase of skunk cabbage (Symplocarpus foetidus) mitochondria Plant Physiol. 101 113–119 Occurrence Handle10.1104/pp.101.1.113 Occurrence Handle8278491
J. Borecký I. G. Maia A. D. Costa P. Jezek H. Chaimovich P. B. Andrade Particlede A. E. Vercesi P. Arruda (2001a) ArticleTitleFunctional reconstitution of Arabidopsis thaliana plant uncoupling mitochondrial protein (AtPUMP1) expressed in Escherichia coli FEBS Lett. 505 240–244 Occurrence Handle10.1016/S0014-5793(01)02835-6
J. Borecký I. G. Maia P. Arruda (2001b) ArticleTitleMitochondrial uncoupling proteins in mammals and plants Biosci. Rep. 21 201–211 Occurrence Handle10.1023/A:1013604526175
O. Boss S. Samec A. Paolonigiacobino C. Rossier A. Dulloo J. Seydoux P. Muzzin J. -P. Giacobino (1997) ArticleTitleUncoupling protein-3: A new member of the mitochondrial carrier family with tissue-specific expression FEBS Lett. 408 39–42
F. Bouillaud D. Ricquier J. Thibault J. Weissenbach (1985) ArticleTitleMolecular approach to thermogenesis in brown adipose tissue: cDNA cloning of the mitochondrial uncoupling protein Proc. Natl. Acad. Sci. USA 82 445–448 Occurrence Handle3855564
M. Brandalise I. G. Maia J. Borecký A. E. Vercesi P. Arruda (2003a) ArticleTitleZmPUMP encodes a maize mitochondrial uncoupling protein that is induced by oxidative stress Plant Sci. 165 329–335 Occurrence Handle10.1016/S0168-9452(03)00159-6
M. Brandalise I. G. Maia J. Borecký A. E. Vercesi P. Arruda (2003b) ArticleTitleOverexpression of plant uncoupling mitochondrial protein in transgenic tobacco increases tolerance to oxidative stress J.␣Bioenerg. Biomembr. 35 203–209 Occurrence Handle10.1023/A:1024603530043
F. F. Calegario R. G. Cosso M. M. Fagian F. V. Almeida W. F. Jardim P. Ježek P. Arruda A. E. Vercesi (2003) ArticleTitleStimulation of potato tuber respiration by cold stress is associated with an increased capacity of both plant uncoupling mitochondrial protein (PUMP) and alternative oxidase J. Bioenerg. Biomembr. 35 211–220 Occurrence Handle10.1023/A:1024655514113 Occurrence Handle13678272
R. A. Cavalheiro F. Fortes J. Borecký V. C. Faustinoni A. Z. Schreiber (2004) ArticleTitleRespiration, oxidative phosphorylation, and uncoupling protein in Candida albicans Braz. J. Med. Biol. Res. 37 1455–461 Occurrence Handle10.1590/S0100-879X2004001000003 Occurrence Handle15448865
A. B. Clarkson E. J. Bienen G. Pollakis R. J. Grady (1989) ArticleTitleRespiration of bloodstream forms of the parasite Trypanosoma brucei brucei is dependent on a plant-like alternative oxidase J. Biol. Chem. 264 17770–17776 Occurrence Handle2808350
M. J. Considine R. C. Holtzapffel D. A. Day J. Whelan A. H. Millar (2002) ArticleTitleMolecular Distinction between Alternative Oxidase from Monocots and Dicots Plant Physiology 129 949–953 Occurrence Handle10.1104/pp.004150 Occurrence Handle12114550
M. J. Considine D. O. Daley J. Whelan (2001) ArticleTitleThe expression of alternative oxidase and uncoupling protein during fruit ripening in mango Plant Physiol. 126 1619–1629 Occurrence Handle10.1104/pp.126.4.1619 Occurrence Handle11500560
M. J. Considine M. Goodman K. S. Echtay M. Laloi J. Whelan M. D Brand L. J. Sweetlove (2003) ArticleTitleSuperoxide stimulates a proton leak in potato mitochondria that is related to the activity of uncoupling protein J. Biol. Chem. 278 22298–22302 Occurrence Handle10.1074/jbc.M301075200 Occurrence Handle12672801
A. D. T. Costa I. L. Nantes P. Ježek A. Leite P. Arruda A. E. Vercesi (1999) ArticleTitlePlant Uncoupling Mitochondrial Protein Activity in Mitochondria Isolated from Tomatoes at Different Stages of Ripening J. Bioenerg. Biomembr. 31 527–533 Occurrence Handle10.1023/A:1005408809619 Occurrence Handle10653480
D. A. Day J. Wiskich (1995) ArticleTitleRegulation of alternative oxidase activity in higher plants J. Bioenerg. Biomembr. 27 379–385 Occurrence Handle10.1007/BF02110000 Occurrence Handle8595973
L. Meis ParticleDe (2003) ArticleTitleBrown adipose tissue Ca2+-ATPase: uncoupled ATP hydrolysis and thermogenic activity J. Biol. Chem. 278 41856–41861 Occurrence Handle10.1074/jbc.M308280200 Occurrence Handle12912988
J. B. Dry A. L. Moore D. A. Day J. T. Wiskich (1989) ArticleTitleRegulation of alternative pathway activity in plant mitochondria: nonlinear relationship between electron flux and the redox poise of the quinone pool Arch. Biochem. Biophys. 273 148–157 Occurrence Handle10.1016/0003-9861(89)90173-2 Occurrence Handle2757390
K. S. Echtay M. D. Brand (2001) ArticleTitleCoenzyme Q induces GDP sensitive proton conductance in kidney mitochondria Biochem. Soc. Trans. 29 763–768 Occurrence Handle10.1042/BST0290763 Occurrence Handle11709071
K. S. Echtay E. Winkler K. Frischmuth M. Klingenberg (2001) ArticleTitleUncoupling proteins 2 and 3 are highly active H (+) transporters and highly nucleotide sensitive when activated by coenzyme Q (ubiquinone) Proc. Natl. Acad. Sci. USA 98 1416–1421 Occurrence Handle10.1073/pnas.98.4.1416 Occurrence Handle11171965
K. S. Echtay T. C. Esteves J. L. Pakay M. B. Jekabsons A. J. Lambert M. Portero-Otin R. Pamplona A. J. Vidal-Puig S. Wang S. J. Roebuck M. D. Brand (2003) ArticleTitleA signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling EMBO J. 22 4103–4110 Occurrence Handle10.1093/emboj/cdg412 Occurrence Handle12912909
K. S. Echtay D. Roussel J. St-Pierre M. B. Jekabsons S. Cadenas J. A. Stuart J. A. Harper S. J. Roebuck A. Morrison S. Pickering J. C. Clapham M. D. Brand (2002a) ArticleTitleSuperoxide activates mitochondrial uncoupling proteins Nature 415 96–99 Occurrence Handle10.1038/415096a
K. S. Echtay M. P. Murphy R. A. Smith D. A. Talbot M. D. Brand (2002b) ArticleTitleSuperoxide activates mitochondrial uncoupling protein 2 from the matrix side. Studies using targeted antioxidants J. Biol. Chem. 277 47129–47135 Occurrence Handle10.1074/jbc.M208262200
K. S. Echtay E. Winkler M. Klingenberg (2000) ArticleTitleCoenzyme Q is an obligatory cofactor for uncoupling protein function Nature 408 609–613 Occurrence Handle10.1038/35046114 Occurrence Handle11117751
B. ElMoualij C. Duyckaerts J. Lamotte-Brasseur F. E. Sluse (1997) ArticleTitlePhylogenetic classification of the mitochondrial carrier family of Saccharomyces cerevisiae Yeast 13 573–581 Occurrence Handle10.1002/(SICI)1097-0061(199705)13:6<573::AID-YEA107>3.0.CO;2-I Occurrence Handle9178508
T. E. Elthon R. L. Nickels L. McIntosh (1989) ArticleTitleMonoclonal antibodies to the alternative oxidase of higher plant mitochondria Plant Physiol. 89 1311–1317
C. Fleury M. Neverova S. Collins S. Raimbault O. Champigny C. Levi-Meyrueis F. Bouillaud M. F. Seldin R. S. Surwit D. Ricquier C. H. Warden (1997) ArticleTitleUncoupling protein-2: A novel gene linked to obesity and hyperinsulinemia Nat. Genet. 15 269–272 Occurrence Handle10.1038/ng0397-269 Occurrence Handle9054939
Y. W. Fridell A. Sanchez-Blanco B. A. Silvia S. L. Helfand (2004) ArticleTitleFunctional characterization of a Drosophila mitochondrial uncoupling protein J. Bioenerg. Biomembr. 36 219–228 Occurrence Handle10.1023/B:JOBB.0000031973.20153.c6 Occurrence Handle15337852
K. D. Garlid D. E. Orosz M. Modrianský S. Vassanelli P. Ježek (1996) ArticleTitleOn the mechanism of fatty acid-induced proton transport by mitochondrial uncoupling protein J. Biol. Chem. 271 2615–2620 Occurrence Handle10.1074/jbc.271.5.2615 Occurrence Handle8576230
A. Gilliland D. P. Singh J. M. Hayward C. A. Moore A. M. Murphy C. J. York J. Slator J. P. Carr (2003) ArticleTitleGenetic modification of alternative respiration has differential effects on antimycin A-induced versus salicylic acid-induced resistance to tobacco mosaic virus Plant Physiol 132 1518–1528 Occurrence Handle10.1104/pp.102.017640 Occurrence Handle12857832
K. Higo Y. Ugawa M. Iwamoto T. Korenaga (1999) ArticleTitlePlant cis-acting regulatory DNA elements (PLACE) database: 1999 Nucleic Acid Res. 27 297–300 Occurrence Handle10.1093/nar/27.1.297 Occurrence Handle9847208
M. Hirabayashi D. Ijiri Y. Kamei A. Tajima Y. Kanai (2005) ArticleTitleTransformation of skeletal muscle from fast to slow-twitch during acquisition of cold tolerance in the chick Endocrinology 146 399–405 Occurrence Handle10.1210/en.2004-0723 Occurrence Handle15471958
C. Hourton-Cabassa A. Rita Matos A. Zachowski F. Moreau (2004) ArticleTitleThe plant uncoupling protein homologues: a new family of energy-dissipating proteins in plant mitochondria Plant Physiol. Biochem. 42 283–290 Occurrence Handle10.1016/j.plaphy.2004.01.007 Occurrence Handle15120112
K. Iba (2002) ArticleTitleAcclimative response to temperature stress in higher plants: approaches of gene engineering for temperature tolerance Annu. Rev. Plant Biol. 53 225–245 Occurrence Handle10.1146/annurev.arplant.53.100201.160729 Occurrence Handle12221974
H. Ikuma F. J. Schindler W. D. Bonner (1964) ArticleTitleKinetic analysis of oxidases in tightly coupled plant mitochondria Plant Physiol. 39 S–1x
K. Ito (1999) ArticleTitleIsolation of two distinct cold-inducible cDNAs encoding plant uncoupling proteins from the spadix of skunk cabbage (Symplocarpus foetidus) Plant Sci. 149 167–173 Occurrence Handle10.1016/S0168-9452(99)00159-4
M. Jabůrek K. D. Garlid (2003) ArticleTitleReconstitution of recombinant uncoupling proteins: UCP1, -2, and -3 have similar affinities for ATP and are unaffected by coenzyme Q10 J. Biol. Chem. 278 25825–25831 Occurrence Handle10.1074/jbc.M302126200 Occurrence Handle12734183
W. Jarmuszkiewicz C. M. Sluse-Goffart A. E. Vercesi F. E. Sluse (2001) ArticleTitleAlternative oxidase and uncoupling protein: thermogenesis versus cell energy balance Biosci Rep. 21 213–222 Occurrence Handle10.1023/A:1013656510245 Occurrence Handle11725870
W. Jarmuszkiewicz R. Navet L. C. Alberici P. Douette C. M. Sluse-Goffart F. E. Sluse A. E. Vercesi (2004) ArticleTitleRedox State of Endogenous Coenzyme Q Modulates the Inhibition of Linoleic Acid-Induced Uncoupling by Guanosine Triphosphate in Isolated Skeletal Muscle Mitochondria J. Bioenerg. Biomembr. 36 493–502 Occurrence Handle10.1023/B:JOBB.0000047331.25248.7a Occurrence Handle15534396
W. Jarmuszkiewicz M. Behrendt R Navet F. E. Sluse (2002) ArticleTitleUncoupling protein and alternative oxidase of Dictyostelium discoideum: occurrence, properties and protein expression during vegetative life and starvation-induced early development FEBS Lett. 532 459–464 Occurrence Handle10.1016/S0014-5793(02)03734-1 Occurrence Handle12482613
W. Jarmuszkiewicz G. Milani F. Fortes A. Z. Schreiber F. E. Sluse A. E. Vercesi (2000) ArticleTitleFirst evidence and characterization of an uncoupling protein in fungi kingdom: CpUCP of Candida parapsilosis FEBS Lett. 467 145–149 Occurrence Handle10.1016/S0014-5793(00)01138-8 Occurrence Handle10675527
W. Jarmuszkiewicz C. M. Sluse-Goffart L. Hryniewiecka F.E. Sluse (1999) ArticleTitleIdentification and characterization of a protozoan uncoupling protein in Acanthamoeba castellanii J. Biol. Chem. 274 23198–23202 Occurrence Handle10.1074/jbc.274.33.23198 Occurrence Handle10438491
W. Jarmuszkiewicz A. M. Wagner M. J. Wagner L. Hryniewiecka (1997) ArticleTitleImmunological identification of the alternative oxidase of Acanthamoeba castellanii mitochondria FEBS Lett. 411 110–114 Occurrence Handle10.1016/S0014-5793(97)00676-5 Occurrence Handle9247153
P. Ježek (2002) ArticleTitlePossible physiological roles of mitochondrial uncoupling proteins—UCPn Int. J. Biochem. Cell Biol. 34 1190–1206 Occurrence Handle10.1016/S1357-2725(02)00061-4 Occurrence Handle12127570
P Ježek J Borecký M Žáčková A. D. Costa P. Arruda (2001) ArticleTitlePossible basic and specific functions of plant uncoupling proteins (pUCP) Biosci Rep. 21 237–245 Occurrence Handle10.1023/A:1013660611154 Occurrence Handle11725872
P. Ježek A. D. Costa A. E. Vercesi (1996) ArticleTitleEvidence for anion-translocating plant uncoupling mitochondrial protein in potato mitochondria J. Biol. Chem. 271 32743–32748 Occurrence Handle10.1074/jbc.271.51.32743 Occurrence Handle8955108
P. Ježek A. D. Costa A. E. Vercesi (1997) ArticleTitleReconstituted plant uncoupling mitochondrial protein allows for proton translocation via fatty acid cycling mechanism J. Biol. Chem. 272 24272–24278 Occurrence Handle10.1074/jbc.272.39.24272 Occurrence Handle9305881
P. Ježek K. D. Garlid (1990) ArticleTitleNew substrates and competitive inhibitors of the Cl- translocating pathway of the uncoupling protein of brown adipose tissue mitochondria J. Biol. Chem. 265 19303–19311 Occurrence Handle2229077
P. Ježek K. D. Garlid (1998) ArticleTitleMammalian mitochondrial uncoupling proteins Int. J. Biochem. Cell Biol. 30 1163–1168 Occurrence Handle10.1016/S1357-2725(98)00076-4 Occurrence Handle9839442
P. Ježek M. Žáčková J. Košařová E. T. Rodrigues V. M. Madeira J. A. Vicente (2000) ArticleTitleOccurrence of Plant-Uncoupling Mitochondrial Protein (PUMP) in Diverse Organs and Tissues of Several Plants J. Bioenerg. Biomembr. 32 549–561 Occurrence Handle10.1023/A:1005648226431 Occurrence Handle15254369
B. Kadenbach (2003) ArticleTitleIntrinsic and extrinsic uncoupling of oxidative phosphorylation Biochim. Biophys. Acta. 1604 77–94 Occurrence Handle12765765
W. A. Kannerworff L. H. W. Plas Particlevan der (1994) ArticleTitleRespiration of bulb scale fragments of tulip after storage at 5°C Plant Sci. 104 31–38 Occurrence Handle10.1016/0168-9452(94)90188-0
S. L. Klein R. L. Strausberg L. Wagner J. Pontius S. W. Clifton P. Richardson (2002) ArticleTitleGenetic and genomic tools for Xenopus research: The NIH Xenopus initiative Dev. Dyn. 225 384–391 Occurrence Handle10.1002/dvdy.10174 Occurrence Handle12454917
M. Klingenberg (1990) ArticleTitleMechanism and evolution of the uncoupling protein of brown adipose tissue Trends Biochem. Sci. 15 108–112 Occurrence Handle10.1016/0968-0004(90)90194-G Occurrence Handle2158156
A. J. Kowaltowski A. D. T. Costa A. E. Vercesi (1998) ArticleTitleActivation of the potato plant uncoupling mitochondrial protein inhibits reactive oxygen species generation by the respiratory chain FEBS Lett. 425 213–216 Occurrence Handle10.1016/S0014-5793(98)00231-2 Occurrence Handle9559650
M. Laloi M. Klein J. W. Riesmeier B. Muller-Rober C. Fleury F. Bouillaud D. Ricquier (1997) ArticleTitleA plant cold-induced uncoupling protein Nature 389 135–136 Occurrence Handle10.1038/38156 Occurrence Handle9296489
A. M. Lambowitz J. R. Sabourin H. Bertrand R. Nickels L. McIntosh (1989) ArticleTitleImmunological identification of the alternative oxidase of Neurospora crassa mitochondria Mol. Cell. Biol. 9 1362–1364 Occurrence Handle2524649
A. Ledesma M. G. Lacoba Particlede E. Rial (2002) ArticleTitleThe mitochondrial uncoupling proteins Genome Biol. 3 3015–1–30159 Occurrence Handle10.1186/gb-2002-3-12-reviews3015
M. Lescot P. Dehais G. Thijs K. Marchal Y. Moreau Y. Peer ParticleVan de P. Rouze S. Rombauts (2002) ArticleTitlePlantCARE, a database of plant cis-acting regulatory elements and a portal to tools for in silico analysis of promoter sequences Nucleic Acid Res. 30 325–327 Occurrence Handle10.1093/nar/30.1.325 Occurrence Handle11752327
L.-X. Li F. Skorpen K. Egenberg I. H. Jorgensen V. Grill (2001) ArticleTitleUncoupling protein 2 participates in cellular defence against oxidative stress in clonal ß-cells Biochem. Biophys. Res. Commun. 282 273–277 Occurrence Handle10.1006/bbrc.2001.4577 Occurrence Handle11264003
I. G. Maia C. E. Benedetti A. Leite S. R. Turcinelli A. E. Vercesi P. Arruda (1998) ArticleTitleAtPUMP: an Arabidopsis gene encoding a plant uncoupling mitochondrial protein FEBS Lett. 429 403–406 Occurrence Handle10.1016/S0014-5793(98)00634-6 Occurrence Handle9662458
W. Mao X. X. Yu A. Zhong W. Li J. Brush S. W. Sherwood S. H. Adams G. Pan (1999) ArticleTitleUCP4, a novel brain-specific mitochondrial protein that reduces membrane potential in mammalian cells FEBS Lett. 443 326–330 Occurrence Handle10.1016/S0014-5793(98)01713-X Occurrence Handle10025957
D. P. Maxwell R. Nickels L. McIntosh (2002) ArticleTitleEvidence of mitochondrial involvement in the transduction of signals required for the induction of genes associated with pathogen attack and senescence Plant J. 29 269–279 Occurrence Handle10.1046/j.1365-313X.2002.01216.x Occurrence Handle11844105
D. P. Maxwell Y. Wang L. McIntosh (1999) ArticleTitleThe alternative oxidase lowers mitochondrial reactive oxygen species production in plant cells Proc Natl Acad Sci USA 96 8271–8276 Occurrence Handle10.1073/pnas.96.14.8271 Occurrence Handle10393984
L. McIntosh T. Eichler G. Gray D. Maxwell R. Nickels Y. Wang (1998) ArticleTitleBiochemical and genetic controls exerted by plant mitochondria Biochim. Biophys. Acta 1365 278–284
B. J. D. Meeuse (1975) ArticleTitleThermogenic respiration in aroids Annu. Rev. Plant Physiol. 26 117–126 Occurrence Handle10.1146/annurev.pp.26.060175.001001
B. J. D. Meeuse R. G. Buggeln (1969) ArticleTitleTime, space, light and darkness in the metabolic flare-up of the Sauromatum appendix Acta Bot. Neerl. 18 159–172
G. Milani W. Jarmuszkiewicz C. M. Sluse-Goffart A. Z. Schreiber A. E. Vercesi F. E. Sluse (2001) ArticleTitleRespiratory chain network in mitochondria of Candida parapsilosis: ADP/O appraisal of the multiple electron pathways FEBS Lett. 508 231–235 Occurrence Handle10.1016/S0014-5793(01)03060-5 Occurrence Handle11718721
A. H. Millar F. J. Bergersen D. A. Day (1994) ArticleTitleOxygen affinity of terminal oxidases in soybean mitochondria Plant Physiol. Biochem. 32 847–852
A. H. Millar J. T. Wiskich J. Whelan D. A. Day (1993) ArticleTitleOrganic acid activation of the alternative oxidase of plant mitochondria FEBS Lett. 329 259–262 Occurrence Handle10.1016/0014-5793(93)80233-K Occurrence Handle8365467
N. Minagawa S. Koga M. Nakano S. Sakajo A. Yoshimoto (1992a) ArticleTitlePossible involvement of superoxide anion in the induction of cyanide-resistant respiration in Hansenula anomala FEBS Lett. 302 217–219 Occurrence Handle10.1016/0014-5793(92)80444-L
N. Minagawa S. Sakajo A. Yoshimoto (1992b) ArticleTitleEffects of unsaturated fatty acids on cyanide-resistant respiration of mitochondria isolated from Hansenula anomala Biosci. Biotechnol. Biochem. 56 1342–1343
P. Mitchell (1961) ArticleTitleCoupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism Naturwissenschaften 191 144–148
I. M. Møller (2001) ArticleTitlePlant mitochondria and oxidative stress: Electron Transport, NADPH Turnover, and Metabolism of Reactive Oxygen Species Annu. Rev. Plant Physiol. Plant Mol. Biol. 52 561–591 Occurrence Handle10.1146/annurev.arplant.52.1.561 Occurrence Handle11337409
A. L. Moore A. L. Umbach J. N. Siedow (1995) ArticleTitleStructure-function relationships of the alternative oxidase of plant mitochondria: a model of the active site J. Bioenerg. Biomembr. 27 367–377 Occurrence Handle10.1007/BF02109999 Occurrence Handle8595972
A. L. Moore J. N. Siedow (1991) ArticleTitleThe regulation and nature of the cyanide resistant alternative oxidase of plant mitochondria Biochem. Biophys. Acta 1059 121–140 Occurrence Handle1883834
A. L. Moore I. B. Dry J. T. Wiskich (1988) ArticleTitleMeasurement of the redox state of the ubiquinone pool in plant mitochondria FEBS Lett. 235 76–80 Occurrence Handle10.1016/0014-5793(88)81237-7
M. R. Moynihan A. Ordentlich I. Raskin (1995) ArticleTitleChilling-Induced Heat Evolution in Plants Plant Physiol. 108 995–999 Occurrence Handle12228523
S. Murayama H. Handa (2000) ArticleTitleIsolation and characterization of cDNAs encoding mitochondrial uncoupling proteins in wheat: wheat UCP genes are not regulated by low temperature Mol. Gen. Genet. 264 112–118 Occurrence Handle10.1007/s004380000289 Occurrence Handle11016840
M. P. Murphy M. D. Brand (1988) ArticleTitleThe stoichiometry of charge translocation by cytochrome c oxidase and the cytochrome bc 1 complex of mitochondria at high membrane potential Eur. J. Biochem. 173 645–651 Occurrence Handle10.1111/j.1432-1033.1988.tb14047.x Occurrence Handle2836196
M. P. Murphy K. S. Echtay F. H. Blaikie J. Asin-Cayuela H. M. Cocheme K. Green J. A. Buckingham E. R. Taylor F. Hurrell G. Hughes S. Miwa C. E. Cooper D. A. Svistunenko R. A. Smith M. D. Brand (2003) ArticleTitleSuperoxide activates uncoupling proteins by generating carbon-centered radicals and initiating lipid peroxidation: studies using a mitochondria-targeted spin trap derived from alpha-phenyl-N-tert-butylnitrone J. Biol. Chem. 278 48534–48545 Occurrence Handle10.1074/jbc.M308529200 Occurrence Handle12972420
I. L. Nantes M. M. Fagian R. Catisti P. Arruda I. G. Maia A. E. Vercesi (1999) ArticleTitleLow temperature and aging-promoted expression of PUMP in potato tuber mitochondria FEBS Lett. 457 103–106 Occurrence Handle10.1016/S0014-5793(99)01017-0 Occurrence Handle10486573
D. G. Nicholls (1976) ArticleTitleHamster brown-adipose-tissue mitochondria. Purine nucleotide control of the ion conductance of the inner membrane, the nature of the nucleotide binding site Eur. J. Biochem. 62 223–228 Occurrence Handle10.1111/j.1432-1033.1976.tb10151.x Occurrence Handle1253787
D. G. Nicholls R. M. Locke (1984) ArticleTitleThermogenic mechanisms in brown fat Physiol. Rev. 64 1–64 Occurrence Handle6320232
S. H. Ordog V. J. Higgins G. C. Vanlerberghe (2002) ArticleTitleMitochondrial alternative oxidase is not a critical component of plant viral resistance but may play a role in the hypersensitive response Plant Physiol. 129 1858–1865 Occurrence Handle10.1104/pp.003855 Occurrence Handle12177499
H. L. Parsons J. Y. H. Yip G. C. Vanlerberghe (1999) ArticleTitleIncreased respiratory restriction during phosphate-limited growth in transgenic tobacco cells lacking alternative oxidase Plant Physiol. 121 1309–1320 Occurrence Handle10.1104/pp.121.4.1309 Occurrence Handle10594118
R. G. Pinhero M. V. Rao G. Paliyath D. P. Murr R. A. Fletcher (1997) ArticleTitleChanges in Activities of Antioxidant Enzymes and Their Relationship to Genetic and Paclobutrazol-Induced Chilling Tolerance of Maize Seedlings Plant Physiol. 114 695–704 Occurrence Handle12223737
V. N. Popov R. A. Simonian V. P. Skulachev A. A. Starkov (1997) ArticleTitleInhibition of the alternative oxidase stimulates H2O2 production in plant mitochondria FEBS Lett. 415 87–90 Occurrence Handle10.1016/S0014-5793(97)01099-5 Occurrence Handle9326375
A. C. Purvis R. L. Shewfelt (1993) ArticleTitleDoes the alternative pathway ameliorate chilling injury in sensitive plant-tissues? Physiol. Plant. 88 712–718 Occurrence Handle10.1034/j.1399-3054.1993.880426.x
J. Rafael I. Pampel X. Wang (1994) ArticleTitleEffect of pH and MgCl2 on the binding of purine nucleotides to the uncoupling protein in membrane particles from brown fat mitochondria Eur. J. Biochem. 223 971–980 Occurrence Handle10.1111/j.1432-1033.1994.tb19075.x Occurrence Handle8055974
I. Raskin A. Ehmann W. R. Melander B. J. D. Meeuse (1987) ArticleTitleSalicylic acid: a natural inducer of heat production in arum lilies Science 237 1601–1602
I. Raskin I. M. Turner W. R. Melander (1989) ArticleTitleRegulation of heat production in the inflorescences of an Arum lily by endogenous salicylic acid Proc. Natl. Acad. Sci. USA 86 2214–2218
S. Rawsthorne T. A. LaRue (1986) ArticleTitleMetabolism under microaerobic conditions of mitochondria from cowpea nodules Plant Physiol. 81 1097–1102
D. M. Rhoads L. McIntosh (1991) ArticleTitleIsolation and characterization of a cDNA clone encoding an alternative oxidase protein of Sauromatum guttatum (Schott) Proc. Natl. Acad. Sci. USA 88 2122–2126 Occurrence Handle1706518
M. Ribas-Carbo J. A. Berry J. Azcon-Bieto J. N. Siedow (1994) ArticleTitleThe reaction of the plant mitochondrial cyanide-resistant alternative oxidase with oxygen Biochim. Biophys. Acta 1188 205–212
D. Ricquier F. Bouillaud (2000a) ArticleTitleThe uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP Biochem J. 345 161–179 Occurrence Handle10.1042/0264-6021:3450161
D. Ricquier F. Bouillaud (2000b) ArticleTitleMitochondrial uncoupling proteins: from mitochondria to the regulation of energy balance J Physiol. 529 3–10 Occurrence Handle10.1111/j.1469-7793.2000.00003.x
D. Ricquier J. -C. Kader (1976) ArticleTitleMitochondrial protein alteration in active brown fat: a soidum dodecyl sulfate-polyacrylamide gel electrophoretic study Biochem. Biophys. Res. Commun. 73 577–583
S. Sakajo N. Minagawa T. Komiyama A. Yoshimoto (1991) ArticleTitleMolecular cloning of cDNA for antimycin A-inducible mRNA and its role in cyanide-resistant respiration in Hansenula anomala Biochim. Biophys. Acta 1090 102–108 Occurrence Handle1883836
D. Sanchis C. Fleury N. Chomiki M. Goubern Q. Huang M. Neverova F. Gregoire J. Easlick S. Raimbault C. Levi-Meyrueis B. Miroux S. Collins M. Seldin D. Richard C. Warden F. Bouillaud D. Ricquier (1998) ArticleTitleBMCP1, a novel mitochondrial carrier with high expression in the central nervous system of humans and rodents, and respiration uncoupling activity in recombinant yeast J. Biol. Chem. 273 34611–34615 Occurrence Handle10.1074/jbc.273.51.34611 Occurrence Handle9852133
Y. Sato T. Murakami H. Funatsuki S. Matsuba H. Saruyama M. Tanida (2001) ArticleTitleHeat shock-mediated APX gene expression and protection against chilling injury in rice seedlings J. Exp. Bot. 52 145–151 Occurrence Handle10.1093/jexbot/52.354.145 Occurrence Handle11181723
G. R. Schonbaum W. D. Bonner B. T. Storey J. T. Bahr (1971) ArticleTitleSpecific inhibition of the cyanide-insensitive respiratory pathway in plant mitochondria by hydroxamic acids Plant Physiol. 47 124–128 Occurrence Handle5543780
R. S. Seymour C. R. White M. Gibernau (2003) ArticleTitleEnvironmental biology: heat reward for insect pollinators Nature 426 243–244 Occurrence Handle10.1038/426243a Occurrence Handle14628037
J. N. Siedow A. L. Umbach (1995) ArticleTitlePlant mitochondrial electron transfer and molecular biology Plant Cell 7 821–831 Occurrence Handle10.1105/tpc.7.7.821 Occurrence Handle12242388
M. Simon G. Adam W. Rapatz W. Spevak H. Ruis (1991) ArticleTitleThe Saccharomyces cerevisiae ADR1 gene is a positive regulator of transcription of genes encoding peroxisomal proteins Mol. Cell Biol. 11 699–704 Occurrence Handle1899286
V. P. Skulachev (1998) ArticleTitleUncoupling: new approaches to an old problem of bioenergetics Biochim. Biophys. Acta 1363 100–124 Occurrence Handle9507078
F. E. Sluse W. Jarmuszkiewicz (1998) ArticleTitleAlternative oxidase in the branched mitochondrial respiratory network: an overview on structure, function, regulation, and role Braz. J. Med. Biol. Res. 31 733–747 Occurrence Handle10.1590/S0100-879X1998000600003 Occurrence Handle9698817
F. E. Sluse W. Jarmuszkiewicz (2000) ArticleTitleActivity and functional interaction of alternative oxidase and uncoupling protein in mitochondria from tomato fruit Braz. J. Med. Biol. Res. 33 259–268 Occurrence Handle10.1590/S0100-879X2000000300002 Occurrence Handle10719376
F. E. Sluse W. Jarmuszkiewicz (2002) ArticleTitleUncoupling proteins outside the animal and plant kingdoms: functional and evolutionary aspects FEBS Lett. 510 117–120
F. E. Sluse A. M. Almeida W. Jarmuszkiewicz A. E. Vercesi (1998) ArticleTitleFree fatty acids regulate the uncoupling protein and alternative oxidase activities in plant mitochondria FEBS Lett 433 237–234 Occurrence Handle10.1016/S0014-5793(98)00922-3 Occurrence Handle9744802
A. M. Smith R. G. Ratcliffe L. J. Sweetlove (2004) ArticleTitleActivation and function of mitochondrial uncoupling protein in plants J. Biol. Chem. 279 51944–51952 Occurrence Handle10.1074/jbc.M408920200 Occurrence Handle15456782
J. A. Stuart J. A. Harper K. M. Brindle M. D. Brand (1999) ArticleTitleUncoupling protein 2 from carp and zebrafish, ectothermic vertebrates Biochim. Biophys. Acta 1413 50–54 Occurrence Handle10524261
D. A. Talbot C. Duchamp B. Rey N. Hanuise J. L. Rouanet B. Sibille M. D. Brand (2004) ArticleTitleUncoupling protein and ATP/ADP carrier increase mitochondrial proton conductance after cold adaptation of king penguins J. Physiol. 558 123–135 Occurrence Handle10.1113/jphysiol.2004.063768 Occurrence Handle15146050
Tai P. Y. P., Lentini R. S., (1998) Freeze Damage of Florida Sugarcane. In: Sugarcane handbook (Anderson D. L. Ed.), Ed. 1. pp. 1–3, Florida Cooperative Extension Service, University of Florida, Florida
S. A. Uemura S. Luo S. N. J. Moreno R. Docampo (2000) ArticleTitleOxidative Phosphorylation, Ca2+ Transport, and Fatty Acid-induced Uncoupling in Malaria Parasites Mitochondria J. Biol. Chem. 275 9709–9715 Occurrence Handle10.1074/jbc.275.13.9709 Occurrence Handle10734123
A. L. Umbach J. N. Siedow (1993) ArticleTitleCovalent and non-covalent dimers of the cyanide-resistant alternative oxidase protein in higher plant mitochondria and their relationship to enzyme activity Plant Physiol. 103 845–854 Occurrence Handle12231983
A. L. Umbach J. T. Wiskich J. N. Siedow (1994) ArticleTitleRegulation of alternative oxidase kinetics by pyruvate and intermolecular disulfide bond redox status in soybean seedling mitochondria FEBS Lett. 348 181–184 Occurrence Handle10.1016/0014-5793(94)00600-8 Occurrence Handle8034038
D. Straeten ParticleVan Der L. Chaerle G. Sharkov H. Lambers M. Montagu ParticleVan (1995) ArticleTitleSalicylic acid enhances the activity of the alternative pathway of respiration in tobacco leaves and induces thermogenicity Planta 196 412–419 Occurrence Handle10.1007/BF00203637
G. C. Vanlerberghe L. McIntosh (1996) ArticleTitleSignals Regulating the Expression of the Nuclear Gene Encoding Alternative Oxidase of Plant Mitochondria Plant Physiol. 111 589–595 Occurrence Handle12226312
G. C. Vanlerberghe L. McIntosh (1997) ArticleTitleAlternative oxidase: from gene to function Annu. Rev. Plant Physiol. Plant Mol. Biol. 48 703–734 Occurrence Handle10.1146/annurev.arplant.48.1.703 Occurrence Handle15012279
G. C. Vanlerberghe D. A. Day J. T. Wiskich A. E. Vanlerberghe L. McIntosh (1995) ArticleTitleAlternative oxidase activity in tobacco leaf mitochondria: dependence on tricarboxylic acid cycle-mediated redox regulation and pyruvate activation Plant Physiol. 109 353–361 Occurrence Handle12228600
G. C. Vanlerberghe L. McIntosh (1997) ArticleTitleAlternative oxidase: from gene to function Annu. Rev. Plant Physiol. Plant Mol. Biol. 48 703–734 Occurrence Handle10.1146/annurev.arplant.48.1.703 Occurrence Handle15012279
G. C. Vanlerberghe A. E. Vanlerberghe L. McIntosh (1994) ArticleTitleMolecular genetic alteration of plant respiration (silencing and overexpression of alternative oxidase in transgenic tobacco) Plant Physiol. 106 1503–1510 Occurrence Handle12232424
G. C. Vanlerberghe C. A. Robson J. Y. H. Yip (2002) ArticleTitleInduction of Mitochondrial Alternative Oxidase in Response to a Cell Signal Pathway Down-Regulating the Cytochrome Pathway Prevents Programmed Cell Death Plant Physiol. 129 1829–1842 Occurrence Handle10.1104/pp.002691 Occurrence Handle12177496
A. E. Vercesi (2001) ArticleTitleThe discovery of an uncoupling mitochondrial protein in plants Biosci. Rep. 21 195–200 Occurrence Handle10.1023/A:1013652409337 Occurrence Handle11725868
A. E. Vercesi I. S. Martins M. A. P. Silva H. M. F. Leite I. M. Cuccovia H. Chaimovich (1995) ArticleTitlePUMPing plants Nature 375 24 Occurrence Handle10.1038/375024a0
A. E. Vercesi H. Chaimovich I. M. Cuccovia (1997) ArticleTitleA plant uncoupling mitochondrial protein, PUMP Rec. Res. Devel. Plant Physiol. 1 85–91
A. E. Vercesi P. Ježek A. D. T. Costa A. J. Kowaltowski I. G. Maia P. Arruda (1998) A plant uncoupling mitochondrial protein I. M. Moller P. Gardeström K. Glimelius E. Glaser (Eds) Plant Mitochondria: From Gene to Function. Backhuys Publishers Leiden, The Netherlands 435–440
C. R. Vianna T. Hagen C.-Y. Zhang E. Bachman O. Boss B. Gereben A. S. Moriscot B. B. Lowell J. E. P. W. Bicudo A. C. Bianco (2001) ArticleTitleCloning and functional characterization of an uncoupling protein homolog in hummingbirds Physiol. Genomics 5 137–145 Occurrence Handle11285367
A. M. Wagner A. L. Moore (1997) ArticleTitleStructure and function of the plant alternative oxidase: its putative role in the oxygen defence mechanism Biosci. Rep. 17 319–333 Occurrence Handle10.1023/A:1027388729586 Occurrence Handle9337486
A. M. Wagner M. J. Wagner (1997) ArticleTitleChanges in mitochondrial respiratory chain components of petunia cells during culture in the presence of antimycin A Plant Physiol. 115 617–622 Occurrence Handle12223830
A. Watanabe M. Nakazono N. Tsutsumi A. Hirai (1999) ArticleTitleAtUCP2: A novel isoform of the mitochondrial uncoupling protein of Arabidopsis thaliana Plant Cell Physiol. 40 1160–1166 Occurrence Handle10635118
A. Watanabe A. Hirai (2002) ArticleTitleTwo uncoupling protein genes of rice (Oryza sativa L.): molecular study reveals the defects in the pre-mRNA processing for the heat-generating proteins of the subtropical cereal Planta 215 90–100 Occurrence Handle10.1007/s00425-001-0714-0 Occurrence Handle12012245
J. Y. H. Yip G. C. Vanlerberghe (2001) ArticleTitleMitochondrial alternative oxidase acts to dampen the generation of active oxygen species during a period of rapid respiration induced to support a high rate of nutrient uptake Physiol. Plant. 112 327–333 Occurrence Handle10.1034/j.1399-3054.2001.1120305.x Occurrence Handle11473689
D. B. Zhou T. Solomos (1998) ArticleTitleEffect of hypoxia on sugar accumulation, respiration, activities of amylase and starch phosphorylase, and induction of alternative oxidase and acid invertase during storage of potato tubers (Solanum tuberosum cultivar Russet Burbank) at 1°C Physiol. Plant. 104 255–265 Occurrence Handle10.1034/j.1399-3054.1998.1040214.x
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Borecký, J., Vercesi, A.E. Plant Uncoupling Mitochondrial Protein and Alternative Oxidase: Energy Metabolism and Stress. Biosci Rep 25, 271–286 (2005). https://doi.org/10.1007/s10540-005-2889-2
Issue Date:
DOI: https://doi.org/10.1007/s10540-005-2889-2