Abstract
Iron loaded persons are at increased risk for infection, neoplasia, arthropathy, cardiomyopathy and an array of endocrine and neurodegenerative diseases. This report summarizes evidence of increased risk of iron loading for osteoporosis. Iron suppresses bone remodeling apparently by decreasing osteoblast formation and new bone synthesis. Low molecular mass iron chelators as well as a natural protein iron chelator, lactoferrin, may be useful in prevention of osteoporosis.
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Angelopoulos NG, Goula AK, Papanikolaou G, Tolis G. (2006). Osteoporosis in HFE2 juvenile hemochromatosis. A case report and review of the literature. Osteoporosis Internat 17:150–155
Chan Y-L., Pang L-M, Chik K-W, Cheng JCY, Li C-K (2002). Patterns of bone disease in transfusion-dependent homozygous thalassemia major: predominance of osteoporosis and desferrioxamine-induced bone dysplasia. Ped Radiol 32:492–497
Chen CH, Ho ML, Chang JK, Hung SH, Wang GJ (2005). Green tea catechins enhances osteogenesis in a bone marrow mesenchymal stem cell line. Osteoporosis Internat 16:2039–2045
Cornish J, Callon KE, Naot D, Palmano KP, Banovic T, Bava U, et al. (2004). Lactoferrin is a potent regulator of bone cell activity and increases bone formation in vivo. Endocrinology 145:4366–4374
De Vernejoul MC, Pointillart A, Golenzer CC, Morieux C, Bielakoff J, Modrowski D, et al. (1984). Effects of iron overload on bone remodeling in pigs. Am J Pathol 116:377–384
Fausto A, Bongiovanni M, Cicconi P, Menicagli L, Ligabo EV, Meizi S, et al. 2006. Potential predictive factors of osteoporosis in HIV-positive subjects. Bone 38, in press
Guggenbuhl P, Deugnier Y, Boisdet JF, Rolland Y, Perdriger A, Pawlotsky Y, et al. (2005). Bone mineral density in men with genetic hemochromatosis and HFE gene mutation. Osteoporosis Internat 16:1809–1814
Lorget F, Clough J, Oliveira M, Daury M-C, Sabokbar A, Offord E. (2002). Lactoferrin reduces in vitro osteoclast differentiation and resorbing activity. Biochem Biophys Res Commun 296:261–266
Rollot F, Wechsler B, de Boutin LTH, de Gennes C, Amoura Z, Hachulla E, et al. (2005). Hemochromatosis and femoral head aseptic osteonecrosis: a nonfortuitous association?. J Rheumatol 32:376–378
Schnitzler CM, Schnaid E, MacPhail AP, Mesquita JM, Robson HJ. (2005). Ascorbic acid deficiency, iron overload and alcohol abuse underlie the severe osteoporosis in black African patients with hip fractures. Calcif Tissue Internat 76:79–89
Shah FT, Chatterjee R, Owusu-Asante M, Porter JB. 2004. Adults with severe sickle cell anaemia and iron overload have a high incidence of osteopenia and osteoporosis. Blood 104, Annual Meeting American Society for Hematology abstract 1684
Vogiatzi MG, Autio KA, Schneider R, Giardina PJ. (2004). Low bone mass in prepubertal children with Thalassemia major: insights into the pathogenesis of low bone mass in Thalassemia. J Ped Endocrinol & Metab 17:1415–1421
Weinberg, ED. 2006. Therapeutic potential of iron chelators in diseases associated with iron mismanagement. J Pharm Pharmacol 58, in press
Weinberg GA, Boelaert JR, Weinberg ED (2002). Iron and HIV infection. In: Friis H. (eds) CRC series in Modern Nutrition: Micronutrients & HIV Infection. CRC Press, Boca Raton, pp. 135–156
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Weinberg, E.D. Iron loading: a risk factor for osteoporosis. Biometals 19, 633–635 (2006). https://doi.org/10.1007/s10534-006-9000-8
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DOI: https://doi.org/10.1007/s10534-006-9000-8